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SPB4

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
767 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
85.43 kDa
Sequence
MSAEPSVQTTSSSGPTELRSAPSYAGSWTKLTPPLTPWVVSLLSDLGFGQMTPVQASTIPLFVSHKDVVVEAVTGSGKTLAFVIPVLEMLARRTTRLKKDEVGALIVSPTRELAEQIYKVLVMFLDAQNHAHVQAQQQQDQDEQDEQDEQEAQSDSDTDPDASTALNNKRKSSNHLVARKNMISGAQLVVGGSKCTPLDDYRQLRDSGADILVGTPGRLEELLSKKGVKKSSLEVLVLDEADRLLDLGFTENLRRILSLLPKQRRTGLFSATMTDALSELVRIGLRNPVRVVVKVEAKHKTSSSIDDSRRTPATLQNLYQLCRAQNKLAQLARIVLFESSQNAISGGARKLIVYFSTCAQVNYFYSVFSQVSILRQHRVKLYALHGKQTPSKRKSMFDTFVASTALDSGASGASVLFCTDVAARGLDLPDVDVVVQYDPPTDPKVFSHRCGRTARAGRNGRAIVMLHTGREQDFVSYMRVKRIPLSPYPYLSSTLHGILEPAEDDASAHDLELSIRDLAKTDREIFELSIRAYVSYVRAYTKHEMSYIFRINELDLAGVARAFALIRLPSMPELKSRQSAGTLIYNQEPIDFSSIPFKDKAKQRIRLAKLSGDQAKPPARIKASVDDAAQLQDDQCDSHDSDDAHPNSSATRAKNKRKLEREKGAWSAQKERKQARLANREKRARKRTFLKTQAAESSSNAKHEPPQDDHDEHDWNDDYRKLQKDKRQQRQRNKADRANSDNDDAMHFNSDSDAAAANADAEPFFVI

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
748 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
84.251 kDa
Sequence
MDAPVPAAPAFGGSWAKLNPPLSPWILDVINSMGFKNMTPVQAGTIPRAVKNQDCVVEAVTGSGKTLAFTIPVLERLSRREEPYKKGEIAAIVVAPTRELATQIHAVFHHFLSSLIPPESEEETGDVEAHAPPFASSSRSPSPQTPDKPLFPLPMLVTSGTPTPYETFQSTHPSILIGTPGRLAAFLLNPRGLAIVRVSELDVLVLDEADRLLSSPDHRRDVERIMRHLPKQRRTHLFSATMTDAVEEMIGLGLRNPVRIVVNLKDKRKDGEEPKERRTPMALQNTYLVCRHAEKTLQLIRLLLCESTKHERSKFIVYFSTCAAVDYFYRILSRLPSLSKFHLTSFHGELPPKIRETALSTFTSHPSSHLSPAVLLCTDVAARGVDFLDIDVVIQYDAPTDPKTFSHRAGRTARAGRRGKAVVLLGKGREEDYVGTFQSANAELMKRKRQKAQRSILDFLNIRKIPLTKQPYINAYLEEVDTPQALDPEATTLLHSIRQIILTDRELSDKAAKSFVSAFRAYSKHEASFIFRTLDFDFNSQAISFGLLRLPAMPEIKDWKKKKEAERQRLEKIKSEGGEVEEKEIIEWEDAGVNWDTFAYASRQREAARLATLAQRADNQSSNDAARAEARAKRKIKAEMREAWSEQKERKVRKEERKEKKDAKKKYEWELEQANGEGDRQSDLANIAKAQAERKKRREREEESWDEEIGKEYKSLKREIKEEKSVKESSKGGAGGGGIGGGMFDDLE

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
748 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
84.251 kDa
Sequence
MDAPVPAAPAFGGSWAKLNPPLSPWILDVINSMGFKNMTPVQAGTIPRAVKNQDCVVEAVTGSGKTLAFTIPVLERLSRREEPYKKGEIAAIVVAPTRELATQIHAVFHHFLSSLIPPESEEETGDVEAHAPPFASSSRSPSPQTPDKPLFPLPMLVTSGTPTPYETFQSTHPSILIGTPGRLAAFLLNPRGLAIVRVSELDVLVLDEADRLLSSPDHRRDVERIMRHLPKQRRTHLFSATMTDAVEEMIGLGLRNPVRIVVNLKDKRKDGEEPKERRTPMALQNTYLVCRHAEKTLQLIRLLLCESTKHERSKFIVYFSTCAAVDYFYRILSRLPSLSKFHLTSFHGELPPKIRETALSTFTSHPSSHLSPAVLLCTDVAARGVDFLDIDVVIQYDAPTDPKTFSHRAGRTARAGRRGKAVVLLGKGREEDYVGTFQSANAELMKRKRQKAQRSILDFLNIRKIPLTKQPYINAYLEEVDTPQALDPEATTLLHSIRQIILTDRELSDKAAKSFVSAFRAYSKHEASFIFRTLDFDFNSQAISFGLLRLPAMPEIKDWKKKKEAERQRLEKIKSEGGEVEEKEIIEWEDAGVNWDTFAYASRQREAARLATLAQRADNQSSNDAARAEARAKRKIKAEMREAWSEQKERKVRKEERKEKKDAKKKYEWELEQANGEGDRQSDLANIAKAQAERKKRREREEESWDEEIGKEYKSLKREIKEEKSVKESSKGGAGGGGIGGGMFDDLE

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Ajellomyces capsulatus (strain NAm1 / WU24)
Length
676 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
75.663 kDa
Sequence
MATSASRIAPTTPQSSHSRAWDALTPPLSEWILDAISAMGFSRMTPVQASTIPLFMAHKDVVVEAVTGSGKTLAFLIPVVERLLRLESPIKKHHIGAILISPTRELATQIYNVLLSLLAFHGPSAARLQRTENNSGEVDESNPASSYPPSTLKIVPQLLLGGTTTPTQDLSAFLKQSPNVLVSTPGRLLELLSSPHAHCSQSSFEVLVLDEADRLLDLGFKEDLQKILQRLPKQRRTGLFSASVSEAVDQIIRVGLRNPVKIAVKVKGAGLEDKRTPASLQMTYLLTPPTHKLPAVKYIVSTLSPTPQRSILYFSTCAAVDYYQHILPCILPDRFTTIPLHGKHPPQVRQKNFTRFVNSVTSSILLTTDVAARGLDIPAVDLVIQIDPPTDPKAFLHRCGRAGRAGRRGLSVIFLHPGREEDYIAFLNVRKTPVTEFQSTSTSTPSQLYSSSHFSASSPKNPQTFHPIQITTADATSTTEKIRALVLRDRAIHDKAQRAFVSWLRSYSKHQASSIFRVADLDWEELGRAWGLLRLPTMPELKGFTGDRNLGVSGVDWDNYAYKDRQREKHRRMEMEGRSSSNVNNNGDATGSDKGPLKRPATSESIPWSQNLERKSEKERRRERKKIRRYHEQWKKMTEEEKERVRETEQMVNAVRKAVQEQDQTVTREEEFEGFD

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Coccidioides immitis (strain RS)
Length
653 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
73.027 kDa
Sequence
MASKKKERGPPPHSRSWQALTPPLSEWILDAVAAMGFTRMTPVQASTIPLFMGHKDVVVEAVTGSGKTMAFLIPVVEKLLRLEAPIKKHHVGAIIVSPTRELAEQIYKVLLSLLAFHAPSAAAIQPSTSDETADGETTLPSYPSSTLKVVPQLLLGGATTPAQDLSTFLKRSPNLFVSTPGRLLELLSSPHVHCPQTSFEVLVLDEADRLLDLGFKDDLQKTLARLPKQRRTGLFSATVSDAVDQIIRVGLRNPVKIAVKVKGAPGTEEKRTPASLQMTYLLTRPSHKIPAIRQILNSIDNTPQKTILYFSTCAAVDYWSHVLPSLLPEIFVTLPLHGKHPPNVRQKNFSRFTNSVSPSVLLTTDVAARGLDIPLVDLVIQFDPPTDPKAYLHRCGRAGRAGRRGLSVILLCPGREEDYIPFLEVRKTPVSLLESPPVALSDTLATEATSKIRETVLRDRALHDKAQKAFVSWVRSYTKHQSSSIFRITDIDWEEAGRAWGLLKLPKMPELQKFSGDRTLGVTLDWDKYSYKDKQREKHRQESLNSATTHNPLKRPAPSSSSNNDTAPWSKTLEKKSDKEKRRERKRAKKEREHWEKMTEEEKTKSRETHQMLEELRKKNRQELNAKSHTSSSVLSKPQEAELDGESEFEGFD

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)
Length
646 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.577 kDa
Sequence
MPPEQVRARKTPRSWGALTPSLAPWILDYLSSMGFEQPTPVQKSCFDIFRGNKDVVVEAVTGSGKTLAFLIPVVERLLRSEDPAKRHHVQAIIISPTRELASQIYNVLVSFLKFHAPSAHLLPHAKGDEKRPATTEPVVVPQLLVGGTTKAAEDLSTFLRLSPNILIGTPGRLAELLSTPYVKAPSSSFEVLVMDEADRLLDLGFSQELTRILGYLPKQRRTGLFSASLSEAVERLITVGLLYPHKITVRVKSLRDGGIVQERKTPMSLQMSYIVTPASQKIPALCQLLERLEPRPSRSIVFFSTCFAVKYFARVLHGILPPGFSIVSLHGKLEPQVREKNFERFVNAASPTVLLTTDIAARGLDIPQVDLVVQHDPPTDTKVFIHRCGRAGRAGRRGLAVVMLQPGREEGYVQLLDVRQTPISPLAKPPVSVTAADADLASSRIRAQARADRDIYQLAQRAFVSWARSYIEHQATSIFRVADLDWADLAQGYGLLELPKMPEVRGLDRSLGLAIDTESIPFRDGAREKKRLAELEQWKKEKAAREAQRASGGGGDATDPLKRKKNEAWSGKHEHEDVKAARREKKRRKREAQRLGDMTEPEREEQRKLDEMIAEVRRRNAEAPTPAAQAAGSGGGGGDEFEGFDD

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
642 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.532 kDa
Sequence
MAPKPPPGTSARAWDGVTPALSEWVLDAVASMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPLKKHHVGAIIISPTRELASQIYNVLTSLLAFHPPSASTLKPSDDDDDAPRQKFPSSTLKVVPQLLLGGSTTPAEDLSTFLKRSPNLLVSTPGRLLELLSSPHVHCPQSSFEMLVMDEADRLLDLGFKDTLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVMVKVKGTSGVQDKRTPASLQMTYLTAPPTHKFPAIKHILYSLEPAPQKTIMFVSTCSGVDYLSAILPSIIGDDFQLIPLHGKHQANVREKNFNRFVNSHTPAILLTTDVASRGLDIPSVDVVIQIDPPSDPKTFIHRCGRAGRAGRKGLSVVLLHPGREEDYVSFLEVRKTPVAPYPHTLTITDADAAAATETARKAVLADRALHDRGQKAFVSWFRSYSKHQASSIFRVADLDWEGLGNAWGLLKLPKMPELRNFQGDRTLGVNLDWENYAYKDKQREKRRKEQVQENAENGVADDQAAGKKRSSESVAWSRNLDNRNKKLKRREAKQARQQKDKWEKMTEEERQKVLETEKMLEQIRVKNEEERLLRRAAKDKESKAAGGDDDDEFKGFD

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
640 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
70.95 kDa
Sequence
MAPKPPSGTSLRAWDAVTPALSEWVLEAMSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHVGAIIISPTRELASQIYNVLSSLLAFHPPSAAAINPSEDDDAPRPKFPSSTLKVVPQLLLGGSTTPAEDLSTFLKRSPNVLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVMVKVKGGSGVDDKRTPASLQMTYLTTPPSHKFAALKRIVSSVQPTPLKTIFFVSTCSGVDYLSAILPLLLGDDFLLIPLHGKHQANVRQKNFNRFINSHDPAILLTTDVAARGLDIPSVDLVVQIDPPSDPKSFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVVPFSPSISFSDADAAAATATARKAVLADRALHDRGQKAFVSWLRSYSKHQASSIFRVSDLDWEALGKAWGLLKLPKMPELKNFTGDKTLGMSLDWDNYAYKDKQREKRRKELLQEAAESGATQSTSNKRRATESVAWSQQAESKNKKLKRREQKKSKQEKARWEKMTEEEKQKVLETEKMVEELRKKNEEERRLRRAVAKAAGAKADGDDEEEFQGFD

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
640 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.002 kDa
Sequence
MAPKPPSGTSSRAWDAVTPALSEWVLEAMSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHIGAIIISPTRELASQIYNVLSSLLAFHPPSAAAINPSEDDDAPRPKFPSSTLKVVPQLLLGGSTTPAEDLSTFLKRSPNVLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVMVKVKGGSGVDDKRTPASLQMTYLTTPPSHKFAALKRILSSVQPTPLKTIFFVSTCSGVDYLSAILPLLLGDDFLLIPLHGKHQANVRQKNFNRFINSHDPAILLTTDVAARGLDIPSVDLVVQIDPPSDPKSFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVVPFSPLITFSDADAAAATATARKAVLADRALHDRGQKAFVSWFRSYSKHQASSIFRVSDLDWEALGKAWGLLKLPKMPELRNFTGDKTLGVSLDWNNYAYKDKQREKRRKELLQEAAESGATQSTSNKRRATESVAWSQQAESKNKKLKRREQKKSKHEKARWEKMTEEEKQKVLETEKMVEELRKKNEEERRLRRAAAKAAGAKADGDDEEEFQGFD

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
639 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.052 kDa
Sequence
MAPNPPKGTSSRAWDAVTPPLSEWVLEAMSSMGFARMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLLPIVEKLLRLEEPIKKHHIGAIIISPTRELASQIHSVMQSLLAFHPPSAAAMTPLDDDDAPRQKFPSSTLKVVPQLLLGGSTTPAEDLSRFLKLSPNVLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKIMVKVKGTSGVDDKRTPASLQMTYLSTPPLHKFAALKNILSSVQPTPQKSIFFVSTCSGVDYLSAILPLLLGDDFLLIPLHGKHQANVRQKNFNRFLSSHSPAILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGLSVVMLHPGREEDYVSFLDVRKTPVVPFSPSISFSDADATSATARARKAVLADRALHDRGQKAFVSWLRSYSKHQASSIFRVADLDWEALGKAWGLLKLPKMPELRSFTGDKTLGVSLDWDNFSYKDKQREKRRKELLQEAAESGVSQPSSNKRRASESVAWSQNAENKNKKLQRREYKKLKQEKTKWENMTEEERQKARETKEMVEELRAKNLEERRFRQAAAKAETAKAGGEDEEFKGFD

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Length
639 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.347 kDa
Sequence
MAPKPPAGTSSRAWEAVSPSLSEWVLDAVASWGFSKMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLVPVVEKLLRLEEPIKKHHIGAIIISPTRELASQIHQVLLSLLAFHPPSAAAIKPPGEDDAPREKFSASTLKVVPQLLLGGSTTPAEDLSYFLKHSPNVLISTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASISEAVDQIVRVGLRNPVKVLVKVKGTSGVQDKRTPASLQMTYLTTPPAHKFLTLRPILTSLQPTPQKTIFFVSTCSGVDYLAAILPLLLGDDFQLIPLHGKHPANVRQKNFNRFINAHTPSILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGVSVVLLHPGREEDYVSFLEVRKTPVTPFPHPISISDSDASTATEAARKIIKQDRALHDRGQKAFVSWLRSYSKHQASSIFRVADLDWEALGHAWGLLKLPKMPELRNFTGDRTLGVDLDWENYAYKDKQREKRRKEVLQESAEAGAQQTSNKRRASESVAWSNKVDQKNKKQKRREQKHLQQEKRRWEKMTEEEKQKARETQKMLEEIRQKNEEARALRRAEKAAGKAADNDGDDDEFEGFD

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
638 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.581 kDa
Sequence
MAPKPPAGTSSRAWDGVSPSLSEWVLEAVSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPIVEKLLRLEEPIKKHHVGAIIISPTRELASQIYHVLLSLLAFHPPSASVINPSEDDDVPRQKFPSSTLKVVPQLLLGGSTTPAEDLSKFLKQSPNLLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNIIRRLPKQRRTGLFSASISEAVDQIVRVGLRNPVKVMVKVKGTSGAQDKRTPASLQMTYLTTPTIHKFDALKHILHSVDPTPQKTIFFASTCSGVDYLSAILPLILGDDFQLISLHGKHPANVREKNFNRFVNSYSPAILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVAPFPHPISFSESEATAATKAVRKAVLADRALHDRGQKAFVSWLRSYSKHQASSIFRVADLDWESLGKAWGLLKLPKMPELRNFTGDRTLGVNLDWDDYKYKDKQREKRRIELLQESKEGDGTQESSNKRKATETTAWSNKLDDRNKKQKRREQKQRRQEKNKWEKMTEEERQKIRETEQMVESIRVKNEEERRLRRAGKAEAANAGKDEEEFEGFD

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
638 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.063 kDa
Sequence
MAPKPPSGTSSRAWDAVNPPLSEWVLDAVSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHVGAIIVSPTRELASQIYNVLTSLLAFHPASAAVINTSETEDVPRPKHSSSVLRVVPQLLLGGSTSPAEDLSTFLKRSPNLLVATPGRLLELLSSPHVYCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVVVKVKGASGVDDKRTPASLQMTYLTQPPTGKFPALKHILNSVQPTPSKSIFFVSTCSGVDYLSVILPLILGNDFQLIPLHGKHPANVRQKNFNRFVNAHNPAILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVAPFPHPITVSDAEAAAATETARKVVKADRAIHDRGQKAFVSWLRSYSKHQASSIFRVADLDWEGLGKAWGLLKLPKMPELKNFKGDKTLGVQMDWDTYAYKDKQREKRRLELLQEMAESGQQQTTNKKRPNETVAWSNNAENRNKKAKRRDMKQVRQERKRWEKMTEEEKKKALETEQMLEQIRAKNEEQRRLKRAAAKADKDAEEGGDEEFTGFD

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
637 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.628 kDa
Sequence
MATEKPKKRSPRAWDTLNPPLSEWIRDAVATMGFDQMTPVQAATLPHFMGNKDVVVEAVTGSGKTLAFLIPLVQKLLRLSEPTKKHHVAAIIVSPTRELAAQIHTVLMKLLQFHEASAEILPHLKDDDEKRPFTTVPAIVPQLLVGGTTTTVQDLRFFLRHSPNVLISSPGRLVELMSSPHVHCPQSSFEVLVLDEADRLLDLGFKPDLQKILSHLPKQRRTGLFSASVSEAVGEIIRVGLRNPVKIEVKVKIKGGGILEDRKTPASLQMTYMVKPASQKLPALAELLRQLPVRPQRSIVFLSTCAAVDYFQHILPLILPEGFALVPLHGKHAAKVREKNFNKFLSSVSPTILLTTDLAARGLDIPQVDLVVQIDAPSDPKVFIHRSGRAGRAGRKGLAVVMLHPGREEDYVQFLEIRKTPIAPLEKPTITTSEDDAAEFAKKTRDFVLTDRGLFDKAQKAFVSWARSYGAHQATSIFRAADLDWADLGNAWGLLRMPRMPELKGWTGDKMCGLEIDWDNYAYKEKTREQQRKVALEEEKSGVKKQDKSEEFKRKRKNNEAWSAKHEKEDDRVERREKRRKRRDAEATSKMTDDEKVKQMELNDLIAEVRRQNREKAAAEAAAAKQEKDGEFKGFDD

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
637 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
72.744 kDa
Sequence
MQTNKGSLLWENLRVDLEPWLKDAIRSLNYPTMTPVQASTIPLLSGNKDVIVEAVTGSGKTLAFAIPVLQKVSKRLYQVPEGEEKPEPVKRGHMLAIVMAPTRELAKQIQMVFDKVLELLPEEDSYEPRIKTQLLVGFLGNVREDLDSYQENRPQILIATPGRLLDFMSLQIVKTSSLEIVILDEADKLLDMSFETDVIKILKMLPKQRRTGLFSATISAAGDTIFRTGMNNPVKLQVKTKNFLGEQNNAPTSLQLSYMMIEPEHKLTTMLQMLRDNQFKKAIVYFPTCTSVKHFYQMLSKLCKSSANDIDISALLFFSLHGQLTTKSRLNTLEKFTEGNDESKKYILMATDVAARGIDIPDVDLVIQIDPPTDPSVFLHRCGRTGRANKVGRAIVMLNNDTQEEDYVGFMEVKSVFMTKIDPPEDKDNHSFHNKFQKKLRKYMLEDRARHELAVKSYVGFVRYYSKHIASLIFRLASLDYIAIAKMYGLLRLPKMPESRYIENEKMPEDGWLGEVVDMDTYAYLDKSAEKARLENLEKDKLAKAENAKRRKELKVKNEAWSSKTEKRETKLERKEKMKRKREAIEKQLEAEQERGGLDEEEVKEDWKDLVRKNKKKQKSNGGGGGGGVLQGSFDDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
633 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.204 kDa
Sequence
MAPQTKIDRSFSALTPALSEWIIDAVDAMGFVKTTPVQHAAIPMFMKNSDVVVEAVTGSGKTLAFLIPIVERLLREDAPTKKHHVGAIIISPTRELATQIHTVLSSLLKFHAPSAAMLEPDDEDTDMEDADTPPKPTFPPGTLKAVPQLLLGGSVTPAQDLSAFLKKSPNILIGTPGRLLELLRSPHVHCPQSSFDALVMDEADRLLDLGFKEDLQKIISRLPKQRRTGLFSASMSEAVDQLIRVGLRNPVRIAVKVKARATGEDGKIEDKRTPASLQMSYLVTPPSHKIPAMKKILSSLQPQPQKSILYLSTCFSVDYFQHVLPEVLQGYDIVPLHGKHPDKVRRKNFNKFVDSVTPSILLTTDVAARGLDIPSVDLVFQLDPPSDPKTFIHRCGRAGRAGRRGLAVTFLNPGREEDYIEFLQVRQTPISPLTTPEITVTDEDAKAVTSKIRKKVREDRALFDKAQRGFVSWVRAYSKHTASSIFRIDDLDWTELGNAWGLLTLPGMPELKKWQGDKRLGIELDLATYAYKDKAREKLRLEELERDKEEGTKKKQHKKEDREKSAWTEQKESKATKEVRREKKKSKREHERLAKMTDEERKEEDRVQAMIEQMRKKVAKQEAEDADFEGFSD

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
631 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
72.353 kDa
Sequence
MKSNTESLAWENLRYDLHSWIKEAISSMGYPTMTPVQASTIPLLSGNKDVVVEAVTGSGKTLSFVIPVLQKISDRLYKPDSDGDLPEPVKRGHMLSIVLSPTRELANQIQSVFNQVLQYLPEDKGTRINTQLLVGSIGNVREDLNQFLTNQPQILIGTPGRILEFLGSSQSIKTSSLEIVILDEADKLLDFSFEKDVINILKKLPKQRRTGLFSATISSAGNTIFRTGMNNPVKVQVKSKNYFGEQSNSPKSLQLSYMMINPELKITTLLTILSKYQYKKAIVYFPTCTSVKHFYQIFNKVYQQESSDEPLKFFSLHGQLNTKSRLKTLDNFTQGDINLYKHILMTTDVAARGIDIPDVDLVIQIDPPTDPNVFLHRCGRTGRANKVGRAIVMLNDNCQEEDYIGFMEVKGIFLTKQDIPTSSATKNLHENFQIKLRQYMLEDRARHELAVKSYVGFIRYYSKHIASSIFRLATLDYLGIAKMYGLLRLPKMPETKYIDNSIMPTDGWLGEIIDMDKYSYADKLQEKTRLENLENDKLKKIQDAKRRKELKIKNEAWSSKSERKENKLDRKEKLKRKREAIEKQIMEEERLNDGGNKDEEDEVVEDWKDMVRKNKKKQKKNNSIQGSFDDL

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Botryotinia fuckeliana (strain B05.10)
Length
626 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
70.178 kDa
Sequence
MAIEGEKKKDPRAWDALTPSLAEWVLDAISSMGFEKMTPVQASTIPLFMGNKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPLKKHHVGAIIVSPTRELATQIHSVLTSLLKFHEPSAEALQPLEEGEKRKPSSTLRVIPQLLLGGTTTPAQDLSRFLKNSPNLLISTPGRLLELLSSPHVHCPQSSFEVLVLDEADRLLDLGFKDDLQKILGRLPKQRRTGLFSASVSEAVGEIVRVGLRNPVKIAVKVKGAGGGDKMTPASLQMSYLLTPPTHKFPALLSLLSQLEPTPQKSIIYLSTCAAVDYFQPLLEAVLPKQFGLVSLHGKHPPNVRQRNFSKYVAAVSPTILLTTDVAARGLDIPQVDLVVQIDPPSDPKVFLHRCGRAGRAGRKGLSVIFLQPGREEDYIPFLEIRKTPITPLKRPEISTTGEAAKILISKMRKEVLSDRALYDKGQRAFVSWVQAYSKHQASSIFRVADLDWTDLGNAWALVRLPKMPELKKWEGDKTLGIKLDMSEYAYKDKIREKARRVAMEEAKNAGPYVPTEEQIAKKKQREAWSQKHEKQDLKELKREKKKRKREIERLEKMTDEEKKEEQAKEKELQDLIEQVKKRKIEDDADVEFEGFAD

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
626 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2 (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
71.091 kDa
Sequence
MSTDWKDLPVAPWLIDTMEQFGFTDMTPVQASVIPMFAGNKDVIVEAVTGSGKTIAFLVPLIQRMLNLLKEGPAVSGRVYSVVVSPTRELARQTYEVLQSILEMGCPEADASDKITLEKKKKGKAAPTMPKKIRGQLIMGGDLPSHMDLKNFLRDKPQIIVATPGRLLELLRAPQIKTSAFDSLVLDEADRLLDLGFGRDITSIINILPKQRRTGLFSATITDAIQNLVKIGLRNPVKIVVKVGGKKEQKTPLSLGLSYVVLEPREKLAYALNLLSIYPYRKAIVYLPTCAAVTYYQQMFSHLNEGREEPYEIYGLHGKLPSSTRIKILNKYQKTGAQAILMTTDIAARGLDIPEVDLVVQLDPPSDADTFQHRCGRAGRAGRQGQAIVLLHKGREEEYVDLMRVRKVKLRPYTGPGSELEGEKLDQEATELYTKLRKWVLEDRQRHDQALLSFVSFVRFYSKHVAQSIFRIQSLDLPGLAASYGLLRLPKMPELRTKDNERPENTWLGEVIDFDTYSYKNPAKEEARLKELEAHKEAMKNKVKIHKTKNDVQKANRAWSSTLQKKEEKSERHQKKQTRINEKIKRDFEEAKDLKQEESKEVVNDWKDMVKKSKKRKVDLPTFDDL

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
Length
625 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
70.228 kDa
Sequence
MAIDGEKKKDPRAWDALTPSLAEWILDAIKSMGFEKMTPVQASTIPLFMGNKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHVGAIIVSPTRELATQIHSVLTSLLAFHEPSAGALKPLEEGEKRKPSSTLRVVSQLLLGGTTTPAQDLSRFLKNSPNLLISTPGRLLELLSSPHVHCPQSSFEVLVLDEADRLLDLGFKDDLQKILSRLPKQRRTGLFSASVSEAVGEIVRVGLRNPVKIAVKVKGAGGDKMTPASLQMSYLLTPPTHKFPALLSLLSQLQPTPQKSIIYLSTCAAVDYFQPLLEAVLPKQFALVSLHGKHPPNVRQRNFSKYVAAVSPTILLTTDVAARGLDIPQVDLVVQIDPPSDPKVFLHRCGRAGRAGRKGLSVIFLQPGREEDYIPFLEIRKTPITLFKRPEISTTDDAAKILISKMRKEVLADRALYDKGQRAFVSWVQAYSKHQASSIFRVADLDWTDLGNAWALVRLPKMPELKKWEGDKTLGIKLDMSEYAYKDKVREKARRVAMEEAKNAGPYVPTEEQIARKKQREAWSQKHEKQDLKELKREKKKRKREIERLDKMTDEEKRVEQEKERELQALIEQVKRRKIEDDADEEFEGFAD

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
617 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
70.79 kDa
Sequence
MGKSLEWADLDYELQPWIKKAINVSGFDSMTPVQASTIPMFAKNKDVVVESVTGSGKTIAFVIPILEKIISEGINNSKFKKGHFYSLILAPTRELSMQIQNVVSSFLEHYPEDQYPIRSQLVVGTNEKSVRDDVNTLLDERPQILIGTPGRVLDFLQSPSVKTSSCGMVVLDEADRLLDVSFFKDVEKILNVLPKQRRTGLFSATISSAGTLIFKTGLRNPVKITVNSQGKNAPTTLNLFYSVMKPEEKLQNLIHIMNNIRFKKCIVYFSTCVSVTFFYQYLKYLQQTDKTLREDLQVISIHGKLTTQSRRKALSTFTESLSDCILLTTDVAARGIDIPDVDLVLQIDPPTDADIFLHRCGRTGRANKIGRAIVFLNEGREEDYIPFMEVKNVDIEETDINKNKISNDNNDEFYQRFTKWLLSDRANYDLSVKSYVAFIRYYSKHSATSIFRLQSLDYVSLGKMYGLFRLPRMPEITKYLQDKEKSGETVVGYYGEGWLMNPPPIDMDKYAYQDKKREKARIEELKNLAQINDKKKLKAELKKKNMAWSSKTMTKEERQERRKKLDLKRKAIELEIAAEAERDESDTEITQDWKDEILQKKKKKKVGSEMQGSFDDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
617 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
70.204 kDa
Sequence
METKKGSLDWKNLQYDLQPWIKEAIASLGFPTMTPVQAATIPLLSGNKDVVVEAVTGSGKTLAFAIPVLQKVSNRLYDSQEEGEAPEKVKQGHMLAIVLSPTRELASQIQSVFNNVIEYLPEDKIPIKTQLLVGSLSTVRDDLDRFLKDKPHILIATPGRMLDFMSSQYVKMNSVEIAILDEADKLLDFSFEKDVVNILKRLPKQRRTGLFSATISAAGNTIFRAGMNNPVKVAVKSKSTTANSAPSALHISYLMIEPEKKITTLIKLLHDYRYKKCIVYFPTCTSVKHFYSIFQKIVNGNDNTESFKFYSLHGQLATKPRLRTLQSFTDGDVALNKHILMTTDVAARGIDIPDVDLVIQLDPPTDPDVFLHRCGRTGRANKVGRAIVMLNDGSRELDYVDFMEVKGVAMQEMPTPDLNQSDHQQFQDKLRKYMLDDRARHEIAIKSYVGFVRYYTKHMATSIFRYQTLDYLGIAKMYGLLRLPKMPESKYIPNDNMPDDGWLGEPIDMDKYSYADNQQEASRLENLNAEKIKKIADAKRRKELKVKNEAWSSKTETKETKQERREKMKRKREAIEKQIMEESSDDEETKVDWKDIVKSNKKKKANSGSMQGSFDDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
614 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
70.389 kDa
Sequence
METREGSLTWSVLKCDLHPWIKEAIKSLGYPTMTPVQASTIPLFSGNKDVVVEAVTGSGKTLAFVIPVLQKLSNRLYNIDEEGENPEPVKKGHMLSIILSPTRELAKQIQTVFDKVLEYIPEDKATIKTQLLVGSLSSVREDIDYFLTNKTHILIATPGRLLDFLSSNYVKTNSVEIAVLDEADKLLDISFERDVIKILKQLPKQRRTGLFSATISSAGDTIFRTGMANPVKIVVKSKNSKNAAPTSLNVSYMHVEPETKISALIALIKDYRFQKCIVYFPTCTSVKHFYSVFQTLVNVEEEDRYKFFSLHGQLSTKPRLKTLQNFSEGDSMLHKHVLLTTDVAARGIDIPDVDLVIQLDPPTDPDVFFHRSGRTGRANKVGQAIVMLNNNSREEDYVNFMEVKGMTMSNMECPNISKIHDKFQKKFRKYMLEDRARHELAIKSYVGFVRYYSKHMASSIFRLQTLDYVGLGKMYGLLRLPKMPESRYIPNEEMPEDGWLGDVIDMDKYEYADKQKEESRKKNLEEDKARKVHDAKKRKELKVKNEAWSSKTDKIETKQERREKMKRKREAIEKQLMDDSSSDEETKVDWKEMVKTNKKKKTPSDSMQGSFDDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
607 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
69.545 kDa
Sequence
MSKSLLWDDLEYPIQPWIRSAVDVMGFENMTPVQAATIPLFARNKDVVVDSVTGSGKTVSFVIPIFEKIVQEEANTTKMKKGHFHSLIVSPTKELAKQIHSVFESFLEHYPENLYPIRSQLLVGTNVKTVRDDVSDFMENKPQILIGTPGRILDFLKIPSVKTSMCSMVILDEADRLLDVSFLKDMENIMNILPKQRRTGLFSATITSAGDNIFKTGLRNPVKVTVNSKSQAPSSLKIDCAVVETDKKLEQVISIINNYKFKKCIAYFPTCHSVTYFYSFMQYLLKKGIIKEEIQIYSLHGKLQTSARIKTLETFTETISNAVLLTTDVAARGIDIPDVDLVLQLDPPTDPEVFLHRCGRTGRANKLGKAITFLTPGREEDYIPFMEVKNINLEEISLDIVNLPDNFYEIFKDWLLEDRARLDQAVKSYVAYIKTYSKHAASSIFRLQSFDYVGLAKFYGLIRLPKMPEITKYFKEDKENARTFGEGWLIDPPINMDKFGYLDKKKEDRRLADLKNLKSIHDKKKLKSELKKKNMSWSNNTQSKEEKVERRTKMALKRKRIEEELSKEADENSSGDDEQNRDWKQVILQNKKSKNSNNGMQGSFDDL

Gene
spb4
Protein
ATP-dependent rRNA helicase spb4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
606 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
68.742 kDa
Sequence
MSFQSINIDKWLKNAVAAQGFKKMTPVQANAIPLFLKNKDLVVEAVTGSGKTLAYLLPCFDKVTRRDTDETGLGALIVAPTRELATQIFNVTKELLAYQPDSLDGGKKLVADMYIGGKGTLTNDLASFREKNPSVVIGTPGRLNEMLSHISSKHLEILILDEADTLIDMGFQRTLQSIISQLPKQRRTGLFSATMNDTVSSFLKIAGLRNSVRVSVTVTSKKIDTRTPSSLAIQSLVIPPIYKVQCMIHLLCTIEYEKAIVFFSSCASVEYFNSLFLTYKLPFEIVALHGQQVQSNRSRNFEKFKKSNKKTVLFTTDIASRGLDIPNVDFVLQLDPPLDPKSFSHRCGRAGRAGRAGVAIVLLNDGREEEYEELLRVRKVPITRIDTPIEALDLSRLKVLTHELRKIVSKDRDLYDKGLRAFVSHVRAYTKHHASFIFRIKDLDLGQLATAYALLHLPKMPELKDTEISENIFKKFDIDYATIPYRDQVREQARRRRLEVEKTEPKKLARPAKIKNEAWSKQKEVKEKRNTRREKRKSKKEFLKAQKNEASNNLKQEIVSKAGAQETENDDLIDEESDALSELEEDYRQLKKSKKRKNQASFGFSM

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
606 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. Also required for recruitment of NOG2 to pre-ribosomes.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
69.422 kDa
Sequence
MSKSLEWDNLGFSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFHSLIIAPTRELSRQIESVVLSFLEHYPSDLFPIKCQLLVGTNEATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAEKLQLLVSILNNYKFKKCIVYFPTCVSVSYFYSFIQYLGKRNILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVELEELDLEVKGITTNFYEDFRNWILEDRDRFDKGVKAYVAFIKYYSNHSATSIFRLQSLDYVGIAKLYGLFRLPRMPEITKYLATEKQEGIFPGNWLVDPPVNMDEYKYKDKKREKERQETLKNISLINDKKKLKSELKKKNLAWSDKTLTKERKLERKEKMSLKRKAIEEELKAEELDENAEEERIKEDWKEIVLQNKRKKVSSKAIQGNFDDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
606 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (PubMed:2408148, PubMed:25579579). Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA (PubMed:21825077). Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2 (PubMed:9769101). Also required for recruitment of NOG2 to pre-ribosomes (PubMed:22735702).
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
69.422 kDa
Sequence
MSKSLEWDNLGFSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFHSLIIAPTRELSRQIESVVLSFLEHYPSDLFPIKCQLLVGTNEATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAEKLQLLVSILNNYKFKKCIVYFPTCVSVSYFYSFIQYLGKRNILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVELEELDLEVKGITTNFYEDFRNWILEDRDRFDKGVKAYVAFIKYYSNHSATSIFRLQSLDYVGIAKLYGLFRLPRMPEITKYLATEKQEGIFPGNWLVDPPVNMDEYKYKDKKREKERQETLKNISLINDKKKLKSELKKKNLAWSDKTLTKERKLERKEKMSLKRKAIEEELKAEELDENAEEERIKEDWKEIVLQNKRKKVSSKAIQGNFDDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
601 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
67.962 kDa
Sequence
MLIARNFILMSKSLAWSQASLQPWIHDAIDSLGFRSMTPVQASTIPLFCGNKDVVVEAVTGSGKTLAFAIPVLERVTKCMKENRGSSGLYGIVISPTRELANQINTVFHTLLQFYPEDQPPIKTQLIVGSLATVREDLNAFAENKPQIIIATPGRLLDFFSSNAVKRSTVEMVVLDEADRLLDISFQNDVVSILKKLPKQRRTGLFSATLSSAGDSIFRTGMSNPVKISVNSNKAESKPQSLTVNYMMVNPETKIAVLINMLSTLQYKKCIVYFPTCASVKYFYSVFQKLHPLEDVNLTSIHGQLLAKARLKAMNKFTEGDVRTSKHVLLTTDVAARGIDIPEVDLVIQLDPPTDPDMFLHRCGRTGRANKVGRAIVMLNNNALESDYVDFMEVKGLKMSEVESPDVIDAYKAFSKNLRNLMLQDRAFHETAIKAYVGFVRYYSKHAATSIFRLQTLDYIGLAKAYGLLRLPKMPESRFVPNDRMPEDGWLGEKIDMNKYAYADPAKEKIRLETMEEEWNKKVNDAKRRKELKVKNEAWSSKNEKKEGKQERREKMKRKREAIEKQIMNESSDEETVVDWKDLVREKKQKTSGISGSFDDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
599 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
67.86 kDa
Sequence
MSKSLSWDTLDYTLQPWIRTAVDAMGYETMTPVQASTIPLFARNKDVVVESVTGSGKTVAFVIPVLERVIQDDANSSKLKKGHFHTIIISPTRELASQIQGVIEAFLTYYPDGEYPIKSQLLIGSNTSSVRDDVAAFLEHRPQILVGTPGRLLDFLKMPNIKTSSCGAAILDEADKLLDMNFEKDVETILKMLPKQRRTGLFSATVSSAGTQVFKTGMRNPVKVSVKTSNKAPSSLDINYIVIEPRMKLQLLLTLLNNYRYKKCIVYLPTCIAVTYFYSILQHLAKLNKMDENLKLYSLHGKLLTNSRMKTLDRFTQELGKAVLLTTDVAARGIDIPDIDLVLQMDPPIDADIFLHRCGRAGRANRAGRAIVFLNQGREEDYIPFLQVKNVEAKELDTVAIKPIEGLPEIIRAWILEDRARFDHSLKVYVAFLRYYSKHTASSIFRLQTLDYIGIAEMHGLIRLPGTPEIQRYLSKDAIPEDGWLVSPPIDLDSFAYADPQREKARKLAKKEAKDVKDNNKLKSEMRKNNEAWSKKTVTKENKLQRKEKMALKRKAIEEKLIENSDDSDNEVETDWKDIVRQRKKKKTNSGMQGDFGDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
596 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
67.941 kDa
Sequence
MSKSLSWDDLKCEIQPWIRTAIESMGFETMTPVQASTIPLFSGNKDVVVESVTGSGKTIAFVIPILERLIKEEANSAKFKKSHFHSLIISPTRELASQIHDVIEDFLKYYPDNLYPIRSQLLVGTSSASVRDDINSFTDNRPQILVGTPGRVLDFLQKTNVKTASCGTVVLDEADKLLDLNFQKDVETILKMLPKQRRTGLFSATIESAGAQIFKTGMRNPVKVAVKSNSSAPSSLSINYIVIPPKDKLQLLLTLLNNYRFKKCIVYFPTCISVTYFYAFINHLKELNLIQDDLKLFSLHGKLQTQSRMKTLDSFTSNLTDAVLFTTDVAARGIDIPDVDLVIQLDPPTDADIFIHRCGRTGRANRIGKALVFLNEGREEDYVPFLEVKNVKLEEESVELKGVENLTKIFHDWILHDRARFDHSVRAYVAFIKYYSKHTASSIFRFHSMDFIGVANFYGLLRLPRMPEITRYAADQIPEEGWLVSPPVNLDTFAYLDKQKEKARLQELQNLKQISDKKKLKSELKKKNMAWSDKTLTKEAKAERRAAMAIKRKAIEEKLLRGDEESEDEVEQDWKDLVRQNKKKKHNSMQGSFDDL

Gene
SPB4
Protein
ATP-dependent rRNA helicase SPB4
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
463 amino acids
Function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
Similarity
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Mass
52.014 kDa
Sequence
MGCKGIEDVAMNGRLKKEIEENGFGKMTEVQLKCIPEVLKGKDVVVQSPTGTGKTMAFLAPILSCIYDGKGRGRPGVTAVVITPTRELALQIREVAGLFDVKCECFIGGMSIEEDYKRMKEEFSIAVGTPGRLLEIVGKETKKFSSLSHLVLDEADKLLGFGFEEKLMQLLAKLPRNRVTGLFSATRNDSVDKLSRVFLRNPVSINVGNNEMPVALEYIVVSPMEKLLVLMDIVTGRRCIVFFATCSEVDFFSGLVSRAGFGNICKIHGKISQDERNRVYEEFFQRDGLLFCTDVAARGIDFRGVDLVVHFDVPKEYSSIVHRSGRTARNGSKGESVLFVMPNERAYVEFLKLKGIPAVESSYRMKSSLSYQDIKSMISPELLGLSVKAFVSYIRSYKEHFVSYILDYKGLDFDSLAELFFLERIPGMAELRNVKFEKFTKPARDGKKRALPKKKYRKKRAIK