Segment-8

Gene

Segment-8

Protein

Non-structural protein NS2

Organism

Epizootic hemorrhagic disease virus 2 (strain Alberta)

Length

376 amino acids

Function

Single-stranded RNA-binding protein.

Similarity

Belongs to the orbivirus non-structural protein NS2 family.

Mass

43.615 kDa

Sequence

MEQKQRRFTKNVFVLDQKRKTICGQIAARQSLPYCQIKIGRNFALRAVATPEPKGYVLEICDVGAYRIQDGNDVISLMISADGVEGTQERWEEWKFESDLMRTNGHSSKYKRSVGRREIKVSKGMGIVPPYTRNDFDRRELPELPGVQRSKYDIRELRQKIREEREKGAVEQPHKPAFKTERGMNRPDSDEDQNPAGGVVNDWTCETQKRDQEAERREALEIRLADNDRESKHSNWIVRGRGKILKEVKNSFRTQEVERKKSDMGEVIIEEDDEDSEEEEGARASYITSAYIERISRIRKIKDERLSMLASMMPQQSGEYTTTLFIKKQKWDNVPLYLIDEMQKKYELQSVGSCERVAFVSKGTNLIILPVASNPR

Protein

Non-structural protein NS2: Segment-8

Gene

Segment-8

Protein

Non-structural protein NS2

Organism

African horse sickness virus 9

Length

365 amino acids

Function

Single-stranded RNA-binding protein.

Similarity

Belongs to the orbivirus non-structural protein NS2 family.

Mass

41.194 kDa

Sequence

MAEVRKQQQFTRSVCVLDLGQKTYCGKVVRAVDGVYYTIKIGRTVQCGVTPTPIPKSYVLEIRECGRYRIQDGTDVLSLMITESGIEVTQNRWEEWSFEALTPVPMAVAVNVGRGSFDTEIKYVRGSGAVPPYTKNGMDRRAMPSLPGITTLDVGVRDLRLKMRENREAEREKMERALSGGLDMGSCRMYGGGRNDVREITLDEAGPSRTPRKLSVQSNESRSDDVARRHAELVEMERLRIMKNEPVRTESMWCQSDSDDQSDEDHEVGGTEPENYITEEYTRRLNEVKTKYSKELSSLAMRVPKNEGNCGKPIFSKKCKWENVPIYNYDEASGNYRFVSVGSRTHYHCCANDLSYMILPAGGSG

Protein

Non-structural protein NS2: Segment-8

Gene

Segment-8

Protein

Non-structural protein NS2

Organism

Bluetongue virus 10 (isolate USA)

Length

357 amino acids

Function

Single-stranded RNA-binding protein.

Similarity

Belongs to the orbivirus non-structural protein NS2 family.

Mass

40.999 kDa

Sequence

MEQKQRRFTKNIFVLDVTAKTLCGAIAKLSSQPYCQIKIGRVVAFKPVKNPEPKGYVLNVPGPGAYRIQDGQDIISLMLTPHGVEATTERWEEWKFEGVSVTPMATRVQYNGVMVDAEIKYCKGMGIVQPYMRNDFDRNEMPDLPGVMRSNYDIRELRQKIKNERESAPRLQVHSVAPREESRWMDDDEAKVDDEAKEIVPGTSGLEKLREARSNVFKEVEAVINWNLDERDEGDRDERGDEEQVKTLSDDDDQGEDASDDEHPKTHITKEYIEKVAKQIKLKDERFMSLSSAMPQASGGFDRMIVTKKLKWQNVPLYCFDESLKRYELQCVGACERVAFVSKDMSLIICRSAFRRL

Protein

Non-structural protein NS2: Segment-8

Gene

Segment-8

Protein

Non-structural protein NS2

Organism

Bluetongue virus 1 (isolate South Africa)

Length

357 amino acids

Function

Single-stranded RNA-binding protein.

Similarity

Belongs to the orbivirus non-structural protein NS2 family.

Mass

41.289 kDa

Sequence

MEQKQRRFTKNIFVLDANGKTLCGRIAKLSSQPYCQIKIGRVIAFKPVKNPEPKGYVLNVPGPGAYRIQDGQDIISLMLTPHGVEATTERWEEWKFEGVSVTPMATRVQHNGVMVDAEIKYCKGMGIVQPYMRNDFDRNEMPDLPGVMRSNYDVRELRQKIQNERESAPRLQVQSVSPREESRWMDDDEAKVDEEAKEMIPGPSRLKKLREARSNVFKEVEAEINWNLDEKDEEDRDEREDEEQVKTLSDDDEQGEDASDDEHPKTHITKEYIEKVAKQIKLKDERFMSLSSAMPPASGGFDRMIVTKKLKWQNVPLYCFDESSKRYELQCVGACERVAFVSKDMSLIILRSAFRRL

Protein

Non-structural protein NS2: Segment-8

Gene

Segment-8

Protein

Non-structural protein NS2

Organism

Bluetongue virus 10

Length

357 amino acids

Function

Single-stranded RNA-binding protein.

Similarity

Belongs to the orbivirus non-structural protein NS2 family.

Mass

41.15 kDa

Sequence

MEQKQRRFTKNIFVLDANAKTLCGRIAKLSSQPYCQIKIGRVIAFKPVKNPEPKGYVLNVPGPGAYRIQDGQDIISLMLTPHGVEATTERWEEWKFEGVSVTPMATRVQHNGVMVDAEIKYCKGMGIVQPYMRNDFDRNEMPDLPGVMRSNYDIRELRQKIKNERESAPRLQVQSVAPREESRWMDDDEAKVDEEAREMIPGTSRLEKLREARSNVFKEVAAGINWNLDEKDEEDGDEREDEERVKTLSDDDEQGEDASDDEHPKTHITKEYVEKVAKQIKLKDERFMSLSSAMPQASGGFDRMIVTKKLKWQNVPLYCFDESSKRYELQCVGACERVAFVSKDMSLIILRSAFRRL

Protein

Non-structural protein NS2: Segment-8

Gene

Segment-8

Protein

Non-structural protein NS2

Organism

Bluetongue virus 17 (isolate USA)

Length

354 amino acids

Function

Single-stranded RNA-binding protein.

Mass

40.584 kDa

Sequence

MEQKQRRFTKNIFVLDITAKTLCGAIAKLSSQPYCQIKIGRVVAFKPVKNPEPKGYVLNVPGPGAYRIQDGQDIISLMLTPHGVEATTERWEEWKFEGVSVTPMATRVQYNGVMVDAEIKYCKGMGIVQPYMRNDFDRNEMPDLPGVMRSNYDIRELRQKIKNERESAPRLQVQSVASREESRWMDDDEAKVDNEAKEIIPGTSGLEKLREARSNVFKEVETVINWNLDERDEEDRDERGDEEQVKTLSDDDDQGEDASDDEHPKTHITKEYIEKVAKQIKLKDERFMSLSSAMPQASGGFDRMIVTKKLKWQNVPLYCFDESLKRYELQCVGACERVAFVSKDMSLIILPVGV

Protein

Non-structural protein NS2: Segment-8

Gene

Segment-8

Protein

Intermediate capsid protein VP8

Organism

Banna virus (strain Indonesia/JKT-6423/1980)

Length

302 amino acids

Function

Self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers, with channels at each of its five-fold vertices.

Mass

32.641 kDa

Sequence

MANRATSAFLDNPHPVGVNYVDEGSRQFVAVAELLASKLIASSRESDESNSDVPFVQAYSKFADDNPRHLRVKTGGKMANALTNVIRSYYSINAPAIVPQVEIDRLASKATVSGDMYNSYAVFNSVPIVEVLSPAQTTVSIVGSDRADVTMLNTGAGAANITFNFGQIAETVILKGSVPFQLARANQPMPAARFTYKLRPLDGPFIVVLPVGNPLVISATAATRIQVPLAFNKALVESGFQTAMNDGLFDAQNVNYYSSFDEFIIAQYHALDGINRVSTCVVLGLALQAYDQMRRALPVRRV

Protein

Intermediate capsid protein VP8: Segment-8

Gene

Segment-8

Protein

Matrix protein 1

Organism

Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99)

Length

234 amino acids

Function

May play a role in virus replication, from virus entry and uncoating to assembly and budding of the virus particle (PubMed:20979983). Interaction of viral NEP with M1-Hsc70 is thought to promote nuclear export of the viral encapsidated genomes (PubMed:28202040).

Mass

26.539 kDa

Sequence

MHERSKPKTTGADQTCLEEEKETRGGLRNGSSSDTGGRERTDRGVSCSRRKNCEGQNLEPIGERDDQSSDDDPLLCDERSTIGRHGNADERPHQELAEGGIRMPGRGWWRGKMGNGVWYDFTRHGRGEDDAEGAENNATQQDADVCSGCKFESPREFRKGHRRCSSSTSGILLDREDGASGVPEVSFKERMEAEKKKLKELDDKIYKLRRRLRKMEYKKMGINREIDKLEDSVQ

Protein

Matrix protein 1: Segment-8

Gene

Segment-8

Protein

Protein P7

Organism

Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99)

Length

183 amino acids

Function

May play a role in inhibition of the host immune system by counteracting the type I interferon response.

Mass

20.34 kDa

Sequence

MREANPKPRELIRHALKKKKRPEVVYAMGVLLTLGGESGLTVEFPVPEGKTVKVKTLNQLVNGMISRATMTLYCVMKDPPSGGMATLMRDHIRNWLKEESGCQDADGGEEKWAMVYGMISPDMAEEKTMLKELKTMLHSRMQMYALGASSKALENLEKAIVAAVHRLPASCSTEKMVLLGYLK

Protein

Protein P7: Segment-8