Sp1

Transcription factor Sp1

786 amino acids

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (By similarity). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter (PubMed:19081374). Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).

Belongs to the Sp1 C2H2-type zinc-finger protein family.

80.772 kDa

MSDQDHSMDEVTAVKIEKGVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESGSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTSQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGAQLGLHGPGGDGIHDETAGGEEGENSPDPQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF

SP1

Transcription factor Sp1

785 amino acids

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).

Belongs to the Sp1 C2H2-type zinc-finger protein family.

80.693 kDa

MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINISGNGF

Sp1

Transcription factor Sp1

784 amino acids

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:24030830). Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (PubMed:27918959).

Belongs to the Sp1 C2H2-type zinc-finger protein family.

80.732 kDa

MSDQDHSMDEVTAVVKIEKDVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIIPNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESSSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTPQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGTQLGLHGSGGDGIHDETAGGEGENSSDLQPQAGRRTRREACTCPYCKDSEGRASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF

SP1

Sex-specific storage-protein 1

747 amino acids

Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.

Belongs to the hemocyanin family.

87.242 kDa

MRVLVLLACLAAASASAISGGYGTMVFTKEPMVNLDMKMKELCIMKLLDHILQPTMFEDIKEIAKEYNIEKSCDKYMNVDVVKQFMEMYKMGMLPRGETFVHTNELQMEEAVKVFRVLYYAKDFDVFMRTACWMRERINGGMFVYAFTAACFHRTDCKGLYLPAPYEIYPYFFVDSHVISKAFMMKMTKAAKDPVLWKYYGITVTDDNLVVIDWRKGVRRSLSQNDVMSYFMEDVDLNTYMYYLHMNYPFWMTDDAYGINKERRGEIMMYANQQLLARMRLERLSHKMCDVKPMMWNEPLETGYWPKIRLPSGDEMPVRQNNMVVATKDNLKMKQMMDDVEMMIREGILTGKIERRDGTVISLKKSEDIENLARLVLGGLEIVGDDAKVIHLTNLMKKMLSYGQYNMDKYTYVPTSLDMYTTCLRDPVFWMIMKRVCNIFTVFKNMLPKYTREQFSFPGVKVEKITTDELVTFVDEYDMDISNAMYLDATEMQNKTSDMTFMARMRRLNHHPFQVSIDVMSDKTVDAVVRIFLGPKYDCMGRLMSVNDKRLDMFELDSFMYKLVNGKNTIVRSSMDMQGFIPEYLSTRRVMESEMMPSGDGQTMVKDWWCKSRNGFPQRLMLPLGTIGGLEMQMYVIVSPVRTGMLLPTLDMTMMKDRCACRWSSCISTMPLGYPFDRPIDMASFFTSNMKFADVMIYRKDLGMSNTSKTVDTSEMVMMKDDLTYLDSDMLVKRTYKDVMMMSSMMN

SP1

Subtilisin-like protease 1

400 amino acids

Major secreted subtilisin-like serine endopeptidase (PubMed:25785714). Mediates the degradation of collagen, the major structural protein in the mammalian host. Degrades the nonhelical regions of collagen that function in the cross-linking of the helical components (By similarity). May function as virulence factor involved in epidermal wing necrosis observed in white nose syndrome (WNS) in bats (Probable).

Belongs to the peptidase S8 family.

40.739 kDa

MKFSQSLIALAACFLPLIAAAPVEAQHAKIRSPRAQDIIPDSYIVVFNKGVNDADIESEFSSVSRILSKRRSAHKGVGHKYNITGFKGYQIETDTGSIGEIAASPLVAWIEMDGKVQANALETRSGATWGLGRISHKATGSNSYIYDGSAGSGSTVYVLDTGIYIEHSEFEGRAKWGANYISGSPDTDENGHGTHCAGTIAGATYGVASKANLVAVKVLDRDGFGATSATIAGINFVGQNGKDGKSVISMSLRGHYSAAVNSAVESTVSNGVTIVVAAGNDGDDASNYSPASAKNAITVGSVDSTDTRASSSNYGSVVDIFAPGVNVKSASIGGKSAFSIKSGTSMATPHVAGLAAYLIGLGGLSSPAAIASKIASIGTKGSVKDPKGSVNLIAYNGNGA

SP1

E3 ubiquitin-protein ligase SP1

343 amino acids

E3 ubiquitin-protein ligase involved in the regulation of protein import in the chloroplast. Associates with TOC complexes and mediates ubiquitination of TOC components, promoting their degradation via the ubiquitin-proteasome system (UPS). Plays a role in the reorganization of the TOC machinery. Involved in a mechanism that regulates plastid biogenesis via UPS (PubMed:23118188). Promotes stress tolerance by depleting the chloroplast protein import apparatus, which limits photosystem assembly and the potential for reactive oxygen species (ROS) formation (PubMed:26387714). May act as negative regulator of programmed cell death (PCD) during biotic stress (PubMed:20972793).

37.908 kDa

MIPWGGVTCCLSAAALYLLGRSSGRDAEVLETVTRVNQLKELAQLLELDSKILPFIVAVSGRVGSETPIKCEHSGIRGVIVEETAEQHFLKHNETGSWVQDSALMLSMSKEVPWFLDDGTSRVHVMGARGATGFALTVGSEVFEESGRSLVRGTLDYLQGLKMLGVKRIERVLPTGIPLTIVGEAVKDDIGEFRIQKPDRGPFYVSSKSLDQLISNLGKWSRLYKYASMGFTVLGVFLITKHVIDSVLERRRRRQLQKRVLDAAAKRAELESEGSNGTRESISDSTKKEDAVPDLCVICLEQEYNAVFVPCGHMCCCTACSSHLTSCPLCRRRIDLAVKTYRH