Spata18

Mitochondria-eating protein

568 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa.

Belongs to the MIEAP family.

63.884 kDa

MAENLKKLAQSESFLSLQDKVCFWANDYQTNSCDQNLNCCIELIEQVAKVQAQLFAILTATAQEGGHNEGVETIKSRLLPLLQTSFSSLGVGKIIQTEIRPIQDFQLRSKNRQSSLDQEQQQSDGDSFIESQPTQVQDDLTESGKNLEGTKNGSAISLLAAEEEINQLKKQLKSLQAQEDARHKTSENRRAEISRTDRRPSGKRNSERPQDVVSNYEKHLKNLKDEIAVLSAEKSGLQASHRQTRSRSPSPGPRGPRGPRGRRRSRSHSRSHSRSHSRSHSHSNSHSNSRSNSPCTTVAKIRSPSPNRSKMSSVARKAALLSRFSDAYSQARLDAQCLLRRCIDRAETVQRIIYIATVEAFHIAKMAFRHFKIRVRKMLTPSHVGSNDFETAVSDYIVCHLDLYDSQSSVNDVIRAMNVNPKISFPPEVDFCLLTDFIQEICCIAFAMQSLEPPLDIAFGADGEVFNEAKYRRSYDSDFTAPLVFYHVWPALMENDCVIMKGEAVTKRGAFWTTVRPVMRCRSRSLSPICPRSRFGISTVHSCVTIPADDLVSRSRSPSPIRCTFARY

SPATA18

Mitochondria-eating protein

560 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).

Belongs to the MIEAP family.

63.3 kDa

MADNLRKLVSTESLRSMQDKLENWLREYNNNSCDQNLNYCLELIEQVAKVQGQLFGILTTAAQEGGHYDGVETIKSRLLPWLEASFTAASLGKPVDSKIPSLQDTFDKERQKESVIRDRNIHQLDADLNTTRNQLNQVQDDLAETEKTLEETKNRSAISLLAAEEEINQLRKQLKCLQAQEESRHRPPEHRSSEKRGSERRRVEPRGADRCGAAQRKAEEICDYEKQLRTLKDEIAVLSAEKSVLQGRSTRSRSPSPASCSRSRSHSHSRSRSHSHSRSGSHSRSHSRNHSRSRSASPSTAVSGVRSPSPNRAKLSSVARKAALLSRFSDAYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIRVRKSLTPSYAGSNDFEDAVLDYIICHLDLYDSQSSVNDVIRAMNVNPKISFPPEVDFCLLSNFIQEICCIAFAMQTLDPPLDIAFGADGEIFNDCKYRRSYDSDFTAPLVFYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSVTRCRSRSLSPICPRSRVGLSTISRSRSPSPIRCGLPRF

SPATA18

Mitochondria-eating protein

538 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.

Belongs to the MIEAP family.

61.109 kDa

MAENLKRLVSNETLRTLQEKLDFWLKEYNTNTCDQNLNHCLELIEQVAKVQGQLFGILTAAAQEGGRNDGVETIKSRLLPWLEASFTAASLGKSVDSKVPSLQDTFDRERHKDPSPRDRDMQQLDSNLNSTRSQCNQVQDDLVETEKNLEESKNRSAISLLAAEEEINQLKKQLKSLQAQEDARHRNTDQRSSENRRSEPWSLEERKREQWNSLKQNADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQGRSSRSRSPSPAPRSRSCSRSRSASPSTAVKVRRPSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIHVRKSLTPSYVGSNDFENAVLDYVICHLDLYDSQSSVNDVIRAMNVNPKISFPPVVDFCLLSDFIQEICCIAFAMQALEPPLDIAYGADGEVFNDCKYRRSYDSDFTAPLVLYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSVSRCRSRSLSPICPRSQIGLNTMSRSRSPSPIRCGLPRF

SPATA18

Mitochondria-eating protein

538 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).

Belongs to the MIEAP family.

60.966 kDa

MAENLKRLVSNEALRTLQEKLDSWLKEYNTNTCDQNLNHCLELIEQVAKVQGQLFGILTTAAQEGGHNDGVETIKSRLLPWLEASFTAASMGKPVDSKVPSLQNTFDRERRKDPSPRDRDMQQLDSNLNSTRSQLNQVQDDLAETEKNLEETKNRSAISLLAAEEEINQLKKQLKTLQAQEDARHRHTDQRSSENRRSEPRSSEERRCEQWSSLKRNADQRDTEVTSDYKKQLRNLKEEIAVLSAEKSALQGRSSRSRSPSPAPRSRSCSRSRSASPSTAVKVRSPSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIRVRKSLTPSYVGSNDFENAVSDYVICHLDLYDSQSSVNDVIRAMNVNPKISFPPVVDFCLLSDFIQEICCIAFAMQALEPPLDIAYGADGEVFNDCKYRRSYDSDFTAPLVLYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSLSRCRSRSLSPICPRSQIGLSTMSRSRSPSPIRCGLPRF

SPATA18

Mitochondria-eating protein

537 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).

Belongs to the MIEAP family.

60.584 kDa

MADNLRRLVSNEALRSLQDKLESWLREYNANSCDQNLNHCLELIEQVAKVQGQLFGILTIAAQEGGHYDGVETIKSRLLPWLEASFTAASLGKPVDSKVPSLQDTFDKDRHKESGTRDIQQLDADLSATRNQLNQVQDDMAETEKTLEEPKNRSAISLLAAEEEINQLKKQLKSLQAQEESRHRNSDRRRSEKRGSERRRVELRGSEQRVSDLDRRSANQRNAEAVCDYEKQLRTLKDEIAVLSAEKSVLQGRSARSRSPSPAPCSRSHSRSRSTSPSSAKARTPSPNRAKLSSVARKAALLSRFSDAYSQGRLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIRVRKSLTPSCAGSNDFEDAVSDYIICHLDLYDSQSSVNDVIRAMNVNPKISFPPEVDFCLLSNFIQEICCIAFAMQTLEPPLDIAFGADGEIFNDCKYRRSYDSDFTAPLVFYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSVSRCRSRSLSPICPRTRIGLGMISRSRSPSPIRCGLPRF

Spata18

Mitochondria-eating protein

537 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).

Belongs to the MIEAP family.

60.398 kDa

MAESLKKLAKSESLQALQDKVTYWVNDYNSNSCDQNLNYCIELIEQVAKVQAQLFGILTVTAQEGGNNEGVETIKCRLLPLLQTSFSSVNMGKTAESEMCATQDFQLRSKNRDNSPDQDQHQSDNESFSETQPTQVQDDLAESGKSLEGAKNGSTISLLAAEEEINQLKKQLKSLQAQEDARHKTSENRRSEALKSDHRSTKRTQDQRPQDVVSNYEKHLQNLKEEIAVLSAEKSGLQGRSARSPSPSTGTRSHRRGRSRSHSRSRSHSRSNSPCTTVAKIRSPSPNRAKMSSVARKAALLSRFSDAYSQARLDAQCLLRRCIDRAETVQRIIYIATVEAFHVAKMAFRHFKIRVRKMLTPSNVGSNTDFETAVSEYIVCHLDLYDSQSSVNDVIRAMNVNPKISFPPEVDFCLLTDFIQEICCIAFAMQSLEPPLDIAFGADGEIFNDCKYRRSYDSDFTAPLVFYHVWPALMENDCVIMKGEAVTKRGAFWSSVRPVMRCRSRSLSPICPRNHFGISTVSRSRSPSPIRCTFARY

spata18

Mitochondria-eating protein

490 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity).

Belongs to the MIEAP family.

55.45 kDa

MADTLRRLVNSSPYSVLQDKLDAWYKDYHVYSCDQNLNRCCELVELTSKIQGQLFTILNLTAQEGGHYSGVDTLKSRLLPWLGSCFTIAASAVSSDTSLSLIQESVEKDRKIRELSSVHESNLQKIEDQLCSTRIELDSVKRELVDTHIELDSTKNKSATTLLATEDEILHLKSELRVAQDQLDLYKRKLDVLDDYERQVRILRDEVSFLNAEKTVLQDRLARSRSPSPLLRRSRSVSPVRGESPTRAQLTSSSRHARLVSRFSDLYATERLESQSLLLKYIDDLETVQRILFIAAVESFQAAKLAYRQFKSRVRKTLSSTHIGPESLEDAVVDYIVRNLDLYDVQTSINDVINAMNVNPRISFPPEVDFVLISSFIREACRIAFAMQTLDPPLDLAFSSDGELYSDVKYRRSFDSEFTAPLVAFHVWPALLEGDTVILKGEAVTRRGALWKSRSRSSSPVRSRSGSPSRTFMASHSRSPSPGRLSSSRL

spata18

Mitochondria-eating protein

485 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity).

Belongs to the MIEAP family.

55.139 kDa

MADILRRLTNSERCRLLQDKLDDWYKDYHINSCDSNLNVCCELLELNSKVQGQLFKILSVTAQEGGQYAGVETIKSRFLPWLGTCFSTASPGSFSENSFVTLNESMERKLSTSHERELNEVESKLSSTRIELNSVRQELLETQMDLEDTKTKSANTLLATEEEILQLRAELRAAREKLELRSLDSIDEYERQIRLLKDEISILSSESSILKSRLSRSRSPSPIRHSSRSSSPFARSESPTSAKLTSASRQARLISRFNDIFANDRLDAQTLLRRYIQDLDMVQRIIFIATVESFHSAKMAFRQFRLRVCKSLSPSHMGPESLEDAVIDYIVGNLDLYDVQSSVNEVISAMNVNPKISFPPEVDFILISGFIQEVCRVAFTMQTLDPPLDIAFTVDGELFTDSKYRRTYDSEHTAPLVYYHVWPALMENDNVIVKGEAVTKRGALWNSIRSRSRSASPLRSHSDSPGHNLTRSRSPSPRRSGTPRF

SPATA18

Mitochondria-eating protein

479 amino acids

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).

Belongs to the MIEAP family.

54.575 kDa

MAGSLKKLAKAESCRLMQEKLESWSKDYEINSCDQNLNQCCELIEMTSVIQGQLFTILNETSRESGHYAGVDTIKTRLLPWLGTWFSHATSGRLFETGLFLNQDSTETERKLRQLATSQTLQLQDLQEELTSTRLELNHVQQDLAQTQLALEDTKTQLATTLLTAADEIIQLRAVLKASRAQEEDSLRRLDHLNDCEQQIERLRDELSILDAQKSVLQSRIARSRSPSPRRIRSRSPSPLPLRSCSPGRARSTNASRHAFLVARFGDIYSKDRFDAERILRTYISDMEMVQRIIYTAAVESFHAAKMAYRQFKMRVRKTLSIGHSGPESLEDTVMDYIVRHEDLYDVQASVNEVIRSMNINPKISSTPECDFAVISSFIRELCRVAFSMQTLTPPLDVAFGMDGEFFSETKYHRSVDSDYTAALVAYHVWPALMENDVVIVKGEAVTKRGALWSHRSRSRSQNRSRSVSPLLSHLSRSR