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STAT2

Gene
Stat2
Protein
Signal transducer and activator of transcription 2
Organism
Mus musculus
Length
923 amino acids
Function
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.
Similarity
Belongs to the transcription factor STAT family.
Mass
105.417 kDa
Sequence
MAQWEMLQNLDSPFLDQLHQVYSQSFLPMDFRQHLASWIEDQNWREAALESDDAKANMLYFSILDQLNQWDHYSSDPKSLLLQHNLRKFSRDIQPFPNGPSQLAEMIFNLLLEEQRILIQAQRAQEVQPPPAPEAVVESQQLEIENRIQGLHVDIEFLVRSIRQLKDEQDVFSFRYTVFSLKKTSSSDPHQSQQAHVVQATANKVDRMRKEVLDISKGLVGRLTTLVDLLLPKLDEWKVQQQKSCIGAPPPVKSAAEQLEQWLTAGAKFLFHLRQLLKQLKEMSCLRYQGDMFAKGVDLRNAQVMELLQRLLQRSFVVETQPCMPQTLHRPLILKTGNKFTVRTRLLVRLQEGSESLKAEVSVDRNSDLPGFRKFNILTSNQKTLTPEKGQRQGLIWDFGFLTLVEQRAVGAGKGNNKGPLAVTEELHVISFVVEYTYQGLKMKLQTDTLPVVIISNMNQLSFAWASILWFNMLSPNPKNQQFFCQAPKAPWSLLGPVLSWQFSSYVARGLDSEQLGMLRTKLFGKSCKMEDALLSWVDFCKRESPPGKIPFWTWLDKILELVHDHLKDLWKDGRIMGFVSRNQERRLLKKMLSGTFLLRFSETSEGGITCSWVEHQDDHKVEIYSVQPYTKEVLQSLPLTEIIRHYQVLAEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLEEQEEYLKHKLIVISNRQVDELQQPLELKQDSESLEVNAELLLAHDQELPLMMQTGLVLGTELKVDPILSTAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVQLEPAPQVLLELAPQVLLEPAPQVLLELAPQVQLEPAHLLQQPSESDLPEDLQQISVEDLKKLSNPSTEYITTNENPMLAGESSGDETSIPYHSHFDADGLLGWTLDTF

Gene
STAT2
Protein
Signal transducer and activator of transcription 2
Organism
Sus scrofa
Length
864 amino acids
Function
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.
Similarity
Belongs to the transcription factor STAT family.
Mass
99.061 kDa
Sequence
MAQWEMLQNLDSPFQDQLHQLYSESLLPVDVRQYLAVWIEDQNWQEAALGNDDSKANMLFFHFLDQLNYDCGRCGQDPECLLLQHNLRKFYRDIQAIPQGPTRLAEMIFNLLLEEKRILIQAQRAQLEQQEPALEAPGENQQHEIESRILELRAMMEKLVKSISQLKDQQDIFCFRYKIKASAKTHSLDPHRTRQEQVLQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKVQQQKACIGAPMDGELEQLEKWFTAEAKLLFHLRQLLKELKGLSSVVKYDEDLLFKGVDLLKAQVTELLQRLLHRAFIVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTAEVSIDRNPPKSQGFRKFNILTSNRKTLTPEKGQSQGLIWDFGYLTLMEQRSGGAGKGNNKGPLGVTEELHIISFTVKYTYQGLKQELTTDTLPVVIISNMNQLSIAWASILWFNLLSSDPQNQQFFSSPPKAPWNLLGPALSWQFSSHVGQGLNSDQLGMLRDKLFGQNSSTEGLSLSWVDFIKRESPPGKLPFWTWLDKILDLVHDHLKDLWKDGHIMGFVSRSEERRLLKKTISGTFLLRFSETLEGGITCSWVEHQDDDKVLIYSLQPFTKEVLQSLPLTKIISQYQLLTEENIPENPLRFLYPRIPRDEAFGCYNQEKANLQERKKYLKHKLIVVSNRQVDELQQPPELKLEPDLESLELDLGLAPGPEPGVGLDLEPLLEAGLDLGPELEPMLQSTLEPVLEPILDEVLQGVPEPNLGPELKLEPILEPVSQPVPEPDLPHDLRHLNTDEMQIFRNSMRIEEIMPNGDPLLASQNTNVDEACVFHRSHFYTDGPLIPSDY

Gene
STAT2
Protein
Signal transducer and activator of transcription 2
Organism
Homo sapiens
Length
851 amino acids
Function
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).
Similarity
Belongs to the transcription factor STAT family.
Mass
97.916 kDa
Sequence
MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLFFHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQPFSQDPTQLAEMIFNLLLEEKRILIQAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYKIQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLTKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSGTFLLRFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLQERRKYLKHRLIVVSNRQVDELQQPLELKPEPELESLELELGLVPEPELSLDLEPLLKAGLDLGPELESVLESTLEPVIEPTLCMVSQTVPEPDQGPVSQPVPEPDLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEVYVSRPSHFYTDGPLMPSDF