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SUZ12

Gene
Suz12
Protein
Polycomb protein Suz12
Organism
Mus musculus
Length
741 amino acids
Function
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.
Similarity
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
Mass
83.026 kDa
Sequence
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAAVAAAASGGKSGGGGCGGGGSYSASSSSAAAAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTSIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSQNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVSEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPVAKPLATRNSESLHQENKPGSVKPAQTIAVKETLTTELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESATPSNEEIAEEQNGTANGFSETNSKEKALETDGVSGVPKQSKKQKL

Gene
SUZ12
Protein
Polycomb protein SUZ12
Organism
Homo sapiens
Length
739 amino acids
Function
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Similarity
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
Mass
83.055 kDa
Sequence
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL

Gene
suz12
Protein
Polycomb protein suz12
Organism
Xenopus tropicalis
Length
700 amino acids
Function
Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (By similarity).
Similarity
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
Mass
80.365 kDa
Sequence
MAPQKHGGSSAPSGKPSAAASLLPVRKPKMEQIQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRSNAKRKTFKVNDLLLKVEKMKGDQESHSVSAHLQLTFTGFFHKIDKPSQNSENEQSSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPELNPAKPSTFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRQGRRDFNGLTNGETNENIDVSEEPPARRKRNSSNRDEGDKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEDCPVNKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTNDTPDKSTAPIAKPLATRNSESLPQEHKPSSVKPAQTVAVKESLSSDLQARKERDVSSEPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKMWNLHVMKHGFIADNQMNHGCMLFVDNYGPQIIQKNLCRNFMLHLVSMHDFNLISITTIDKAVSRLREIQQKVERDECLAPPSDEAFEEPNRTTSSSSSFMETNGKDRVVENDCVSGQPPKHSKKQKP