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SPC3

Gene
SPC3
Protein
Microsomal signal peptidase subunit 3
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
190 amino acids
Function
Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Similarity
Belongs to the SPCS3 family.
Mass
21.768 kDa
Sequence
MFNIVTRFQYAANQALTSSIIIAGIVIVSSLLQLYSNNAWSLGTTSISNIKPQVSLKHSFNYGSVNRKPKENSRIQFDLETDLSPLFNWNTKQLFVYLTAEYPGKSDGSSNKITYWDKIITSKEDAVLSLKNQKSKYSVWDIEPSFRQRDAVVKLEWNLQPHIGPLIFGETDEIADFKFAEYVDKKKEQK

Gene
SPC3
Protein
Microsomal signal peptidase subunit 3
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
189 amino acids
Function
Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Similarity
Belongs to the SPCS3 family.
Mass
21.845 kDa
Sequence
MFSLNQRFQHVSSLALSCSFLVIALIAATSWLQLVKDNVFELESQLSHIRSATRFAKQKRYGGSAVNPTEVSKIRFNADFDFSRLFNWNTKQVFAYVTAEYEGDENPHTMNEITIWDKIIPSRDNATFTLSDIDAKYQLWDLESKITERPLTFKLHWNIQPWFGFLINGETTGSKTIELKKPVDKQKGK

Gene
spc3
Protein
Probable microsomal signal peptidase subunit 3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
185 amino acids
Function
Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Similarity
Belongs to the SPCS3 family.
Mass
21.643 kDa
Sequence
MIVDTFTNRGSTFFSKLSTVLFFLCAVITFQGVIQRREVELDTPVYVHYAKYRSARFYHAFRNVRQQYAQVKFNMDADLSELWDWNTKHVVVYLVASYSTEKHEKNQVVVWDKILSSPEESKMFMKDTLSNIQAHPFNEYSNQFEGKNATYTLHWTVSPKMGFLSWGAGPGSYEIPFHKIITQPK

Gene
SPC3
Protein
Microsomal signal peptidase subunit 3
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
185 amino acids
Function
Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Similarity
Belongs to the SPCS3 family.
Mass
20.925 kDa
Sequence
MHTSIQRIQQTFSQASTVLSIIAAIVFVVSYIQLVVANVWSLPEANFNLRGSKAARRFSRQYGANDPKKGKENVALKFDLDADLSPLFNWNTKLVFAYLTATYDGKRDDIVNEITIWDQIITDKDDSHIKLKGANSKYSLYDVEESFRNRNATVKLHWNIQPHVGAKIYGSLDATKGSIKFPQLV

Gene
SPC3
Protein
Signal peptidase complex subunit SPC3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
184 amino acids
Function
Component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum. SPC3 is required for signal peptidase activity and is essential for viability.
Similarity
Belongs to the SPCS3 family.
Mass
21.349 kDa
Sequence
MFSFVQRFQNVSNQAFSMGIVMVVFIMASSYYQLINNNAFSVPSNIDNVKTLINVRTSRYFGSQRGKAKENMKIKFDLNTDLTPLFNWNTKQVFVYLTAEYNSTEKITSEVTFWDKIIKSKDDAVIDVNDLRSKYSIWDIEDGKFEGKDLVFKLHWNVQPWVGLLTYGETVGNYTLTVENKNKV