Protein
S-adenosylmethionine sensor upstream of mTORC1
Organism
Drosophila melanogaster
Function
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1 (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Similarity
Belongs to the BMT2 family.
Sequence
MATEEHQRLASIVKSCHESLRQLTKEYGATAAWQEHTSPRNAKQLAEYAKAMKQLAAIWETNDGKVELQARSRIKWAIDYITKYFFTEGIYLQKRQREQRLLESYRAEGKLGEVQCRLMEEPPDRLHVLDVGSCFNPFSSAPHLEVTALDLCPATEDVLQADFLKVEVVPGIREPELEEGSVRRLPASHYECVIFSLLLEYMPSAEQRLQCCLQAYDLLLPEGILVLITPDSQHVGKNAHLMKNWRYSLARIGLLRVRFEKLPHISCMVFRKAISRELSQHWASIHREEGMCEEIRIPQDDS