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SPC25

Gene
SPC25
Protein
Kinetochore protein SPC25 homolog
Organism
Arabidopsis thaliana
Length
315 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity to ensure proper cell division.
Similarity
Belongs to the SPC25 family.
Mass
35.578 kDa
Sequence
MEQISNIAGGDTTKETMASLGLICEKDIHEQRLKIDSFIASPFRRSMNSLVERAQATAQSQVELMNLKADLREAEDELVKVLAVKTRKEARQMGIRDSISATQSRIEVLRRNLQLQKSKKDDSVRIISQQLQALSKSKDNAGKVTEDKADIHEAISWYNHALGFHVEAGHGVKFTFTNIDAKRPTREFSFTVHYGNDIYTLLDSDLQLDYINEMVQELNKTNDLFRFVRLMREQFLKSTLSELPTHSGQLQQETSAISASAPAISFSTDTNMSTPENKRSKVQVNRRQKRGSESPLLAPVSTSATRRSSRFKGKK
Protein
Kinetochore protein SPC25 homolog: SPC25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
272 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
30.873 kDa
Sequence
MAPTTYAVPPRPASLHFLLESSTSKNGVPSLDLRWEPFQRHIESFLNAIDAYTQAARTEIVARATDHTAAVRDLKADKEEMERGIQLQRESEGEMLATLEAERHVVADLNASLSHLQSSLTKIKEKSSALDAELQSERKEVKAMQAEKERQTNVLNNMRERDTTELKQLEEALGWRVEGIKQDQLLMRFTLIDPEDPAREFSIIVDVSKQVYSVPNCDPPIPSLPDLVRQLNFDRDLFAFIKRVRIAFRALIPNPPNPSTKFDDLTGPSRSR
Protein
Probable kinetochore protein SPC25: SPC25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
272 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
30.873 kDa
Sequence
MAPTTYAVPPRPASLHFLLESSTSKNGVPSLDLRWEPFQRHIESFLNAIDAYTQAARTEIVARATDHTAAVRDLKADKEEMERGIQLQRESEGEMLATLEAERHVVADLNASLSHLQSSLTKIKEKSSALDAELQSERKEVKAMQAEKERQTNVLNNMRERDTTELKQLEEALGWRVEGIKQDQLLMRFTLIDPEDPAREFSIIVDVSKQVYSVPNCDPPIPSLPDLVRQLNFDRDLFAFIKRVRIAFRALIPNPPNPSTKFDDLTGPSRSR
Protein
Probable kinetochore protein SPC25: SPC25

Gene
spc25
Protein
Probable kinetochore protein spc25
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
264 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
30.709 kDa
Sequence
MASSFEPSLSTSGMRPPLTSADAPSMADSLPSINFGFEDLRNRMAQFTARFDAFIEKGRKQILEERNQFKIGLAELQEDQRMKQRDIEILNLKSQTHDQTIQKEAAEAAEMHGTIASVTMERDSRLAKRDRLKQQINETQKAINQKLEAQKAHARHLDAQARLNIPELEFWQDYLCLRIEGAGREDRLKFIFSHLLEKDWEAEAWFELGTSSRDYDVFHTRPKVDRDALNGELDILNEDRDFGAFLKRMRRLLVEKMQQKRPTI
Protein
Probable kinetochore protein spc25: spc25

Gene
spc25
Protein
Probable kinetochore protein spc25
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
257 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
30.152 kDa
Sequence
MSSFDPSLSTSGMRPPLASATAPSMADSLPSINFGFEELRSRMAQFTAQFDAFIERGRKQVLEERNQFKIGLAELQEDERMRQRDIEILNLKSQTHEQTLQKEAAEAAEMHAAVSSVTLERDSRLTKRDRLKQQIEETQKAINQKLEAQRSHSRYLDAQARLNVPELEFWQDYLCLRIEGAGREDRLKFVYSHLLEKDWEAEAWFELGTSSRDYEVFHSRPKLDREYLDRELDILNEDRDFGAFLKRMRRLFIEALK
Protein
Probable kinetochore protein spc25: spc25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
257 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
30.146 kDa
Sequence
MATDFRSSFSASMRQSMPPVGPSVANQLPNINFGFDDLRDRMAKFTARFDAFIEEGRKRVLDERNQFRMNVAELQEDQRMKKRDIEIVQTKTATHQQTIEKEKAETREMETAINSLASQRDNHLSTRDSLKAEIAQTQAEIETRLAAQREYAQHQQSQSRFNVPELDFWITNLCLKIEGAGHDDRLKFVYTHVDEKDWEREAWFELVTSSRDYDVKHCRPKVEREKVEKVLDKLNESRELVVLLKGMRELFVEAMKS
Protein
Probable kinetochore protein SPC25: SPC25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
239 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
27.936 kDa
Sequence
MDTAERAYEKFQNQMIAFDNLKIEMNELAVDLDQQLSDKQSLILQQEQDHKQKVNDLTNQEYKLKLQAKSLKEKENATRDKLNLAMRSLEQQKSKVEDLVKKKQSLVDTKQDLESQIKQLETAIDQGTRELNKSNDNMSLQMNKNLVELNKYEIYTGLKIEVQSNELMCFKFFNLDPNDYDREFAITLNIGGSTYSIENTSPKLSDETVEQIQGKLNQGRQLSKFLKEVRTLFKDFVQY
Protein
Probable kinetochore protein SPC25: SPC25

Gene
spc25
Protein
Kinetochore protein spc25
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
238 amino acids
Function
Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
28.811 kDa
Sequence
MSLANFPTIELDYDSLKSKISNFNSIFDRFLQEERKKLLNNKNEYLRQLSEINEAQKKAEKSLEQTEARKQNFTELLEKEHEEQAITEQEIFSFQEKLDAMLKRKQKLSEELDHYRAIISSKRELRAQEMEAKRKQDSYNNPELKFWEDYLGLKMEGVHDEVIRFIFTNIDEKDWNKQFSFQINLAERDYKVVHCHPPLPHVDDLVNKVNRTRDFYQFLKDMRKGFRELHRKDLSQLI
Protein
Kinetochore protein spc25: spc25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
237 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
27.923 kDa
Sequence
MENNGKSRGTQLVGQIDDLTRELQDAQKVVVSRINERNRLVSDMMERYRSNLRILQEQRVTVLSELDRYKEEESRMKEALQNLNSTKEEFKREMDAYQLKAEKMRLQKQQLQKQLDDLNKMFADRANEIQKYKEMVTRQRQLDSPEIKLYEKLLGLQIDKADTHMLKFTFTDFGREREYKSVIVDVSQLNDDSSPLRIKEIESGVSASTVNELETVLNQQGIVQFLIEVRKVLVKSE
Protein
Probable kinetochore protein SPC25: SPC25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila persimilis
Length
236 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
26.615 kDa
Sequence
MADLKASEGDLSDYYMRLKKIFSNETRLQSREASISKRSSRVHKNIISAKEAIERQERDFGKLQKVLLNRNQELERRFTLGEALAQQLEVTRQRNADMEAQLLRHTTEGRQRSNELMECMHSLKQATGTYINHEALPARLNGVSVVRADDGDIKLIPFSLDGNDADGLHTLWRSLHTRTDNNASKWRKLISDQEVAGASPVTPSGSERPKATSKHSNFMPTSIIEIDLTSPTNDAS
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila pseudoobscura pseudoobscura
Length
235 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
26.565 kDa
Sequence
MTDLKASEGDLSDYYMRLKKIFSNETRLQSREASISKRSSRVHKNILSAKEAIERQERDFGKLQKVLLNRNQELERRFTLGEALAQQLEVTRQRNADMEAQLLRHTTEGRQRSNELMECMHSLKQATGTYINHEAFPARLNGVSVVRADDGDIKLIPFSLDGNDADGLHTLWRSLHTRTDNASKWRKLISDQEVAGASPVTPSGSERPKATSKHSNFMPTSIIEIDLTSPTNDAS
Protein
Kinetochore protein Spc25: Spc25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
232 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
27.063 kDa
Sequence
MTTLPTLPPLPEDIVTGMEELKIVMSAALERQRSQLVQSRQDVNRVLKELEEESKGVSLEIESHMARQHDLRLQISELDKQIEDSKGTIVEYSRRRSELESKVEAAQRACDEGRQRLEEQQSLRRRQVQHVMEQSVRNVPELMYMEDLLGMKIEAVQDDQLRFVFVKLDPNDYAREFAFVLDMADVNYRVEQLEPTLDLSVVDRVVGKLNSSRNFPQFLKEIRQAFKDAIME
Protein
Probable kinetochore protein SPC25: SPC25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
231 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
26.658 kDa
Sequence
MSTANKSPIDEFESLQSLMNDFSAKFDTALTQKRSAIINDKQLHYVKVNELKNQETQLQSDIEGLKQKEIKVKDTIKRTMEDLQMQQLKVDELARKQDSLLDEKDELQTEIDNLSSQVQTTTDSLEKSSNNLAEQLRKDYPELLKYEQHLGLKIEVIGQDSLKFVFSNIDPNDLDKEVWCELLVGGELFKVGDSFPPLAPDIITLLENEFNHHREFVKFLKTVRALLMDLI
Protein
Probable kinetochore protein SPC25: SPC25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
231 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
26.094 kDa
Sequence
MSLEGFAELRAQMEAFQGRVHGHLGQQRHAMEQLLAAHRQEVEKLRLRTGAVQQQLARLAGEEQELRQNISSLQERTQHTTAQRDAYAAQRQKLAAERTQLEHDRAELHAMLARKQAELQRQREAIKRQHMRDNPEVRVYEQLLGLYVRASRPDSLEFAFRNVSEADARAECSFTLDLGADGYRVAAAQPPLPLERLRDLERDLGSSGDLPAFLKAIRAALVTAMAGQADA
Protein
Probable kinetochore protein SPC25: SPC25

Gene
spc25
Protein
Kinetochore protein Spc25
Organism
Xenopus laevis
Length
228 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
26.704 kDa
Sequence
MSALKMDDEQSLNVYMQEFRTRFINKSSDEMTSQALKESYKESAATDAWFKKYRDGELMIEKVLEFRNEITLQNKRIEEKQKNILQEAAKQDDHEQLKGELTERIQRLREELNQKREVALANRKANKERIKELQKSATLFKERLGLEIRKLRGDKLQFVFRCINPKDLDQPYSCIISLNAEGDYEVAGCDPPLECIAEFQEKIRETRNFSALLANLRKSFTALGSQVK
Protein
Kinetochore protein Spc25: spc25

Gene
spc25
Protein
Kinetochore protein Spc25
Organism
Xenopus tropicalis
Length
228 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
26.858 kDa
Sequence
MSALKMDEEQSLNVYMQEFRTRFINRSSEEVTSQALKESYKDSAQTDAWFKKYRDGELMIEKVLEFRNEITLQNKRIEEKQKNILQEAAKQGEHEQIKEELTERIQRLREELNKKREVALANRKANKERIKELQKSATLFRERLGLEIRKLRGDKLQFVFRCINPKDLDQPYSCIISLNAEGEYEVTGCDPPLECIAEFQEKVRETRNFSALLANLRKSFTALGSQVK
Protein
Kinetochore protein Spc25: spc25

Gene
SPC25
Protein
Probable kinetochore protein SPC25
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
227 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
26.12 kDa
Sequence
MGIDDFNELKLKMDDFQSKIHQFLIKNNQDLATKSETYWNSESEKIKKIEALKDKLRQLEEHQISLEEEFESSQREVSEVNAQSKAFLTKRDKLIGEREFLHKELDKLDILLKEQTKDLEREKQSRLLQSSKDTNEVALFETLLGLHISANAQDAITFHFTSRTVDVSPQLSITLDVSQDTYKITDSNPKLPQIIKNDLLNNLAATDDLRSFLKAARSHLSALTEAT
Protein
Probable kinetochore protein SPC25: SPC25

Gene
SPC25
Protein
Kinetochore protein Spc25
Organism
Bos taurus
Length
226 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
26.608 kDa
Sequence
MVEDELALFDKSINEFWNKFKSTVSDTSCQMVGLRETYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQICRQNKLIQEKKENLLKLIAEVKDKKQEVEALTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYKDRLGLEIRKIYGDKLQFIFTDIDPKHPDRPFMFSLCLNEARDYEVSDCAPRLECLAEFQEKVRQTNNFSAFLANVRKAFTALVYN
Protein
Kinetochore protein Spc25: SPC25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Mus musculus
Length
226 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
26.457 kDa
Sequence
MGEDELALLNQSINEFGDKFRNRLDDNHSQVLGLRDAFKDSMKAFSEKMSLKLKEEERMTEMILEYKNQLCKQNKLIQEKKENVLKMIAEVKGKEQESEELTAKIQELKEEYARKRETISTANKANEERLKGLQKSADLYRDYLGLEIRKIHGNKLQFIFTSIDPKNPESPYMFSMSINEAKEYEVYDSSPHLECLAEFQEKVRKTNNFSAFLANIRKAFIAKVHN
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Rattus norvegicus
Length
226 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
26.189 kDa
Sequence
MGEDELAAFEKSINEFGDKFRYRLSDNRSQVLGLKDAFKDSIRALSEKLSLKLKEEERMAEMILEYKNQLCKQNKLIQEKKDNVLKMIAEVKGKGQEVEVLTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYRDRLGLEIRKIPGDKLQFIFTSIDPKNPESPFMFSLSINEAKEYEVSDCSPHLECLAEFQEKVRKTNNFSAFLANVRKAFIAKVHN
Protein
Kinetochore protein Spc25: Spc25

Gene
SPC25
Protein
Kinetochore protein Spc25
Organism
Homo sapiens
Length
224 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Similarity
Belongs to the SPC25 family.
Mass
26.153 kDa
Sequence
MVEDELALFDKSINEFWNKFKSTDTSCQMAGLRDTYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQISRQNKLIQEKKDNLLKLIAEVKGKKQELEVLTANIQDLKEEYSRKKETISTANKANAERLKRLQKSADLYKDRLGLEIRKIYGEKLQFIFTNIDPKNPESPFMFSLHLNEARDYEVSDSAPHLEGLAEFQENVRKTNNFSAFLANVRKAFTATVYN
Protein
Kinetochore protein Spc25: SPC25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila lutescens
Length
223 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.447 kDa
Sequence
MAKAVDESTYEQRVRALYDKQIRMEAREAGVIKKISKFNSNLLDLKEAVVRHHQKVGKVRKVKMLRCGELEKRANFMEELTQELEATKQRNLVMRDQIKQLNVLARQHRNEVMESIHTLSKTTGTYLNHEALPARVKGVTVLRNDNSDQLIPFDLKATDVEGLESLCQHLQGFNIDAFQWRQLVSLATEMSMDSHTTPTTPPKEAAEGKSIIEIDLTSPTSHI
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila teissieri
Length
223 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.648 kDa
Sequence
MAIIIPESSYERRVKALYEKQIRMEALEGKFIKKVYKFNSNLLDVKEAVLRHQRKVGKLQKVVMERREELEKRVSFMEELAQELEATKLRNLAMKEQIKQRKMIARQRKNEIMERIQTLSKTTGTYVNQEALPARVKGVTVLRGDKRDQLIPFDLNATDAEGLNSLCQHLESLNVDVSQWQQLVSLAMDVAMEARAPTTPPKEVANCKSIIEIDLTSPTSHQA
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila yakuba
Length
223 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.629 kDa
Sequence
MAIIMAESSYERRVKALYEKQIRMEALEGKFIKKVYKFNSNLLDVKEAVLRHQRKVGKLQKVVMERREELEKRVSFMEELAQELEATKLRNLAMKDQIKQRKMLARQRKNEIMERIHTLSKTTGTYVNHEALPARVKGVTVLRGDKRDQLIPFDLNATDAEGLDSLCQHLESLNVDVSQWQQLVSLAMDVAMEARAPITPPKEAANCKSIIEIDLTSPTSHQA
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila mauritiana
Length
222 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.619 kDa
Sequence
MAIIMAESSYERRVKALYEKQIRMEALEAKFIKKVYKFNSNLLDVKEAACRHQRKVGKLQKVLMERREELDKRVSFIEELDRELEATKLRDLAMKDRIKQQKMLARQRKNEIMESIHTLSKTTGTYINQDALPARVKGVTVLRGDKRNQLIPFDLKSTDVEGLDSLCQHLESLNVDMAQWQQLISLAMDVAMESRAPTTPPKEATNCNSIIEIDLTSPTCHI
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila melanogaster
Length
222 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis (PubMed:17895365, PubMed:17333235). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:17895365, PubMed:17333235). Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics (PubMed:17333235). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity).
Similarity
Belongs to the SPC25 family.
Mass
25.742 kDa
Sequence
MAIIMTESSYERRVKALYEKQIHMEALEAKFIKKVFKFNSNLLDVKEAASRHQRKVGKLQKVLMERREELDKRVSFIEELDRELEATKLHNLAMKDWFKQQKMLAKQRKNEIMESIHTLSKTTRTYINQEALPARVKGVTVLRGDKRDQLIPFDLKATDVEGLDSLCQHLESLNVDVAQWQQLISLAMDMAMESRAPTTPPKEADNCKSIIEIDLTSPMSHT
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila sechellia
Length
222 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.678 kDa
Sequence
MAIIMTESSYERRVKALYEKQIRMEALEAKFIKKVYKFNSNLWDVKEAACRHQRKVGKLQKVIMERREELDKRVSFIEELDRELEATKLRSLAMKDRIKQQKMLARQRKNEIMESIHTLSKTTGTYINQEALPARVKGVTVLRGDKRNQLIPFDLKSTDVEGLDSLCQHLESLNVDMAQWQQLISLAMDVAMESRAPTTPPKEAANCNSIIEIDLTSPTCHI
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila simulans
Length
222 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.643 kDa
Sequence
MAIIMAESSYERRVKALYEKQIRMEALEAKFIKKVYKFNSNLLDVKEAACRHQRKVGKLQKVLMERREELDKRVSFIEELDRELEATKLRDLAMKDRIKQQKMLARQRKNEIMESIHTLSKTTETYINQDALPARVKGVTVLRGDKRNQLIPFDLKSTDVEGLDSLCQHLESLNVDIAQWQQLISLAMDVAMESRAPTTPPKEAANCNSIIEIDLTSPTCHI
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila eugracilis
Length
221 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.327 kDa
Sequence
MAITTAESSYEKRIKALFDKQVQMEAREASVIKKVFKFNSNLLDVKEAVVHHHRDVEKLQKVVIQRREEMEKRVSFMEELAQEVEATKQRNLVMREQIKQQKMLVRQRKNEIMESIHTLSKATGTYINREALPARVKGVTVLHGDNRDELIPFDLKATDVEGLDSLCQHLHSLNIDVSQWQQLVSLATEMSMKSHPATPPKDAAKCKSIIEIDLTSPTIQA
Protein
Kinetochore protein Spc25: Spc25

Gene
SPC25
Protein
Kinetochore protein SPC25
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
221 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.
Similarity
Belongs to the SPC25 family.
Mass
25.244 kDa
Sequence
MASIDAFSDLERRMDGFQKDVAQVLARQQNHARQQLQQFQAEMRQLHNQHQHLIDELQRLATQRTALQQQIHAAQQATNTTREQWRSYHERESELSRRQSTLAAQSRELDSLLQQRGKECVQLRARWAAQSGNDAAEVALYERLLQLRVLPGASDVHDVRFVFGDDSRCWIEVAMHGDHVIGNSHPALDPKSRATLEHVLTVQGDLAAFLVVARDMLLASL
Protein
Kinetochore protein SPC25: SPC25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila erecta
Length
220 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.243 kDa
Sequence
MAIIMAESSYERRVKALYEKQIRMETLEGKFIKKVFKFNSILLDVKEAAARHQRKVEKMQKVVIERREELEKRVSFMGQLAQEVEATKLRNLAMKDRIKQQKMLARERNNEIMERIHTLSKTTGTYVNQEALPARVKGVTVLRGDKRDQLIPFDLNATDAEGLNSLCQHLESLNVDVSQWQQLVSLVMDVTMEARAPTTPPKEAANCKSIIEIDLTSPTS
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila orena
Length
220 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
25.06 kDa
Sequence
MAIIMAESSYERRIKALYEKQIRMEALEGKFIKKVFKFNSVLLDIKETSARHQRKVGKMQKVVTERREELGRRVTFMGHLTQEVEAIKLRNLAMKDQIKQQKMLNNQRKNEIMERIHTLSKTTGTYVNQEALPARVKGVTVIPGDRRNQLIPFDLNATDDEGLNSLCQHLESLNVDVSQWQQLVSLAMDVALGARAPTTPPKEAANCKSIIEIDLTSPTS
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila ananassae
Length
215 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
24.974 kDa
Sequence
MAVGLDRADKSNYALRLKEMFNKEIRLQCRETNISKMSSKFHDNLLTAMEKADWQQRELERIERQLVLNRQELEKRLLLEKELTRELEATKLQEATVREHNNELMECIHALKRATGTSINHDALPARVKGVTVLRNTDGDQWIPFDLAVTDTEGLNSLCQKLQSNNIDVNKWRQLVSLATEMSMKWNYSTPNRRDNAKVDIIEIDLTSPTNQIIL
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila virilis
Length
210 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
23.882 kDa
Sequence
MSNQFNTRKRLMAMLANEMRLEQEENAIAKQSAKFHSKFATTMENIKRQQHESKKLNTLLNQRRDEVEKRNALKNAVRDKLAEEEQHCAEMQAQLGKKKQERDKLIACAHILSEAANTYINRKALPERVKGVAVSPDNGQWIPFDFNAHDRQGLAALWTQVNRSSRNINKWRQLSSVGNSSMPAPSGKENANVSMTSVIEIDLTSPPSQK
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila grimshawi
Length
209 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
23.9 kDa
Sequence
MTEQFDTRRRLMAMFRNEMRMEKLENTIAKKSTKFHTNSAALMTTIDLQQRKFEKLNALITRRCEDINTRTAFTRAVREKLAEERQKNAEMQAQLEKANDERIEQMDCVRTLSDASNTFINPSALPARLKGVTVLREEGRWISLDYDGDDLKGLSTFWAQAHSGSASQKWQQLLSMDKAIMPTLNDKGNVNVSVSSIIEIDLTASPSHK
Protein
Kinetochore protein Spc25: Spc25

Gene
Spc25
Protein
Kinetochore protein Spc25
Organism
Drosophila mojavensis
Length
208 amino acids
Function
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the SPC25 family.
Mass
23.968 kDa
Sequence
MRKRLMAMLQNDISLQQQENALAKQSAKFHSKIAAKHQLIKRQQRKLEKLNQVANERKEDQENRSAFEQSMRDKLLREQQNLSEMQTELATKKQRRDELMGFVRTMSEATNTYINLKALPARVKGVALRPEQGEWIPFNCDAYDLKGLNALWSRLNEPSASTDKWQQLFSAEPTAKEKENANASLSSIIEIDLTSPTAHRSLAKMLEK
Protein
Kinetochore protein Spc25: Spc25