STAM2

Signal transducing adapter molecule 2

525 amino acids

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Belongs to the STAM family.

58.164 kDa

MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL

Stam2

Signal transducing adapter molecule 2

523 amino acids

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Belongs to the STAM family.

57.455 kDa

MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDRVGSTPSGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRSVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGVTFPSAGSQTVAAAAKNGTSLNKNKEDEDIAKAIELSLQEQKQQYTETKALYPPAESQLNNKAARRVRALYDFEAVEDNELTFKHGELITVLDDSDANWWQGENHRGTGLFPSNFVTTDLSTEVETATVDKLNVIDDDVEEIKKSEPEPVYIDEGKMDRALQILQSIDPKESKPDSQDLLDLEDVCQQMGPMIDEKLEEIDRKHSELSELNVKVLEALDLYNKLVNEAPVYSVYSKLHPAHYPPAAAGVPVQTYPVQSHGGNYLGHGIHQVSVAQNYNLGPDPMGSLRSLPPNMNSVTAHTVQPPYLSTGQDTVSNPSYMNQSSRLQAAAGTAAYTQPVGMSTDVSSFQNTASGLPQLAGFPVAVPAPVAAQPQASYHQQPLL

Stam2

Signal transducing adapter molecule 2

523 amino acids

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Belongs to the STAM family.

57.159 kDa

MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDRVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKAMKEEGVTFPSAGSQTVSAAAKNGASLNKNKEDEDIAKAIELSLQEQKQQYPETKALCPPAESQLSNKVARRVRALYDFEAVEDNELTFKHGEIITVLDDSDANWWEGENHRGAGLFPSSFVTTDLSTEVEAATVDKSNVIDDDVEEIKKSEPEPVYIDEGKMDRALQILQSIDPKDPKPDSQDLLDLEDICQQMGPMIDEKLEEIDRRHSELSELNVKVLEALELYNKLVNEAPMYSVYSKLHPAPYSATAAGVPVQTYPVQSHGGNYLGHGIHQVPVAQSYNLGPDPMGSSRSLPPNMNSVTAHTIQPPYLSTGQDAVSNPSYMTQSSHLQAAAGTAAYTPAMGVSADLSSFQSTASGLPQLAGFPVAVPVPPAPQPQASYHQQPLL

STAM2

Signal transducing adapter molecule 2

468 amino acids

Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Belongs to the STAM family.

52.407 kDa

MPLSASNPFEQDVEKATNEHNNSEDWGLIMDICDKVGSTPNGAKDCLKAIMRRVNHKVPHVALQALTLLGACVSNCGRIFHLEVCSRDFATEARGIINKAHGKVSEKLKTLMVEWSEEFQKDPQCSLISATIKSLKEEGVTFPAAGSQATTNAAKNGSSLSKNKEDEDIRKAIELSLQEQKQQQMETKSLYPSAEIQQTNQNLRKVRALYDFEAVEDNELTFKSGEIIFVLDDSDTDWWKGENHRGVGLFPSNFVTSDLNVEPEAATVDNSCVPEDATEEIKKAEPEAVYIDEDKMDKTLQVLQSIDPTDLNLDTDLLDSEVICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLMNETPMYSAYSKLHHPAQYPPTSSGVSVQSYPVQPPSGNYMIQGVHQVTVSQGYGLGPDQMGQLRSLPQNINSSDCNLYTKSNRQRMCHMKAITTWQRFSKHTSER