SRB4

Mediator of RNA polymerase II transcription subunit 17

691 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

78.12 kDa

MSNSFTLPLRPARQKANREDDLAVKIAQINAQKGSFRDVTEASLLAEIEAARAVGDGEAEAVDVKTGEDEEENREEKLFKSRLEISQFAMNAHMEATYALEFVSLLLSKHAPRQAETSMSPLLKQKVPLGSLGADHIKPPEQSETQKRDVDAVSRGWKLESFDAAANKLLQSAQRLEEDIAAETKYWSEVLKIKEKGWKVCRLPQERQTLGVHFGFLESTQNFRDRGLAALRKGEAGRLILDRGIQLKPPRFVRVRVQRGDQTLGLTIPAISKQLDDQCLDGRIREARDSLYEEELFYELNREARVLLQYGVEIRRDLLKFPADDNKHIFVDLVGLDEALPDIGGLDPLDNLLAEGVAKSFRILLSYAHRKNHHRRTRVPPPVTPNKRPAPEYNIIRPLLCYFQHRSHYQWFTSFFGTLSKTLRSAGLKCSYTLYPLMKRPQSRAGSSQQTLTVSSVERLIDTLINPSESIISCNLISQGSVFRVRITTNVNPNGLGSEFELVTNLAHFPAQQSPFRFGLREDVRDLIIHLFTLDLVYLVPSLVKGSASAGASQYLISRYTGSQAFVEEESTDENEFAPSPAAKQDDVYLLPWQPTFPQQGELTAYSPARCRTKKLQIQLQSDQLQLRCFWVRHRGPSTKADEQPGERLFTWRAVDMLGGAEESSRPTLQRVMELLGEKYDDQTVQNIGSK

SRB4

Mediator of RNA polymerase II transcription subunit 17

687 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.

Belongs to the Mediator complex subunit 17 family.

78.476 kDa

MTTEDPDSNHLSSETGIKLALDPNLITLALSSNPNSSLHSPTSDEPVPESAGKADTSIRLEGDELENKTKKDNDKNLKFLKNKDSLVSNPHEIYGSMPLEQLIPIILRQRGPGFKFVDLNEKELQNEIKQLGSDSSDGHNSEKKDTDGADENVQIGEDFMEVDYEDKDNPVDSRNETDHKTNENGETDDNIETVMTQEQFVKRRRDMLEHINLAMNESSLALEFVSLLLSSVKESTGMSSMSPFLRKVVKPSSLNSDKIPYVAPTKKEYIELDILNKGWKLQSLNESKDLLRASFNKLSSILQNEHDYWNKIMQSISNKDVIFKIRDRTSGQKLLAIKYGYEDSGSTYKHDRGIANIRNNIESQNLDLIPHSSSVFKGTDFVHSVKKFLRVRIFTKIESEDDYILSGESVMDRDSESEEAETKDIRKQIQLLKKIIFEKELMYQIKKECALLISYGVSIENENKVIIELPNEKFEIELLSLDDDSIVNHEQDLPKINDKRANLMLVMLRLLLVVIFKKTLRSRISSPHGLINLNVDDDILIIRPILGKVRFANYKLLLKKIIKDYVLDIVPGSSITETEVEREQPQENKNIDDENITKLNKEIRAFDKLLNIPRRELKINLPLTEHKSPNLSLMLESPNYCNALIHIKFSAGTEANAVSFDTTFSDFKEVEDFLHFIVAEYIQQKKV

SRB4

Mediator of RNA polymerase II transcription subunit 17

676 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

76.905 kDa

MTQLTENTDELHSIRLAIDPNLITLPIGSKSTSPHSNSTSDGNPESHNTENEEVDNKAGSLPPEQFSNNSAKLIVNPYEKYGRMSLGQLIPLISQQRGPNFKFADINEDILKQELAIENDNGKQESKDDTKAEDGIDTMDIDQNDNSEANTNDIGYNEWSNEPKEDTGILDNTQDTNINGEMESQLTQEEFNKIRKVMLEHINMAMNESSLAMEFVSLLLSPVRESTAVSSMSPFLKKTVNPGSLNSEKVKMPAVSRRDKLSLSILSRGWKLRALNEARAILKKNFTEISSSLKQEHHYWSSIAYNISNKDVLFKIRDKQTTKRSLGLKYGYEDSGSTFRNDRGTAILRGTDEANGLELIPLTLGRTSTVGSVYKGGKFLRVRIFTKIESEGDYILSGESSLDKLFKNHSENSDSKNDDVRLQISKLKFFIFEQELMHQLKKECAYLISYGVTVENEHKIVIELPNEKFEIEYLSLDDDSVVNHEQDAPKANDRRANLMLVTLRMLLIVIYKKNLRQKMVSNTRKHIASTEKDILLIRPLLGKMRHSNHKKLIRKILKECVLEVVPDTELQERSIQSLDKEDFETFDLQDAHIVKLTKDINAFRNVLDVGKTEFTIDMKQSGKLSLILESPNYCNAQVSIKYDNQTSNTHFNTVSTEFKEVEEFLHFLISTYVNPE

SRB4

Mediator of RNA polymerase II transcription subunit 17

671 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

75.889 kDa

MDGFSEYDPEKGIPLAIDPNLISIPVSTSLTTNGNGDEGVNNEDATVFAADDADNAKSQKSLIQNPYEYFGQMPLEQFIPLMLQQRGTGTKFADIHEETLLEEISRENSSKSNNAIQEEDNDDSAIQNVDEKTTTVVNEGVSDSHEMKDEDGDVNMDVPSVESSPKLAEEREPTADANDAQRAISGNQEESITLEEFKMIKKNVLEHVNMALNESSLSLEFVSLLLSSTRTSAGISSMSPYLKKIAPPASLNADKVPLDILDEHEKLTYDIIHKGWNLRSLEDCKRLLKQHYQILSKSVESEYHYWKQISDNITNKDVLFKMKDKNTGRRTLGIKYGFDDSGSCYSADKGIALLRATSEGSQLELVPIIDSGINVGISRGSSEQFVRVRIFTKIEQEDDYLLSGQSSLNELLLSSRSDIKSQIAKLRFFIFEKELMHQLKKEAGQLLPYGVSVENENKVLLELSNEKIEFELINLDEEVTSNYQQEAAKVNDKRANLILVMLNMLLVVMYKKQLWKRLNPNPHSSKSSKGYGKDLVLLRAILGKIRHKKYTQLIEKIVNNAILEKKEDSIMTTNTDITSNDNEPSKNKELATLQREIALFDKILSMPRTDFTINIPEKGKLELSLRSTNHCNAIIHMKYIDVGQVVKFDTRFSEFTEFEEFLNFVYNEFLI

srb4

Mediator of RNA polymerase II transcription subunit 17

641 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

71.618 kDa

MSDQFTLPLRPLIEERDHQDLLPVEIAQISAQWGSFRDVNEETLRAKIEEEKNKEYTIDDEEGEGASVDLDTTERLDQLYKKRAEITQFAMQAHMEAMFALDFISLLLSKYTPRQAETSMSAFLKQVAPLGSLTAELVNPPPKSEAAVRDAKAVSRGWRLQSFNAAADKLLKSAARLETEVASETRYWSEVLAVKDKGWKVCRLPREGQALGVQYGFLEATPIFRDRGLAALRRSEDGGLILDKGLVPAKAKTVRVRVKNRGVVTGCSKPYRSAVQDSESIEGRILQARDTLYEEELFYELVREARIMGSQGVSTGQNLVQFSVSEDEEVLLDLVDPDVAYADDSETSLEHTVVADALAHSIRILLSYAHRQNRRRRTQPPPPLTQKRRHVPEYLLLRPTMAYLQHSFHVRWLESFLGDVYGVLRAAGLESKFTATPYASVDLAHIDRSVPTVEGLVKQFLLPLESTFSADLITPQTSFNVKTRTNLLVPPFGTHFEIALNMPHYPDVQPPSRIGQHDQVAMMVTHFLLLDIVSTISHGQGQPVKSETKTTPLSWEVTYPHHGELLAVASDGRQKKMKVQLSRSELSVQMFETHGTDSYSRLVGAEGGMLPLPSQSQTWTADAATPHPSLMEFVASVSKSA

SRB4

Mediator of RNA polymerase II transcription subunit 17

639 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

72.164 kDa

MEPDDGHNSLNQDNGIPIVLDPNLINLRSRAASATVTTNGTTADSSEDSGSQQSVSSAPIQQNSEEHSLVSNPYETYGRMPLQKLIPLILQMRNASSFSELTEEDLLRDIEREEKGILTTGLDVEGDIEMGDADEESDLKPQEITDDDSNARLKPNNDSAIPQEEFNQMKREVLEHINLALNESSLSLEFISLLLSSVRPSVGVGSMSPFLKRSVPTASLNADKVELPPKNKTETLTLAVINRGWKLRSLEDSKALLKENYAKLQKSLEVEHAHWAMISQHISSTDVVFKMRDRQTGKRSLAVKYGYEDSGSLYKQDRGVAVLRHNMDLNKLELVPISNSKEEVHITANSVERFMRVHIYTKIEEEDDYILSGESSIDDQSLLQPCHDDISRQIARLKFFIFERELMYQLKKEAVSLMPYGVNFENENKVVLESPGERIEFEMVPLDDSALLSTHEPRRVNDKRANIILILLRMLLVVIHKKQLRRGLKPATSKHKYRADGDLLLLRPVLGRIRHRNYLQVVKRVVTECVLNIVPGSSIELLPQRSEPDTLHAREANIASLNKQIGLFDKILRMPRSELRTSLGAKGVIDLTLKSSNYCNAIIQVIYADSAGKTVFDTVFTELKELEEFLHFIVSEYVL

srb4

Mediator of RNA polymerase II transcription subunit 17

639 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

72.232 kDa

MADDRFTLPLRPLIEKRDRPDPLPLEIAQINAQWGSFRDVSEESLRAKIEEEKSKEYTIEEEEGEGAGAELDTTERLDQLYKRRAEIIQFAMQAHMEAMFALDFVSMLLSKHTPRQAETSMSAYLKQVAPLGSLHSEIINPPPKSEAVVRDTKTVSRGWRLQSFNAAADKLLKSASRLENEVASETRYWHEVLAVKDKGWKLCRLPRQGQTLGVQYGFLEATPIFRDRGLAALRRSEDGTLILDKGLVPTKAKTVRVRVKDCGIITGCSKPYRSAAQDPDSIEGRILQARDTLYEEELFHELFREARIMGSQGVTTRQNLVQFPVSEEQEILLDLVDPDQEVYVDDEATKSEEHNVLADALAHLIRILLCYAHRQNLRRRTQPPPALSPKRRHIPEYQLLRPIMAYLQHSFHVRWLETFMKDVYGVLQSAGLSCSFTATPYSSVNLSNIDRSVPKVEGLIRQFLLPLESTFSADLLTPQSSFKVKSRTNLSVPPFGTQFEILLNLPHYPDVHPPHRIGLHDQAANIITHFIMLDIVAAIELQTSPALSISKTEAKSVSWEATYPHHGELLSVSIDGKQKKMKVILSRDELTIQTYDVLGLERYSRAAPETTPGLQTHTWKAGPTTAPSLMEYVAAVSQR

srb4

Mediator of RNA polymerase II transcription subunit 17

639 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

72.201 kDa

MADDKFTLPLRPLIEKRDRPDPLPLEIAQINAQWGSFRDVSEESLRAKIEEEKSKEYTIEEEEGEGAGAELDTTERLDQLYKRRAEIIQFAMQAHMEAMFALDFISLLLSKHTPRQAETSMSAYLKQVAPLGSLNSEIISPPPKSEAVVRDTKTVSRGWRLQNFNAAADKLLKSASRLENEVASETRYWHEVLAVKDKGWKLCRLPRQGQTLGVQYGFLEATPIFRDRGLAALRRSQDGALILDKGLVPMKAKTVRVRVKDHGIITGCSKPYRSAAQDPDSIEGRILQARDTLFEEELFHELFREARIMGSQGVTTRQNMVQFPVSEEQDILLDLVDPYQEAYVDDEETKSEEHNVLADALAHSIRILLCYAHRQNLRRRTQPPPALSPRRRHIPEYQLLRPIMAYLQHSFHVRWLETFMKDVYGVLQSAGLSCSFTATPYSSVNLSNSDRSVPKVEGLIRQFLLPLETTFSADLLTPQSSFKVKTRTNLSVPPFGTHFEILLNLPHYPDVHSPHRIGLHDQAATIITHFIMLDIVAAIESQTSPASSISKTEAKSVSWEATYPHHGELLSVSIDGKQKKMKVILSRDELTVQTYDVQGVERYSRATPETTPGLQTHTWKAGPTTAPGLMEYVAAVSQR

srb4

Mediator of RNA polymerase II transcription subunit 17

638 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

71.749 kDa

MSDSFNLPLRPLTEKRERPDPLPVEIAQINAQYGSFRDVTEDSLRAKIEADKNKDPWFDKEENDNASADEDTTERLDQLYKRRAAITQFALQAHMEAMFALDFVSLLLSKHTPRQAEMSMSAYLKQVAPLGSLNSEIVNPPPKPESAARDTKNVSRGWRLQNFNSAASKLLDSATRLEAEVASETRYWDEVLAVKEKGWKVSRLPRERQALGVQYGFLEATPIFRDRGLAALRRTNDGSLILDKGLIPLKARTVRVRVRSRGQITGCSKNQPASDNTESIESRILQARDTVYEEELFHELVREARILGSQGVTTRQNLVQFPVSEEQEVLLDLIDSDQISPENDVVSSNEHAVVADALAHAIRILLAYAHRQNLRRRTQLPTPLTPKRRQTPEYQLLRPVMAYLQHSSHVRWLESLLNDINQILKSAGITCDFTATPFSSLSLRRTISGLPKVEALVQEFLLPYESTFSAQLVTPQSSFRVKVRTNVTTPPLGTHYEISVNMPQYPDVRPPNRIGLQDEAASILTHFVLLDILTAITHAKGSSVKGIKQETGHLLTWQAAYPHNGELLALSSTGQHKKMKVSLSRHELTVRVYSIRGIDGFGKPAVDKTPAMRSQTWKCDGTPDQPNLMDFIAEVSKE

srb4

Mediator of RNA polymerase II transcription subunit 17

634 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

71.308 kDa

MPDSLSLPLRPLIDKREHQDSLPVEIAQINAQWGAFRDVSEDSLRAQIEADKHKDPWAEDEESDGQSAADVDTSERLEQLYKRRAEITNFALQAHMEAMFALDFVSLLLSKYAPRQAETSMSAILKQVAPLGSLNAEVVNPPPKPESTAKDIKTVSRGWRLQNFDAAANRLLDAATRLESEVASETRYWEEVLAVKNKGWKVCRLPRERQALGVQYGFMEATPIFRDRGLAALRRADDGRLFLDKGLAPQRTRMLRVRVKHCGGISGCSKVQPAVTEDVESIENRILQARDTLYEEELFHEVFREARMLGNQGVITRQNLVQIPVSEEQDILLDLVDDQDLLSDETPMSHEHDTLANAISHSIHILLAYAHRQNLRRRTQPPPPLSTKRRHTPEYLLLRPVMAYLQHSSHVRWVESFLNDIHRVLQSAGLQCEFKATPFSSIRLPTKHTIPTVEALVQTFLAPLESTFSCKLPSSHGSFRVRVRTNAVVPPFGTHFDISVDMPEYPDIQPPSRIGLQEEVATALTHLTMLDILTAIRQDQKSAVEPSEDSKPTEQCLTWSAVYPHHGELVALSPTGPNKKIKVELSAQGLSVQSYTMRGEFTESIDEKASRAQSWKPDSTTPGSPGLMEFVRAV

srb4

Mediator of RNA polymerase II transcription subunit 17

632 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

71.644 kDa

MSDSFTVSLRPIREKRDRPDSLPREIAQINAQWGSFRELSEAKLREMIEEDKHKDHWEEDDEGDKESTDLETSEQLDQLYKRRAEIIQYALQAHMEASFALDFVSLLLSKHQPRQAETSMSPFLKSAAPLGSLNSEVVNPPPRPDSTLKDIKSVARGWRLQNFNSAADKLLNAGSRLETEVNSETKYWNEVLAVKEKGWKICRLPRESQALGVQYGFLEATPIFRDRGLAALRRTDDGSLFLDKGLIPLKSQGVRVRVRRGDRIVGCSKVCRPPQDAESIESRILQARDTVFEEELFYEVMREARILGTQGVKTRQNLVQVPVSDEQEILLDLVDWDQDRDPDAADSTEQDVFADAVAHSIRILLTYAHRQNLRRRTQPPPPLAPKRRPVPEYHILRPIMAYLQHKSHIQWLESLINDLRGVLQSAGIPCDFKATQFSSIGTLQPSNQVPKVEAVAGVFLAPFLSTFSGNLVTPQSSFRIQIRTNLAVPPFGTFYELSVNLPQYPDVQPPNHVGLQDEVSAILTHVIMLDIAAAIPLQCRDTADKEAKERVSWDVDYPHHGELHFLSRNGQSRKMKISLSRQELTIETYQLNRMRGVTPGAATSPTLWQTWRADSPETRPTLSEFVAQASQP

SRB4

Mediator of RNA polymerase II transcription subunit 17

587 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

67.458 kDa

MFSNGHFHIDLDPDAYGDANKDPFIQDEDKLTIAELIPRILIERNSFLNVTEESLQEEIDNPRAEDEANNEVDVASELDIGDESVENGSILMATLAETSLDPVELFQKQKLDLSKSINSALNETSLSLDFVSLLISSVKPNLAKSTISPHLNKSVPLGSLNSDRLSNENDDDDRNKSVAPKETPKVGHGWKLESLHKVTSLFREASENLNEQVLKERRYWNMINSVLTNDEVLFKTRDPLNNARAIGVKYGYGDSGSNFHDKGLAILRKDTVTGEISFNPINYAHKLTSKVFRYIRIKILSEIDGDFMLTGQSLFENDFSSSKDQIINDIEKARFFLFEEDLFYQLTREAKTLINYNVSIISNKIIIEINNEIIEIESVVYDENNDDELNNYYQNINAYSSINNGKCQLILKFFKIMLCCYYKYNLKLKQKIPTSLTKWKQSNSHPLVLRPLLGNIRHELNLKNMQSIIDRLIAKFKESLECKLQVDKFANLEHRSENPFQKSIERPVSKFNIVLKSKRSAYLKIDLELTTNEIFVNLIINMNVIKFKCEDDFKNNFNGVNVLQINFNDFHEIEECLDWTLLNFVNG

SRB4

Mediator of RNA polymerase II transcription subunit 17

565 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

65.595 kDa

MVEKQFNIDLELNDTGHIDPFLQDEDKLKLEELIPRILFERKSFLNVTEDSLRKEIDNSLKISEEDALDTEESREDTVEADQQEVFNKHKFELSKNINNALNETQLSLDFVSLLISSVKPSLAKSTISPHLSKFVKPTSLNSDRLGQDSNDNQESKATDSFGQGWKLESLGKITDLFREASTNLNDQVIKERRYWNMINLVLANDEVLFRMRDPQNNARAIGVKYGYGDSGSNFHDQGLALLRKDNQTGEISFHPISSINNAKIVEKVSRFIRVKILSQIDGDYMLTGQSIFNFDFEKSKQSIINDIEKARFFLFEEDLFHQLIREAKLLVNYNVSIISNKIIIEINNIIIEIESIVYDELNEEELENYYQNVNEYSTLHNKKCQLILNYLKLMLCCYYKYNLKLKQKVPTALTKWKQSNSHPLILRPLVGNMRHELNLLNMKSVLDRLMHAHESELSYSKLDVEKFINLATRSKKQNPFQKSIEKPISKFHLVLCNKTSNMLDVNIQLTTNESFVNLIINMTIIRFETEDDFKNNVNGINVLQLGFSDFNEIEECLDWSIQNFV

SRB4

Mediator of RNA polymerase II transcription subunit 17

511 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 17 family.

56.15 kDa

MSDIKVTLAVEDRAENQDTLSISEIVPRIVAERKSFVDVTEESLLEEIANCVADSADDNVKDEVDEKPDESPFDQHRLKLLENVKAAYNESALALDFVSLLISSVRPTSASTSMSPHLKTHIPVGSLGADRVPAPQVANEPGVGIGWKIESLTNARDRLKTCASRLRTEAAKEKTYWAGVASIAATGEVLFKVRNSDTRGLGIKYGFGDAGSKYRDPGIGVLKRSATGTVDFEPKEEVQKKFVRVTIKSEEGEVTKSVSNVYTRDSKPPTDPTLAAIHETRHALFEEELFFEIAREARLLTSRKVTVADGAVTVDLGEGDMVVIEWVEVPEEPTTTFAPSLANLFVLALRLLLANAHRQQLEKMRTPPAPLQSKGGPNPNPPLPILRPLLAHILHKRLVSRARRSLYLLSTTHSGLSFEITTNNSTDKESSSLGRLMAAPVSNLKIKFSDKGNAKVVIPSPLQSHQSMFDVTMFKGTSQETVTSHTGFHELVELEEWVRWAADRSEPKKSN