SPINK6

Gene

Spink6

Protein

Serine protease inhibitor Kazal-type 6

Organism

Mus musculus

Length

105 amino acids

Function

Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK5 and human KLK2, KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit human KLK1 and KLK8.

Mass

11.609 kDa

Sequence

MKVAGVFLLLSLALLCFFSGAFSQGGQDKRGWITRSEGRFPGKGVLRHRLFQINCGEFRDPKVFCTRESDPLCGSDGQTYGNKCAFCKALEKSSGKINLKHRGKC

Protein

Serine protease inhibitor Kazal-type 6: Spink6

Gene

Spink6

Protein

Serine protease inhibitor Kazal-type 6

Organism

Rattus norvegicus

Length

105 amino acids

Function

Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.

Mass

11.667 kDa

Sequence

MKVAGVFLLLSLALLCFFSGEFSQGGQDKRGWITRSEGRFPGKGVLRHRLFQINCGEFRDPKVFCTRESDPLCGSDGQTYGNKCAFCKALEKSSGKINLKHRGKC

Protein

Serine protease inhibitor Kazal-type 6: Spink6

Gene

SPINK6

Protein

Serine protease inhibitor Kazal-type 6

Organism

Bos taurus

Length

80 amino acids

Function

Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. Inhibits acrosin, trypsin, and chymotrypsin.

Mass

8.663 kDa

Sequence

MKTSGVFLLLSLALFCFFSGVFGQGAQVDCAEFKDPKVYCTRESNPHCGSDGQTYGNKCAFCKAVMKSGGKINLKHRGKC

Protein

Serine protease inhibitor Kazal-type 6: SPINK6

Gene

SPINK6

Protein

Serine protease inhibitor Kazal-type 6

Organism

Homo sapiens

Length

80 amino acids

Function

Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.

Mass

8.585 kDa

Sequence

MKLSGMFLLLSLALFCFLTGVFSQGGQVDCGEFQDPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGKC

Protein

Serine protease inhibitor Kazal-type 6: SPINK6