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SNF7

Gene
snf7
Protein
Vacuolar-sorting protein snf7
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
242 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB).
Similarity
Belongs to the SNF7 family.
Mass
27.203 kDa
Sequence
MWSWFGGAAAQKRKEAPKNAILQLRSHLDMLQKREKHLENQMNEQEAIAKKNVTTNKNAAKAALRRKKVHEKNLEQTQAQIVQLEQQIYSIEAANINHETLAAMKAAGAAMEKIHNGMTVEQVDETILRDKLREQQAINDEIAIAITNPGFGEQVDEEDLEAELEGMEQEAMDERMLHTGTVPVADQLNRLPAPANAERKALPFPPQKRTPTDSLPAAKAKQKAEEEDEEAELEKLRAEMAM

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
240 amino acids
Function
Acts a component of the ESCRT-III complex required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB) (PubMed:11559748, PubMed:12194857). The sequential action of ESCRT-0, -I, and -II together with the ordered assembly of ESCRT-III links membrane invagination to cargo sorting (PubMed:12194857). Membrane scission in the neck of the growing vesicle releases mature, cargo-laden ILVs into the lumen (PubMed:24139821, PubMed:24711499). ESCRT-III is critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery (PubMed:24139821, PubMed:24711499). SNF7 is the most abundant ESCRT-III subunit which forms membrane-sculpting filaments with 30 Angstrom periodicity and a exposed cationic membrane-binding surface (PubMed:26670543). Its activation requires a prominent conformational rearrangement to expose protein-membrane and protein-protein interfaces (PubMed:26670543). SNF7 filaments then form spirals that could function as spiral springs (PubMed:26522593). The elastic expansion of compressed SNF7 spirals generates an area difference between the two sides of the membrane and thus curvature which could be the origin of membrane deformation leading eventually to fission (PubMed:26522593). SNF7 recruits BRO1, which in turn recruits DOA4, which deubiquitinates cargos before their enclosure within MVB vesicles (PubMed:11029042, PubMed:15935782). ESCRT-III is also recruited to the nuclear envelope (NE) by integral INM proteins to surveil and clear defective nuclear pore complex (NPC) assembly intermediates to ensure the fidelity of NPC assembly (PubMed:25303532).
Similarity
Belongs to the SNF7 family.
Mass
26.987 kDa
Sequence
MWSSLFGWTSSNAKNKESPTKAIVRLREHINLLSKKQSHLRTQITNQENEARIFLTKGNKVMAKNALKKKKTIEQLLSKVEGTMESMEQQLFSIESANLNLETMRAMQEGAKAMKTIHSGLDIDKVDETMDEIREQVELGDEISDAISRPLITGANEVDEDELDEELDMLAQENANQETSKIVNNNVNAAPISENKVSLPSVPSNKIKQSENSVKDGEEEEDEEDEDEKALRELQAEMGL

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
237 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
26.685 kDa
Sequence
MWSYLFGSGNAKQKKELPKKAILELREHIQLLSKKQAHLQTQMTSQEESARHFLSKGNKNMAKAALKRKKVFESQLLKIDKQVDSLEQQLYSIENANLNLETMKAMKQGASAMKHIHEGLDVERVDETMDEIREQVELGEEISEAISRPLYTGVNEIDEDELDEELDMLAQEEVARKVMEPGAAVPAAAPATKVSLPSVPSSDMPQQDRGQPVTLGMDQEEDEDERALRELQAEMGL

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
232 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
26.644 kDa
Sequence
MWGYFFGTSKQQKELPKKAIVDLREHIQLLNKKQAHLQTQIDQQQQLAKKSLQSGNKNNAKTYLKKKKLYESQLDKLQSQIDSLDQQLYSIENANLNLETLKAMKQGASAMKNIHKGLDLDKVDDTMDEIREQVELNQEISEAISKPLILQDELDEDELDQELELLESENLQKEHIAPVPQQQIQQPSIDLPSVPDVKLSTPELNSAQADEEDEEEDEDERALRELQAEMGL

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
228 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
25.827 kDa
Sequence
MWASIFGGKGNTNKELPKKAIIELREHINLLSKKQAHLQGQITAQENEARKFLTRGNKTMAKNALKKKKVYEGQLVKLESQMDSLEQQLFSIESANLNLETMRAMKQGAKAMKSIHSGLDIDRVDETMDEIREQVELGEEISDAISRPLYTGANEIDEDELDEELDMLAQETEPQVATKEQALPESKQALSMPNIPNTKIDESKTKIEEEEEDEDERALRELQAEMGL

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
226 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
Similarity
Belongs to the SNF7 family.
Mass
25.89 kDa
Sequence
MWGYFFGGNSQQKKDLPKKAIVELREHIQTLNKKKNHLQQQMDDQDQLARKYVSSKQTTLAKSALKRKKGYESNLLKVENQIETLETQLISIEGANLNLETMKAMKQGAKAMKQIHGEYDVDKVEDTMDEIREQVELADEISEAISRPVGNEFVDEDELDEELKELEAEAKEQEQEHRVPAQKAKPQPVSREEELPQFPSVNKKAPVVEEDEDEEALKALQAEMGL

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
226 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
25.675 kDa
Sequence
MWNYLFGGNKQQKKEYPKKAIVELREHIQMLNKKRSHLESQIADQDALARKYITTNKALAKNALKRKKGYEANLMKIENQIDSLETQLTSIEGANLNLETMKAMKQGAQAMKQIHGEYDVDKVENTMDDIREQVELADEISEAISRPVGTEFVDEDELDEELAMLQEEEKEHKQQTPAQKAPVAKVSAPEEEMPDFPTVNKNKPAASTEDDEDEEALKALQAEMGL

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
226 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
25.057 kDa
Sequence
MSGVWGWFGGNAAQRRKDTPKNAILGLRSQLDMLQKREKHLQNQISEQDAIARKNISTNKNAAKAALKRKKTHEHSLDQTLSQIGTLEQQINAIESANINMETLEAMKKAGKAMEDIHGKLTVEKVDETMDKLREQNALSEEIVNAITNNQLGNEAIDDADLEDELEAMEQEQLDEKILKTGTGPVSDAIQRLPAAANGELKGKATTVEEDDEEAELRKLQAEMAM

Gene
snf7
Protein
Vacuolar-sorting protein snf7
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
222 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB).
Similarity
Belongs to the SNF7 family.
Mass
25.302 kDa
Sequence
MSGFLRWFGGNRSKDTTKDTIVRFQEMLALYDKKEEVLERQIAEQTEIARKNATTNKRLALTALKRKKMHENELVKIEGSRNNIEQQLFSIQNANLNFETLQAMRQGAEAMKSIQRGMDADKVDQIMDKIRDQQTISEEISTMISTPVGLNAEIDEDELANELDELQQMELDSKMLGAEKPPVHTPAVPAVPSQVKDLPSISKPQELDEEEELRKLQAEFSL

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
220 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
24.334 kDa
Sequence
MSGWMSYFTGRKDTRESARDAIVGLRQQLLMLEKKEEFLQKKIEEEMKKAKANATGNKRLAMAALRQKKAHENELDRIAGTRLTLETQVNAIESANLNAETMVAMKKGADALKGIHSNLTAEGVDATMDKIREQMDLTNDISDAISNPVGMGIVLDEDDLKEELEALEQEQLDDRLAGADRVPSHLPASPVGQTTGRAAVEEDEDDEEAQLRKLQAELAM

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
220 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
24.334 kDa
Sequence
MSGWMSYFTGRKDTRESARDAIVGLRQQLLMLEKKEEFLQKKIEEEMKKAKANATGNKRLAMAALRQKKAHENELDRIAGTRLTLETQVNAIESANLNAETMVAMKKGADALKGIHSNLTAEGVDATMDKIREQMDLTNDISDAISNPVGMGIVLDEDDLKEELEALEQEQLDDRLAGADRVPSHLPASPVGQTTGRAAVEEDEDDEEAQLRKLQAELAM

Gene
SNF7
Protein
Vacuolar-sorting protein SNF7
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
215 amino acids
Function
Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
24.334 kDa
Sequence
MWGFFGGAKKQDPKDTIISLRQQIIVLNKKNDNLIVQIQEQENLARKHVTTNKLMAKNALKKKKNLEKQQETVQGSIDSLQTSINTLETANLNLETMKAMQEGAKAMKQIHGNMNIDKVDKIMDETRDQVALSEEVSEAISRPYANAYDDEELEDELEALEQETLEGELTNAGHVKQDGVQVTPHDLPAAPNQVPAEEEDDEEEELRRLQREMAL