Protein
Tsukubadiene synthase
Organism
Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 / 9993)
Function
Catalyzes the formation of the 5-9-5 ring skeleton (3S,6S,11R,14S)-tsukubadiene from geranylgeranyl diphosphate (GGPP) via a 1,11-cyclization and a 10Re,14Re-cyclization.
Similarity
Belongs to the terpene synthase family.
Sequence
MIEVPPFWCPLPIAIHPAADQAEKDARAWAERYGVRLRIADQVQPGRLGAYWAPHGTYEGMLAVGCWNFWAFAFDDHLDEPLPLDVPVTTSLVQQAVDIPSPPITDDPWAAGAQAVFNMFRDLATPTQVRYCADNHRRWLHGACWRHSNHVNRRLPPLAEYIPLRMQDAAAQATCLIAVLIGSDISVPEQEMDSPRVRALLETASWTATIDSDLHSFQLEDTQRPVSQHIVSVLMHERGIGVDEALRQSVALRDRFMTRFLHLQQECARTGSSELARFAHTLGYVISGYLQWAVDTSRYGQTEATFSFTDTPRDDTPEPPPGIPSVEWLWTL