SSL5

Protein STRICTOSIDINE SYNTHASE-LIKE 5

371 amino acids

Belongs to the strictosidine synthase family.

41.642 kDa

MPMFYSSRFLFFFTIVPLLVSIALYQLDTFDPAPVPSEAYASSTTSIPPLISDKYLTGAEFIGVGLLDKPEDIAYHQDSNLIYTGCIDGWVKRVSVHDSANDSVVEDWVNTGGRPLGIAFGVHGEVIVADAYKGLLNISGDGKKTELLTDQAEGVKFKLTDVVAVADNGVLYFTDASYKYTLHQVKFDILEGKPHGRLMSFDPTTRVTRVLLKDLYFANGVSMSPDQTHLIFCETPMRRCSKYYINEERVEVFIQGLPGYPDNIRYDGDGHYWIAMVSGASTLWRLSMKYPFLRKITAIAAKYGVELMFMKNAGVLQVDLDGNPIAYYHDQRLSHITTGIKIGNYLYCGNILHSYIIRLDLLKYPAQKKKL

ssl5

Staphylococcal superantigen-like 5

234 amino acids

Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection (PubMed:17132726). Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity (PubMed:20479083, PubMed:29462623, PubMed:29328525). Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation (PubMed:21552524).

Belongs to the staphylococcal/streptococcal toxin family.

27.17 kDa

MKMTAIAKASLALGILATGTITSLHQTVNASEHKAKYENVTKDIFDLRDYYSGASKELKNVTGYRYSKGGKHYLIFDKNRKFTRVQIFGKDIERFKARKNPGLDIFVVKEAENRNGTVFSYGGVTKKNQDAYYDYINAPRFQIKRDEGDGIATYGRVHYIYKEEISLKELDFKLRQYLIQNFDLYKKFPKDSKIKVIMKDGGYYTFELNKKLQTNRMSDVIDGRNIEKIEANIR

ssl5

Staphylococcal superantigen-like 5

234 amino acids

Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation.

Belongs to the staphylococcal/streptococcal toxin family.

27.17 kDa

MKMTAIAKASLALGILATGTITSLHQTVNASEHKAKYENVTKDIFDLRDYYSGASKELKNVTGYRYSKGGKHYLIFDKNRKFTRVQIFGKDIERFKARKNPGLDIFVVKEAENRNGTVFSYGGVTKKNQDAYYDYINAPRFQIKRDEGDGIATYGRVHYIYKEEISLKELDFKLRQYLIQNFDLYKKFPKDSKIKVIMKDGGYYTFELNKKLQTNRMSDVIDGRNIEKIEANIR