Protein
ATP-dependent RNA helicase SUB2-1
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Function
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).
Similarity
Belongs to the DEAD box helicase family. DECD subfamily.
Sequence
MSHEGEEDLLEYSDNEQDIQVDASKAAEPSELDATTAEDASNGDAEKKGSYVGIHSTGFKDFLLKPELARAIIDCGFEHPSEVQQHTIPQSIHGTDVLCQAKSGLGKTAVFVLSTLQQLDPVPGEVSVVVICNARELAYQIRNEYLRFSKYMPDVKTAVFYGGTPINKDAELLKNKETAPHIVVATPGRLKALVRDKLIDLSHVKNFVIDECDKVLEELDMRRDVQDIFRATPRDKQVMMFSATLSEEIRPICRRFLQNPLEIFVDDEAKLTLHGLQQYYTKLQENEKNRKLAQLLDDLEFNQVIIFVKSTKRANELTKLLNESNFPAITVHGHMKQAERIARYKAFKEFEKRICVSTDVFGRGIDIERINLAINYDLTTEADQYLHRVGRAGRFGTKGLAISFVSSPEDEEVLGKIQERFDVKIAEFPEEGIDPSTYLNN