spty2d1

Protein SPT2 homolog

800 amino acids

Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).

Belongs to the SPT2 family.

83.745 kDa

MDFHSVLRMAAAKPGPDGVMKRYSLAVGPPRKDPKVKGVNSAAVQAFLRKKDQEIQNKEVEAKRKKEGLLAKRKELKHDRKARAMASRTKDNFRGYNGIPVEEKPKKHKGSGLEEGPNESMQSTEEDEEYMTEEELYEYSQSESEREEEQEEMPPQKVAKAAPGKKPPPPALNFTELLRLAERKQHEPVEVIRPLKKEERLRTAEELKELEFLERKAQKADRKDPMRNGQVVKISKGSGDKYYSLKGSHSVEKRSHENSKSSSTEQNGTFRKSSSDNRSREEKSGSVFHTKDSKFPTKSSSAKDCGAKGFRPSATGDCKNRNDSTRASGSTSLRPSSGGSSSVSGRPSGSSEKPGSSSGKPMGGSGSSSARSSSGSGKPTGATGSGKPTGASGSGSARSVGESGSRSGKPTGASGSGLARSVGASGSGSGKPTGATDSGRPTGVSGSGSARSVGASGSGKPTGASVSGSARSVGASGSGKPTGASGSGSARSVGASRSVSGKPTGASGSGKPTGAPGASSGKPAGVSGSVSSFARPRSNSSMAPAKPAASSGSARPSSSGTPRASSTGNSSSNYSRQASSSGAVRPSSGPPTGGTPKGPSPRPGTGPNSVRHNTTSISVSARSSLGSGPGRPVAASATGQSAMAKPKCTVVAETISSKNFVPKSINGHMNGMRSAVPPGHRPNMQPPGRPLPPITSSYKRRIDDDEYDSEMDDFIDDGGECQDEISKHIREIFGYDRNRYRDESDYALRYMESSFREQQKEEARSLRLGIQEDLEELRREEEELKQKAKQLKSAKKMKSR

spty2d1

Protein SPT2 homolog

778 amino acids

Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).

Belongs to the SPT2 family.

81.318 kDa

MDFHSVLKMAAAKPGSDGIAKRYSLAVGPPKKDPKVKGVDSAAVQAFLRKKDEESRRKETVEKRKKEDLLAKRKELKHDRKARAMASRTKDNFKGYNGIPIEEKPRKRKRSGTEEDQNDNMAAEGEEYMTEEELYEYSQSESEQEEEEELPPQKVPKPAPGKKPPTPALNFNDLLRLAERKQYEPVEVVRPVKKEERLRTAEELKELEFLERKAQKADRKDPKRNEQLVKVSKGSGDKYSSLKGTHSGNSKSSSTEQNGTIRKSSSDTGSRTEKSGSVFHTKESKKPSSAKDLGGKGSRPNVTGDGKDRHSSSQPSAASNSAFGRPSGSARPSGSSGPGRPLGGSGSSSGKSTGGSASGSARSVGGSGSGSGKPMGGSGSGKPIGGLHSSHGSGKPTGGTGSGSGKPTGASGSGSGKPTGSSGSAKSVRESGSGSRSVRESGSGSRSVRESGSGSGSARSVRESGSGSGSARSVRESGSGSGSARSVRESGSAKQAGGPGSGRALGSGSSFARPSSNSSPAPGKPAAGSGSARPSSSGTPRSSSMGHSTSNSSRQPSSSGAVRPSSGPPTGATPKGPSPRPGAGPTSVRPNSTSVPGSARSSLGSGPGRPVAASATGQLAPAKPKCTVVAETISSKNFVPKSINGHMNGIRTAAPPGHRPAMRPPGPPLPPITSSYKRRIDDDDDYDSEMDDFIDDGGECQDEISKHIREIFGYDRTKYRDESDYALRYMESTFREQQKEEARSLRLGIQEDLEELQREEEELKRKAKQLKAAKKMSR

SPTY2D1

Protein SPT2 homolog

690 amino acids

Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro) (By similarity). Modulates RNA polymerase 1-mediated transcription (PubMed:23378026). Required for optimal growth in the presence of the DNA damaging agents actinomycin D or mitomycin C (in vitro) (PubMed:23378026). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).

Belongs to the SPT2 family.

74.06 kDa

MDFHNILVMASEQQGLNAVPKRYSLAVGPPKKVPKVKGVESAAVQAFLRRKEEEKRKKELEEKRKKERLLAKRIELKHDRKARAMASRTKDNFYGYNGIPVEEKPKKRRRTCENVSQAPEAEYATENEAEQLEFAQTESEYEQEEYDEKPSKAAVKPKAPPKSAPAPLNFADLLRLAEKKQYEPVEIKVVKKIEERPRTAEELREREYLERKNKRVETQKKKSEKEVKSAGISSSSKKATSLKECADAKLSRSAADKHAPPKSSLSSLSGTDKKPKAPALTEKHSRSFSSSKLSQMEKGKTSQNSSLKSPAAGSHSKLPANGMGKTGSSFPVPSSKPMANGAQRLPSAKESSLKKPVHTKPGNAAALQHETNSSAKRPSSSLGKGGSGHPAGGSSAGPGRSSSNSGTGPGRPGSVSSPGPGRQGSSSAAGPGRPSSSSSLGPGRLGSGSGVGPGRPGGSSSTGLGRPGGSSGTGPGRPGNSTNTAPGRLGSGMGTGPGRPGVGPSAGPGRPGSSSGTGPGRPGVSPSAGPGRPGLTAVKPRCTVVSETISSKNLVTRPSNGQINGMRSPPGHRPVFRPQGIGRPPVGYKRQIDDDDDDDEYDSEMDDFIEDEGEPQEEISKHIREIFGYDRKRYKDESDYALRYMESSWREQQKEEARSLRLGVQEDLEELRREEEELKRKRQSKKLRTR

SPTY2D1

Protein SPT2 homolog

685 amino acids

Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026).

Belongs to the SPT2 family.

75.599 kDa

MDFREILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR

Spty2d1

Protein SPT2 homolog

682 amino acids

Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).

Belongs to the SPT2 family.

74.818 kDa

MDFREILLIASKGQGVNHVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLRRKEEELRQKALEEKKRKEELVKKRIELKHDKKARAMAKRTKDNFHGYDGIPVEEKTKKKQLVESHLNQGTDQEYDVEEEDFIDYNQAELDQDYEEEQEPPKAESKPKAPLKSAPSPMNFTDLLRLAEKKQFEPVEIKVVKKAEDRPLTAEELREREFLERKHRKKKPEPDAKLPPPVLKKAPSHKDIMGTKPSRGAGDRQLASKGLPFPQAEKKFRPSTASEKQAALSSPKSLPGERTKVGSGSSTQPSLREGHNRPVFNGAGKPRPSTCSPSVPKTPASGTQKSASEHKAKKPLPSHPSHSKPGPTVLSHNKSKSPGVRQPGSNSGSAPGQPNPGTARPTLSSGPVPRRQNGSSSSGPEQSAGGIRKLASNSHLSGRTLNGTNGPGRPASSSSGPGRPISGSAGSGRPVGSSGGPGQPVNNPHDLRRPMNSLSSPGRAVSGPGRSISGSIPAGRTVNSGPGRPVSSLGPGRAVSNPGLPTKPRCTVVSETISSKNIISRSSNGQINGMKPLLSGYRSAQGPQRLPFPTGYKRPREYEEDDDDEYDSEMDDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEELKRRKAKKLKRH

spty2d1

Protein SPT2 homolog

629 amino acids

Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).

Belongs to the SPT2 family.

69.438 kDa

MDFDSVLSIASQNQGLSSLPKRYSLKTGPPKKDLKVGGVNSAAVQAFLKKKAVEQKNKEQQDKKAKEDLLAKRVELKSDRKARAMASRTKDNFRGYNGIPVIDQPKKRQSKGSSTEEQQSSTKYEGGDYDDEDNFDYEGTDSESEPSRPVKPQAISRPEYSNRVENKPKKLSAPARPASSSMNFADLLKLAEKKQFEPVELKVVKKTEERLRTAEEIRELEMERRVKKLDKGKDVRSDKNSGQKDSRSQTSSNPQKKHVDRDGKNGRFPRPSEEKHQSSSTSKKPKLQASSERTPTSAKLHGDRSNSGSSGALNSKSAMKNGASFQAKQAPPRPSQGQRPATPSDLTPRKGNVSLTQAKSSISGSCPPGAARPGQGPHKNSAHGRPSNFSTSGPSQKPANPGKLSRPGSNAPPRPGGSGVVRPFTGDPSKQPRPGGNLQSQQFPGSSRASLNGPKRMERGVSGSQINRMSSGPGRSQCTVVSETISTKNITPRPGMVQRPPGPQGPRTVIGPSGHRILVKPSGPALPPITSSYKRKFEDEEEYDSEMDDFIDDEGEDQDEISKHIREIFGYDKNKYKDESDYALKFMESSWKEQQKEEARSLRMAVLEDEEEERRELEEMQRKNAKKRK