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SULT1E1

Gene
SULT1E1
Protein
Estrogen sulfotransferase
Organism
Cavia porcellus
Length
296 amino acids
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol.
Similarity
Belongs to the sulfotransferase 1 family.
Mass
35.245 kDa
Sequence
MMDSSEHDYYEYFDEFRGILLYKQFIKYWDNVEAFQARPDDLVIAAYPKSGTTWISEVVCMIYAEGDVKKCRQDAIFNRVPFLECRNDKMMNGVKQLEEMNSPRIIKTHLPPRLLPASFWEKRCKMICICRNAKDVAVSYYYFFLMVANHPDPGSFPEFVEKFMQGQVPYGSWYDHVKSWWEKSTDPRILFIFYEDMKEDIRKEVLKLIHFLGRKPSEELVDKIIKHTSFQEMKNNPSTNYTMLPEEIMNQKVSPFMRKGISGDWKNHFTVALNESFDKHYQQQMKGSTLQLRTEI

Gene
SULT1E1
Protein
Estrogen sulfotransferase
Organism
Bos taurus
Length
295 amino acids
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol.
Similarity
Belongs to the sulfotransferase 1 family.
Mass
34.64 kDa
Sequence
MSSSKPSFSDYFGKLGGIPMYKKFIEQFHNVEEFEARPDDLVIVTYPKSGTTWLSEIICMIYNNGDVEKCKEDVIFNRVPYLECSTEHVMKGVKQLNEMASPRIVKSHLPVKLLPVSFWEKNCKIIYLSRNAKDVVVSYYFLILMVTAIPDPDSFQDFVEKFMDGEVPYGSWFEHTKSWWEKSKNPQVLFLFYEDMKENIRKEVMKLLEFLGRKASDELVDKIIKHTSFQEMKNNPSTNYTTLPDEVMNQKVSPFMRKGDVGDWKNHFTVALNEKFDMHYEQQMKGSTLKFRTKI

Gene
Sult1e1
Protein
Estrogen sulfotransferase, testis isoform
Organism
Mus musculus
Length
295 amino acids
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol.
Similarity
Belongs to the sulfotransferase 1 family.
Mass
35.59 kDa
Sequence
METSMPEYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIATYPKSGTTWISEVVYMIYKEGDVEKCKEDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKFRMEL

Gene
Sult1e1
Protein
Estrogen sulfotransferase, isoform 1
Organism
Rattus norvegicus
Length
295 amino acids
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol (By similarity).
Similarity
Belongs to the sulfotransferase 1 family.
Mass
35.509 kDa
Sequence
METSMPEYYEVFGDFHGFLMDKRFTKYWEDIETFLARPDDLLIVTYPKSGSTWISEIVDMIYKEGDVEKCKEDALFNRIPDLECRNEDLINGIKQLKEKESPRIVKTHLPAKLLPASFWEKNCKIIYLCRNAKDVVVSYYYFFLIMKSYPNPKSFSEFVEKFMEGQVPYGSWYDHVKSWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERDPSAELVDRIIQHTSFQEMKNNPCTNYSMLPETMIDLKVSPFMRKGIVGDWRNHFPEALRERFEEHYQRHMKDCPVKFRAEL

Gene
SULT1E1
Protein
Estrogen sulfotransferase
Organism
Homo sapiens
Length
294 amino acids
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.
Similarity
Belongs to the sulfotransferase 1 family.
Mass
35.126 kDa
Sequence
MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRTEI