SUPV3L1

ATP-dependent RNA helicase SUPV3L1, mitochondrial

794 amino acids

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).

Belongs to the helicase family.

88.776 kDa

MRRCAWPLLRLSSRVGLALRHGGAVRLRQAAASSSSSSSGGGGLRAPDTSLFVPVPLKPVEGAAEEDVGAELTRPLDKGEVLKNLNKFYKRKEIQRLGTENGLDARLFHQAFISFRKYIMESSSVSADLHIILNDICCGAGHVDDLFPFFLRHAKQIFPMLDCMDDLRKISDLRLPPNWYPEARAIQRKIIFHAGPTNSGKTYHAIQRFLSAKSGIYCGPLKLLAHEIFQKSNAANVPCDLVTGEERVYASEDAKQASHIACTIEMCSTNTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEIHVCGEGAAIDLVTELMYTTGEEVEVRNYKRLTPLTVLDYALESLDNLQPGDCIVCFSKNDIYSVSRQIEARGLECAVIYGSLPPGTKLEQAKKFNDPNDPCKILVATDAIGMGLNLCIKRIIFNSIVKPTVNEKGEKEIDSITTSQALQIAGRAGRFGSSFKQGEVTAMHRDDLLQLKEILSEAVPPVKAAGLHPTPEQIEMFAYHLPDATLSNLIDIFVSLSQVDGLYFVCNIDDFKFLADMIQHIPLNLRSRYVFCTAPLNRKEPFVCTTLLKFARQFSRNEPLTFDWLCRHTKWPLAPPKNIKELVHLEAVHDVFDLYLWLSYRFMDMFPDAALVRDIQKKLDDIIQIGVCNITKLIRASQSGAAPGAAEVMSEGFPLSRTKRDARTVSDHRDAKSAEPLSIALEVPGERRAKSLRTYRSATRQEDLKSHGRGSLANRLLREGLLTQEMLRQLESEWQDQHRSGRYGLASKRNDQSSSKEMGKKKK

SUPV3L1

ATP-dependent RNA helicase SUPV3L1, mitochondrial

786 amino acids

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Belongs to the helicase family.

87.991 kDa

MSFSRALLWARLPAGRQAGHRAAICSALRPHFGPFPGVLGQVSVLATASSSASGGSKIPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKVLDKFYKRKEIQKLGADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDLRKISDLRIPPNWYPDARAMQRKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERVTVQPNGKQASHVSCTVEMCSVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDYKRLTPISVLDHALESLDNLRPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINEKGERELEPITTSQALQIAGRAGRFSSRFKEGEVTTMNHEDLSLLKEILKRPVDPIRAAGLHPTAEQIEMFAYHLPDATLSNLIDIFVDFSQVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQKELDGIIQDGVHNITKLIKMSETHKLLNLEGFPSGSQSRLSGTLKSQARRTRGTKALGSKATEPPSPDAGELSLASRLVQQGLLTPDMLKQLEKEWMTQQTEHNKEKTESGTHPKGTRRKKKEPDSD

Supv3l1

ATP-dependent RNA helicase SUPV3L1, mitochondrial

779 amino acids

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Belongs to the helicase family.

87.005 kDa

MSLPRCTLLWARLPAGRGAGPRAAPCSALRALVGSFPGASGRVPCLAASSSASGGSKAPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKILDKFYKRQEIQKLSADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFSAAHVDDLFPFFLRHAKQIFPVLECKDDLRKISDLRIPPNWYPEARARQRKIIFHSGPTNSGKTYHAIQRYLSATSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERLTVEPEGKQATHVSCTVEMCNVATPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGESAAINLVSELLYTTGEEVEVQKYERLTPISVLDHALESLDNLQPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQARKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINEKGEKELEPITTSQALQIAGRAGRFSSHFKEGQVTTMHRDDLALLKDILNRPVDPIQAAGLHPTAEQIEMFAYHLPETTLSNLIDIFVDFAQVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVFDLYLWLSYRFIDMFPDSSLVRSLQKELDAIIQEGVHNITKLIKISESRKLLNLESLPSGDQSRLSGASKSPARRTRGTKSAGNKATEPLSPSDKELPLASRLVQQGLLTADMLRQLQKEWLTQQPEHSREKVGTRRKKKDPDSD

Supv3l1

ATP-dependent RNA helicase SUPV3L1, mitochondrial

776 amino acids

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Belongs to the helicase family.

86.706 kDa

MSLPRCALLWARLPAGRGAGPRAAPCSALRALVGSFPGASGRVPCLAASSSASGGSKAPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKILDKFYKRQEIQKLSADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFSAAHVDDLFPFFLRHAKQIFPVLECKDDLRQISDLRRPPNWYPEARAIQRKIIFHSGPTNSGKTYHAIQRYLSATSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERLTVEPEGKQATHVSCTVEMCNVATPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGESAAIDLVTELLYTTGEEVEVQKYERLTPISVLDRALESLDNLRPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQARKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINEKGEKELEPITTSQALQIAGRAGRFSSHFKEGEVTTMHRDDLALLKEILNRPVDPIQAAGLHPTAEQIEMFAYHLPETTLSNLIDIFVDFAQVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVFDLYLWLSYRFIDMFPDSSFVRSLQKELDVIIQEGVHNITKLIKISESHKLLNLEPSGSQSRLPGASKSPARRTRGTKTGNKAAEPPSPSDKELPLASRLVQQGLLTADMLKQLQKEWLTQRPEQGKEKVGTRRKKKDPNSD

supv3l1

ATP-dependent RNA helicase SUPV3L1, mitochondrial

763 amino acids

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).

Belongs to the helicase family.

86.255 kDa

MSVNRCIYLLSRSHIRYRVCASTNLSTVSTLSTTQHSTRRTFDKLSTRHSSSGSSRPLDTSLFIPLPVKTDEDAEGSVGAELTKPLDKNELLKVLNRFYKRKEMQKLASDQGLDARLFHQAFVSFRKYVLEMNSLNADLHIILNDICCGAGHIDDIFPYFMRHAKQIFPMLDCIDDLRKISDLRVPANWYPEARAIQRKIVFHAGPTNSGKTYHAIKRYLEAKSGVYCGPLKLLAHEIYEKSNAAGVPCDLVTGEERIFVDPEGKPSGHIASTIEMCSVTTPYEVAVIDEIQMIKDPARGWAWTRALLGLCAEEIHVCGEAAAVDFITELMFTTGEEVEVHNYKRLTPFSISNHAVESLDNLKPGDCIVCFSKNDIYSISRQIEIRGLECAVIYGSLPPGTKLAQAKKFNDPDDPCKILVATDAIGMGLNLSIRRIIFNSLVKHSLNEKGEKEVDTISTSQALQIAGRAGRFSSVFKEGEVTTMHRDDLPVLKEILGKPVDPIATAGLHPTAEQIEMFAYHLPQATLSNLIDIFVSLSQVDGLYFVCNIDDFKFLADMIQHIPLNLRSRYVFCTAPINKKQPFVCTSFLKFARQFSRDEPLTFNWVCRQVNWPLSPPKNIKDLVHLEAVHDVLDLYLWLSYRFMDMFPDSNQIREIQKELDENIQIGVRNITRLIRAIDSQPTDTESNSSSTVPESETSQRKGRVLRSQNQRKELPRKSSLSSRLLRDGLLTKELLSQLQKEWAREQNEDNSIPVNNGKRKKK