SSK1

Osmolarity two-component system protein SSK1

712 amino acids

Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, maintained in a phosphorylated and inactive state by the phosphorelay intermediate protein YPD1. Under conditions of high osmolarity, the histidine kinase SLN1 is no longer active and the unphosphorylated form of SSK1 interacts with and activates SSK2 and SSK22, two MAPKKKs that further stimulate the PBS2-HOG1 MAPKK-MAPK cascade. Unphosphorylated SSK1 is subsequently degraded by the UBC7-dependent ubiquitin-proteasome system to down-regulate the HOG1 pathway after completion of the osmotic adaptation.

78.529 kDa

MLNSALLWKVWLRIDNSTDEVNQPIAVQFDEIDTVDDLKSRFFQKLSSTRWREINDNASIAIGLYAPKFDNQADNTSSNNTNDNSCRSKSNGAGSGANLSVNSNTKSSVSPTAGSFGLSKDLAKDRNVLQHPKPTQKRGALYDAFAAVPTVAATTNVDFPPNEAPMLSPQRPYSTSPKQFPATTKSPLLRFASVSPYPKFHSDNQIMASAGLTYVSPHNKNKYTRPLIRKGLNFTTESVNDCTYKIIFEPDELAINIYKELFGTMGSQPASQPLLIFSNVNLRQDVPPLDILNVVDYVPTNEEISQQKTQPTDHGAVGVFHLDDHISPGEQGLKQTIGDKADLKGKDGNSSPQEFKLITDEEQLRRASQELKDEEKDAESPWQAILLLPKGYKGGVDFRNKPVAHTDSSFNNEDTITHSELEVNTGSPSQESGSLNEAGIGITQPMSEVQRRKEDVTPASPILTSSQTPHYSNSLYNAPFAVSSPPDPLPNLFTTTSEKVFPKINVLIVEDNVINQAILGSFLRKHKISYKLAKNGQEAVNIWKEGGLHLIFMDLQLPVLSGIEAAKQIRDFEKQNGIGIQKSLNNSHSNLEKGTSKRFSQAPVIIVALTASNSQMDKRKALLSGCNDYLTKPVNLHWLSKKITEWGCMQALIDFDSWKQGESRMTDSVLVKSPQKPIAPSNPHSFKQATSMTPTHSPVRKNSNLSPTQIEL

SSK1

Oxidative stress response two-component system protein SSK1

674 amino acids

Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to oxidative stress and probably also to the osmolarity of the extracellular environment. Involved in cell wall biosynthesis, hyphal growth, and virulence. Regulates the expression of CHK1, as well as of a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Provides at least partial adaptive functions for the survival following encounter with human neutrophils.

73.56 kDa

MNFLYNNSDYSSTSHTMKSPSAYNQFPKLQASNSTAGNNNTATTATAAAAAASASASASVTPQLISPTTLTTPQNKYKRGGLDNTLPKIETTRKNRPDDGNSITPSNSINSGTTKLTLPPRRVWVKKPQTNNPTTVLCYVNDIIDDLKVAVVNKYPNTIGRYEDAADLLVKIDLNNIRVPVSPSVNRVSQRTPFDNCIILEPDQNVWQILDNYFPNGMAMHDALIIETPTFKPDHQMLTPITANMNNNSNTFIPFQERQSSIGNNNNNNSNVNNNNKAQAVKHPQPMQPNNTRVGLHKSYAMNRSSFSTNNNPVPSIIKDRSVSPSNLGVSRNSPVSHKRSYSNPVSSPNSVATQANNPSAVLLLPRNFSLANNNSNQASQSSGGTPAKKVLSEDGSKSVNDKTEEVVSSKLKPNDNNKSYQAKQQEQQTAEQSENGFSETSASPEAVHNSKAAPLPLTKSSTTATTTSSNSISNNNNTSSKGKPSQSKLKAANDPTPTDIVLPSISVLVVEDNAINQAILGAFLRKRKIHYQIAKNGQEAIDKWKKGGFHLVLMDIQLPVKSGIEATKEIRHLEKLNRIGVFHENEIGKNVIINEEDRLTSNTFRSPVIIVALTASSNSSVDKTNALTAGCNDYLTKPVNLVWLQNKITEWGCMQALIDFDGWKDKNRRLNKA