SPSB1

Gene

SPSB1

Protein

SPRY domain-containing SOCS box protein 1

Organism

Bos taurus

Length

273 amino acids

Function

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity).

Similarity

Belongs to the SPSB family.

Mass

30.811 kDa

Sequence

MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGKGRLGEIHALPLPASLKAYLLYQ

Protein

SPRY domain-containing SOCS box protein 1: SPSB1

Gene

SPSB1

Protein

SPRY domain-containing SOCS box protein 1

Organism

Homo sapiens

Length

273 amino acids

Function

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).

Similarity

Belongs to the SPSB family.

Mass

30.942 kDa

Sequence

Protein

SPRY domain-containing SOCS box protein 1: SPSB1

Gene

Spsb1

Protein

SPRY domain-containing SOCS box protein 1

Organism

Mus musculus

Length

273 amino acids

Function

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links the NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity).

Similarity

Belongs to the SPSB family.

Mass

30.785 kDa

Sequence

Protein

SPRY domain-containing SOCS box protein 1: Spsb1