SPT16

FACT complex subunit SPT16

1074 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (Probable).

Belongs to the peptidase M24 family. SPT16 subfamily.

120.586 kDa

MADSRNGNARAPPSGVPPKAGNTYSIDVKNFISRARALYEHWKKHSADLWGSADALAIATPPASDDLRYLKSSALNIWLLGYEFPDTIMVFTKKQIHFLCSRNKASLLEVVKKPAHDELKLDVIMHVKPKGDDGTGLMDAIFRAIRDLSRGDGNDSQVVGHIAREAPEGKLLETWTERLKNANFQFVDITGGLSDLFAVKDDTEVMSVKKAAYLAYSVMKNVVVPNLESAIDEEKDVTHSALMDLTEKAILEPTKASVKLKPENVDICYPPIFQSGGKFDLKPSAASNDELLTYDPASIIICAVGARYNSYCSNVARTYLIDATSLQSKAYEVLLKAHEAAIDALRSGRKINTVYQAALSVVEKNAPEFVDKLTKSAGTGIGLEFRESGLNINAKNDKVLRPKMAFNVSLGFQNLECESESRSKNKKFSLLLADTVLVTDQKPELLTKCSKSVKDVAYSFKEDEEEEKPRKKARTSGSENYITKTALRSDDHVVSKEELRKQHQAELARQKNEETARRLAGDSSGAGDSRSTAKTSADVVAYKNVNDMPHKELMIQVDTRNEAVLLPIYGSLVPFHVATIRTVSGNQDTNRNCYIRIIFNVPGTPFNPHDSNSLKNQGAIYLKEVSFRTKDSRHSSEVTQQIKTLRRQVMARESERAERATLVTQEKLQLAGNKFKPLRLSELWIRPPFSGRKKIPGTLEAHANGFRYSTTRPDERVDVLFANIKHAFFQPAEKEMITLLHFHLHNHIMVGTKKTKDVQFYVEVMDVVQSLGGGRRSAYDPDEIDEEQRERDRKNKINMDFNHFANRVNDMWQLPQFASLDLEFDQPLRELGFHGVPHKTSAFIIPTSSCLVELIEYPFLVVSLSEIEIVNLERVGFGQKNFDMAIIFKDFKKDVLRVDSVPTSSLEGIKEWLDTTDIKYYESKLNLNWRQILKTITDDPQSFIDDGGWEFLNLDGSDSESGGSEESDKGYEPSDVEVESESEDEASESESLVESDDDEEEDSEQESEEEKGKTWDELEREATNADREHGVESDSEEERKRRKMKAFGKSRPGTSGGGGSSSMKNMPPSKRKHR

spt16

FACT complex subunit SPT16

1072 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

120.903 kDa

MSQSTTTTTTTTAAPAVPTGPREATLDAGNFCKRVKILYDSWNSDSNLWKSANSLVLALGQPNESNPYQKVTSLQTWLFGYELKDTIIVFLEKEIYIVSTSKKINLFQKLSETEQVKTELSSIKFNFLTIDKSDKNKSNFEKLIGEATKAGSNIGVIIKETYIGDLALQWEAALNECPLTKVDITPALSSCLLVKDLQEQKNIITSAKITSKVLKSHILPKIETIIDKGERQTHNQLADYAADIFESPEKISSKLTVEHVDYSYVPIIQSGGIYDLRASASSDDNPLHFGTIIVSCGARYKNYCSNIARTYIIDPTSDQKKNYAILLNVQSNVIKAIKPDVTFSSLYEKAIQTIKESSKPELVDHFPKNVGYGIGIEFQESLAVLNATNSRTLKAGMTLNIACGFQKISNPEGKDEKSKTYSLLISDTVLLNDEGKVEVLTDVGKKASDVVYMLGGEDDDDDNDNDPSVKLELPDDVKGITGRTIETKEKSKSVEERRRDHQKMLEQKNLQEAENKIKAMTDPNGKKGTPEVDYTAITKLQPIYSSVGAYPQDIVKNKMYIDPKKETVLFPIFGYMVPFHISTIKNISKSEEYIRVNFNTPTSYTQEQIDAGFVPPQLMYIREVTYKVNDPKVLANNIRLIKELKKKFTTRETEDREKRNLITQEKLILLRGKFPRLPEVHARPTLSGARRTIGILEAHENGIRFNPTSTKDRTPIDVLYKNIKHAIYQQADQESMAVIHFHLHDALMIGKKKTKDVQFYIEISEMSQSLDVSSRFNDEEEEERRERALKEKINNDFKTFIKRVEEIAPEPGLEFDVPYRELGFYGVPNVSTVFIQPSVHCLLSILEPPFFVLTLDDVEIACFERAIRSLKNFDLSFVFKDYNRPPIRISVIPRNYFETVKEWLDSFNIKFYQSERNYNWKRIMDTIKSDVKKFHDDGGWSFLDLEEEEEEEDSGDDDYHSNSDESESSDYISSMSSGSDDDDEDSSEGENWEDLEQKAERDDKMKTFDETNKRKRDEKSVSSSNRPSSSKSGSSSSGGGGGGGGSSRSKSSSSSSKGSSSSSSKSSSSKRK

SPT16

FACT complex subunit SPT16

1056 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. SSRP1 binds specifically to double-stranded DNA (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

118.588 kDa

MADNGNAKPGGGGSGAYTINLDNFSKRLKVFYDHWKEHNSDLWGSSNAIAIATPPPSEDLRYLKSSALDVWLLGYEFPETIIVFMHKQIHFLCSQKKANLIGTLKKAANDAVGADIVLHVKAKNDSGVGLMEDIVRAVCAQSKSDDPIVGHIAKEAPEGKLLEAWADKLSSSSVQLTDITNGFSELFAMKDTSEITCVKKASYLTSSVMKNFVVPKLEKVIDEERKVTHSSLMDETEKAILDPLKVKVKLKAENVDICYPPVFQSGGKFDLKPGASSNDDYLYYDSASVIICAIGARYGNYCSNMARTFLIDATPTQIKAYETLMKAHEAALEALKPGNRMSAVYQAAVDVIEKNAPELLRNLTKSAGTGIGLEFRESGLNLNPKNDRIIKAGMVFNVSLGLHNLQAEKKSEKTKQYSLLLADTCLVPLENLTASCSKLVKDVAYSFNDEDEVLPVKKVEVNAKEALPPTKATLRSDNQEMSKEELRRQHQAELARQKNEETARRLAGVGSGSGDGRGPSRSSNELVAYKNVNDVPYARELVIQVDQKNEAVLLPIYGSMVPFHVSTVKSVTSHQDNRTCTIRIFFNVPGMPFSNDSNLKSQGAIYLKEITFRSKDPRHSSEVVQQIKTLRRQVASRESERAERATLVTQEKLQLTSNRNKPVRLSDVWIRPAFGGRGRKLTGTLESHVNGFRYSTSRADERVDIMYGNVKHAFFQPAEKEMITLLHFHLHNHIMVGNKKTKDVQFYVEVMDVVQTLGGNRRSALDPDEIEEEQRERDRKNRINMDFQNFVNKVNDHWSQPQFKGLDLEFDVPLRELGFHGVPYKASAFIIPTSTCLVELIETPFLVVTLSEIEIVNLERVGFGTKNFDMAIVFKDFKKDVLRIDSIPSTSLDAIKEWLDTTDLKYYESRLNLNWRPILKTIIDDPQKFIDDGGWEFLNMEASDSETEETEESDQGYEPSDAEPESESEDEDSDSESLVESDEDDEDDSEEDSEEEKGKTWEELEREASNADRENGAESDSEEERRRRKVKTFSKSRPPPERSSFKGGPSKKPKFR

SPT16

FACT complex subunit SPT16

1055 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. SSRP1 binds specifically to double-stranded DNA (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

118.504 kDa

MADNGDAKGGSGAYAINIENFSKRLKVFYDHWKEHKSDLWGSSDAIAIATPPPSDDLRYLKSSALDIWLLGYEFPETIIVFMHKQIHVLSSQKKGNLIGTLKKAANEAVGVDIVLHVKTKNSDGADLMDDIVHAARNQSKSDKPVVGHIAKEAPEGKLLETWIKKLSGSGLRLVDVTNGFSELFAVKDTTEITCVKKAAYLTSSVLKNFVIPKLEKVIDEEKEVSHSSLMDDAEKAILDPLKVKVKLKPDNVDICYPPVFQSGGKFDLKPGASSNDEYLYYDSASIIICAIGSKYSSYCSNVARTYLIDATPTQNKAYETLRKAHEAAIQQVKPGNQMSAVYQAAVAVIERDAPELLPNLTKSAGTGIGLEFRESGLNLNAKNDRRIKKGMVFNVSLGLHNIQAETTSEKTKQFSLLLADTVLVNERGHEILTAPCSKAFKDVAYSFNEDDDAVAAEVKIKSKTIDVMPTKATLRSDNQEMSKEELRRQHQAELARQKNEETARRLAGVGTGSGDGRGPARASNELVAYKNVNDVPFVRDLVIQVDQKNEAVLLPIYGSMVPFHVSTVKSVTSHQDNRTCTIRIFFNVPGMPFSNDSKFNSQGAIYLKEITFRSKDPRHSSEVVQQIKTLRRQVASRESERAERATLVTQEKLQIGSNRMKMMRLSDVWIRPAFGGRGRKLTGNLEAHFNGFRYSTSRSDERVDIMFGNIKHAFFQPAEKEMITLLHFHLHNHIMVGNKKTKDVQFYVEVMDVVQTLGGSRRSALDPDEIEEEQRERDRKNRINMDFQNFVNKVNDHWSQPQFKGLDLEFDVPLRELGFHGVPYKASAFIIPTSTCLVELIETPFLVVSLSEIEIVNLERVGFGTKNFDMAIVFKDFKKDVLRIDSIPSASLDAIKEWLDTTDLKYYESRLNLNWRPILKTIIDDPQKFIDDGGWEFLNMEASDSETEDTEESDQGYVPSDAEPESESEDDDSDSESLVESDDDDEESDEDSEEEKGKTWEELEREASNADREHGAESDSEEERRRRKAKTFGKSRAPERSSFKGAPPSKKPKFR

spt16

FACT complex subunit spt16

1042 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

117.534 kDa

MAEEIVIDKSAFFNRLSSFFAAWKADKRPGHAVFGGVGSIVILMGKTDEANSFQKNNAMHFWLLGYEFPATLMVFTTDMMYVVTTAKKGEDWPNTDSAYLSANTGLLNVAKHLEPLKGGKIPVEILVTSKDPDEKSRSFEKCLEVIKNAGKRVGVLPKDTAAGPFAEDWKRAFANITQDVEEVDISPALSSAAFSVKDTDELVAIRNASRACSGLMSEYFVDEMSRLLDEEKQMTHKALSMRIDAKIDDAKFFKKLAKLPAEFDPQQIDWAYGPVIQSGGKYDLRLTATSDNSHLQAGIIVAGFGIRYKTYSSIIARTYLVDPSKSQEANYAFLLNLHDTVMKDVRDGTMAKDLFNKAIGLVRAKKPELESHFVKSVGAGIGIELRDSNMVLNGKNNKILKSGMTLSITVGLTDVEELESKDKNTAVYSMIITDTVRVGENGPHIFTKDAGIDMDSVSFYFGDEEEPQKPAKEKKEVKSNAMTSRNVTRTKLRAERPTQVNEGAEARRREHQKELATKKTKEGLDRFAGTTGDDNGVTQKKFKRFESYKRDNQLPTKVKDLTIYVDHKASTVIVPIMGRPVPFHINTIKNASKSDEGEYAYLRINFLSPGQGVGRKDDQPFEDISAHFLRNLTLRSKDNERLAQVAQDITELRKNALRREQEKKEMEDVVEQDKLVEIRNRRPVRLPDVYLRPPLDGKRVPGEVEIHQNGLRYMSPFRNEHVDVLFSNVKHLFFQPCAHELIVLIHVHLKTPIMIGKRKTRDVQFYREATEMQFDETGNRRRKHRYGDEEEFEAEQEERRRRAALDREFKAFAEKIADAGKDEGVDVDIPFREIGFTGVPNRSNVLIQPTTDALVQLTEPPFLVITLNEIEIAHLERVQFGLKNFDLVFVFKDFHRPPVHVNTIPVESLEGVKDWLDSVDIAFTEGPLNLNWTTIMKTVVSDPYGFFADGGWSFLAAESDSEGGASDEEESAFELSESELAAADESSEDDSEFDDDASAEASEDFSADEDSGEDWDELERKAKKKDRESGLDDEERGKKRKR

SPT16

FACT complex subunit SPT16

1035 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Transcription elongation is promoted by the repression of transcription initiation from cryptic sites. Also acts in establishing transcription initiation complexes and promotes SPT15/TBP-binding to a TATA box. Together with replication factor-A protein (RPA), FACT may play a role in nucleosome deposition during DNA replication.

Belongs to the peptidase M24 family. SPT16 subfamily.

118.63 kDa

MEELNIDFDVFKKRIELLYSKYNEFEGSPNSLLFVLGSSNAENPYQKTTILHNWLLSYEFPATLIALVPGKVIIITSSAKAKHLQKAIDLFKDPESKITLELWQRNNKEPELNKKLFDDVIALINSAGKTVGIPEKDSYQGKFMTEWNPVWEAAVKENEFNVIDISLGLSKVWEVKDVNEQAFLSVSSKGSDKFMDLLSNEMVRAVDEELKITNAKLSDKIENKIDDVKFLKQLSPDLSALCPPNYKFNFDLLDWTYSPIIQSGKKFDLRVSARSTNDQLYGNGCILASCGIRYNNYCSNITRTFLIDPSEEMANNYDFLLTLQKEIVTNILKPGRTPKEVYESVIEYIEKTKPELVPNFTKNIGSLIGLEFRDSNFILNVKNDYRKIQRGDCFNISFGFNNLKDSQSANNYALQLADTVQIPLDETEPPRFLTNYTKAKSQISFYFNNEEEDNNKKKSSPATKVPSKPDRNSKILRTKLRGEARGGAEDAQKEQIRKENQKKLHEKLEKNGLLRFSAADANGPDSEPRQYFKKYESYVRDSQLPTNIRDLRIHVDWKSQTIILPIYGRPVPFHINSYKNGSKNEEGEYTYLRLNFNSPGSSGGISKKVEELPYEESADNQFVRSITLRSKDGDRMSETFKQIADLKKEATKREQERKALADVVQQDKLIENKTGRTKRLDQIFVRPNPDTKRVPSTVFIHENGIRFQSPLRTDSRIDILFSNIKNLIFQSCKGELIVVIHIHLKNPILMGKKKIQDVQFYREASDMSVDETGGGRRGQSRFRRYGDEDELEQEQEERRKRAALDKEFKYFADAIAEASNGLLTVENTFRDLGFQGVPNRSAVFCMPTTDCLVQLIEPPFLVINLEEVEICILERVQFGLKNFDMVFVYKDFNKPVTHINTVPIESLDFLKQWLTDMDIPYTVSTINLNWATIMKSLQDDPYQFFLDGGWNFLATGSDDEASDESEEEVSEYEASEDDVSDESAFSEDEEGSEVDDDISGDESEDYTGDESEEGEDWDELEKKAARADRGANFRD

SPT16

FACT complex subunit SPT16

1035 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

115.842 kDa

MSDIRLDSATFFKRAAKIFDSWEKPSGDTQALEDINSIAIILGDPNDEVASYTKTTALQLWLLGYEFPSTLMVFEKSPRKVTFVCGSSKAKLIRQLQPSDGIEIDVKVRSKDATAAKETMEEVVASLNGKFGSLPKDRPIGKLVDEWNSAVESKSDLEVVDVAIPISAVLAEKDGEELKTIITSAKLTSTVMINYFKSKMESIIDRGTKMSHEALAQLVEEKIGNEEKGPDMKLWNKNPSLGEIDFASSEFVYSPVIQSGGKYDLKVTAASNNDNLKPGIILANMGIRYKNYCSNMGRTFLISPSKKQETQYTTLLEVRKEALALLKTGAVASDVYNSVHQSLETKNATLADSFLKNLGFATGMEYRDSSFLLNAKNNRELKENMVLVLTIGVADLPDAKNKGKTYSLLLSDTVKIGQNGAVVLTEGCTRLSDVVMDMEEEEEEDVKPQIDKKPKINNSPKKPRSSTVGGRVLNAKTRGANREQATQTTAEKIKTNQQRLHAQLNADGVKRWEADAGGKNGAQQKVVKRYESYRREEQLPRAVEDRRIYVDEQRQSVVLPINGYAVPYHISTIKNVTKTEESNHMVLRINFQSPGQIAGKKEDMPFEDPDANFIRSVSFRSQDQRHMLKVYEAITALKKAAVKRETERKELADVIEQEKLIEVKGRHPYVLKNVFPRPGPEGKKTDGNVEIHQNGIRFRPDGPASKIDILFSNIKHLFFQPSEKELIVIIHVHLKAPIMLGKKKTSDVQFYREVADMSFDETGGKKRRARYGDEDEIEQEQEDRKRRAELDKLFHDFARRIETAAQAQQFELEVDVPFRELGFNGVPHKSIVALLPTTNCLIHISELPFTVITLSEVEIVHLERVQFGLKNFDMVFVLQDLKKPPVHINSIPVAHLDNVKEWLDSCDVPISEGPVNLSWPAIMKTVNEDPHAFYAEGGWNFLTGSGSDDGSEESEEGSEFEGDSDVFDESSGSDEDSESAFEGDSDSASAESLSDEGEDWDELERKAKRADEKHRTDRGGDSDDDGKKKKKGSRR

SPT16

FACT complex subunit SPT16

1035 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

115.812 kDa

MSDIRLDSATFFKRAAKIFDSWEKPSGDTQALEDINSIAIILGDPNDEVASYTKTTALQLWLLGYEFPSTLMVFEKSPRKVTFVCGSSKAKLIRQLQPSDGIEIDVKVRSKDATAAKETMEEVVASLNGKFGSLPKDRPIGKLVDEWNSAVESKGDLEVVDVAIPISAVLAEKDGEELKTIITSAKLTSTVMINYFKSKMESIIDRGTKMSHEALAQLVEEKIGNEEKGPDMKLWNKNPSLGEIDFASSEFVYSPVIQSGGKYDLKVTAASNNDNLKPGIILANMGIRYKNYCSNMGRTFLISPSKKQETQYTTLLEVRKEALALLKTGAVASDVYNSVHQSLETKNATLADSFLKNLGFATGMEYRDSSFLLNAKNNRELKENMVLVLTIGVADLPDAKNKGKTYSLLLSDTVKIGQNGAVVLTEGCTRLSDVVMDMEEEEEEDVKPQIDKKPKINNSPKKPRSSTVGGRVLNAKTRGANREQATQTTAEKIKTNQQRLHAQLNADGVKRWEADAGGKNGAQQKVVKRYESYRREEQLPRAVEDRRIYVDEQRQSVVLPINGYAVPYHISTIKNVTKTEESNHMVLRINFQSPGQIAGKKEDMPFEDPDANFIRSVSFRSQDQRHMLKVYEAITALKKAAVKRETERKELADVIEQEKLIEVKGRHPYVLKNVFPRPGPEGKKTDGNVEIHQNGIRFRPDGPASKIDILFSNIKHLFFQPSEKELIVIIHVHLKAPIMLGKKKTSDVQFYREVADMSFDETGGKKRRARYGDEDEIEQEQEDRKRRAELDKLFHDFARRIETAAQAQQFELEVDVPFRELGFNGVPHKSIVALLPTTNCLIHISELPFTVITLSEVEIVHLERVQFGLKNFDMVFVLQDLKKPPVHINSIPVAHLDNVKEWLDSCDVPISEGPVNLSWPAIMKTVNEDPHAFYAEGGWNFLTGSGSDDGSEESEEGSEFEGDSDVFDESSGSDEDSESAFEGDSDSASAESLSDEGEDWDELERKAKRADEKHRTDRGGDSDDDGKKKKKGSRR

SPT16

FACT complex subunit SPT16

1034 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

117.686 kDa

MAEIKIDSKIFQERISHFATAWKNDLRSKDGLFNGAQSLVVMMGKVEEVPEFHKNNAIHFWLLGYEFPTTLMLFTLDTLYILTTAKKAKHLEQLKGGRFPIEVLVRGKDAAENEKLFVKLTDKIKEAGNKVGTIAKDTSRGPFVDEWKKVLAEHCKEVSQVDISAALSTYAFAVKDESELRAMRTASKACVALMTPYFLDEMSNILDAEKKVKHSTLADKVDKKLDDTSFWKTVQLPSKGKLPSDLDPAQLDWILGPAIQSGGKYDLRFAGESNDDNLHAGIIIAAMGLRYKSYCSTIARTYLVDPNKAQESSYKLLTLIHNTIIKEIRDGMTAKEVYGRAVGIIKSKKPEMEKHFLKNVGWGVGLENKDPTLVLNAKNQRVLKDGMTLIINTGFQDIENPHPQDKNSKVYALVLTDTIRVTSSEPVVFTAEAPTSADANSFFFKDDEETEPAPKKEKKDSRVGAVATKNITTTRLRSERTTQVANDDIEKKRREHQKELAAKKQREGLARFSESTNDQNGGEVKKFKRFESYKRDNQFPVKIKNLEVVVDSKNSTVVLPIMGRPVPFHINTIKNASKSDEGEWSFLRINFLSPGQGVGRKDDQPFEDASAHFVRSLTFRSSDGERYNEIATQISNMKRDVVKKEQEKKDMEDVVEQDKLVEIRNRRPAVLDNVYIRPAMEGKRVPGKVEIHQNGIRYISPLNAQHRVDVLFSNVKHLFFQPCQHELIVIIHIHLKDPIIVGNKKKTKDVQFYREATDIQFDETGNRKRKYRYGDEDEFEAEQEERRRRAELDRLFQGFAQKIAEAGRNEGIEVDMPIRELGFHGVPFRSNVFVQPTTDCLIQVVEPPFMVITIEEVEIAHLERVQFGLKNFDMVFVFKDFTRAPYHVNTIPVEFLDQVKDYLDSSDIAYTEGPLNLNWPTIMKTVTADTHQFFADGGWSFLQADSDDDGGDPSDEESAFEMDEDEFDEESESSDEGSDFGSNASDDEGSDAELDSEDEGEDWDELERKAKKRDRESAMEEEDRGANKKKQRKR

SPT16

FACT complex subunit SPT16

1033 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

117.433 kDa

MSEVKIDSNSFHKRLSLIQKNLTSIQDKQSCLLLLVGASDDENTYKKTTVLQTWLLGYEFVHTGIYITQDKCVFITSEGKAKYLTNLTSKPTENSSSVEIWPRYKDAEKNKETFKKLIEELKKMSSREKPIGHIAKDQYRGKFIDEWNEVSADAGLSFSDCALLLSESMEIKDSEEFANTKIASKSSTVLMDAFANEMMVVVDEEKKTSNSDLSEKIEDKIDSNKWYTKSATGKKLLQSMKEFDPSLVDWCYSPIIQSGGEYDLKPSAQSTTKALVGDGVILASLGLRYKSYCSNVARTFFIDPTPAMETNYDFLLKLQNHVTSTLLRDGTVASQVYQGALDFIKSEKPDLVQHFTKNCGWLMGIEFRDSTFVLNSKNERKLQNGQIISLTLGFSNLTNDKASNPKLKQYSLILTDTFKVSESEPILLTTYPKARSETSFYFKDDEPTAVKSENGGDKKLKSEKNIKTEKNLAANEANSKILKSKLRHESSAADDSNNTEKIRQEIQSKLHEKRQHEGLARFSKADATDASDFKPVFKKYESYVRESQIPSNVRDLKIHVDYKNQTIILPICGRPVPFHINSFKNGSQNEEGDFTYLRLNFNSPGAGGNVSRRAELPYEDSPENSFLRSVTLRSRDHQRMVDVYKAIQDLKKDAVKREQEKKQMADVVSQANLVELKGSRVKKLDQVFIRPQPDTKKIGGVLQIHENGLRYQSSIRMDQKVDILFSNIKHLFFQSCKDELIVIIHCHLKNPIMIGKKKTHDVQFYREASDMAFDETGGRKRRYRYGDEDELQQEQEERRRKALLDKEFKAFAELISDSSSGMVDLDIPFRELGFSGVPFRSSVLCMPTRDCLIQLIDPPYLVVTLEEIEIAHLERVQFGLKNFDLVFVFKDFNKSVVHINTIPMELLEDVKSWLTDVDIPISEGQMNLNWATIMKTVQSDPYQFFADGGWSFLTGEGDSEEEDEEDEESEFEVSDPDPSDEDVESEAGSEDDYSSDASGSDASGGESEEEEEGEDWDEMERKAAREDKRLGAS

SPT16

FACT complex subunit SPT16

1033 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

117.891 kDa

MSDGGIEIDFQAFYDRFTKLGKAYSGFEGSPNSLLFVLGSTNEENPYQKTTILHNWLLGYEFPATLIAFFKDKGVIITSSAKAKHLLPAVTKFEGSDYKLEIWQRNNKDANHNKKLFEDLIKLLSENGNTVGVPTKDSYQGKLILEWKPLWEEAKKTHSLNVIDCSAGLSSTWKGKDDKEKAYLSVSSKGSDKFMDLMSNEIVNAVDEELKISNSKLSDKIENKIDDSKFLKKLSSDLNPLCPTDEKFDVNFLDWAYSPIVQSGSKFDLKVSARSNNDSLFGKGSILASCGIRYKNYCSNITRTFLIDPTDEMTDNYDFLLILQEKIIDDLLKVEADPTSIYEKTLEFIKEKKPELLSHFTKNVGSLMGLEFRDSAGMINAKPTAHKISENCCYNISLGFGNLKDSKTGQVYAVQLADTVQLSSDGKPSTLTKYTKARSQISFYFNNEEENKAATVKSEKSKPPALPKPDGTSKILRSKLRGESRADDEEKEQIRKENQRKLHERLQKEGLLRYSDADAVDGDEKPKHFFKKYESYVRETQIPSNVRDLKIHVDWKSQTIILPIYGRPVPFHINSYKNGSKNEEGEYTYLRLNFHSPGAGGVGKKTEELPYEENPENQFVRSLTLRSKDGARMSDVFKQITDLKKESTKREQERKALADVVVQAKLVENKTGRTKRLDQIFVRPSPDTKRVPGTVFIHENGIRYQSPLRTDSRIDILFSNIKNLFFQSSKGELIVIIHVHLKNPILMGKKKIQDIQFYREASDMAVDETGNSRRNNMKFRRYGDEDELEQEQEERRKRAALDKEFRYFAEAIAEASDGLLDVDSPFRDLGFQGVPSRSAVFCMPTRDCLIQLVEPPFLVINLNEVEICILERVQFGLKNFDMVFVYKDLTKPVSHINTVPIEQLEFIKTWLTDVDIPYTVSTINLNWSTIMKSLQDDPHQFFLDGGWSFLATGSDDERSDESEEEISEYEASDEDPSDEEVYSEEEEDYSDDEKFSDEGSDDFADGSEDDEGDDWDDLEKKAAKADRNSNYKE

SPT16

FACT complex subunit SPT16

1032 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

116.222 kDa

MSEQIQIDTGAFQRRVNKLLSCWKDSSADFEQLNQVDSLLVVMGGQNDDLIYSKTTAIHSWLLGYEFPSTVILFTKDSVTFVTSASKAVHLEPLKRSSTGFNLEILKRSKDEASNRALWDDLVSRIDAQGSKVGCLPKDKPIGKFADEWQSVFEKAQSSKDFKMIDVSASLSAVWATKDDDEIKAIRYASKMSSAVMSGYFENEMSTILDEGKKVTHEQLSERIEGKLDDTKLWKRVKGLEGADLSLADWCYTPIVQSGGEYDLKTSAVSSTKRLQGADGNGGVVIASMGIKYRNYCSNIGRTYLIDPHNSQQKMYAFLHEIQTQLADKHLRAGATCKEIYSKAVEIVRAKDEKLVASFVKNVGFGIGLEFRDSAYVLSAKNNRALQRDMVVNLSVGFQDLDDPNHKGEVYSLLLIDTLRINDNAPATFLTDRVRGTNDMSFFFKDDEEEEEEEERRSPAKPDGKVTPGGKVLRNKNRGAAHDDTAAEKMKLHQKELAKQKQEDGLARFAGEDGEGNASNEKVFKKFESYKRENLLPTKVADLKIMVDHRAQSIILPIYGYAVPFHINTLKNVSKSDEGEYTYLRLNFVTPGQIAGKKEDVPFDDPDATFVRSMSYRSSDSSRFTELFREITELRKSATKREAEEKELADVVEQDKLILTKSRAYTLPEVFPRPAMEGKRVPGDLTIHQNGLRFSSPLRPDQKIDLLFSNMKHLFFQPCDKELIVIVHIHLKSPIMIGKRKAKDIQFYREASDVQFDETGNRKRKYRSGDEDEIELEQEERRRRSQLNKEFKVFAERIAEASEGRVSVDVPYRELGFNGVPFRTNVLLQPTTDCLVHLTDPPFLVITLTDVEIVHLERVQFGLQSFDMVFVFSDFSRAPMHVTSIPTTSLDDVKQWLDSVDICVTEGAVNLNWGAIMKTVNEDPYDFFAEGGWGFLQSGSDDGGSSESESGSEFGSEMDDGQEETDEDSDSGSDFGDSAEDESGSEGFEDESEEGEDWDELERKAARADEKKRRQQGGSDDDEDSGKKGKRR

SPT16

FACT complex subunit SPT16

1031 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

117.773 kDa

MSEVIIDFSTFENRLLALRDRFPSFDGSPSSLVFILGSADEENPYQKTTILHNWLLGYEFPTTLIAVFKEGCVVITSAAKTRYLEEGVAQMNKKLENTFKIELWQSSKEPGHNLKLFEDLVERVREAGSAVGLATKDSYQGKFITEWKGVWDTAVEKHGLNGVDVSLGLSSLWAVKDEKEQAYLQVSSRGSDKFMNLLSDELVRAVDEEIKITDAKLSDNVENEIDKSRFLKKLSPELTPLCPKGEKFDVNYLDWAYSPIIQSGPKYDLRVSARSSETQLDGNGCILASCGIRYKNYCSNISRTFLIDPSDEMTDNYDFLLLLQEEIINNLLRVGATPKQIYDGAVNYINSKKPELSAGFTKNVGSLMGLEFRDSQFVLNNKNDYRKVENGDCFNISLGFNNLKDSKTGASYALQLADTVQLTSGGPKVLTNYTKSRSQISFYFNNEDDGTTKVKSEESKTASIPTKPDPKSKILRSKLRGESRAEDDEKEQIRKENQRKLHEKLQREGLLRFTDTDAADKDQKPVVHFKKYESYVRETQIPNTVRDLRIHVDWKNQTFILPIYGRPVPFHINSYKNGSKNEEGEYTYIRLNFHSPGTGGVSKKTEELPYEDSPDHQFVRSLTLRSKDGDRMADIFKQITELKKESTKREQERKVLADVVEQAKLVENRTGRTKRLDQIFVRPSPDTKRVPGTVFIHENGIRYQSPLRTDSRIDILFSNVKNLFFQPCKGELIVIIHIHLKNPILMGKKKIQDVQFYREASDMAVDETGNGRRNQMKFRRYGDEDELEQEQEERRKRAALDKEFRYFAEAIAEASNGLVEVDHPFRDLGFQGVPSRSAVFCMPTRDCLIQLVEPPFLVVNLSEVEICILERVQFGLKNFDMVFVYKDFTKPVTHINTIPIEQLEFIKSWLTDVDIPYTVSTINLNWATIMKSLQDDPHQFFLDGGWSFLATGSDDEMSGTSEEEVSEYEVSDEDPSDEEVDSEDDYSEGDNEEFSDEGSEDFSGEESEEGEDWDELEKKAAKADRGNRFAD

SPT16

FACT complex subunit SPT16

1027 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

117.896 kDa

MSELNIDAEAFKARVELLHGKYREFENEPNSMVFALGSSNPENPYQKTTALHYWLMGYEFPATLIVFTPGKVVIITSGPKAKHLEKVVELFKNNNNGVELEIWQRNNKDVEHSQKLFKDIIELINTAGKTVGIPEKDVYEGKFMKEWKPIWDAAIKEHEFKLVDISAGLSSTWEVKDDKEKAYISIASKCSDRFMNLLSDEMVRAVDDELKITNSKLSDKIENKIDDLKFLKKITNDLSAMCPPNHKFTLDLLDWTYSPIIQSGNKFDLRVSAHSNNDQLHGNGCILASCGIRYNNYCSNTTRTFLIDPSEEMVNNYVFLLDLQKHIIENELKAGRTGKEVYESVVEFIKKVRPELAGNFTKNIGSLIGLEFRDSFFVLNSKNDKRKIQVGDCFNISFGFNALKDMKTNTNYALQLADTVILNEDGPKILTEYTKSKSQVSFYFNNDEVEKEKKPAASTKIPTNLDGNSKILRSKLRGDARGESQDAQKEQIRKENQRKLHEKLQKEGLLRFTAEDATTEGSETRQYFKKYESYVRESQIPNNVRDLRIHVDWRSQTIIVPIYGRPVPFHINSYKNGSKNEEGEYTYLRLNFHSPGSAGGISKNVVELPYDDSPDNQFMRSITLRSKDGDRMSETFKQITDLKKESTKREQERKALADVVQQDKLIENKTGRTKRLDQIFVRPSPDTKRVPSTVFIHENGIRYQSPLRTDSRIDILFSNIKNLIFQSCKGELIVIIHIHLKNPIMMGKKKIQDVQFYREASDVSVDETGTGRRNQNKFRKYGDEDELEQEQEERRKRAMLDKEFKYFADAIAEASNGLVSVESTFRDLGFQGVPNRSAVFCMPTTDCLVQLIEPPFLVVNLEEIEVAILERVQFGLKNFDLVFVYKDFKKPVTHINTIPIESLDFLKQWLTDMDIPYAISTINLKWSTIMQSLQEDPHQFFLDGGWSFLNANSDEEGSDESEEEISEYEASEEEPEDESAYSDEDDYSEDISDGSYSGADSEEEEGEDWDELEKKAAKADRTAGLRD

spt16

FACT complex subunit spt16

1019 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

116.451 kDa

MAEYEIDEITFHKRLGILLTSWKNEEDGKTLFQDCDSILVTVGAHDDTNPYQKSTALHTWLLGYEFPSTLILLEKHRITILTSVNKANMLTKLAETKGAAADVNILKRTKDAEENKKLFEKIIEYIRATNKKVGVFPKDKTQGKFINEWDSIFEPVKSEFNLVDASLGLAKCLAIKDEQELANIKGASRVSVAVMSKYFVDELSTYIDQGKKITHSKFSDQMESLIDNEAFFQTKSLKLGDIDLDQLEWCYTPIIQSGGSYDLKPSAITDDRNLHGDVVLCSLGFRYKSYCSNVGRTYLFDPDSEQQKNYSFLVALQKKLFEYCRDGAVIGDIYTKILGLIRAKRPDLEPNFVRNLGAGIGIEFRESSLLVNAKNPRVLQAGMTLNLSIGFGNLINPHPKNSQSKEYALLLIDTIQITRSDPIVFTDSPKAQGDISYFFGEDDSSLEDGVKPRKPPTRGTATISSHKGKTRSETRDLDDSAEKRRVEHQKQLASRKQAEGLQRFAQGSVPSSGIEKPTVKRFESYKRDSQLPQAIGELRILVDYRAQSIILPIFGRPVPFHISTLKNASKNDEGNFVYLRLNFVSPGQIGGKKDELPFEDPNAQFIRSFTFRSSNNSRMSQVFKDIQDMKKAATKRETERKEFADVIEQDKLIEIKNKRPAHINDVYVRPAIDGKRLPGFIEIHQNGIRYQSPLRSDSHIDLLFSNMKHLFFQPCEGELIVLIHVHLKAPIMVGKRKTQDVQFYREVSDIQFDETGNKKRKYMYGDEDELEQEQEERRRRAQLDREFKSFAEKIAEASEGRIELDIPFRELAFNGVPFRSNVLLQPTTDCLVQLTDTPFTVITLNEIEIAHLERVQFGLKNFDLVFIFQDFRRPPIHINTIPMEQLDNVKEWLDSCDICFYEGPLNLNWTTIMKTVNEDPIAFFEEGGWGFLGAPSDDEGDDSVEEVSEYEASDADPSDEEEEESEEYSEDASEEDGYSESEVEDEESGEDWDELERKARQEDAKHDAFEERPSKKRHR

spt16

FACT complex subunit spt16

1019 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

115.21 kDa

MAEEIVIDKTLFFNRLSSFYAAWRADKRSSHPTFGGVGSIVILMGKTDEASTFQKNNAMHFWLLGYEFPATLLVFTLEAVYVVTTAKKAKHLEPLRGGKIPVEILITTKDPEGKLRSFEKCIEVIRSAGNKVGVLPKDTTTGPFAEDWKRTFAMLSAEIEEVDISPALSAAFAVKDTDELVSIRNASRACSGLMSEYFVEEMSRLLDEEKQMTHKALSARVDAKIDDAKFFNKLGKLPAEFDAQQIDWAYGPVIQSGGKYDLRLTAVSDNSNLEPGIIIAGFGIRYKTYSSMIARTYLVDPSKSQETNYAFLLALHEAVMRDVRDGTIAKDLYNKAINLIRTKKPELESHFVKSVGAGIGIELRDPNMVLNGKNSRTLKSGMTLSITVGLTDVEDPELKGSKSSTYSMIITDTVRVGENGPHVFTKDAGLDMDSVSFYFGDEEEPQKPIKEKKEAKTSAIASRNITRTKLRAERPTQINEGAEARRREHQKELAAKKTREGLDRFAGTTGDDNGVTQKKFKRFESYKRDNQLPTKVRELTIYVDQKASTVIVPIMGRPVPFHINTIKNASKSDEGEYAYLRINFLSPGQGVGRKDDQPFEDLSAHFLRNLTLRSKDNERLAQVAQDITELRKNALRREQEKKEMEDVVEQDKLIEIRNRRPVKLPDVYLRPPLDGKRVPGEVEIHQNGLRYMSPFRNEHVDVLFSNVKHLFFQPCAHELIVLIHVHLKTPIMIGKRKTRDVQFYREATEMQFDETGNRRRKHRYGDEEEFEAEQEERRRRAALDREFKAFAEKIADAGKDEGVDVDIPFREIGFTGVPNRSNVLIQPTTDALVQLTEPPFLVITLNEIEIAHLERVQFGLKNFDLVFVFKDFHRAPVHINTIPVESLEGVKDWLDSVDIAFTEGPLNLNWTTIMKTVVSDPYGFFADGGWSFLAAESDSEDGSEEEEESAFELSESELAAADESSEDDSEFDDDASAEASDFSAEEESGEDWDELERKAKKKDREGGLDDEEHGKKRKR

spt16

FACT complex subunit spt16

1019 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

115.311 kDa

MGDEIVIDKTAFFNRLSSFYAAWKADKRSTNSVFGGAGSIIILMGKTDEANSYQKNNAIHFWLLGYEFPATLFVFTPEVMYVVTTAKKAKHLEPLKGGKIPVEILVTTKDQEEKTRLFEKCVDIIKSAGNKVGILPRDTTTGPFVEDWKRVYGKISGDVEEVDISPALSAACFSVKDTDELVSIRNASRACSGLMSDYFVDEMSRLLDEEKQMTHKALSMRIDAKIDDAKFFNKLAKLPSEFDPQQIDWAYGPVIQSGGKYDLKLTAVSDDNNLEPGIIIAGFGIRYKTYSSIIGRTYLVDPTKSQEANYSLLLSVHEAVLKEARDGVVAKELYNKAIGIVRARKPELESHFVKNVGAGIGIELRDSNMILNGKNTRVLKSGMTFSITVGLVDVEEPSVKDKKKNVYSMMITDTVRVGEQGPHVFTKDAGIDMDSVSFYFGDEEEPQKPAKEKKETKSSAIASRNVTRTKLRAERPTQVNEGAEARRREHQKELAAKKTKEGLDRFAGTTGDDNGVTQKKFKRFESYKRDNQLPAKVKDLTVYVDHKASTVIVPVMGRPVPFHINTIKNASKSDEGEYAYLRINFLSPGQGVGRKDDQPFEDLSAHFLRNLTLRSKDNDRFAQVAQDITELRKNALRREQEKKEMEDVVEQDKLVEIRNRRPVKLPDVYLRPPLDGKRVPGEVEIHQNGLRYVSPFRNEHVDVLFSNVKHLFFQPCAHELIVLIHVHLKTPIMIGKRKTRDIQFYREATEMQFDETGNRRRKHRYGDEEEFEAEQEERRRRAALDREFKAFAEKIADAGKDEGVDVDIPFREIGFTGVPNRSNVLIQPTTDALVQLTEPPFLVISLNEIEIAHLERVQFGLKNFDLVFVFKDFHRAPVHINTIPVENLEGVKDWLDSVDIAYTEGPLNLNWTTIMKTVVSDPYGFFADGGWSFLAAESDSEDGSDEEEESAFELSESELAADESSEEDSDYDDDASADDDFSADEDESGEDWDELEHQAKKKDRESGLDDEDRGKKRKR

SPT16

FACT complex subunit SPT16

1003 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).

Belongs to the peptidase M24 family. SPT16 subfamily.

113.416 kDa

MEVKISESAFNTRVEKLQGALNTHKDAFGGADSVLLLIGKGGDDNPYIKTAVAQNWLLGYEFFSTALLVTPKRVIFVTNSSKAVHLEGLKKDDKVEVWVRPKEGGKEVMEKLAKVAKEAGNKLGVVVKDKFRGPIVDEFEAALKDSGIEKVDIEVGLSHLLEAKDDDEIKSIRVASRASTAYLTKFFTDQMLGIVDEERRLSHSKFSEQIENKLQDEGFFAQNQVKLGSDFHQTNLEWCYMPIIQSGGKYDLRPSAVSDDANLHGGTIVCTLGTRYKGYCSNVGRTFMINPTKAQEQNYEVLVGLREKVFDSIKVGAKACDVYNAAVSYIKSKAPKLEAHLLKTIGWSIGIDFRDAKFLLNAKCQREIVDGSTFDVSLGFQNLTNSAATDPKNKTYSLALVDTVRVTRAGVAVLTDSAPVALSEVTYFFEDDDEDAEKEKKKKEQAKKEKKQQQAAATVSSITRTKLRHEARAEDNNDQKRKDDQKALHEKLNKAGLERFKNTEGALNGEEKVVIKKFESYKRDTQLPQNLLKDLRVHVDTRSQSIILPINGRPVPFHINTYKSGSKTDEGDYVYIRLNLSSPGQIAGSKKDAPQVFEDPDAQFLRSITFRSRHVEHMNDVFKQIQDLKKASTKKEAEKKEMEDVVAQDSLVEVRARRPLKLDAVFVRPAPDGKRVAGTLEIHQNGLRYVSPIRSDHKIDVLFDNIKHLFFQPTEGELIVCIHAHLKNPILIGKKKTWDVQFYREASDMAFDETGNRKRKYRYGDEDELEAEQEERRRRLQLDKEFKAFSEKISEASDRKVDVDTPFRELGFHGVPFRSNVLLQPSADCLVQLIDTPFSVITLGEIELAHLERVQFGLKNFDLVFVYKDFNRPVTHINSIPVDQLDAVKDWLNEVEIPYSEGPVNLNWGSIMKTVVADPQEFFTSGGWSFLDLESDDEDQEEEESEFEVSDDEPEDEDEDSEEFASEDDSEGDFDSEEESGEDWDELEKQAAAEDGEPPRKKR