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SMDT1

Gene
SMDT1
Protein
Essential MCU regulator, mitochondrial
Organism
Bos taurus
Length
107 amino acids
Function
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling.
Similarity
Belongs to the SMDT1/EMRE family.
Mass
11.45 kDa
Sequence
MASGAARWLALVRVGSGASRSWLSLRKGGDVSAGRSCSGQSLVPTRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Gene
SMDT1
Protein
Essential MCU regulator, mitochondrial
Organism
Homo sapiens
Length
107 amino acids
Function
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988).
Similarity
Belongs to the SMDT1/EMRE family.
Mass
11.441 kDa
Sequence
MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Gene
Smdt1
Protein
Essential MCU regulator, mitochondrial
Organism
Mus musculus
Length
107 amino acids
Function
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:27001609). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (By similarity).
Similarity
Belongs to the SMDT1/EMRE family.
Mass
11.542 kDa
Sequence
MASTAARRLAWVAVRPGALWSGPRGRRGGDVYTVPGSSGLSQVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Gene
smdt1
Protein
Essential MCU regulator, mitochondrial
Organism
Xenopus tropicalis
Length
99 amino acids
Function
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling.
Similarity
Belongs to the SMDT1/EMRE family.
Mass
10.457 kDa
Sequence
MAARVGVLSVAGFRAAARAGGLLRASKQSSAVSHVPCRTAIATSAGTVLPKPEKVSFGLLRVFTVVIPFLYIGTLISKNFAALLEEHDIFVPEDDDDDD

Gene
smdt1
Protein
Essential MCU regulator, mitochondrial
Organism
Xenopus laevis
Length
97 amino acids
Function
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling.
Similarity
Belongs to the SMDT1/EMRE family.
Mass
10.273 kDa
Sequence
MAARMGVLSVAGFRAAARAGGLLARPKQSTAVVPCRTVIASSAGAILPKPEKVSFGLLRVFTVVIPFLYIGTLISKNFAAVLEEHDIFVPEDDDDDD