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SPINK2

Gene
Spink2
Protein
Serine protease inhibitor Kazal-type 2
Organism
Mus musculus
Length
86 amino acids
Function
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:21705336, PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (PubMed:21705336). It also inhibits trypsin (PubMed:21705336).
Mass
9.722 kDa
Sequence
MLRLVLLLLVTDFAASHETLDSSDSQIMKRSQFRTPDCGHFDFPACPRNLNPVCGTDMNTYSNECTLCMKIREDGSHINIIKDEPC

Gene
Spink2
Protein
Serine protease inhibitor Kazal-type 2
Organism
Rattus norvegicus
Length
86 amino acids
Function
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis. It also inhibits trypsin.
Mass
9.697 kDa
Sequence
MLRLVLLLLATDFAASDDSLDSSDSQLIKRSQFRTPDCHRFDYPVCSKHLSPVCGTDMNTYGNECTLCMKIREDGSHINIIKDEPC

Gene
SPINK2
Protein
Serine protease inhibitor Kazal-type 2
Organism
Homo sapiens
Length
84 amino acids
Function
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.
Mass
9.291 kDa
Sequence
MALSVLRLALLLLAVTFAASLIPQFGLFSKYRTPNCSQYRLPGCPRHFNPVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC

Gene
SPINK2
Protein
Serine protease inhibitor Kazal-type 2
Organism
Macaca fascicularis
Length
81 amino acids
Function
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (By similarity). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin (By similarity).
Mass
9.171 kDa
Sequence
MALAVLRLALLLLAVTFAGPLFRRFSKYKTPFCARYQLPGCPRDFNPVCGTDMITYPNECTLCMKIRESGQNIKILRRGPC