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STAC

Gene
stac
Protein
Protein unc-13 homolog 4B
Organism
Drosophila melanogaster
Length
1153 amino acids
Function
Essential for tracheal development in embryos. Functions with the GTPase Rab39 and downstream of dnd, to regulate lumen fusion between previously separate tracheal branches (anastomosis). Essential component of secretory lysosome-related organelles (SLs) that are present in the tracheal fusion tip cells (FCs). Mediates intracellular fusion of the extending tracheal stalk cell lumen in the FCs by recruiting the SNARE complex component Syx1A to the SLs, this may then enable the SLs to interact with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells. May also function in the maturation and exocytosis of the SLs.
Similarity
Belongs to the unc-13 family.
Mass
131.921 kDa
Sequence
MDEEQMWKGFFFKLQELKMNPPTEHEHQLQDGDDGFFEKFGSLLRQKSQIDEGVLKSSLAPLEENGSGGEEDSDESPDGTLQLSQDSECTSIDTFATESTLASSSDKDISTSVLDSAPVMNVTDLYEEILFEIFNNIGCENNEECTNSLVEFVQDAFKIPNATHEEIYEAARLKEPPNVRLNVEIIKAENLMSKDSNGLSDPFVTLYLESNGSHRYNSSVKPATLNPIWEEHFSLPITENARDEVLIVEVWDFDAAETVKEKVNKILDVKGVKGLSKLMKEIAVTASSGKHDNELIGRAAITLKSIPVSGLTVWYNLEKGSKGRSRGSLLVNLALSAEKNKSVAVQEHKNLLKLLLMYELETSQVANYWWSGKFSPNAELIRSQHAAQSGLTPFDCALSQWHAYSTIHETHKLNFTLFNSILDVVVPVITYMQNDSEDVKTFWDGVKRLLPSCFAVLRKLRSKNTSDKNIIRALNEVLDILKKIKELEVPESVDIFPKSVYGWLHTNDTDETCNIDTAIEDAINTGTREWLEHIVEGSRQSKNTETDDEKLQYVIKLIQMVRSDLQRAMEYFDKIFYHKIQLNYSAVLYLFYDSKLAEICKSIIIEVCNNIKRLDVPDDQFEYLPNLENVNMGTTLFEVYLILKRYVQLGESLCSEPLELSNFYPWFERGVTHWLDISIIKALSRIQKAIDLDQLKAVDETVKYSSSAVDTLSIFYQIKIFWQQLDWPEVEGSYIFVAKIVNDLCRCCIFYAQQMSRRVENIFIADDNNKNFILSEEWCIAINNMDYIRQSLPSFIKELSIDDIIKRLGEYRTNLEAERCASTIKTVIENALDTERNQIVELIEIVARKMAPPIRRYLAEGAEVLAKDSNSMDQLMMYLESSLATLYDTLNEINFQRILDGIWSELSIIMYDLIQSNLDKRRPPAFFQNLNNTLQTMMDCFKMGNLQTSDIKILSSIQSRLRLYSLETSDLIHQYYLERLENQKSQESSPYGQLTITAQLTDTGLLLNILNARNLLPMDSNGSVDSFVKASFMPTSRFNDVPTVKTNVHNKSCFPLYDQEFRINLSDHQRSEKNSLIVFSIKDKDLFGMSSQYIAESYISFADLEATPPGEQIMMNLSRPEYTDSESLRALEYRLGDKQAKDFLKKLKNRSFS

Gene
STAC
Protein
SH3 and cysteine-rich domain-containing protein
Organism
Bos taurus
Length
403 amino acids
Function
Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.
Mass
44.487 kDa
Sequence
MIPPSGAREDGVDGLPKETASAEQPPSPASTGSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSDVKLQADVLAGVSPGSSPLPAPGSLTCTPTRAGLYPGGGGKAHAFQEHIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCMDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKSSSGSGSDSPHRTSTSDLVEVPEEADGPGDGYDLRKRSNSVFTYPENGTDDFRDQAKNINHQGPLSKDPLQMNTYVALYKFVPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRIGFFPANFVQRVHQNEKIFRCVRTFSGCKEQGQITLKENQICVASEEEQDGFIRVLSGKKRGLVPLDVLENI

Gene
Stac
Protein
SH3 and cysteine-rich domain-containing protein
Organism
Mus musculus
Length
403 amino acids
Function
Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity (PubMed:27149520). Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163). Slows the rate of calcium-mediated inactivation of CACNA1C calcium channel activity (PubMed:29363593).
Mass
44.319 kDa
Sequence
MIPPSGAREDSGDGLTGEATGTEQPPSPASTSSLESKLQKLKRSLSFKTKSLRSKSADNFFPRTNSDVKPQADLLAKASPGPSPIAIPGSPASMPTKAGLHPGSNSKLHAFQEHVFKKPTFCDVCNHMIVGTHAKHGLRCGACKMSIHHKCADGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYEALRFGTSLAQRTKKGGSGSGSDSPPRTSTSELVDVPEEADGPGDGSDMRTRSNSVFTYPENGMDDFRDQMKTTNHQGPLSKDPLQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRVGFFPANFVQRVEEHEKIYRCVRTFIGCKDQGQITLKENQICVTSEEEQDGFIRVLSGKKRGLVPLDVLVDV

Gene
STAC
Protein
SH3 and cysteine-rich domain-containing protein
Organism
Homo sapiens
Length
402 amino acids
Function
Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.
Mass
44.554 kDa
Sequence
MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI