Protein
Leucine aminopeptidase 2
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Function
Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
Similarity
Belongs to the peptidase M1 family.
Sequence
METRTPRDPNTLSNYHNYVTRHTSLDFEIEFERKRLVGSVVLRMESLTDAEVDVVLDSSFLDVSAIKVDRQSAEFSIGERIEPYGSPLTIKLPAAVPKGKTVEIELTVATTEKCTALQWMEPAQTSNKKHPYMFSQCQANHARSVFPCQDTPDVKSTFSFALRSPLPVLASGLPTGASKYQPAKKDGASGTLKYTFEQPVAITSYLMAVASGDLACASIGPRSTVWSGPEELLECQQELEGEIEPFMKAIESIVKPTYQWTQYNVLILPPSFPYGGMENPVWTYATPSIISGDKQNIDVIAHELSHSWSGNLVSAASWEHFWLNEGWTTYLERRIQGVLHGESHRHFSAIIGWKALEESIERYGADHDFTKLVIDLKGKDPDDAFSSIPYEKGFHALYQFELLLGKDKWDNFIPHYFETFKFKSIDSYDFKACLIDFFAKDTEANKKLAEFDWDKLFYAPGYPPKPDFDQTMVKSCYKLADKWQYLITNNSSSDFKPHHSDVADWVSNQSVVFLEKVQSFAEKFSAEQIHLLGHTYGYDKTQNIEVLSRYLSAGLMAKAPETYQPSAELLGRIGRMKFVRPMYRLLEKADRKLAVETFEKNKDFYHPICRSMVEKDLFGDEKK