SPINK1

Gene

Spink1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Mus musculus

Length

80 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (PubMed:9828198, PubMed:14645103, PubMed:16083722, PubMed:22228629).

Mass

8.488 kDa

Sequence

MKVAVIFLLSALALLSLAGNTFSAKVTGKEASCHDAVAGCPRIYDPVCGTDGITYANECVLCFENRKRIEPVLIRKGGPC

Protein

Serine protease inhibitor Kazal-type 1: Spink1

Gene

SPINK1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Bos taurus

Length

79 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

Mass

8.467 kDa

Sequence

MKVASIFLLTALVLMSLSGNSGANILGREAKCTNEVNGCPRIYNPVCGTDGVTYSNECLLCMENKERQTPVLIQKSGPC

Protein

Serine protease inhibitor Kazal-type 1: SPINK1

Gene

SPINK1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Homo sapiens

Length

79 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

Mass

8.507 kDa

Sequence

MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC

Protein

Serine protease inhibitor Kazal-type 1: SPINK1

Gene

Spink1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Rattus norvegicus

Length

79 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (By similarity).

Mass

8.528 kDa

Sequence

MKVAIIFLLSALALLSLAGNPPAEVNGKTPNCPKQIMGCPRIYDPVCGTNGITYPSECSLCFENRKFGTSIHIQRRGTC

Protein

Serine protease inhibitor Kazal-type 1: Spink1

Gene

SPINK1

Protein

Pancreatic secretory trypsin inhibitor

Organism

Struthio camelus

Length

69 amino acids

Function

This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas.

Mass

7.656 kDa

Sequence

EPDSAADTGTEAACSNYDLKKGCAKIFDPVCGTDNILYSNECLLCFQNLQRKTNVRIKRRGTCQEPSPR

Gene

SPINK1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Canis lupus familiaris

Length

57 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

Mass

6.319 kDa

Sequence

NNMLQRQANCNLKVNGCNKIYNPICGSDGITYANECLLCLENKKRQTSILVEKSGPC

Gene

SPINK1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Equus caballus

Length

56 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

Mass

6.093 kDa

Sequence

DSLGREAKCNNNAGGCTKIYNPVCGTDGNTYPNECMLCVENQKRQMPVLIQRSGPC

Gene

SPINK1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Sus scrofa

Length

56 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

Mass

6.023 kDa

Sequence

TSPQREATCTSEVSGCPKIYNPVCGTDGITYSNECVLCSENKKRQTPVLIQKSGPC

Gene

SPINK1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Ovis aries

Length

56 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

Mass

6.145 kDa

Sequence

NILGREAKCTNEVNGCPRIYNPVCGTDGVTYANECLLCMENKERQTPVLIQKSGPC

Gene

SPINK1

Protein

Serine protease inhibitor Kazal-type 1

Organism

Monodelphis domestica

Length

55 amino acids

Function

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.

Mass

6.206 kDa

Sequence

DQGRDANCNYEFPGCPRNLEPVCGTDGNTYNNECLLCMENKKRDVPIRIQKDGPC