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SRB2

Gene
SRB2
Protein
Mediator of RNA polymerase II transcription subunit 20
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
237 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 20 family.
Mass
26.703 kDa
Sequence
MVSAVLLIQKATPETITQFHDQLSNELPTLRGKWNFNFKIFRNNPYSIPQELAETATVAPESKWLYTLSPSYLSDSSISLINGKSVGVFTNLIKEEAGEHGHSVELSIPNSHLHKGATTDLNDPFDFFVAQKLQSLWTQRQLIRGDGGRIYELENGNLTIRTSNVFLHGNFRGLLVQIEINQNLCNVDDVSSFASTFETIRNKYGIPAGDLSCEVLDPKRLDTYADLIYQYSKILNF

Gene
SRB2
Protein
Mediator of RNA polymerase II transcription subunit 20
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
236 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 20 family.
Mass
26.425 kDa
Sequence
MVSALILIQKATPETIVQFHDQLSNELPTLKGKWSFSFKIFRNNPYSIAPELAETSVTSSESKFLYTLAPSYLVGSCISLINKNSACVFSNVIEEESAEISNGSEFSIPDSHLHQGATTGLNDTFDFFVNQKMQSLWTQKQNIKGDGGQIYELENGSLIIRTSNVFLHGIFKGLLIQIEVENESSEHETSSLSEPFERVLSKYNIPRGKMSCNVLDSKLLDKYGDLCLQYSEILNF

Gene
SRB2
Protein
Mediator of RNA polymerase II transcription subunit 20
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
218 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 20 family.
Mass
23.835 kDa
Sequence
MVTILQYSADVTATTISTYRSELSAQLAQNLGKWSFELKMYKPNPASIGRSEHHNGNIPQGQQEAAAADQEIGGVAALYTLTQAHSKGDMVYVTQGSAVQGQPGVVVSDSFDMVLQNKMKSIWILRQTLRGDGAEYELMGDAYGRVKVRLANVFLQGTFRGLLFQYEYEGDTLDDRQQQHLMEFIQSSGFPSSNLIIGGNGSGLVQTGTQFVEALAQK

Gene
SRB2
Protein
Mediator of RNA polymerase II transcription subunit 20
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
215 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 20 family.
Mass
23.786 kDa
Sequence
MSSAVIFVESATPGTLTEFKDLLAKQLLEVRETWSLEFRTYRTLVKDFPSREKLLYSLTFPHHDKKTVLIRNSLAWVLGTAEIPDNLQTCSTGLSESIDQLLASKLSNMWAQRQVIRGDAGQTLLITGDVTVRIINLFAATGFKGLLIELDNLQSATSLANITDLLNEMKVKVFKVASAPGLKSEDVEVVDSSSTMESGNEALFTLAKQYIEVLE

Gene
SRB2
Protein
Mediator of RNA polymerase II transcription subunit 20
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
211 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 20 family.
Mass
23.605 kDa
Sequence
MTYYGVLFVEKCTPSTITQLQDVLSTDLISMGDKWSFELKTFRTSAKNTDPNDTKVMHTVQLSHKNNETVTIKNQSAIITPTYVTKALYDNGCVFGTPEPFDYMLSNKLSNIWTQRQSIKGEFGVSYQTADLSIRVNNAFSYSGFQGLILELESKSSDNLEAFEKNVERVRTMLSGMGLSDVRVSSDKSQGSKQEDSSLFDLAAHYLKVLG

Gene
SRB2
Protein
Mediator of RNA polymerase II transcription subunit 20
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
210 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Similarity
Belongs to the Mediator complex subunit 20 family.
Mass
22.894 kDa
Sequence
MGKSAVIFVERATPATLTELKDALSNSILSVRDPWSIDFRTYRCSIKNLPADVSKLMYSITFHHHGRQTVLIKDNSAMVTTAAAADIPPALVFNGSSTGVPESIDTILSSKLSNIWMQRQLIKGDAGETLILDGLTVRLVNLFSSTGFKGLLIELQADEAGEFETKIAGIEGHLAEIRAKEYKTSSDSLGPDTSNEICDLAYQYVRALEL

Gene
SRB2
Protein
Mediator of RNA polymerase II transcription subunit 20
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
209 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 20 family.
Mass
23.536 kDa
Sequence
MKRTAVIFIEKATPSTITQFHDILSTHVLAIQEKWSFELKTFRSSIKNLPPSDTKVLYSLQLTHRDNQTVVIKNQSAIVTGQHSTDALTSNGCSSGFPEPFDNILTSKLSNIWTQRQSTKGNFGTTYKTSELIIRASNVFSSSGFKGLLLEIECTDPVSAEEFDRRVANIRAMLSEIDINDYKLNKDEMNEGKPVFLCDLAYQYVKVLD