Protein
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase
Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Function
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the sesquiterpene (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol via a putative 1,10-cyclization, which could require the abstraction of the pyrophosphate from FPP to yield the (E,E)-germacradienyl cation. The only accepted substrate is farnesyl diphosphate (FPP).
Similarity
Belongs to the terpene synthase family.
Sequence
MTSQASAPKIPQLWVPLPSGIHPSWREIDQGSAAWLDRFGLYSDHAQRERLTRISVGEITGRGGPDGRLAALQWTADFLMWLFAFDDEYCDEGPAAASPDATLLIITKLQRIVEVPWAAPADDNYSAALLELRLRLDDLTTPVQTARWAASFRAYLQGQIWMAANSTYGRIPTLSDHLAVRLDSSGVKIFSTLSEIIHGYDLPAADYDRHDVRGFVEVFAAIIGWSNDLVSYHKERRRSQDSYGNVVDLIAHERQCSVEEAVSETATMHTRAMALYLRLRDQILRDAEPELRKWITDCDSWIRADYDWSLTTHRYVNPDDPADLPVGSAEAPFRAREADQPLPIASVSWWWTLLKD