SPB4

ATP-dependent rRNA helicase SPB4

767 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

85.43 kDa

MSAEPSVQTTSSSGPTELRSAPSYAGSWTKLTPPLTPWVVSLLSDLGFGQMTPVQASTIPLFVSHKDVVVEAVTGSGKTLAFVIPVLEMLARRTTRLKKDEVGALIVSPTRELAEQIYKVLVMFLDAQNHAHVQAQQQQDQDEQDEQDEQEAQSDSDTDPDASTALNNKRKSSNHLVARKNMISGAQLVVGGSKCTPLDDYRQLRDSGADILVGTPGRLEELLSKKGVKKSSLEVLVLDEADRLLDLGFTENLRRILSLLPKQRRTGLFSATMTDALSELVRIGLRNPVRVVVKVEAKHKTSSSIDDSRRTPATLQNLYQLCRAQNKLAQLARIVLFESSQNAISGGARKLIVYFSTCAQVNYFYSVFSQVSILRQHRVKLYALHGKQTPSKRKSMFDTFVASTALDSGASGASVLFCTDVAARGLDLPDVDVVVQYDPPTDPKVFSHRCGRTARAGRNGRAIVMLHTGREQDFVSYMRVKRIPLSPYPYLSSTLHGILEPAEDDASAHDLELSIRDLAKTDREIFELSIRAYVSYVRAYTKHEMSYIFRINELDLAGVARAFALIRLPSMPELKSRQSAGTLIYNQEPIDFSSIPFKDKAKQRIRLAKLSGDQAKPPARIKASVDDAAQLQDDQCDSHDSDDAHPNSSATRAKNKRKLEREKGAWSAQKERKQARLANREKRARKRTFLKTQAAESSSNAKHEPPQDDHDEHDWNDDYRKLQKDKRQQRQRNKADRANSDNDDAMHFNSDSDAAAANADAEPFFVI

SPB4

ATP-dependent rRNA helicase SPB4

748 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

84.251 kDa

MDAPVPAAPAFGGSWAKLNPPLSPWILDVINSMGFKNMTPVQAGTIPRAVKNQDCVVEAVTGSGKTLAFTIPVLERLSRREEPYKKGEIAAIVVAPTRELATQIHAVFHHFLSSLIPPESEEETGDVEAHAPPFASSSRSPSPQTPDKPLFPLPMLVTSGTPTPYETFQSTHPSILIGTPGRLAAFLLNPRGLAIVRVSELDVLVLDEADRLLSSPDHRRDVERIMRHLPKQRRTHLFSATMTDAVEEMIGLGLRNPVRIVVNLKDKRKDGEEPKERRTPMALQNTYLVCRHAEKTLQLIRLLLCESTKHERSKFIVYFSTCAAVDYFYRILSRLPSLSKFHLTSFHGELPPKIRETALSTFTSHPSSHLSPAVLLCTDVAARGVDFLDIDVVIQYDAPTDPKTFSHRAGRTARAGRRGKAVVLLGKGREEDYVGTFQSANAELMKRKRQKAQRSILDFLNIRKIPLTKQPYINAYLEEVDTPQALDPEATTLLHSIRQIILTDRELSDKAAKSFVSAFRAYSKHEASFIFRTLDFDFNSQAISFGLLRLPAMPEIKDWKKKKEAERQRLEKIKSEGGEVEEKEIIEWEDAGVNWDTFAYASRQREAARLATLAQRADNQSSNDAARAEARAKRKIKAEMREAWSEQKERKVRKEERKEKKDAKKKYEWELEQANGEGDRQSDLANIAKAQAERKKRREREEESWDEEIGKEYKSLKREIKEEKSVKESSKGGAGGGGIGGGMFDDLE

SPB4

ATP-dependent rRNA helicase SPB4

748 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

84.251 kDa

MDAPVPAAPAFGGSWAKLNPPLSPWILDVINSMGFKNMTPVQAGTIPRAVKNQDCVVEAVTGSGKTLAFTIPVLERLSRREEPYKKGEIAAIVVAPTRELATQIHAVFHHFLSSLIPPESEEETGDVEAHAPPFASSSRSPSPQTPDKPLFPLPMLVTSGTPTPYETFQSTHPSILIGTPGRLAAFLLNPRGLAIVRVSELDVLVLDEADRLLSSPDHRRDVERIMRHLPKQRRTHLFSATMTDAVEEMIGLGLRNPVRIVVNLKDKRKDGEEPKERRTPMALQNTYLVCRHAEKTLQLIRLLLCESTKHERSKFIVYFSTCAAVDYFYRILSRLPSLSKFHLTSFHGELPPKIRETALSTFTSHPSSHLSPAVLLCTDVAARGVDFLDIDVVIQYDAPTDPKTFSHRAGRTARAGRRGKAVVLLGKGREEDYVGTFQSANAELMKRKRQKAQRSILDFLNIRKIPLTKQPYINAYLEEVDTPQALDPEATTLLHSIRQIILTDRELSDKAAKSFVSAFRAYSKHEASFIFRTLDFDFNSQAISFGLLRLPAMPEIKDWKKKKEAERQRLEKIKSEGGEVEEKEIIEWEDAGVNWDTFAYASRQREAARLATLAQRADNQSSNDAARAEARAKRKIKAEMREAWSEQKERKVRKEERKEKKDAKKKYEWELEQANGEGDRQSDLANIAKAQAERKKRREREEESWDEEIGKEYKSLKREIKEEKSVKESSKGGAGGGGIGGGMFDDLE

SPB4

ATP-dependent rRNA helicase SPB4

676 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

75.663 kDa

MATSASRIAPTTPQSSHSRAWDALTPPLSEWILDAISAMGFSRMTPVQASTIPLFMAHKDVVVEAVTGSGKTLAFLIPVVERLLRLESPIKKHHIGAILISPTRELATQIYNVLLSLLAFHGPSAARLQRTENNSGEVDESNPASSYPPSTLKIVPQLLLGGTTTPTQDLSAFLKQSPNVLVSTPGRLLELLSSPHAHCSQSSFEVLVLDEADRLLDLGFKEDLQKILQRLPKQRRTGLFSASVSEAVDQIIRVGLRNPVKIAVKVKGAGLEDKRTPASLQMTYLLTPPTHKLPAVKYIVSTLSPTPQRSILYFSTCAAVDYYQHILPCILPDRFTTIPLHGKHPPQVRQKNFTRFVNSVTSSILLTTDVAARGLDIPAVDLVIQIDPPTDPKAFLHRCGRAGRAGRRGLSVIFLHPGREEDYIAFLNVRKTPVTEFQSTSTSTPSQLYSSSHFSASSPKNPQTFHPIQITTADATSTTEKIRALVLRDRAIHDKAQRAFVSWLRSYSKHQASSIFRVADLDWEELGRAWGLLRLPTMPELKGFTGDRNLGVSGVDWDNYAYKDRQREKHRRMEMEGRSSSNVNNNGDATGSDKGPLKRPATSESIPWSQNLERKSEKERRRERKKIRRYHEQWKKMTEEEKERVRETEQMVNAVRKAVQEQDQTVTREEEFEGFD

SPB4

ATP-dependent rRNA helicase SPB4

653 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

73.027 kDa

MASKKKERGPPPHSRSWQALTPPLSEWILDAVAAMGFTRMTPVQASTIPLFMGHKDVVVEAVTGSGKTMAFLIPVVEKLLRLEAPIKKHHVGAIIVSPTRELAEQIYKVLLSLLAFHAPSAAAIQPSTSDETADGETTLPSYPSSTLKVVPQLLLGGATTPAQDLSTFLKRSPNLFVSTPGRLLELLSSPHVHCPQTSFEVLVLDEADRLLDLGFKDDLQKTLARLPKQRRTGLFSATVSDAVDQIIRVGLRNPVKIAVKVKGAPGTEEKRTPASLQMTYLLTRPSHKIPAIRQILNSIDNTPQKTILYFSTCAAVDYWSHVLPSLLPEIFVTLPLHGKHPPNVRQKNFSRFTNSVSPSVLLTTDVAARGLDIPLVDLVIQFDPPTDPKAYLHRCGRAGRAGRRGLSVILLCPGREEDYIPFLEVRKTPVSLLESPPVALSDTLATEATSKIRETVLRDRALHDKAQKAFVSWVRSYTKHQSSSIFRITDIDWEEAGRAWGLLKLPKMPELQKFSGDRTLGVTLDWDKYSYKDKQREKHRQESLNSATTHNPLKRPAPSSSSNNDTAPWSKTLEKKSDKEKRRERKRAKKEREHWEKMTEEEKTKSRETHQMLEELRKKNRQELNAKSHTSSSVLSKPQEAELDGESEFEGFD

SPB4

ATP-dependent rRNA helicase SPB4

646 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.577 kDa

MPPEQVRARKTPRSWGALTPSLAPWILDYLSSMGFEQPTPVQKSCFDIFRGNKDVVVEAVTGSGKTLAFLIPVVERLLRSEDPAKRHHVQAIIISPTRELASQIYNVLVSFLKFHAPSAHLLPHAKGDEKRPATTEPVVVPQLLVGGTTKAAEDLSTFLRLSPNILIGTPGRLAELLSTPYVKAPSSSFEVLVMDEADRLLDLGFSQELTRILGYLPKQRRTGLFSASLSEAVERLITVGLLYPHKITVRVKSLRDGGIVQERKTPMSLQMSYIVTPASQKIPALCQLLERLEPRPSRSIVFFSTCFAVKYFARVLHGILPPGFSIVSLHGKLEPQVREKNFERFVNAASPTVLLTTDIAARGLDIPQVDLVVQHDPPTDTKVFIHRCGRAGRAGRRGLAVVMLQPGREEGYVQLLDVRQTPISPLAKPPVSVTAADADLASSRIRAQARADRDIYQLAQRAFVSWARSYIEHQATSIFRVADLDWADLAQGYGLLELPKMPEVRGLDRSLGLAIDTESIPFRDGAREKKRLAELEQWKKEKAAREAQRASGGGGDATDPLKRKKNEAWSGKHEHEDVKAARREKKRRKREAQRLGDMTEPEREEQRKLDEMIAEVRRRNAEAPTPAAQAAGSGGGGGDEFEGFDD

spb4

ATP-dependent rRNA helicase spb4

642 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.532 kDa

MAPKPPPGTSARAWDGVTPALSEWVLDAVASMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPLKKHHVGAIIISPTRELASQIYNVLTSLLAFHPPSASTLKPSDDDDDAPRQKFPSSTLKVVPQLLLGGSTTPAEDLSTFLKRSPNLLVSTPGRLLELLSSPHVHCPQSSFEMLVMDEADRLLDLGFKDTLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVMVKVKGTSGVQDKRTPASLQMTYLTAPPTHKFPAIKHILYSLEPAPQKTIMFVSTCSGVDYLSAILPSIIGDDFQLIPLHGKHQANVREKNFNRFVNSHTPAILLTTDVASRGLDIPSVDVVIQIDPPSDPKTFIHRCGRAGRAGRKGLSVVLLHPGREEDYVSFLEVRKTPVAPYPHTLTITDADAAAATETARKAVLADRALHDRGQKAFVSWFRSYSKHQASSIFRVADLDWEGLGNAWGLLKLPKMPELRNFQGDRTLGVNLDWENYAYKDKQREKRRKEQVQENAENGVADDQAAGKKRSSESVAWSRNLDNRNKKLKRREAKQARQQKDKWEKMTEEERQKVLETEKMLEQIRVKNEEERLLRRAAKDKESKAAGGDDDDEFKGFD

spb4

ATP-dependent rRNA helicase spb4

640 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

70.95 kDa

MAPKPPSGTSLRAWDAVTPALSEWVLEAMSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHVGAIIISPTRELASQIYNVLSSLLAFHPPSAAAINPSEDDDAPRPKFPSSTLKVVPQLLLGGSTTPAEDLSTFLKRSPNVLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVMVKVKGGSGVDDKRTPASLQMTYLTTPPSHKFAALKRIVSSVQPTPLKTIFFVSTCSGVDYLSAILPLLLGDDFLLIPLHGKHQANVRQKNFNRFINSHDPAILLTTDVAARGLDIPSVDLVVQIDPPSDPKSFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVVPFSPSISFSDADAAAATATARKAVLADRALHDRGQKAFVSWLRSYSKHQASSIFRVSDLDWEALGKAWGLLKLPKMPELKNFTGDKTLGMSLDWDNYAYKDKQREKRRKELLQEAAESGATQSTSNKRRATESVAWSQQAESKNKKLKRREQKKSKQEKARWEKMTEEEKQKVLETEKMVEELRKKNEEERRLRRAVAKAAGAKADGDDEEEFQGFD

spb4

ATP-dependent rRNA helicase spb4

640 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.002 kDa

MAPKPPSGTSSRAWDAVTPALSEWVLEAMSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHIGAIIISPTRELASQIYNVLSSLLAFHPPSAAAINPSEDDDAPRPKFPSSTLKVVPQLLLGGSTTPAEDLSTFLKRSPNVLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVMVKVKGGSGVDDKRTPASLQMTYLTTPPSHKFAALKRILSSVQPTPLKTIFFVSTCSGVDYLSAILPLLLGDDFLLIPLHGKHQANVRQKNFNRFINSHDPAILLTTDVAARGLDIPSVDLVVQIDPPSDPKSFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVVPFSPLITFSDADAAAATATARKAVLADRALHDRGQKAFVSWFRSYSKHQASSIFRVSDLDWEALGKAWGLLKLPKMPELRNFTGDKTLGVSLDWNNYAYKDKQREKRRKELLQEAAESGATQSTSNKRRATESVAWSQQAESKNKKLKRREQKKSKHEKARWEKMTEEEKQKVLETEKMVEELRKKNEEERRLRRAAAKAAGAKADGDDEEEFQGFD

spb4

ATP-dependent rRNA helicase spb4

639 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.052 kDa

MAPNPPKGTSSRAWDAVTPPLSEWVLEAMSSMGFARMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLLPIVEKLLRLEEPIKKHHIGAIIISPTRELASQIHSVMQSLLAFHPPSAAAMTPLDDDDAPRQKFPSSTLKVVPQLLLGGSTTPAEDLSRFLKLSPNVLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKIMVKVKGTSGVDDKRTPASLQMTYLSTPPLHKFAALKNILSSVQPTPQKSIFFVSTCSGVDYLSAILPLLLGDDFLLIPLHGKHQANVRQKNFNRFLSSHSPAILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGLSVVMLHPGREEDYVSFLDVRKTPVVPFSPSISFSDADATSATARARKAVLADRALHDRGQKAFVSWLRSYSKHQASSIFRVADLDWEALGKAWGLLKLPKMPELRSFTGDKTLGVSLDWDNFSYKDKQREKRRKELLQEAAESGVSQPSSNKRRASESVAWSQNAENKNKKLQRREYKKLKQEKTKWENMTEEERQKARETKEMVEELRAKNLEERRFRQAAAKAETAKAGGEDEEFKGFD

spb4

ATP-dependent rRNA helicase spb4

639 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.347 kDa

MAPKPPAGTSSRAWEAVSPSLSEWVLDAVASWGFSKMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLVPVVEKLLRLEEPIKKHHIGAIIISPTRELASQIHQVLLSLLAFHPPSAAAIKPPGEDDAPREKFSASTLKVVPQLLLGGSTTPAEDLSYFLKHSPNVLISTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASISEAVDQIVRVGLRNPVKVLVKVKGTSGVQDKRTPASLQMTYLTTPPAHKFLTLRPILTSLQPTPQKTIFFVSTCSGVDYLAAILPLLLGDDFQLIPLHGKHPANVRQKNFNRFINAHTPSILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGVSVVLLHPGREEDYVSFLEVRKTPVTPFPHPISISDSDASTATEAARKIIKQDRALHDRGQKAFVSWLRSYSKHQASSIFRVADLDWEALGHAWGLLKLPKMPELRNFTGDRTLGVDLDWENYAYKDKQREKRRKEVLQESAEAGAQQTSNKRRASESVAWSNKVDQKNKKQKRREQKHLQQEKRRWEKMTEEEKQKARETQKMLEEIRQKNEEARALRRAEKAAGKAADNDGDDDEFEGFD

spb4

ATP-dependent rRNA helicase spb4

638 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.581 kDa

MAPKPPAGTSSRAWDGVSPSLSEWVLEAVSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPIVEKLLRLEEPIKKHHVGAIIISPTRELASQIYHVLLSLLAFHPPSASVINPSEDDDVPRQKFPSSTLKVVPQLLLGGSTTPAEDLSKFLKQSPNLLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKETLQNIIRRLPKQRRTGLFSASISEAVDQIVRVGLRNPVKVMVKVKGTSGAQDKRTPASLQMTYLTTPTIHKFDALKHILHSVDPTPQKTIFFASTCSGVDYLSAILPLILGDDFQLISLHGKHPANVREKNFNRFVNSYSPAILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVAPFPHPISFSESEATAATKAVRKAVLADRALHDRGQKAFVSWLRSYSKHQASSIFRVADLDWESLGKAWGLLKLPKMPELRNFTGDRTLGVNLDWDDYKYKDKQREKRRIELLQESKEGDGTQESSNKRKATETTAWSNKLDDRNKKQKRREQKQRRQEKNKWEKMTEEERQKIRETEQMVESIRVKNEEERRLRRAGKAEAANAGKDEEEFEGFD

spb4

ATP-dependent rRNA helicase spb4

638 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.063 kDa

MAPKPPSGTSSRAWDAVNPPLSEWVLDAVSSMGFTRMTPVQASAIPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHVGAIIVSPTRELASQIYNVLTSLLAFHPASAAVINTSETEDVPRPKHSSSVLRVVPQLLLGGSTSPAEDLSTFLKRSPNLLVATPGRLLELLSSPHVYCPQSSFEMLVLDEADRLLDLGFKETLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKVVVKVKGASGVDDKRTPASLQMTYLTQPPTGKFPALKHILNSVQPTPSKSIFFVSTCSGVDYLSVILPLILGNDFQLIPLHGKHPANVRQKNFNRFVNAHNPAILLTTDVASRGLDIPSVDLVVQIDPPSDPKTFIHRCGRAGRAGRRGLSVVLLHPGREEDYVSFLEVRKTPVAPFPHPITVSDAEAAAATETARKVVKADRAIHDRGQKAFVSWLRSYSKHQASSIFRVADLDWEGLGKAWGLLKLPKMPELKNFKGDKTLGVQMDWDTYAYKDKQREKRRLELLQEMAESGQQQTTNKKRPNETVAWSNNAENRNKKAKRRDMKQVRQERKRWEKMTEEEKKKALETEQMLEQIRAKNEEQRRLKRAAAKADKDAEEGGDEEFTGFD

SPB4

ATP-dependent rRNA helicase SPB4

637 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.628 kDa

MATEKPKKRSPRAWDTLNPPLSEWIRDAVATMGFDQMTPVQAATLPHFMGNKDVVVEAVTGSGKTLAFLIPLVQKLLRLSEPTKKHHVAAIIVSPTRELAAQIHTVLMKLLQFHEASAEILPHLKDDDEKRPFTTVPAIVPQLLVGGTTTTVQDLRFFLRHSPNVLISSPGRLVELMSSPHVHCPQSSFEVLVLDEADRLLDLGFKPDLQKILSHLPKQRRTGLFSASVSEAVGEIIRVGLRNPVKIEVKVKIKGGGILEDRKTPASLQMTYMVKPASQKLPALAELLRQLPVRPQRSIVFLSTCAAVDYFQHILPLILPEGFALVPLHGKHAAKVREKNFNKFLSSVSPTILLTTDLAARGLDIPQVDLVVQIDAPSDPKVFIHRSGRAGRAGRKGLAVVMLHPGREEDYVQFLEIRKTPIAPLEKPTITTSEDDAAEFAKKTRDFVLTDRGLFDKAQKAFVSWARSYGAHQATSIFRAADLDWADLGNAWGLLRMPRMPELKGWTGDKMCGLEIDWDNYAYKEKTREQQRKVALEEEKSGVKKQDKSEEFKRKRKNNEAWSAKHEKEDDRVERREKRRKRRDAEATSKMTDDEKVKQMELNDLIAEVRRQNREKAAAEAAAAKQEKDGEFKGFDD

SPB4

ATP-dependent rRNA helicase SPB4

637 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

72.744 kDa

MQTNKGSLLWENLRVDLEPWLKDAIRSLNYPTMTPVQASTIPLLSGNKDVIVEAVTGSGKTLAFAIPVLQKVSKRLYQVPEGEEKPEPVKRGHMLAIVMAPTRELAKQIQMVFDKVLELLPEEDSYEPRIKTQLLVGFLGNVREDLDSYQENRPQILIATPGRLLDFMSLQIVKTSSLEIVILDEADKLLDMSFETDVIKILKMLPKQRRTGLFSATISAAGDTIFRTGMNNPVKLQVKTKNFLGEQNNAPTSLQLSYMMIEPEHKLTTMLQMLRDNQFKKAIVYFPTCTSVKHFYQMLSKLCKSSANDIDISALLFFSLHGQLTTKSRLNTLEKFTEGNDESKKYILMATDVAARGIDIPDVDLVIQIDPPTDPSVFLHRCGRTGRANKVGRAIVMLNNDTQEEDYVGFMEVKSVFMTKIDPPEDKDNHSFHNKFQKKLRKYMLEDRARHELAVKSYVGFVRYYSKHIASLIFRLASLDYIAIAKMYGLLRLPKMPESRYIENEKMPEDGWLGEVVDMDTYAYLDKSAEKARLENLEKDKLAKAENAKRRKELKVKNEAWSSKTEKRETKLERKEKMKRKREAIEKQLEAEQERGGLDEEEVKEDWKDLVRKNKKKQKSNGGGGGGGVLQGSFDDL

SPB4

ATP-dependent rRNA helicase SPB4

633 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.204 kDa

MAPQTKIDRSFSALTPALSEWIIDAVDAMGFVKTTPVQHAAIPMFMKNSDVVVEAVTGSGKTLAFLIPIVERLLREDAPTKKHHVGAIIISPTRELATQIHTVLSSLLKFHAPSAAMLEPDDEDTDMEDADTPPKPTFPPGTLKAVPQLLLGGSVTPAQDLSAFLKKSPNILIGTPGRLLELLRSPHVHCPQSSFDALVMDEADRLLDLGFKEDLQKIISRLPKQRRTGLFSASMSEAVDQLIRVGLRNPVRIAVKVKARATGEDGKIEDKRTPASLQMSYLVTPPSHKIPAMKKILSSLQPQPQKSILYLSTCFSVDYFQHVLPEVLQGYDIVPLHGKHPDKVRRKNFNKFVDSVTPSILLTTDVAARGLDIPSVDLVFQLDPPSDPKTFIHRCGRAGRAGRRGLAVTFLNPGREEDYIEFLQVRQTPISPLTTPEITVTDEDAKAVTSKIRKKVREDRALFDKAQRGFVSWVRAYSKHTASSIFRIDDLDWTELGNAWGLLTLPGMPELKKWQGDKRLGIELDLATYAYKDKAREKLRLEELERDKEEGTKKKQHKKEDREKSAWTEQKESKATKEVRREKKKSKREHERLAKMTDEERKEEDRVQAMIEQMRKKVAKQEAEDADFEGFSD

SPB4

ATP-dependent rRNA helicase SPB4

631 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

72.353 kDa

MKSNTESLAWENLRYDLHSWIKEAISSMGYPTMTPVQASTIPLLSGNKDVVVEAVTGSGKTLSFVIPVLQKISDRLYKPDSDGDLPEPVKRGHMLSIVLSPTRELANQIQSVFNQVLQYLPEDKGTRINTQLLVGSIGNVREDLNQFLTNQPQILIGTPGRILEFLGSSQSIKTSSLEIVILDEADKLLDFSFEKDVINILKKLPKQRRTGLFSATISSAGNTIFRTGMNNPVKVQVKSKNYFGEQSNSPKSLQLSYMMINPELKITTLLTILSKYQYKKAIVYFPTCTSVKHFYQIFNKVYQQESSDEPLKFFSLHGQLNTKSRLKTLDNFTQGDINLYKHILMTTDVAARGIDIPDVDLVIQIDPPTDPNVFLHRCGRTGRANKVGRAIVMLNDNCQEEDYIGFMEVKGIFLTKQDIPTSSATKNLHENFQIKLRQYMLEDRARHELAVKSYVGFIRYYSKHIASSIFRLATLDYLGIAKMYGLLRLPKMPETKYIDNSIMPTDGWLGEIIDMDKYSYADKLQEKTRLENLENDKLKKIQDAKRRKELKIKNEAWSSKSERKENKLDRKEKLKRKREAIEKQIMEEERLNDGGNKDEEDEVVEDWKDMVRKNKKKQKKNNSIQGSFDDL

spb4

ATP-dependent rRNA helicase spb4

626 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

70.178 kDa

MAIEGEKKKDPRAWDALTPSLAEWVLDAISSMGFEKMTPVQASTIPLFMGNKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPLKKHHVGAIIVSPTRELATQIHSVLTSLLKFHEPSAEALQPLEEGEKRKPSSTLRVIPQLLLGGTTTPAQDLSRFLKNSPNLLISTPGRLLELLSSPHVHCPQSSFEVLVLDEADRLLDLGFKDDLQKILGRLPKQRRTGLFSASVSEAVGEIVRVGLRNPVKIAVKVKGAGGGDKMTPASLQMSYLLTPPTHKFPALLSLLSQLEPTPQKSIIYLSTCAAVDYFQPLLEAVLPKQFGLVSLHGKHPPNVRQRNFSKYVAAVSPTILLTTDVAARGLDIPQVDLVVQIDPPSDPKVFLHRCGRAGRAGRKGLSVIFLQPGREEDYIPFLEIRKTPITPLKRPEISTTGEAAKILISKMRKEVLSDRALYDKGQRAFVSWVQAYSKHQASSIFRVADLDWTDLGNAWALVRLPKMPELKKWEGDKTLGIKLDMSEYAYKDKIREKARRVAMEEAKNAGPYVPTEEQIAKKKQREAWSQKHEKQDLKELKREKKKRKREIERLEKMTDEEKKEEQAKEKELQDLIEQVKKRKIEDDADVEFEGFAD

SPB4

ATP-dependent rRNA helicase SPB4

626 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2 (By similarity).

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

71.091 kDa

MSTDWKDLPVAPWLIDTMEQFGFTDMTPVQASVIPMFAGNKDVIVEAVTGSGKTIAFLVPLIQRMLNLLKEGPAVSGRVYSVVVSPTRELARQTYEVLQSILEMGCPEADASDKITLEKKKKGKAAPTMPKKIRGQLIMGGDLPSHMDLKNFLRDKPQIIVATPGRLLELLRAPQIKTSAFDSLVLDEADRLLDLGFGRDITSIINILPKQRRTGLFSATITDAIQNLVKIGLRNPVKIVVKVGGKKEQKTPLSLGLSYVVLEPREKLAYALNLLSIYPYRKAIVYLPTCAAVTYYQQMFSHLNEGREEPYEIYGLHGKLPSSTRIKILNKYQKTGAQAILMTTDIAARGLDIPEVDLVVQLDPPSDADTFQHRCGRAGRAGRQGQAIVLLHKGREEEYVDLMRVRKVKLRPYTGPGSELEGEKLDQEATELYTKLRKWVLEDRQRHDQALLSFVSFVRFYSKHVAQSIFRIQSLDLPGLAASYGLLRLPKMPELRTKDNERPENTWLGEVIDFDTYSYKNPAKEEARLKELEAHKEAMKNKVKIHKTKNDVQKANRAWSSTLQKKEEKSERHQKKQTRINEKIKRDFEEAKDLKQEESKEVVNDWKDMVKKSKKRKVDLPTFDDL

spb4

ATP-dependent rRNA helicase spb4

625 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

70.228 kDa

MAIDGEKKKDPRAWDALTPSLAEWILDAIKSMGFEKMTPVQASTIPLFMGNKDVVVEAVTGSGKTLSFLIPVVEKLLRLEEPIKKHHVGAIIVSPTRELATQIHSVLTSLLAFHEPSAGALKPLEEGEKRKPSSTLRVVSQLLLGGTTTPAQDLSRFLKNSPNLLISTPGRLLELLSSPHVHCPQSSFEVLVLDEADRLLDLGFKDDLQKILSRLPKQRRTGLFSASVSEAVGEIVRVGLRNPVKIAVKVKGAGGDKMTPASLQMSYLLTPPTHKFPALLSLLSQLQPTPQKSIIYLSTCAAVDYFQPLLEAVLPKQFALVSLHGKHPPNVRQRNFSKYVAAVSPTILLTTDVAARGLDIPQVDLVVQIDPPSDPKVFLHRCGRAGRAGRKGLSVIFLQPGREEDYIPFLEIRKTPITLFKRPEISTTDDAAKILISKMRKEVLADRALYDKGQRAFVSWVQAYSKHQASSIFRVADLDWTDLGNAWALVRLPKMPELKKWEGDKTLGIKLDMSEYAYKDKVREKARRVAMEEAKNAGPYVPTEEQIARKKQREAWSQKHEKQDLKELKREKKKRKREIERLDKMTDEEKRVEQEKERELQALIEQVKRRKIEDDADEEFEGFAD

SPB4

ATP-dependent rRNA helicase SPB4

617 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

70.79 kDa

MGKSLEWADLDYELQPWIKKAINVSGFDSMTPVQASTIPMFAKNKDVVVESVTGSGKTIAFVIPILEKIISEGINNSKFKKGHFYSLILAPTRELSMQIQNVVSSFLEHYPEDQYPIRSQLVVGTNEKSVRDDVNTLLDERPQILIGTPGRVLDFLQSPSVKTSSCGMVVLDEADRLLDVSFFKDVEKILNVLPKQRRTGLFSATISSAGTLIFKTGLRNPVKITVNSQGKNAPTTLNLFYSVMKPEEKLQNLIHIMNNIRFKKCIVYFSTCVSVTFFYQYLKYLQQTDKTLREDLQVISIHGKLTTQSRRKALSTFTESLSDCILLTTDVAARGIDIPDVDLVLQIDPPTDADIFLHRCGRTGRANKIGRAIVFLNEGREEDYIPFMEVKNVDIEETDINKNKISNDNNDEFYQRFTKWLLSDRANYDLSVKSYVAFIRYYSKHSATSIFRLQSLDYVSLGKMYGLFRLPRMPEITKYLQDKEKSGETVVGYYGEGWLMNPPPIDMDKYAYQDKKREKARIEELKNLAQINDKKKLKAELKKKNMAWSSKTMTKEERQERRKKLDLKRKAIELEIAAEAERDESDTEITQDWKDEILQKKKKKKVGSEMQGSFDDL

SPB4

ATP-dependent rRNA helicase SPB4

617 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

70.204 kDa

METKKGSLDWKNLQYDLQPWIKEAIASLGFPTMTPVQAATIPLLSGNKDVVVEAVTGSGKTLAFAIPVLQKVSNRLYDSQEEGEAPEKVKQGHMLAIVLSPTRELASQIQSVFNNVIEYLPEDKIPIKTQLLVGSLSTVRDDLDRFLKDKPHILIATPGRMLDFMSSQYVKMNSVEIAILDEADKLLDFSFEKDVVNILKRLPKQRRTGLFSATISAAGNTIFRAGMNNPVKVAVKSKSTTANSAPSALHISYLMIEPEKKITTLIKLLHDYRYKKCIVYFPTCTSVKHFYSIFQKIVNGNDNTESFKFYSLHGQLATKPRLRTLQSFTDGDVALNKHILMTTDVAARGIDIPDVDLVIQLDPPTDPDVFLHRCGRTGRANKVGRAIVMLNDGSRELDYVDFMEVKGVAMQEMPTPDLNQSDHQQFQDKLRKYMLDDRARHEIAIKSYVGFVRYYTKHMATSIFRYQTLDYLGIAKMYGLLRLPKMPESKYIPNDNMPDDGWLGEPIDMDKYSYADNQQEASRLENLNAEKIKKIADAKRRKELKVKNEAWSSKTETKETKQERREKMKRKREAIEKQIMEESSDDEETKVDWKDIVKSNKKKKANSGSMQGSFDDL

SPB4

ATP-dependent rRNA helicase SPB4

614 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

70.389 kDa

METREGSLTWSVLKCDLHPWIKEAIKSLGYPTMTPVQASTIPLFSGNKDVVVEAVTGSGKTLAFVIPVLQKLSNRLYNIDEEGENPEPVKKGHMLSIILSPTRELAKQIQTVFDKVLEYIPEDKATIKTQLLVGSLSSVREDIDYFLTNKTHILIATPGRLLDFLSSNYVKTNSVEIAVLDEADKLLDISFERDVIKILKQLPKQRRTGLFSATISSAGDTIFRTGMANPVKIVVKSKNSKNAAPTSLNVSYMHVEPETKISALIALIKDYRFQKCIVYFPTCTSVKHFYSVFQTLVNVEEEDRYKFFSLHGQLSTKPRLKTLQNFSEGDSMLHKHVLLTTDVAARGIDIPDVDLVIQLDPPTDPDVFFHRSGRTGRANKVGQAIVMLNNNSREEDYVNFMEVKGMTMSNMECPNISKIHDKFQKKFRKYMLEDRARHELAIKSYVGFVRYYSKHMASSIFRLQTLDYVGLGKMYGLLRLPKMPESRYIPNEEMPEDGWLGDVIDMDKYEYADKQKEESRKKNLEEDKARKVHDAKKRKELKVKNEAWSSKTDKIETKQERREKMKRKREAIEKQLMDDSSSDEETKVDWKEMVKTNKKKKTPSDSMQGSFDDL

SPB4

ATP-dependent rRNA helicase SPB4

607 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

69.545 kDa

MSKSLLWDDLEYPIQPWIRSAVDVMGFENMTPVQAATIPLFARNKDVVVDSVTGSGKTVSFVIPIFEKIVQEEANTTKMKKGHFHSLIVSPTKELAKQIHSVFESFLEHYPENLYPIRSQLLVGTNVKTVRDDVSDFMENKPQILIGTPGRILDFLKIPSVKTSMCSMVILDEADRLLDVSFLKDMENIMNILPKQRRTGLFSATITSAGDNIFKTGLRNPVKVTVNSKSQAPSSLKIDCAVVETDKKLEQVISIINNYKFKKCIAYFPTCHSVTYFYSFMQYLLKKGIIKEEIQIYSLHGKLQTSARIKTLETFTETISNAVLLTTDVAARGIDIPDVDLVLQLDPPTDPEVFLHRCGRTGRANKLGKAITFLTPGREEDYIPFMEVKNINLEEISLDIVNLPDNFYEIFKDWLLEDRARLDQAVKSYVAYIKTYSKHAASSIFRLQSFDYVGLAKFYGLIRLPKMPEITKYFKEDKENARTFGEGWLIDPPINMDKFGYLDKKKEDRRLADLKNLKSIHDKKKLKSELKKKNMSWSNNTQSKEEKVERRTKMALKRKRIEEELSKEADENSSGDDEQNRDWKQVILQNKKSKNSNNGMQGSFDDL

spb4

ATP-dependent rRNA helicase spb4

606 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

68.742 kDa

MSFQSINIDKWLKNAVAAQGFKKMTPVQANAIPLFLKNKDLVVEAVTGSGKTLAYLLPCFDKVTRRDTDETGLGALIVAPTRELATQIFNVTKELLAYQPDSLDGGKKLVADMYIGGKGTLTNDLASFREKNPSVVIGTPGRLNEMLSHISSKHLEILILDEADTLIDMGFQRTLQSIISQLPKQRRTGLFSATMNDTVSSFLKIAGLRNSVRVSVTVTSKKIDTRTPSSLAIQSLVIPPIYKVQCMIHLLCTIEYEKAIVFFSSCASVEYFNSLFLTYKLPFEIVALHGQQVQSNRSRNFEKFKKSNKKTVLFTTDIASRGLDIPNVDFVLQLDPPLDPKSFSHRCGRAGRAGRAGVAIVLLNDGREEEYEELLRVRKVPITRIDTPIEALDLSRLKVLTHELRKIVSKDRDLYDKGLRAFVSHVRAYTKHHASFIFRIKDLDLGQLATAYALLHLPKMPELKDTEISENIFKKFDIDYATIPYRDQVREQARRRRLEVEKTEPKKLARPAKIKNEAWSKQKEVKEKRNTRREKRKSKKEFLKAQKNEASNNLKQEIVSKAGAQETENDDLIDEESDALSELEEDYRQLKKSKKRKNQASFGFSM

SPB4

ATP-dependent rRNA helicase SPB4

606 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. Also required for recruitment of NOG2 to pre-ribosomes.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

69.422 kDa

MSKSLEWDNLGFSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFHSLIIAPTRELSRQIESVVLSFLEHYPSDLFPIKCQLLVGTNEATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAEKLQLLVSILNNYKFKKCIVYFPTCVSVSYFYSFIQYLGKRNILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVELEELDLEVKGITTNFYEDFRNWILEDRDRFDKGVKAYVAFIKYYSNHSATSIFRLQSLDYVGIAKLYGLFRLPRMPEITKYLATEKQEGIFPGNWLVDPPVNMDEYKYKDKKREKERQETLKNISLINDKKKLKSELKKKNLAWSDKTLTKERKLERKEKMSLKRKAIEEELKAEELDENAEEERIKEDWKEIVLQNKRKKVSSKAIQGNFDDL

SPB4

ATP-dependent rRNA helicase SPB4

606 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (PubMed:2408148, PubMed:25579579). Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA (PubMed:21825077). Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2 (PubMed:9769101). Also required for recruitment of NOG2 to pre-ribosomes (PubMed:22735702).

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

69.422 kDa

MSKSLEWDNLGFSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFHSLIIAPTRELSRQIESVVLSFLEHYPSDLFPIKCQLLVGTNEATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAEKLQLLVSILNNYKFKKCIVYFPTCVSVSYFYSFIQYLGKRNILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVELEELDLEVKGITTNFYEDFRNWILEDRDRFDKGVKAYVAFIKYYSNHSATSIFRLQSLDYVGIAKLYGLFRLPRMPEITKYLATEKQEGIFPGNWLVDPPVNMDEYKYKDKKREKERQETLKNISLINDKKKLKSELKKKNLAWSDKTLTKERKLERKEKMSLKRKAIEEELKAEELDENAEEERIKEDWKEIVLQNKRKKVSSKAIQGNFDDL

SPB4

ATP-dependent rRNA helicase SPB4

601 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

67.962 kDa

MLIARNFILMSKSLAWSQASLQPWIHDAIDSLGFRSMTPVQASTIPLFCGNKDVVVEAVTGSGKTLAFAIPVLERVTKCMKENRGSSGLYGIVISPTRELANQINTVFHTLLQFYPEDQPPIKTQLIVGSLATVREDLNAFAENKPQIIIATPGRLLDFFSSNAVKRSTVEMVVLDEADRLLDISFQNDVVSILKKLPKQRRTGLFSATLSSAGDSIFRTGMSNPVKISVNSNKAESKPQSLTVNYMMVNPETKIAVLINMLSTLQYKKCIVYFPTCASVKYFYSVFQKLHPLEDVNLTSIHGQLLAKARLKAMNKFTEGDVRTSKHVLLTTDVAARGIDIPEVDLVIQLDPPTDPDMFLHRCGRTGRANKVGRAIVMLNNNALESDYVDFMEVKGLKMSEVESPDVIDAYKAFSKNLRNLMLQDRAFHETAIKAYVGFVRYYSKHAATSIFRLQTLDYIGLAKAYGLLRLPKMPESRFVPNDRMPEDGWLGEKIDMNKYAYADPAKEKIRLETMEEEWNKKVNDAKRRKELKVKNEAWSSKNEKKEGKQERREKMKRKREAIEKQIMNESSDEETVVDWKDLVREKKQKTSGISGSFDDL

SPB4

ATP-dependent rRNA helicase SPB4

599 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

67.86 kDa

MSKSLSWDTLDYTLQPWIRTAVDAMGYETMTPVQASTIPLFARNKDVVVESVTGSGKTVAFVIPVLERVIQDDANSSKLKKGHFHTIIISPTRELASQIQGVIEAFLTYYPDGEYPIKSQLLIGSNTSSVRDDVAAFLEHRPQILVGTPGRLLDFLKMPNIKTSSCGAAILDEADKLLDMNFEKDVETILKMLPKQRRTGLFSATVSSAGTQVFKTGMRNPVKVSVKTSNKAPSSLDINYIVIEPRMKLQLLLTLLNNYRYKKCIVYLPTCIAVTYFYSILQHLAKLNKMDENLKLYSLHGKLLTNSRMKTLDRFTQELGKAVLLTTDVAARGIDIPDIDLVLQMDPPIDADIFLHRCGRAGRANRAGRAIVFLNQGREEDYIPFLQVKNVEAKELDTVAIKPIEGLPEIIRAWILEDRARFDHSLKVYVAFLRYYSKHTASSIFRLQTLDYIGIAEMHGLIRLPGTPEIQRYLSKDAIPEDGWLVSPPIDLDSFAYADPQREKARKLAKKEAKDVKDNNKLKSEMRKNNEAWSKKTVTKENKLQRKEKMALKRKAIEEKLIENSDDSDNEVETDWKDIVRQRKKKKTNSGMQGDFGDL

SPB4

ATP-dependent rRNA helicase SPB4

596 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

67.941 kDa

MSKSLSWDDLKCEIQPWIRTAIESMGFETMTPVQASTIPLFSGNKDVVVESVTGSGKTIAFVIPILERLIKEEANSAKFKKSHFHSLIISPTRELASQIHDVIEDFLKYYPDNLYPIRSQLLVGTSSASVRDDINSFTDNRPQILVGTPGRVLDFLQKTNVKTASCGTVVLDEADKLLDLNFQKDVETILKMLPKQRRTGLFSATIESAGAQIFKTGMRNPVKVAVKSNSSAPSSLSINYIVIPPKDKLQLLLTLLNNYRFKKCIVYFPTCISVTYFYAFINHLKELNLIQDDLKLFSLHGKLQTQSRMKTLDSFTSNLTDAVLFTTDVAARGIDIPDVDLVIQLDPPTDADIFIHRCGRTGRANRIGKALVFLNEGREEDYVPFLEVKNVKLEEESVELKGVENLTKIFHDWILHDRARFDHSVRAYVAFIKYYSKHTASSIFRFHSMDFIGVANFYGLLRLPRMPEITRYAADQIPEEGWLVSPPVNLDTFAYLDKQKEKARLQELQNLKQISDKKKLKSELKKKNMAWSDKTLTKEAKAERRAAMAIKRKAIEEKLLRGDEESEDEVEQDWKDLVRQNKKKKHNSMQGSFDDL

SPB4

ATP-dependent rRNA helicase SPB4

463 amino acids

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

52.014 kDa

MGCKGIEDVAMNGRLKKEIEENGFGKMTEVQLKCIPEVLKGKDVVVQSPTGTGKTMAFLAPILSCIYDGKGRGRPGVTAVVITPTRELALQIREVAGLFDVKCECFIGGMSIEEDYKRMKEEFSIAVGTPGRLLEIVGKETKKFSSLSHLVLDEADKLLGFGFEEKLMQLLAKLPRNRVTGLFSATRNDSVDKLSRVFLRNPVSINVGNNEMPVALEYIVVSPMEKLLVLMDIVTGRRCIVFFATCSEVDFFSGLVSRAGFGNICKIHGKISQDERNRVYEEFFQRDGLLFCTDVAARGIDFRGVDLVVHFDVPKEYSSIVHRSGRTARNGSKGESVLFVMPNERAYVEFLKLKGIPAVESSYRMKSSLSYQDIKSMISPELLGLSVKAFVSYIRSYKEHFVSYILDYKGLDFDSLAELFFLERIPGMAELRNVKFEKFTKPARDGKKRALPKKKYRKKRAIK