Protein
Sulfotransferase 1A1
Organism
Macaca fascicularis
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity).
Similarity
Belongs to the sulfotransferase 1 family.
Sequence
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFRARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCRRAPIFMRVPFLEFKVPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSHTHPVLYLFYEDMKENPKREIWKILEFVGRSLPEETVDLMVQHTSFKEMKKNPMANYTTIPQELMDHSISPFMRKGMTGDWKTTFTVAQNEHFDVDYAEKMAGCSLSFRSEL