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SSL1

Gene
SSL1
Protein
General transcription and DNA repair factor IIH subunit SSL1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
461 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the GTF2H2 family.
Mass
52.29 kDa
Sequence
MAPVVISESEEDEDRVAITRRTKRQVHFDGEGDDRVDQQQQQHSSSHRDRDKHVQRKKKKRLSNRNLQGSNGGYAWEDEIKRSWDLVKVDDEGDMASLVASIVEARKKRTAKKNITPYQRGIIRSLILTLDCSEAMLEKDLRPNRHAMIIQYAIDFVHEFFDQNPISQMGIIIMRNGLAQLVSQVSGNPQDHIDALKSIRKQEPKGNPSLQNALEMARGLLLPVPAHCTREVLIVFGSLSTTDPGDIHQTIDSLVSEKIRVKVLGLSAQVAICKELCKATNYGDESFYKILLDETHLKELFNEAVTPLPVNKINKGFTLVKMGFPTRIFEDTPTFCSCHSKLVYGGYFCPNCHSKVCSLPTVCPCCDLMLILSTHLARSYHHLMPLKTFAEVPTTEKFRSEDCFSCQSRFPILKNHKNGKLLTSSRYRCEDCKQEFCVDCDVFIHEILHNCPGCESKPVIT

Gene
ssl1
Protein
General transcription and DNA repair factor IIH subunit ssl1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
421 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the GTF2H2 family.
Mass
47.067 kDa
Sequence
MNENQKSFDSDKSESEDEQKNGRVKVRSRKTDDNEGYTWEGEYQRSWDIVQEDAEGSLVGVIAGLIQSGKRKRLLRDTTPLQRGIIRHMVLVLDLSNSMEERDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAHRITDLHGNPQSHIQKLKSLRDCSGNFSLQNALEMARASLSHIASHGTREVLIIFGSILSSDPGDIFKTIDALVHDSIRVRIVGLAAEVAICKEICNKTNSSTKNAYGVVISEQHFRELLLESTIPPATDSAKTTDASLVMMGFPSKVVEQLPSLCACHSIPSRGGFHCPRCKAKVCTLPIECPSCSLVLILSTHLARSYHHLFPLKNWSEIPWSANPKSTHCFACQLPFPKPPVSPFDESTSSMRYACPSCKNHFCLDCDVFAHEQLHECYGCQCSGN

Gene
SSL1
Protein
Protein STRICTOSIDINE SYNTHASE-LIKE 1
Organism
Arabidopsis thaliana
Length
394 amino acids
Similarity
Belongs to the strictosidine synthase family.
Mass
44.391 kDa
Sequence
MESLLLIAYAFLYLFLLSHEAEYKINADQSENSNVGRFGGNYGRLGRLSGSIHHWTGEYRGLEKRPNHSEDNPPSRGWTGEPGLDPRGEGPYVGVTDGRILKWSGEDLGWIEFAYSSPHRKNCSSHKVEPACGRPLGLSFEKKSGDLYFCDGYLGVMKVGPKGGLAEKVVDEVEGQKVMFANQMDIDEEEDAIYFNDSSDTYHFGDVFYAFLCGEKTGRAIRYDKKTKEAKVIMDRLHFPNGLALSIDGSFVLSCEVPTQLVHRYWAKGPNAGTRDIFAKLPGYADNIRRTETGDFWVALHSKKTPFSRLSMIHPWVGKFFIKTLKMELLVFLFEGGKPHAVAVKLSGKTGEIMEILEDSEGKNMKFISEVQERDGRLWFGSVFLPSVWVLDRQ

Gene
ssl1
Protein
Staphylococcal superantigen-like 1
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
226 amino acids
Function
Mediates virulence by proteolytically cleaving host proteins, including collagens types I and IV as well as human cytokines IL8, IL17A, and IFN-gamma.
Similarity
Belongs to the staphylococcal/streptococcal toxin family.
Mass
25.647 kDa
Sequence
MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFKYTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVTKSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNGLKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK

Gene
ssl1
Protein
Staphylococcal superantigen-like 1
Organism
Staphylococcus aureus (strain Newman)
Length
226 amino acids
Function
Mediates virulence by proteolytically cleaving host proteins, including collagens types I and IV as well as human cytokines IL8, IL17A, and IFN-gamma.
Similarity
Belongs to the staphylococcal/streptococcal toxin family.
Mass
25.647 kDa
Sequence
MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFKYTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVTKSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNGLKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK