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SSQG_00965

Gene
SSQG_00965
Protein
(-)-alpha-amorphene synthase ((2E,6E)-farnesyl diphosphate cyclizing)
Organism
Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494)
Length
338 amino acids
Function
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene (1R,6S,7S)-(-)-alpha-amorphene via a probable 1,6-cyclization, which could involve the abstraction of the pyrophosphate from FPP to yield a (R)-bisabolyl cation (PubMed:23307484, PubMed:27666571, PubMed:27829890). The only accepted substrate is (2E,6E)-farnesyl diphosphate (FPP) (PubMed:27829890).
Similarity
Belongs to the terpene synthase family.
Mass
37.003 kDa
Sequence
MAKMSTTHEEIALAGPDGIPAVDLRDLIDAQLYMPFPFERNPHASEAAAGVDHWLSTWGLTDDPAVAAMISCTRPAELAAFNGPDMDSGLLQIAANQIAYQFVFDDRAEDIGRHSPGRLLPMLSESVAILRDGQPPTTPLGAALADLHRQVQERCTPAQAARWAWNSREYVHGLLYEAVAQAHPAPVESGLCRSIRSLIAGVEPFYPLCEAAQRCELAPEELHHPAMRRLSRLSADAAVWIPDLFSAVKEQRAGGMINLALAYRRTHRCSLPAAVTLAVRHINSTIREFEDLYGEVRPELSPSGIGYVEGMAGWIRGCYFWSRTVPRYADTLTAPAGL