Spt6

Transcription elongation factor SPT6

1831 amino acids

Transcription elongation factor which binds histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII). Required for the transcriptional induction of heat shock response genes and for maximal recruitment of two other elongation factors, Spt5 and Paf1, to the induced Hsp70. Plays a critical role in normal fly development throughout the lifecycle.

Belongs to the SPT6 family.

208.599 kDa

MAEFLDSEAEESEEEEELDVNERKRLKKLKAAVSDSSEEEEDDEERLREELKDLIDDNPIEEDDGSGYDSDGVGSGKKRKKHEDDDLDDRLEDDDYDLIEENLGVKVERRKRFKRLRRIHDNESDGEEQHVDEGLVREQIAEQLFDENDESIGHRSERSHREADDYDDVDTESDADDFIVDDNGRPIAEKKKKRRPIFTDASLQEGQDIFGVDFDYDDFSKYEEDDYEDDSEGDEYDEDLGVGDDTRVKKKKALKKKVVKKTIFDIYEPSELKRGHFTDMDNEIRKTDIPERMQLREVPVTPVPEGSDELDLEAEWIYKYAFCKHTVSEQEKPESREKMRKPPTTVNKIKQTLEFIRNQQLEVPFIAFYRKEYVKPELNIDDLWKVYYYDGIWCQLNERKRKLKVLFEKMRQFQLDTLCADTDQPVPDDVRLILDSDFERLADVQSMEELKDVHMYFLLNYSHELPRMQAEQRRKAIQERREAKARRQAAAAENGDDAAEAIVVPEPEDDDDPELIDYQLKQASNSSPYAVFRKAGICGFAKHFGLTPEQYAENLRDNYQRNEITQESIGPTELAKQYLSPRFMTTDEVIHAAKYVVARQLAQEPLLRKTMREVYFDRARINIRPTKNGMVLIDENSPVYSMKYVAKKPVSDLFGDQFIKLMMAEEEKLLEITFLEEFEGNACANGTPGDYVEESKALYQLDQFAKHVQEWNKLRAECVQLALQKWVIPDLIKELRSTLHEEAQQFVLRSCTGKLYKWLKVAPYKPQLPPDFGYEEWSTLRGIRVLGLAYDPDHSVAAFCAVTTVEGDISDYLRLPNILKRKNSYNLEEKAQKLADLRKLSDFIKMKKPHIVVIGAESRDAQNIQADIKEILHELETSEQFPPIEVEIIDNELAKIYANSKKGESDFKEYPPLLKQAASLARKMQDPLVEYSQLCDADDEILCLRYHPLQERVPREQLLEQLSLQFINRTSEVGLDINLMVQNSRTINLLQYICGLGPRKGQALLKLLKQSNQRLENRTQLVTVCHLGPRVFINCSGFIKIDTSSLGDSTEAYVEVLDGSRVHPETYEWARKMAIDAMEYDDEETNPAGALEEILESPERLKDLDLDAFAVELERQGFGSKSITLYDIRNELSCLYKDYRTPYTKPSAEELFDMLTKETPDSFYVGKCVTAMVTGFTYRRPQGDQLDSANPVRLDSNESWQCPFCHKDDFPELSEVWNHFDANACPGQPSGVRVRLENGLPGFIHIKNLSDRQVRNPEERVRVSQMIHVRIIKIDIDRFSVECSSRTADLKDVNNEWRPRRDNYYDYVTEEQDNRKVSDAKARALKRKIYARRVIAHPSFFNKSYAEVVAMLAEADQGEVALRPSSKSKDHLTATWKVADDIFQHIDVREEGKENDFSLGRSLWIGTEEFEDLDEIIARHIMPMALAARELIQYKYYKPNMVTGDENERDVMEKLLREEKANDPKKIHYFFTASRAMPGKFLLSYLPKTKVRHEYVTVMPEGYRFRGQIFDTVNSLLRWFKEHWLDPTATPASASASNLTPLHLMRPPPTISSSSQTSLGPQAPYSVTGSVTGGTPRSGISSAVGGGGSSAYSITQSITGYGTSGSSAPGAGVSSSHYGSSSTPSFGAINTPYTPSGQTPFMTPYTPHASQTPRYGHNVPSPSSQSSSSQRHHYGSSSGTGSTPRYHDMGGGGGGGVGGGGGSNAYSMQPHHQQRAKENLDWQLANDAWARRRPQQHQSHQSYHAQQQHHHSQQQPHMGMSMNMGITMSLGRGTGGGGGGGYGSTPVNDYSTGGGHNRGMSSKASVRSTPRTNASPHSMNLGDATPLYDEN

SPT6

Transcription elongation factor SPT6

1723 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

193.945 kDa

MADEERVPAPYFQDDEEGGASDEGEGVDLIKSHGNLVGSGGEDSSDEEEDDDPEEARRVAEGFIAEDDEEEEEDSEARRDRRRRRKKKRKQNEQDFEVDEDDLELLAENTGQPRRKEAGRLKRFRRGSASPPADDEAAARQRTLDQIFEDDDEDEDDIRSGRRGVNYDDDDEDLPSVGQALRAGVARKQREVVGAYEDDGLDDFIEEDEDDEEMQGLDEEEREARRQQRREEKRKARLSGSAADPAKAGIDHEAWDEIHEIFGNGEDYFWALEDEEEDAFDEEKKNKMEYKDIFEPAQIAERMLTEDDERIKRIDIPERLQLACPGEEGLKLLERKLTDTELFEAAKWASTRISQRTAAEFLDEAGLFHRQRSEFINAVQLMLSYMLNDLLEVPFLFQHRFDELEHLTFDEVERQYRSIDLLTRRELYTLSGLGLKFKTLLVRKDQLRATFNKIHVDVKTEPIQDDELDGGLDAMPADESRAARVESSQRQRAIFEDMLAQAASLEEISDITEYLTLRYGQQMRDAQALTSNGTDQAASDLQGLTLTSDPLVSATPAFKKPSLVGQYERNKKTVLAELAKKFGITSDELASNVTSHTRQYSPRDPEESPFKFAEQFTGSAWGAHSPEIALAKAKMMLSQEIGKDPILKREMRQLFKDAAEINIEPTERGMTVIDDQHPYANFKFIANKPARLVPQNPSQYLQMLQAEDELLIKLDIDLKDVVLTRFEARLYNNYASEGVGELSNAWNEQRRDVIREALKTHLVPNGRIWLKEFLREESRETLLRHVDVLMTKRVQEGPFMSKSMMARNRDPKIEEEDRIPRVLAVSHGGGDPRKDVVQAVYLDERGRFREHATFDDLRPLSARQMQERELELERTRGKAEFVDHRADFVKLLKQRRPDIVVVSGWSVRTAELKRHVQELADTAHQEICDADRLHSDLERDQAVIDVVTCHDDVARIYQHSSRAAEEFPELSELGRYCLALARYAQSPVNEFAALGSDLTAVILDPNQRLLPQDRLRLHFERCIGAVVNENGVEINQAMTSTYLQTMLPFVAGLGPRKAHALVNAISTKLEGTLINRTLLISRNILTFQVFQNCASFLRIEQDMLLEADEDDVPDVLDSTRIHPEDYDFPRKMAADALNKHEEDLEGEHPSLPCKELMEDADPADKLNTLDLDNYATMLFERKGERKRATLHSCRTELIKPYDDLREKQSEPSLEEMLTMFTGETSKTLAEGFVVSVEVTRVQEGNRMQEGHIKCRLDSGIEGTIEAEHAVEHYTPGSVRLRDLVRPQQTLDALVRKIDYKMCTVQLSISPWELQHRATHQGKTPIDIKFYDRRKADQWNEHAAAKAKLRIQARRQNRVIDHPNYHNFNYKAAVTFLRSQPRGTVVVRPSSKGDDHLAVTWKVDDDVYQNIDVTELDKESEYSLGRVLRIEGMGSYSDLDELIVNHVKPMVHMVEMMMNHEKYKGADEEDLHRFLTNWSLANPSRSVYAFGLNKDRPGYFNLSFKANRDAAIQTWPVKVLPNAFKLGPADQLADVAALCNAFKTQYTTQASMARGAKTPYGGGRTPAPGMGGATPLGGRTPYGGVRNGMAGSATPGQGVAGGYTTPMINVASATPNPYGGAYGRNGAAGGYGAPAAGGPPGRPPSMPGAPPMMPPGMASGGGAPSYAPPFAGAGEPGPPPARPPVPHGMHPDRFAQAEYGGASQQSYGENSGGAGGYGGGYRGY

SPT6

Transcription elongation factor SPT6 homolog

1647 amino acids

Transcription elongation factor that enhances the transcription elongation by RNA polymerase II (RNAPII) (By similarity). Plays an important role in regulating embryo apical and basal patterning during early embryogenesis, partly through negative regulation of the transcription factors PHABULOSA and PHAVOLUTA.

Belongs to the SPT6 family.

185.034 kDa

MARNAISDDEEDHELEDDDGEPVHGDPAEHDENDDEEDDDDVGNEYENDGFIVNDEDEEEEEEEDEERKDSDEERQKKKKKRKKKDEGLDEDDYLLLQDNNVKFKKRQYKRLKKAQREQGNGQGESSDDEFDSRGGTRRSAEDKIKDRLFDDVDVDDPPDDVGDEEDLVVEEDVVGSEDEMADFIVDEDDEHGPPKRGNSKKKKYRQGSDITAMRDANEIFGDVDELLTIRKKGLASNQRMERRLEDEFEPTVLSEKYMTGNDDEIRQLDIPERMQISEESTGSPPVDEISIEEESNWIYAQLASQLRESDGTFDGRGFSVNKDDIAKFLELHHVQKLEIPFIAMYRKEQCRSLLDTGDFDGANQGKKPETKWHKVFWMIHDLDKKWLLLRKRKMALHGYYTKRYEEESRRVYDETRLNLNQYLFESVIKSLKVAETEREVDDVDSKFNLHFPPGEIGVDEGQYKRPKRKSQYSICSKAGLWEVANKFGYSAEQLGLALSLEKLVDELEDAKETPEEMAKNFVCAMFENSLAVLKGARHMAAVEISCEPSVKKYVRGIYMENAVVSTSPTADGNTVIDSFHQFSGIKWLREKPLSKFEGAQWLLIQKGEEEKLLQVTFKLPENYMNRLISDCNEHYLSVGVSKYAQLWNEQRKLILEDALHAFLLPSMEKEARSLLTSRAKSRLLSEYGQALWNKVSAGPYQKKEMDINLDEEAAPRVMACCWGPGKPPNTFVMLDSSGEVLDVLYAGSLTSRSQNVNDQQRKKSDQDRVLKFMMDHQPHVVALGAVNLSCTRLKDDIYEVIFQMVEEKPRDVGHGMDDLSIVYVDESLPRLYENSRISGEQLPQQSGNVRRAVALGRYLQNPLAMVATLCGPGREILSWKLHPLENFLQLDEKYGMVEQVMVDITNQVGIDINLAASHDWFFSPLQFISGLGPRKAASLQRSLVRAGSIFVRKDLIMHGLGKKVFVNAAGFLRIRRSGLAASSSQFIDLLDDTRIHPESYSLAQELAKDIYDEDVRGDSNDDEDAIEMAIEHVRDRPASLRKVVLDEYLASKKRENKKETYSNIIRELSCGFQDWRIPFKEPSPDEEFYMISGETEDTIAEGRIVQASVRRLQNGRAICVLDSGLTGMLMKEDFSDDGRDIVDLADQLKEGDILTCKIKSIQKQRYQVFLICKESEMRNNRHQHNQNVDAYYHEDRNSLQLVKEKARKEKELVRKHFKSRMIVHPRFQNITADQATEYLSDKDFGESIVRPSSRGLNFLTLTLKIYDGVYAHKEIAEGGKENKDITSLQCIGKTLTIGEDTFEDLDEVMDRYVDPLVSHLKTMLNYRKFRKGTKSEVDDLLRIEKGENPSRIVYCFGISHEHPGTFILSYIRSTNPHHEYIGLYPKGFKFRKRMFEDIDRLVAYFQRHIDDPLQESAPSIRSIAAKVPMRSPADHGSSGGSGWGSSQSEGGWKGNSDRSGSGRGGEYRNGGGRDGHPSGAPRPYGGRGRGRGRGRRDDMNSDRQDGNGDWGNNDTGTADGGWGNSGGGGWGSESAGKKTGGGSTGGWGSESGGNKSDGAGSWGSGSGGGGSGGWGNDSGGKKSSEDGGFGSGSGGGGSDWGNESGGKKSSADGGWGSESGGKKSDGEGGWGNEPSSRKSDGGGGGW

SPT6

Transcription elongation factor SPT6

1506 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

171.709 kDa

MSDRPGSASEGEGDEIRPYGEDRDSSEESEDDDPEEAKRIAEGFIVDEDEEDGEGEDDEEDEETRRRRRKEEKRRRKKERRMRREREEAELSEDELELIEENRGLREGRPLKRLRRRSGSEGSENDRAVPTLQDMFRDDEDRMEDDDDDLMDFIEEDEEDEANQGETEEQRRERKRAEKLKRREQARSRPELTGVDRSSWDEIFAVFGDGQDYDWALEGEDGMDLDEEEEAAKKDLRLEDVFDPAEIKARRLQDEDKAVANADRPERHQIVNSTLSDNPVFATDTLYPPPDFAAKWVAPKVSFRTQYLFYNQHPEGSYPIPTIDNPQPYPVYRRPDLEIEFEKAVSTALNMMFVQHLEVPYLWHYKRDVFSLLENQGQSSVLFLERDELWQVYVLGQRYRAIHERNEQTRQQWGKIKARKGDIEDEYFTKGLLGKACVASIEAAGEGDEWLAYHYASDIKAIKEEEAFDEVSKKLPERAEREDIRRGRIMKLVEAFGIDANKVASSFQDVHGQPAPVMNPDKMPLELADEFTGAAYSSPEQALSAASFVLVQELSKDPAIRQQARDFMDTCGLVTVNATDRGMSVIDQYHLYYNFKFLTNKPVPDFRDSPQFVHMLKAEEEGLINIAFDIREDMLASFTDALIRCCRSNDYGEIASAWNEVRMEVCNTLVKKHLMPMASKWIKEHLRTQAEEYIAERCREELELRVNVRPYASSGMEQGETPSVLAITNGKGDIRDAVMAVMLDDEGNVRTQTKFDNLRDEEDKTMFIELLEKRKPKVVVIGGFSAQTARLKDAALVAIRQHAIELLGQNPPVSDAYPDHEGFQYAMAEYDEKLKAHLIPLIFVNDATARLYMSSEEAEKEHPNLPLNGRYALGLARYAQNPLNAYCKLGKHIASVTFMEHHQKLIPQEKLLYHLERGLVNSVCFMGIEINSCVADPYQRAMLPYIAGLGPRKADAVIYGIQKHGALINRMAFTDLGLFGPTIFENTAGFLTIESDLKDMMLEAENPQEQPDPLDMTRIHPENYEFAQKMCQDALDLDVEDVADRHKSEVVQTLMLDDKRGKKLGELNLDDFAFNLQRQGEGNKRHTLGEIVSELIRYRSDRRPAFYVPTDWEIVTMVTGETERTVGRGLKVTATVRKAISARVFCQLESGLDAVLERDYVADEDQAPVTSCDEVFKPRQAIKGVVIMPEPARFQVRISTRPSDLRQGVDFVQPFKDEEYNSKDRRDAAEAATAAKKQRRAGKVQRIVNHPNWHVLNSGQAEQFLASQHRGDCVIRPSSKGPDRIAVTWKVDEDVYQHIDVQEIDKPNEYSLGRILMVSGQYRYSDLDDLIINHVKATARKFDEIQMHEKYKPEHELDAFLKNYVQAHPGRSIYGFSVDSDRPGYLKLCFLSKPTKDGGVIQTWPVRVLPGAYKLGNAIVPGVTELSNAFKMQYSEKLAEQGHQGKTPGIYLGKTPMHLGGRTPALGSRTPAMGSRTPALGSRTPALGSRTPALGSRTPAQGGPRY

SPT6

Transcription elongation factor SPT6

1506 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

171.725 kDa

MSDRPGSASEGEGDEIRPYGEDRDSSEESEDDDPEEAKRIAEGFIVDEDEEDGEGEDDEEDEETRRRRRKEEKRRRKKERRMRREREEAELSEDELELIEENRGLREGRPLKRLRRRSGSEGSENDRAVPTLQDMFRDDEDRMEDDDDDLMDFIEEDEEDEANQGETEEQRRERKRAEKLKRREQARSRPELTGVDRSSWDEIFAVFGDGQDYDWALEGEDGMDLDEEEEAAKKDLRLEDVFDPAEIKARRLQDEDKAVANADRPERHQIVNSTLSDNPVFATDTLYPPPDFAAKWVAPKVSFRTQYLFYNQHPEGSYPIPTIDNPQPYPVYRRPDLEIEFEKAVSTALNMMFVQHLEVPYLWHYKRDVFSLLENQGQSSVLFLERDELWQVYVLGQRYRAIHERNEQTRQQWGKIKARKGDIEDEYFTKGLLGKACVASIEAAGEGDEWLAYHYASDIKAIKEEEAFDEVSKKLPERAEREDIRRGRIMKLVEAFGIDANKVASSFQDVHGQPAPVMNPDKMPLELADEFTGAAYSSPEQALSAASFVLVQELSKDPAIRQQARDFMDTCGLVTVNATDRGMSVIDQYHLYYNFKFLTNKPVLDFRDSPQFVHMLKAEEEGLINIAFDIREDMLASFTDALIRCCRSNDYGEIASAWNEVRMEVCNTLVKKHLMPMASKWIKEHLRTQAEEYIAERCREELELRVNVRPYASSGMEQGETPSVLAITNGKGDIRDAVMAVMLDDEGNVRTQTKFDNLRDEEDKTMFIELLEKRKPKVVVIGGFSAQTARLKDAALVAIRQHAIELLGQNPPVSDAYPDHEGFQYAMAEYDEKLKAHLIPLIFVNDATARLYMSSEEAEKEHPNLPLNGRYALGLARYAQNPLNAYCKLGKHIASVTFMEHHQKLIPQEKLLYHLERGLVNSVCFMGIEINSCVADPYQRAMLPYIAGLGPRKADAVIYGIQKHGALINRMAFTDLGLFGPTIFENTAGFLTIESDLKDMMLEAENPQEQPDPLDMTRIHPENYEFAQKMCQDALDLDVEDVADRHKSEVVQTLMLDDKRGKKLGELNLDDFAFNLQRQGEGNKRHTLGEIVSELIRYRSDRRPAFYVPTDWEIVTMVTGETERTVGRGLKVTATVRKAISARVFCQLESGLDAVLERDYVADEDQAPVTSCDEVFKPRQAIKGVVIMPEPARFQVRISTRPSDLRQGVDFVQPFKDEEYNSKDRRDAAEAATAAKKQRRAGKVQRIVNHPNWHVLNSGQAEQFLASQHRGDCVIRPSSKGPDRIAVTWKVDEDVYQHIDVQEIDKPNEYSLGRILMVSGQYRYSDLDDLIINHVKATARKFDEIQMHEKYKPEHELDAFLKNYVQAHPGRSIYGFSVDSDRPGYLKLCFLSKPTKDGGVIQTWPVRVLPGAYKLGNAIVPGVTELSNAFKMQYSEKLAEQGHQGKTPGIYLGKTPMHLGGRTPALGSRTPAMGSRTPALGSRTPALGSRTPALGSRTPAQGGPRY

SPT6

Transcription elongation factor SPT6

1460 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

169.61 kDa

MSDKEDEKQSQPVLKDDKQDQTEEPAIDDNVNGDEGPSDEEEGDDVFDSSEEDEDLDNDEEEAQKVREGFIVDDDEEGGEEDEVVKKKSRRKRRAREEENEALDEDDLDLLMENAGFKRPSASEAAKQRSGKLKRLKRVGDDEEESASAEPESEVARTNKLDDFFSEEEEEEELEDDGTGRAPSRKGVEKTVTLADDMDDFIEEDEFSDEDEEARKFRIAEKKRIKEQRLAQPTQITGLSPDKVDEMFEVFGDGHDYDWALELENEEELDRLEESSENEQDENELGIDSKRKKKLTLQDIYDLQDLKKNLLTEEDMNIRKADIPERYQELRTGLKNYGKLSPEDLELEKNWISDKIAVDKNFDADYDTTEFKEAIGNAINFIQQENLEVSFIYAYRRNYISSRSKDGFVLIEDDLWDIVFYDTEFHSIIYKRDYVKTFYEKLDIHDPIVDEYFSNQSMTELNSLQDIYDYVEFKYAQEINDVLLSTQQDATSKKHLKNSSYEKFKASALYQAINDTGITAEQVGENISAEHQLHPVVDHPSLKPTDSVANILEGPEAKDLQIFSQNPKLALETIEKYYALELSKNPKVRQKIRDDFYKYYIVDVALTSKGRKEIQRGSPYEDIKYALGRTPAHFRSEPDVFLRMLEAESLHLMNIQIHVSSQDQYTNHLFQTSLETSNTSEIASEWNSFRRDAFDSALNKVFSDVSQEIKDELKKTCLRLVTKSVRHQFMFKLDQAPFIPNPKDPKIPRVLTITCGQGKFGSDAIIAVYLNRKTEFVRDYKIVENPFDRKEPELFENALDDIIQHCQPNVIGINGPNPSTQRLYKKIQEIVQKKQIVDNRGSHVPVIYVEDEVAVRYQSSERAAQEFPSKPTLVKYCIALGRYIHSPLLEYANLTNEELLSLSIHSHQSLLTRELFLQALETSFVDIVNLVGIEVNKATDNHYYAKALRYIAGFGRRKSADFLESLQRLNEPLLARQQLITHDILTKTIFMNSAAFLYISWNEKNQRYEDLEHDQLDGTRIHPEDYHLATKVAADALEFDPDAIAEKEEQGTMSEFIELLREDPDRRTKLESLNLEAYAEELEKNTGQRKLNNLNTIVLELLEGFEELRNDFHPLHGDEVFKSLTGESEKTFFKGCIIPVRVERFRHNDIYGVTNSGVECVINAQRHIGAQLKRPAEEVYEIGKTYPAKVIYIDYDNISCEVSLLEHDIRRQYVPIHYSKDPSIWNVEQEMKDQEIEKKLALEEARAKRTHRVINHPYYGNFTGPQAEDYLRSRERGDFVIRQSSRGDDHLAITWKLDKDLFQHVDILEKDKENPLALGKTLIVEDQKYHDLDQIIVEYLQNKVRLLNEITSNEKFKKGTKKEVIKFIEDYSKVNPNRSVYYFSFNYEHPGWFYLMFKINAQSQLYVWNVKLTHTGFFLVNYNYPTVIQLCNGFKTLLKSSSRNKTQDNNNNNSGGYYGY

SPT6

Transcription elongation factor SPT6

1451 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.

Belongs to the SPT6 family.

168.291 kDa

MEETGDSKLVPRDEEEIVNDNDETKAPSEEEEGEDVFDSSEEDEDIDEDEDEARKVQEGFIVNDDDENEDPGTSISKKRRKHKRREREEDDRLSEDDLDLLMENAGVERTKASSSSGKFKRLKRVGDEGNAAESESDNVAASRQDSTSKLEDFFSEDEEEEESGLRNGRNNEYGRDEEDHENRNRTADKGGILDELDDFIEDDEFSDEDDETRQRRIQEKKLLREQSIKQPTQITGLSSDKIDEMYDIFGDGHDYDWALEIENEELENGNDNNEAEEEEIDEETGAIKSTKKKISLQDIYDLEDLKKNLMTEGDMKIRKTDIPERYQELRAGITDYGNMSSEDQELERNWIAEKISVDKNFDANYDLTEFKEAIGNAIKFITKENLEVPFIYAYRRNYISSREKDGFLLTEDDLWDIVSLDIEFHSLVNKKDYVQRFYAELHIDDPIVTEYFKNQNTASIAELNSLQDIYDYLEFKYANEINEMFINHTGKTGKKHLKNSSYEKFKASPLYQAVSDIGISAEDVGENISSQHQIHPPVDHPSSKPVEVIESILNANSGDLQVFTSNTKLAIDTVQKYYSLELSKNTKIREKVRSDFSKYYLADVVLTAKGKKEIQKGSLYEDIKYAINRTPMHFRRDPDVFLKMVEAESLNLLSVKLHMSSQAQYIEHLFQIALETTNTSDIAIEWNNFRKLAFNQAMDKIFQDISQEVKDNLTKNCQKLVAKTVRHKFMTKLDQAPFIPNVRDPKIPKILSLTCGQGRFGADAIIAVYVNRKGDFIRDYKIVDNPFDKTNPEKFEDTLDNIIQSCQPNAIGINGPNPKTQKFYKRLQEVLHKKQIVDSRGHTIPIIYVEDEVAIRYQNSERAAQEFPNKPPLVKYCIALARYMHSPLLEYANLTSEEVRSLSIHPHQNLLSSEQLSWALETAFVDIVNLVSVEVNKATDNNYYASALKYISGFGKRKAIDFLQSLQRLNEPLLARQQLITHNILHKTIFMNSAGFLYISWNEKRQKYEDLEHDQLDSTRIHPEDYHLATKVAADALEYDPDTIAEKEEQGTMSEFIELLREDPDRRAKLESLNLESYAEELEKNTGLRKLNNLNTIVLELLDGFEELRNDFHPLQGDEIFQSLTGESEKTFFKGSIIPVRVERFWHNDIICTTNSEVECVVNAQRHAGAQLRRPANEIYEIGKTYPAKVIYIDYANITAEVSLLDHDVKQQYVPISYSKDPSIWDLKQELEDAEEERKLMMAEARAKRTHRVINHPYYFPFNGRQAEDYLRSKERGEFVIRQSSRGDDHLVITWKLDKDLFQHIDIQELEKENPLALGKVLIVDNQKYNDLDQIIVEYLQNKVRLLNEMTSSEKFKSGTKKDVVKFIEDYSRVNPNKSVYYFSLNHDNPGWFYLMFKINANSKLYTWNVKLTNTGYFLVNYNYPSVIQLCNGFKTLLKSNSSKNRMNNYR

SPT6

Transcription elongation factor SPT6

1449 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

168.864 kDa

MSDQESASLREEKNEIINGMGSGAPSDEEEGEDVFDSSEEEEEDDEDEARKISEGFIVNDEDEDEDEDDENVADKKKKRRHKRRAREEEDDRLSEDDLDLLMENAGVKRPTTEGSSGGKLKRLKRVGDEVESGAADREQESSQEKESSRLNDFFSDDEDEEPYDEENRERSRGSREYDRGESNHQGDNRKSGMLDELDDFIEEDEFSDEDEETRQQRLLERKMMREQRMKAPTKITGLSSDKIDEMYDVFGDGHDYDWALEIENEELEGGDINEQSEEFDEETGMTKSSKKKISLQDIYDLQDLKKNLMTDEDMLIRKTDIPERYQELRSGLVNHGNLSDNDQELEKNWISEKIAVDKNFSADYDLTEFKEAVGNAIKFITKENLEVPFIYAYRRNYISSRERDGFLLTEDDLWEIVHLDIEFQSIINKRDYVKRFYSELGISDPLVDEYFKNQSTGSVAELNSLQDIYNYLEFKYAQEINDNLQKESDKSGKKHLKNSNYEKFKSSALYKVIEAVGVSADQIGNNISSQHQIHIPKDHEALKPLELIELVLNENAGDLQVFLSNIKLAMDTIQKYYSWEISKNTKVREKVRADFYRYYLVDVVLTTKGKREIQRGSLYEDIKYAINRTPLHFRREPEIFLKMLEAESLNLMTLKLHMSSQKQYVDHLFQIALETTNTSDLAIEWNNFRKAAFTQAIEKIFNDIAQEIKDDLEKTCQKLVCKVVRHKFMTKLDQAPYVPDLKDPKLPKILTLTCGQGRFGSDAIIAAYVNRKGEFVRDFKITENPFDRSNPDKFEEVFEDIVQTCQITAIGINGPNPKTQKLFKKLIEVIHKKNLVDSKGTHIPIIYVEDEIAIRYQNSERAAQEFPNKPPYVKYCIALARYMHSPLMEYANLSPEELKSLSIHPFQSFLSPEYLNRAIETAFVDIVNLVGVEVNKATDNSYYASVLRFVSGFGKRKAIDFLESLQRLNEPLLARQQLITHNILHKVIFMNSAGFLYISWSKKRQRYEDLEHDQLDSTRIHPEDYHLATKVAADALEYDPDTIAEKEENGTMSEFIEFLREDPNRRSKLESLNLESYAEELEKNTGQRKLNNLNTIVLELLDGFEELRNDFHIMQSEEVFSSLTGETDKTLFKGCVIPVRVERFWHNDIVCVTNSEVECIVNAQRHLGAQVRRPPNEIYELNKTYPAKVIFIDYPNITAEVSLLEHDVKNEYNPLTYSKDPAIWDLKQELEDSEEEKKVTMAESRAKRTHRVINHPYYFPFNGKQAEDYLRSKERGDFVIRQSSRGDDHLAITWKLDKDLFQHVDIQELEKENPLALGKVLVVEGQRYHDLDQIIVEYLQNKIRLLNELTSNEKFKAGTKKEVVKFIEDYSKVNPKKSVYYFSLNYENPGWFYLIFKLNAESKLYIWNVKLTHTGFFLVNYNYPTVIQLCNGFKTLLKSSNTRNRSGYR

SPT6

Transcription elongation factor SPT6

1439 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

165.357 kDa

MAKEDIEEEREIRNDASENSSDEEGDDVLDSSEEDDDDDDEEAIKRVREGFIVDDDEDESQKRKRRKHKKRKREERTNDDENNALDQDDLELLMENSGARPQPSSNKLKRLKRAYTEDTEGAEEEEIGAKSGRGGLTDIFSDEDNNEEERADLGETRVDDDRNILDEFEDFIEEDEYSDEDEERQRKLTQQRERAQKKGPRLDTSKLSNVDRESLQQLFEVFGNGAEYEWALEAQEMEDEGNGENLEPTSLDEVFEHAELKERMLTEEDNLIRIVDIPERFQKYRANLNYIDLEGEELKSEQGWVANILFMEKQGSFSGFLEEPFKEAVSKVVEFISKDVYEVPFIWTHRRDFLLYSEEIKNEDGSVTNSVHKLLFEDDLWRIFQLDIEYHSLYEKRVNIEKLIESLNLDDDLVKDVKSLETMVAIQDLQDYINFTYSTEIRKLYDDKETEGIDANITKKHSKYAIFERIKSNVLYDAVNAFGISAKEFGENVQDQSSKKFEVPYRIHATDDHIESPEDLIERLCEDDEVLFKDPKNALNAVRKTFAEEIFHNPKIRHEVRTTFKDFASIRVAVTEKGKAIDNHSPYADIKYAINRSPADLVRNPDVLLRMLEAEAAGLVVVKVETKDYDSWFQCIFNCLKSDGSSEIFEKWNKEREFVLNMAFKRLTSMVSMNTKEDLRRECERLIASEVRRRFLARIDQAPFTPFGFDKGTKPNVLALSFGKGDFDSAVIGAFLRESGKVDEFFKSEDNPIRDRESEDKFSGQLKEFFDKNLRNQKPDVIVVSGYNAISKKLFDSVKSFVETNNVTANTEELTDVQNPPLIQVIWGQSETATLFQNSERARIEFSDKPTLAKYCVGLARYVQSPLLEYLSLGEGILSLTFFEHQKLISTDLVMEAIESAYVDIINMVGVEINEAIRDPYIAQLLPYVAGLGPRKASGLLRNINSKLGSTLANRSDLIENELSTANIFINCSSFLNIPYDEGLSMRDSSVELLDATRIHPEDYDLARKMAADALDLDEEDMAHVEEQGGIIYQLMQDGVNKVDDLNLTAYGKELESKFGKKKYATLQSIKEELVNNFEEIRRSFHILESHEVFHMLTGETTESFTRNTIVPVTVNKVGQNFRDFENSKIKFAKVTTSSFIQGNIEEASIPQGIDLAQGQVVQAVVLDAYYDSFTASFSLLEADIQKGAAPKFHKDPLKWNFEAEQADKQKEMAKERAQLAKTRNIQHPLFHNFSYKQAEEFLAPQAVGDCVLRPSSKGPNYLTVTWKVSNNLFQHLSIQENTQGMGKEYIVEHKKYADLDQLIFQHVQAIAKHVDEMCRHPKFREGTMSEVNEWLESYTKANPKNSAYVFCFDHKAPGWFLLLFKVNVNTPITTWHVKTECDGYRLKGFSYPSMLRLCNGFKQTFKSYVKGIADRSRSTKPAPVNNQAQASTYGGYGY

SPT6

Transcription elongation factor SPT6

1432 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

166.707 kDa

MSSEGLASARELEERDLGATRDTEEIPSDEEEGEDVFDSSEEDEDLDEDEEEARKVKEGFIVSDDEEDDSSVKQRRRRKHKRRPRHEEDDGKLSEDDLDLLMENAGVKRTTRPETDATKGRFKRLKRAGSPDESEGQQDTDGRHENRLEDFFSEEEDEEHLGGTENRRLRTGGKDVLDELDDFIEEDEFSDEDEATRQQRRKLKEQRSKQSVQITGLSSDKIDEMYDIFGDGHDYDWALAVENEDDLENLDEYQQEEDDDETSDQKAKKKKITLQDIYDMQDLKKNLMTEEDMVIRRSDIPERYQELRAGLKNYGQLTPEDQLLEQNWISDKIAVDKNFDATYDISEFREAVGDAVRFISKENLEVSFIYAYRRNYISSRDKNGFILSEDDLWDIVFYDIEFHSIIYKRDYVKKFYEQLGIRDSLVDDYFNDESMTELNSLQDIYNYLEFRYAHEINDALLADSSSKTKKHLKNSSYEKFKSSSLYQAVKDVGITAEQIGENIGAETQIHPVVDHPNLKPSESISQILDAASADLQVFAKNHKLAWDTVQKYFAAEIGNNPKVRQKIRNDFYKYYIVDVVLTTKGRKEIQRSSPYEDIKYAINRTPGHFRSAPDVFLRMLEAESLHLMNIKIHMSSQEQYCEHLFQIALETTNTSEIAIEWNNFRRNAFYQALEKIFEDIAQEIKDELKKTSQKLVANSVRHRFMSKLDQAPFIPNPREPKIPRVLTITCGQGRFGLDAIIAVLLNRKGDFVKDFKIVQNPFDRDQPQAFEAVLDNIIQEAQPNVIGINGPNPKTQKLFKKIQEVIQKKQIVDNRGHNIPVIFVEDEIAIRYQSSERGAQEFPNKPTLVKYCIALARYIHSPLLEYTNLSEEELQSLLIHPHQSLLPRHIFKRALETSFVDIVNLVGVEVNKANDNPYYAKALQYIAGLGKRKAIDFLESLQRLNEPLLARQQLITHDILHKTIFMNSAGFLYISWNEKNQRYEDLEHDHLDSTRIHPEDYHLATKVAADALEYDPDAIREKEEQGAMSEFIELLRDDPDRRMKLESLNLEEYADELERSTGQRKLNNLNTIVLELLEGFEELRNDFHPLQGDEIFTSLTGETDKTFFKGSIIPVRVERFKHNDIICISNSQVECIVNAQRHLGVQLKRPASDIYEVGKTYPAKIIFIDYENISAEVSLLDHDVKHQYIPVDYSKDPTIWNLKQELEDVEEEKKISMAEARAKRTHRVINHPYYFPFNGKQAEDYLRSKERGEFIIRQSSRGDDHLAITWKLDKDLFQHVDILELDKENPLALGKTLIVDNNKYNDLDHVIVEYLQNKIKLLNEITSNEKFKKGTKKEVVKFIEDYSNVNPNRSVYYLSFNYEHPGWFYLMFKINAQSKLCTWNVKLTHNGFSLADYNYPTVIQLCNGFKTLLKSSSRARTQEASGSGYYGY

spt6

Transcription elongation factor spt6

1422 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

163.737 kDa

MSARDLVEGEAMLDDEENEEELADDYDGEGEAHQGAGTANPYDSSEEDDDDDDDEEAARAVREGFIVDEDEELEDRAERRREKRKRRREEREREDEHLDEEDLELIGELNPSLQAPVAAESKFKRLKRGHKDRDLRQPSQGIDDIFNSDEEEEAAGDYGRHGHRRHMHDEMDDFIEEDVFSDEELQREREDLEIARPAKKGMTGLGATDAAGLDENALEDMRAAFGDGNEYLFALEMEDQEEEQEEDEEKHLDLKDVFEPSQLAEKMLTEEDNQIRLLDEPERHQIARKPYRNVVLTEEQFREEAAWISNLMLLKKRIEPELREPFQRSVAKVLEFLVTDDWEVPFIFQHRKDYMIHAVKAPVEGAGEDGDASQYTVRAEKLLNMTDLWDIFDHDLKFKALVEKRNTIQKTYDNLQSLFNVSDSVVEEMLPAAVTMEELQDVQDYIHFQYASQLRDMTLMNSDVNGETHRRKASSKTFFERVRNGKAYGLVRAFGITADAFAQNALKEGRRQYTEDPAERPEEMADGFVDNDFSNASHVIKAAKSLFAEEIVMSPKMRKVIRQAYYMNGAVDCFRTEKGLRRIDEQHPYYEFKYLRNQQLSDIARRPELYLRMLKAEEEGLVEVKVRFENFDQFRQRLYPDIESDNYSEIADGWNRSRRDVLDMALGKLERLINRSVKENIRQECENHVAKECRETFSQRLDQAPYKPKGMVLGTVPRVLALSTGSGVVGREPIHWAYIEEDGRVLENGKFVDLSIGDRDRNIPDGKDVEAFVELVDRRRPDVIGVSGMSPETRRLYKLLAEVVDKKDLRGAPYTDDHDEEISDRLEVIIVNDEVARLYQHSERAKKDHPSFAPLTHYCVALAKYLQSPLKEYASLGRDIVSIQFKPGQQLVTQELLLKQLETALVDMVNLVGVDINEAVTDSSTANLLPYVCGLGPRKAAHLLKIVNMNGGVVNNRVELLGVNAQYPAMGVKVWNNCASFLYIDFENVDPDADPLDNTRVHPEDYDIARKMAADALELDEEDIKAETDENGTGAIVRKLFREEAQDRVNDLILEEYAEQLEKNLNQRKRATLETIRAELQQPYEELRKQYVFLSTDDIFTMLTGETSDTLAEGMVVPISIKRVSDDHIDGKLDCGIDALVPESELTDRYDIPVRALYSPHQTVSAKILFLNRKNFTCNVSLREEQVSRPVSNTQDRLRGEWDERQEQQDRESLQEKTQSGGRTMRVIKHPLFRPFNSTQAEEFLGSQSRGDVVIRPSSKGHDHLAVTWKVADGIFQHIDVLELDKENEFSVGRTLKVGGRYTYSDLDDLIFNHVKAMAKKVDEMMLHEKYQDGTKDATYSWLETYTKANPKRSAYAFCIDPKHAGYFFLCFKAGENARLHSWPVKVIPQGYELQRNPYPDMRALCNGFKLLFTNMQAGKRR

spt6

Transcription elongation factor spt6

1420 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

163.634 kDa

MSARDFVEGEAVLDDEENENEEEQEEDYDGEVHEGAGTMNHYNDSSEEEEEDDDDEEAARAIREGFIVDEDEEIEERAERRREKRKRRREEREREDEHLDEEDLELIGELNPAFQSAAATESKFKRLKRGHKDHRQASQGIDDIFNSDEDEEAAGDYGRPSHRRPMHDEMKDFIEEDVFTDDELEREREDLEIARPAKRGVTGLGATDAAGLDENALEDMRAAFGDGNEYLFALEMEEQEEEQEEDQEKHLDLKDVFEPSQLAERMLTEEDNQIRLLDEPERHQLARKPYRNLVLTEEQFREEAAWIANLMLLKKRIEPELREPFQRSVAKVLEFLVTDDWEVPFIFQHRKDYMIHATKVPVAGAPADGDTSQYTIKAEKLLNMTDLWDIFDHDLKFRALVEKRNTIQKTYDNLQSLFNVNDSVVQDMLSTAVTMEELQDVQDYVHFQYASQLRDINLMNGEANGDTHRRKATGRSFFERVRNGKAYGLVRAFGITADAFAQNALKEGRRQYTEDPAERPEEMADSFIDNDFSNASHVLKAAKALFAEEIVMSPKMRKVIRQAYYMNGAVDCFRTEKGLRRIDEQHPYYEFKYLRNQQLSDIARQPELYLRMLKAEEEGLVEVKVRFENFDHFRQRLYPDIESDNYSEIADAWNRTRREVLDMALGKLERLINRSVKENIRQECENHVAKECREAFSQRLDQAPYKPKGMVLGTVPRVLAMSTGTGIVGRDPIHWAYVEEDGRVLENGKFVDLSIGDRDRSIPDGKDVEALIELLERRRPDVIGVSGMSPETRKLYKLLTELVEKKDLRGATYTDERDEEISDPLEVVIVNDEVARLYQHSERAKKDHPSFGPLTHYCVALAKYLQSPLKEYASLGRDIVSIQFKRGQQLVAQELLLKQLETALVDMVNLVGVDINEAVTDPATANLLPYVCGLGPRKAAHLLKIVNMNGGVVNNRVELLGVNAQYPAMGVKVWNNCASFLFIDFENADPDADPLDNTRVHPEDYDIARKMAADALELDEEDIKAETDENGPGAIVRKLFRDEAQDRVNDLILEEYAEQLEKNLNQRKRATLETIRAELQQPYEELRKQFALLSTDDVFTMLTGETSDTLAEGMVVPISIKRITDDHIDGKLDCGVDVLVPESELTDRYDIPVRALYSLHQTLPAKVLFLNKKNFLCNVSLREEQVSRPTPRPRDHMRGEWDDRQEAKDREMLQEKTQSGGRVMRVIKHPLFRPFNSTQAEEFLGSQSRGDVVIRPSSKGPDHLAVTWKVADGIFQHIDVLELDKENEFSVGRTLKVGGRYTYSDLDDLIFNHVKAMAKKVDEMMLHEKYQEGSKDATYSWLNTYTKANPRRSAYAFCIDPKHPGYFQLCFKAGENAQLHSWPVKVIPQGYELQRNPYPDMRALCNGFKLLFTNMQAGKR

spt6

Transcription elongation factor spt6

1417 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

163.079 kDa

MSARDFVEGEAMLDEEENEEELVDDYGDGEERLETGGNHYDSSEEDEDEDDDEDAVRAVREGFIVDEDEEEEERAERRRERRKRRREEREREDEHLDEEDLELIGELNPGLQYAAAADSKFKRLKRGHKDRDSRQPSQAINDFFNSDEEDEPAPDYGRHRRHPGDEMDDFIEEDVFSDDELQREREDLEVARPRKTIGFGATDTTGLDENALEDMRAAFGDGNEYDFALAMEEEEEQQEEDVEKHLDLKDVFEPSQLAEKMLTEEDNQIRLIDEPERHQIARKPYRNVVLSEDQFREEAAWIANLMLLKKRLEPELREPFQRSVAKVLEFLVTDDWEVPFIFQHRKDYMIHTVKVPVNGASADDSSSQYTIKAEKLLNMTDLWDIFDYDLKFKALVEKRNTIQKTYDNIRSVFSVEDPIVEEMLPIATTMEELQDIQDYLHFQYASQIRDLTLTNGDTNGEVQRRKALTRNFFERVRNSKAYGLVRAFGITADAFAQNALKEGRRQYTEDASERPEDMADGLVDNDFNNSSQVLKAAKGMFAEEIVMSPKMRKVIRQAYYMNGAVDCFRTEKGLRRIDEQHPYYEFKYLRDQQLSDIARSPELFLRMLKAEEEGLIEVKVRFENFENFRKRLYPNIESDNYSELADSWNRLRREAVDLALGKLERVINRSVKENIRQECENHVAKECREAFSQRLDQAPYKPKGMILGTVPRVLALSTGTGIIGRAPIHWAYVEEDGRVLENGKFTDLSLGDKDRGIADGKDLEALVELVNRRRPDVIGVSGMSPETRRLYKLLTEIVDAKDLRGALYTDDRDEEVSDRLEVVIVNDEVARLYQNSDRAKKDHPSFAPLTHYCVGLAKYLQSPLKEYASLGRDIVSIQFKPGQQLVAQELLLKQLETALVDMVNLVGVDINEAVSDPATANLLPYVCGLGPRKAAHLLKIVNMTGGVVNSRFSLLGVGVQYPAMGVKVWNNSASFLYIDYESADADSDPLDNTRVHPEDYDIARKMAADALELDEEDIKAETDENGPGAIVRKLFREDAQDRVNDLILEEYAEQLEKNLNQRKRATLETIRAELQQPYEELRKHFVFLSTDDIFTMLTGETAQTLAEGMVVPISIKSIRDDHIEGKLDCGVDALVGESEMTDRYDIPVRAIYSLHQTVPAKVMFLNRKTFTCNVSLREEQVSRPSRPAADRAHAGEWDYRQEEQDREALEAKTQDGGRTMRVIKHPLFRPFNSTQAVEFLGSQSRGDVVIRPSSKGPDHLAVTWKVADGIFQHIDVLELDKENEFSVGRTLKVGGRFTYSDLDDLIFNHVKAMAKKVDEMMLHEKYQEGSKDSTYQWLETYTKANPRRSAYAFCIDPKHAGYFFLCFKAGEHAQVHSWPVKVIPQGYELQRNPYPDMRALCNGFKLLFTNMQSGKRR

SPT6

Transcription elongation factor SPT6

1408 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

162.213 kDa

MSNSMRDLISGEAELDDEEEDESFDERGGQRRHKNAVEDSSEEEEDDDDEEEARKVREGFIVDEDEDEDEGGESDADVRPLHKRKREHRDREEEAQLDEDDLDLIGEQFGERPKPTTQSKFKRLKRGTRDEDRGNQRRGLDDIFSDEEDDAGEQRAYNNRSSYRQADEFDDFIEEDFPDDPEELEQQREDAEVARPRDRVIGNIADTANLDKDALDDMEAIFGNGEDYDWALQMEEEEEDREREEQAIELKDVFEPSQLKEKLLTDEDNEIRFTDEPERFQIDRKTFKSLQLTAEQFKEEARWITNQLWPKKGLASDLQSPFGKAVGKVLEFFIVDEVEVPYVFQHRKDYLLHTRKTRNPNRDDPDAPEYVISADKLLNQDDLWKILELDIKFRSFVDKRNALEKTVDNLKGMEIHDAMVDEMIPEATTMEELQDLQDYLHFQYGQQLKDLAALAGNLSLTKRPGSKSNLLERVRQGKAYGFVRAYGISADQLAKNALRHGKKVTPDDDAQYPMDLADSLIDDVFSTGDQVISAARQMYSEELFASPRMRKHFRNSYYQAAEISCRRTEKGLRRIDDSHPYYEIKYLQNQAIADLVHQPELFLKMMKAEEEGLVTIKLDMPARYDFRQHLYQEFESENFSDRAEQWREERKKVLDLAYPKLEKIIAKNVKEVIRTFCQDEVLKMCREEYAKRLDQAPYKPKGMILGTTPRVLVLSNGMSDPARDPICWAWVEEDGRVIEQGKLGNLARDERQREEFEELVKRRRPDVIGVSGWSAETTKLVRDLEGLVNEKGLMGPEFEDPDTNDYRTEPLEVVVVNDEVARLYKDSPRALAEHPSLNPITRYCVALARYMQNPMKEYAALGKDVSSLSYHPCQNLLPADKLAKYLDSAMVDMVNLCGVDINEAMNDTYTANLLPYVSGLGPRKATSVIKAINANGGAVGTRDELVGDPDSGKLPVVGPRVWNNCASFLFIEYEATNPSSDPLDNTRVHPEDYELGRKMAADALELDEEDVKGETDENGPGAIVRKLFKMDEQDKVNELVLEEYAEQLERNYSQRKRATLETIRAELQAPYEELRRNFALLSASEIFTMFTGETKHTLCEGMIVPVNVRVVKDDFAIVKLDCGIEGRVEGHEVSHRSSIKEVLSSGQTSQAKILDINYKDFMAKLSMREDALRIPYKRPINLGRDGWDYVLEAADKEELREKDKTTGRTQRVVKHPNFKPFNGLQAEEYLGSQPNGEVVIRPSSKGNDHLAVTWKVADGVFQHIDVLEMQKETEFAVGKLLRVGGKYTYTDLDELIVEHVKAMARKVEELMRHDKYQNRSRGETEKWLTTYIDANPNRSTYAFCIDTKHPGYFWLCFKASRAAKVIALPVRAIPQGFELKGYQYPDMRALCNGFKLRYQNEFSKMGQR

SPT6

Transcription elongation factor SPT6

1401 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

162.067 kDa

MMKKKISAKKKNQQQQQLHQPTMSEVTEEERTRYEEEEDVRDSPSDSSEESEDDEEEIQKVREGFIVDDEEDEVQTKKRKSHKRKRDKERPHYDDALDDDDLELLLENSGLKRGSSSSGKFKRLKRKQIEDDEDEIESQDHQGEQQLRDIFSDDEEVEEEAAPRIMDEFDGFIEEDDFSDEDEQTRLERREQRKKKKQGPRIDTSNLSNVDRQSLSELFEVFGDGNEYDWALEAQELEDAGAIDKEEPASLDEVFEHSELKERMLTEEDNLIRIIDVPERYQMYRSALTYIDLDDEELELEKTWVANTLLKEKKAFLRDDWVEPFKQCVGQVVQFVSKENLEVPFIWNHRRDYLEYVDPDAPIPGSVRELMISEDDVWRIVKLDIEYHSLYEKRLNTEKIIDSLEIDDELVKDIKTLDSMVAIQDMHDYIQFTYSKEIRQREETQNRKHSKFALYERIRENVLYDAVKAYGITAKEFGENVQDQSSKGFEVPYRIHATDDPWESPDDMIERLIQDDEVIFRDEKTARDAVRRTFADEIFYNPKIRHEVRSTYKLYASISVAVTEKGRASIDAHSPFADIKYAINRSPADLIAKPDVLLRMLEAERLGLVVIKVETKDFANWFDCLFNCLKSDGFSDISEKWNQERQAVLRTAISRLCAVVALNTKEDLRRECERLIASKVRHGLLAKIEQAPFTPYGFDIGSKANVLALTFGKGDYDSAVVGVYIKHDGKVSRFFKSTENPSRNRETEDAFKGQLKQFFDEDETPDVVVVSGYNANTKRLHDVVYNFVSEYGISVKSEFDDGSSQLVKVIWGQDETARLYQNSERAKKEFPDKPTLVKYAISLGRYLQDPLLEYITLGDDILSLTFHEHQKLISNDLVKEVVESAFVDLVNAVGVDINESVRDSRLAQTLKYVGGLGPRKASGMLRNIAQKLGSVLTTRSQLIEYELTTRTIFINCSAALKISLNKSINVKDFEIEILDTTRIHPEDYQLAMKMAADALDMDEESELHEKGGVIKELLENDPSKLNLLNLNDFANQIYKLTHKLKFRSLQAIRLELIQGFAEIRSPFRILTNEDAFFILTGEKPQMLKNTVIPATITKVTKNHHDPYARIRGLKVVTPSLIQGTIDENAIPRDAEYVQGQVVQAVVLELYTDTFAAVLSLRREDISRAMKGGVVREYGKWDYKAEDEDIKREKAKENAKLAKTRNIQHPFYRNFNYKQAEEYLAPQNVGDYVIRPSSKGASYLTITWKVGNNLFQHLLVEERSRGRFKEYIVDGKTYEDLDQLAFQHIQVIAKNVTDMVRHPKFREGTLSVVHEWLESYTRANPKSSAYVFCYDHKSPGNFLLLFKVNVSAKVVTWHVKTEVGGYELRSSVYPNMLSLCNGFKQAVKMSSQQTKSYNTGYY

spt6

Transcription elongation factor spt6

1365 amino acids

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

Belongs to the SPT6 family.

157.21 kDa

MSENEVVGSPTTNGDKNEDGYPAENGEGTNVDDNNNEEEKDGIPLDNDNDENDSSEESATDEEAERQVREGFIVEDEEDEVPQEIRRKKKRKKHAESTADQDMLDEEDLELVMENTGQGSRFSKLRRLKRGRDQEETLENIFSEEEEEEENEVDDEAPNRTQGHRAGVIDEFADFIEQDEFEDEERQEEKYETGPPIESVRPEALGISDDDYIQIYEVFGDGTDYAFALEDEDAEDELEESVSLKTIFEPSELKDKMLTEEDEIIRITDEPERMQLYMKRNIDCSEDEFREQVAWIIDYLLKNRRDIDAELYEPFQTAVRYVVHFFIRDSLEVPFIWQHRRDYIVHNNRERNTITPLLSQNDLWNIFFLCTKFWSLHSKKQDILKLYSDLGINDDLVVPFCEAASSLDAIDDLNDYIHFTYSEQIRDRALLMGTGLRRPQGSKYSFFEKFRKSSLYNLVKEFGMSAKDFSFNVAQGARLRFVEDNTLSPEELSRTYVTNELSSPEQVLQKARRVLAEEIIHDPQFRKSFRDKLYNAGVVTVLATQKGVRKIGSEHPYYEFKYLKRKPLGSFELEPILFLKMLKAEEEGLIQLSIEFEDPDDVFKGLLELFVSDNFSENAMQWNAQRELVLKEVFKRFSALAPDAIRETLRSRYLDELGMRCRNQLFSRLDQAPYEPSTKNFDRGTIPSVLAVSNGKGESSDAIICVFVDDVGEPTDSLKLADLRDLANQAMFAEFVEKVKPDVIGVSGMSVSAHKIRQHVQDSLTSHEPVDLIMVNDEVARLYQNSTRAVDEFPTLPTISCYCVALARYVQNPLFEYAAMGRDLMSLSFDPWQHLLPPDVLWKYLETALVDISSLVGIDINEAVTNKYEANILPYIAGLGPRKADYVLKKIAATGGRIDNRSDLISKQIMSRKVFINCSSFFIIPNDEYPNMDILDSTRIHNEDYELARKMASDALELDEEDIEELETNRGVVYHLLEENETGKLDELVLEEYADQLEREFHQKKRNTLEKIRLELKDPYGEQRNVFHKLTPSEIFLMLTGENPEELQADAIVPVNVRRVTNRFVAVKLDCGIDGNIKADEVSDDFIPPPQLLQVGQTVEGVIISLDEANFMVDLSLRNSVLQSANSKRQTSSHRTSYWDTEAEKRDTERMQAETQAEQRVARVIKHPLFKDLNASQAEAYLSKMQVGDLVIRPSSKGSDHIVVTWKVAEGSYQHIDVLELEKENEFTIGQKLLVKGRFEKMTYQYSDLDELIVLHIKAIAKKIDEMCIHDKFRKGTQAETEKWLESYSEANPKRSCYAFCFDHQHPGYFILCFKASVNSPVTAWPVKVIPNAFFLQGNVYGDMTALCNGFKLLYAARTKNFRRM