SPP1

Sucrose-phosphatase 1

425 amino acids

Catalyzes the final step of sucrose synthesis.

Belongs to the sucrose phosphatase family.

47.878 kDa

MDQLTSAARLMIVSDLDHTMVDHHDPENLSLLRFNALWEANYRENSLLVFSTGRSPTLYKELRKEKPMLTPDITIMSVGTEITYGNSMEPDDGWEAFLNDKWDRKIVTEETSKFPELTLQSETEQRPHKVSFYVQKDKAQDITGTLSKRLEERGLDVKIIYSGGMDLDILPQGAGKGRALAYLLKKLKSEGKLPNNTLACGDSGNDAELFSIPDVYGVMVANAQEELLQWRAANAKDSPKVIHATERCAAGIIQAIGHFNLGPNTSPRDVTDMSDCKMENFVPAYEVVKFYLFFEKWRRGEIENSDLHLSNLKAVCRPSGTFVHPSGVEKYLEDCINTLRTCHGDKQGKQFRIWVDLVLPTQVGSDSWLVSFKKWELCGEERQCCITTVLLSSKNVTVADGLTWTHVHQTWLQGAAASDSASWFF

spp1

Set1 complex component spp1

424 amino acids

The Set1 complex specifically methylates 'Lys-4' of histone H3.

48.683 kDa

MELTQENTEENEKTHVESIVKFEDSNRGTITDFHIETANNEEEKDANVILNKSVKMEVEEVNGHVDSSSTETDIEMQVIQQPTIPKKPPVSAHRRGPRKHRGNANSQLNLSTADHQRPLYCICQKPDDGSWMLGCDGCEDWFHGTCVNIPESYNDLTVQYFCPKCTEEGKGITTWKRKCRLRECSNPTRPNSNYCSDKHGVDFFREKVKLSTVEPSAIKNLVLFAKKREEFQNLGTVGPTLPSQVPPEVVYNFEIEEANRLNAEIVQLNKEKEVASNKKIFLQLIKDSSRRAVLAYKEREGIKKDLCGFDSRLLFNQQQMNELWEKVSNGAPLSLDMSIDPSPESTCFTEKRRCAKHTSWQVIFTEDFELQESNILQKLNMKQTAKDVMLEHQKQRCLPGIQYDGYARFCHEQLSPEKMANLLK

SPP1

Probable sucrose-phosphatase 1

423 amino acids

Catalyzes the final step of sucrose synthesis.

Belongs to the sucrose phosphatase family.

47.846 kDa

MERLTSPPRLMIVSDLDETMVDHHKDPENLALLRFNSLWEDAYRHDSLLVFSTGRAQTMYKKLRKEKPLLTPDVIITSVGTEIAYGNSMVPDDNWVEILNKKWDRGIVQEETSKFPELTLQGETEQRPHKLSFNIDKSKVKAVTKELSPRLEKRGVDVKFIFSGGNAFDVLAKGGGKGQALAYLLKKLKTEGKLPINTLACGDSGNDTELFTIPNVYGVMVSNAQEELLEWYAENAKDNANIIHASERCAGGITQAIGHFKLGPNLSPRDVSDFLECKADNVNPGHEVVKFFLFYERWRRGEVENCTTYTSSLKASCHPSGVFVHPSGAEKSLRDTIDELGKYYGDKKGKKFRVWTDQVLATDTTPGTWIVKLDKWEQTGDERKCCTTTVKFTSKEGEGFVWEHVQQIWSEETEIKDDSNWII

SPP1

Sucrose-phosphatase 1

423 amino acids

Catalyzes the final step of sucrose synthesis. Inactive with fructose 6-phosphate as substrate.

Belongs to the sucrose phosphatase family.

47.214 kDa

MDKLSGSARLMIVSDLDHTMVDHHDEENLSLLRFGALWESVYCEDSLLVFSTGRSPTLYKELRKEKPMLTPDITIMSVGTEITYGEAMVPDDGWEEYLNNKWDRNIVVAETVSFSELKLQPETEQRPHKVSFFVDKKNAQEVIKSVAERLDKCGLDAKIIYSGGQDLDILPQGAGKGQALAYLLEKLSSCGKPPNNTLVCGDSGNDAELFSIPGVHGVMVSNAQEELLQWYTENAKDNPKIIHSNERCAAGIIQAIGHFKLGPNISPRDLQFPYAKEASFKPTDAVVKFYVLYEKWRRAEVPKSDSVIKYFKNITHANGVTIHPAGLELSLHASIDALGSCYGDKQGRKYRAWVDRLFITQTGSDSWVGRFDLWESEGDVRVCSLSSLALILKAESPEGFVLTHIQKTWLNGYSSGVEQAFKL

SPP1

Probable sucrose-phosphatase 1

423 amino acids

Catalyzes the final step of sucrose synthesis.

Belongs to the sucrose phosphatase family.

47.065 kDa

MDKLSGSARLIIVSDLDHTMVDHHDEENLSLLRFGALWESVYCQDSLLVFSTGRSPTLYKELRKEKPMLTPDITIMSVGTEITYGEAMVPDDGWEEYLNNKWDRNVVVEETAKFSELKLQPETEQRPHKVSFFVDKKSAQEVIKSLSGNMEKCGLDVKIIYSGGQDLDILPQGAGKGQALAYLLKKLSSCGKPPNNTLVCGDSGNDAELFSIPGVHGVMVSNAQEELLQWYAENAKGNPKIIHATERCAAGIIEAIGHFKLGPSVSPRDVGFPYVKEDHIKPTDAVVKFYVLYEKWRRAEVPKSDSVVQYFKNITHANGVIIQPSGLECSLHASVDALSSCYGEKQGKKYRTWVDRLFVSQSGSDSWLVRFDLWEAEGDARLCCLTSLALNVKPETPAGFLITHVHKTWLKGYSSADEQSSKL

SPP1

COMPASS component SPP1

353 amino acids

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.

41.468 kDa

MSLPQWCPPHSTLKRNPTTGEDVYCICKRPDYGELMVGCDGCDDWFHFTCLHIPEQFKDLVFSFYCPYCQAGITGKNKDAIINGEGSLPKTLWKRKCRISDCYKPCLQDSKYCSEEHGREFVNDIWSRLKTDEDRAVVKKMVEQTGHIDKFKKFGQLDFIDNNIVVKTDDEKEIFDQIVVRDMTLKTLEDDLQEVQEISLPLFKKKLELLEVYLGWLDNVYTEMRKLDDDAASHVECGKEDSKGTKRKKKKNSSRSRARKNICGYCSTYERIPCSVEEFVRDFGSNEEATKIHEVCTKWKCNRHLDWVSTNQEQYLQQIDSLESMQERLQHLIQARKKQLNIQYYEEILRRGL

SPP1

Signal peptide peptidase 1

343 amino acids

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm.

Belongs to the peptidase A22B family.

37.922 kDa

MKTHERAANLALAGLSLAPLVVKVEPNVNVILTACLAVYVGCYRSVKPTPPSETMSKEHAMRFPLVGSAMLLSLFLLFKFLSKDLVNAVLTAYFFILGIAALCATLLPSIKRFLPKEWNDNAIVWCAPFFHSLSVEFTKSQVVASIPGFFFCIWYAAKKHWLANNVLGISFCIQGIEMLSLGSFKTGAILLAGLFFYDIFWVFFTPVMVSVAKSFDAPIKLLFPTGDAARPFSMLGLGDIVIPGIFVALALRFDVSRGIKNRYFNSAFLGYTVGLTVTIIVMNWFQAAQPALLYIVPGVIGFVAVHCLWNGEVKPLLEYNESKAEEEDAVEEDTDSKQNKKEE

Spp1

Osteopontin

317 amino acids

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Belongs to the osteopontin family.

34.963 kDa

MRLAVVCFCLFGLASCLPVKVAEFGSSEEKAHYSKHSDAVATWLKPDPSQKQNLLAPQNSVSSEETDDFKQETLPSNSNESHDHMDDDDDDDDDGDHAESEDSVNSDESDESHHSDESDESFTASTQADVLTPIAPTVDVPDGRGDSLAYGLRSKSRSFPVSDEQYPDATDEDLTSRMKSQESDEAIKVIPVAQRLSVPSDQDSNGKTSHESSQLDEPSVETHSLEQSKEYKQRASHESTEQSDAIDSAEKPDAIDSAERSDAIDSQASSKASLEHQSHEFHSHEDKLVLDPKSKEDDRYLKFRISHELESSSSEVN

SPP1

Osteopontin

314 amino acids

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Belongs to the osteopontin family.

35.423 kDa

MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN

SPP1

Osteopontin

311 amino acids

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Belongs to the osteopontin family.

35.172 kDa

MRIAVICFCLLGMAYALPVKHADSGSSEEKQLYHKHPDALATWLNPDPSQKQNLLTPQNAMSSEEKDDLKQETLPSKSIESHDHMDDIDEDEDDDHVDNRDSNESDDADHPDDSHHSDESHQSDESDEVTVYPTEDAATTVFTEVVPTVETYDGRGDSVAYRLKRSKSKMFHVSNAQYPGASEEDLSSHVDSEDLDDTPRAIPVAQHLNVPSDWDSQEKDSHDVSQVDDHSVETQSHEQARQYKREANDNSVEHSHSIDSQESSKVSQESQSREFRSHEDKLAIEPKSEEDEEHRQLRVSHELDSTSSEIN

SPP1

Osteopontin

303 amino acids

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Belongs to the osteopontin family.

33.669 kDa

MRIAVIAFCLWGFASALPVKQTNSGSSEEKLLSNKYTDAVATLLKPDPSQKQTFLAPQNTISSEETDDFKQETLPSKSNESPEQTDDVDDDDDEDHVDSRDTDSEEADHADDADRSDESHHSDESDELVTDFPTDTPATDVTPAVPTGDPNDGRGDSVVYGLRSKSKKFRRSEAQQLDATEEDLTSHVESEETDGTPKAILVAQRLHVASDLDSQEKDSQETSQPDDRSVETRSQEQSKEYTIKTYDGSNEHSNVIESQENPKVSQEFHSHEDKLVPDSKSEEDKHLKLRVSHELESASSEIN

Spp1

Osteopontin

294 amino acids

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Belongs to the osteopontin family.

32.459 kDa

MRLAVICFCLFGIASSLPVKVTDSGSSEEKLYSLHPDPIATWLVPDPSQKQNLLAPQNAVSSEEKDDFKQETLPSNSNESHDHMDDDDDDDDDDGDHAESEDSVDSDESDESHHSDESDETVTASTQADTFTPIVPTVDVPNGRGDSLAYGLRSKSRSFQVSDEQYPDATDEDLTSHMKSGESKESLDVIPVAQLLSMPSDQDNNGKGSHESSQLDEPSLETHRLEHSKESQESADQSDVIDSQASSKASLEHQSHKFHSHKDKLVLDPKSKEDDRYLKFRISHELESSSSEVN

SPP1

Osteopontin

278 amino acids

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Belongs to the osteopontin family.

30.904 kDa

MRIAVICFCLLGIASALPVKPTSSGSSEEKQLNNKYPDAVATWLKPDPSQKQTFLAPQNSVSSEETDDNKQNTLPSKSNESPEQTDDLDDDDDNSQDVNSNDSDDAETTDDPDHSDESHHSDESDEVDFPTDIPTIAVFTPFIPTESANDGRGDSVAYGLKSRSKKFRRSNVQSPDATEEDFTSHIESEEMHDAPKKTSQLTDHSKETNSSELSKELTPKAKDKNKHSNLIESQENSKLSQEFHSLEDKLDLDHKSEEDKHLKIRISHELDSASSEVN

SPP1

Osteopontin

278 amino acids

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Belongs to the osteopontin family.

31.052 kDa

MRIAVICFCLLGIASALPVKPTSSGSSEEKQLNNKYPDAVATWLKPDPSQKQTFLEPQNSVSSEETDDNKQNTLPSKSNESPEQTDDLDDDDENSQEVNSDDSDDAETPDDSDHSNESHHSDESDEADFPTDIPTIAVFTPPFPTESTNDGRGDSVAYGLKSKSKKFRRSNVESPDATEEDFTSHIESEEMHDAPKKTSQLTDHSEETNSDELPKELTPKAKEESKHSNRIESQENSKLSQEFHSLEDKLDLDHKSEEDKRLKIRISHELDSVSSEVN

SPP1

Osteopontin

264 amino acids

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Belongs to the osteopontin family.

29.162 kDa

MKLAFLCLCFISIAAAWPVSKSRQHAISASSEEKYDPRSHHTHRYHQDHVDSQSQEHLQQTQNDLASLQQTHYSSEENADVPEQPDFPDIPSKSQEAVDDDDDDDNDSNDTDESDEVVTDFPTEAPVTPFNRGDNAGRGDSVAYGFRAKAHVVKASKLRKAARKLIEDDATAEVGDSQLAGLWLPKESREQDSRELAQHQSVENDSRPRFDSPEVGGGDSKASAGVDSRESLASRSAVDTSNQTLESAEDAEDRHSIENNEVTR