Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Function
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
Similarity
Belongs to the archease family.
Sequence
MTRFEFFDHTADIGIIAYGRSLEEAFESAALAVFEVMTDTSKIEYKVEVEIEEIGSDLENLLYRWIESLLVYYDSDLLLFGKFKVSIDLNNMTLKGKAYGEKFNPEKHERRTVVKAMTYHEMLISQNDGTYILRFVVDI