SLN1

Histidine protein kinase SLN1

1373 amino acids

Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably also to changes in the osmolarity of the extracellular environment. Plays a role in the regulation of alternative oxidase (AOX) gene family expression. Required for hyphal formation and virulence.

150.742 kDa

MRRLKIGIRPQLIIIVCFASLFSLLILGIVTGIYFSANLKNLRLERLLVISQLKRTQVQQAIQYIAYQVMTVSEVDSLTVPLSNYRAGNNSKAVFSEAQNYLQQYVLTTDSFTAARLYDLDLQVVASSFDNMTLISESAQDVVYPLQPNRSMPPVLGTPSGLYFTGPIANNSDNFNSRYFMGITVPVLSNSSIILSQPSISGYLTIVAAAESIRSALNSTSEDDYQAMAVQPVYGDPQKGIDNLSQNAYNGDNEVIGFKLVFPVENSLLEAGTIYNINSSSSMKTALASNSGTATGVKSFFGKKVAIGFSRISVQDNLNWSIVIVQSNSVFNGPANKLRKITIGVVIGIGAFMCFVTFPLAVWFIRPITKLKEATEAITKYKKEKLNSVNSNSPTSGSGSGSGSGSGSRANSDSSADQSLSLDTGKRNSINSSSFSSSYSTGIRLPARIPRSKKIFKDELTELSEAFNIMTEELDKQYTHLEDRVKLRTKELEASKIQAEAANEAKTVFIANISHELRTPLNGILGMTSIAMEEEDPNVIHDSLKLIHRSGELLLHILTELLTYSKNTLNRSKLEKSNFQILEIVYQVRSIFNKLAHDQRVNFKILVKPNIFRKLIIYGDSNRIIQIVMNLVSNSLKFTPVDGSVSVSFKLLGEYDHERSKKLDYKKVCILNDSSSSTVAVPPPTPPSDTKPNPKPKSTPTPKPDPTRSHLVDHNNRSANTTSPLTPVRKPTNQTKNKSITNNVTKQNMKIRKKKKTNKNLHNNNNNNKNDNSDFLMNRRLSGSHKFNNTNDEELSPTAIEKNIDKYLTSSADSDNISVTTLSTVQYETTIFESQFKSKPLPALPVDAKPQVSGKIDENDVNDEDPSGGSIKDDDSEDTINEKQGISSSPSSSSSSNEKQENSPRSNDSTTVTVTRPRHNMMPSAQDFKSYPTFDKKPEYDSNMSNNEIVKNNRVYRIRNMYQPKVWVIQIEVTDTGPGIEPALQEKVFEPFVQGDQTLSRSYGGTGLGLSICRQLATMMHGTLTLKSTIGKGSTFTLTLPLPQTGEIMVPPEDMAEFCEDEFNPAAKINRKVAFEDGDIDTESQQQENPSSEEDTQGDRNVQSSTSSSPPNSSSTDSALPASDSSDIGGTNKSKTTSHGNNKNINAKKRIITNSSASSTKGTKRHTNNDGGGGVNGNHSDDNKDLTLTIDKPSLFTRGSTGTANSGTTSSHSDKKILYPTPTTTTTTTTTTDHTTVLDDISHLRVLVAEDNSVNQEVISRMLKQEGITNLTMACNGAKAIDFVKESIENNENFDLIFMDVQMPEVDGLKATKMIRKNLQYNKPIIALTAFADESNVKECLNSGMSGFITKPISKTNIKKVLVEFLSNEVVTS

SLN1

Osmosensing histidine protein kinase SLN1

1220 amino acids

Histidine kinase that acts as an osmosensor at the plasma membrane. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, the histidine kinase autophosphorylates His-576. This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1. Under high osmolarity conditions, the histidine kinase is no longer active.

134.435 kDa

MRFGLPSKLELTPPFRIGIRTQLTALVSIVALGSLIILAVTTGVYFTSNYKNLRSDRLYIAAQLKSSQIDQTLNYLYYQAYYLASRDALQSSLTSYVAGNKSADNWVDSLSVIQKFLSSSNLFYVAKVYDSSFNAVLNATNNGTGDLIPEDVLDSLFPLSTDTPLPSSLETIGILTDPVLNSTDYLMSMSLPIFANPSIILTDSRVYGYITIIMSAEGLKSVFNDTTALEHSTIAIISAVYNSQGKASGYHFVFPPYGSRSDLPQKVFSIKNDTFISSAFRNGKGGSLKQTNILSTRNTALGYSPCSFNLVNWVAIVSQPESVFLSPATKLAKIITGTVIAIGVFVILLTLPLAHWAVQPIVRLQKATELITEGRGLRPSTPRTISRASSFKRGFSSGFAVPSSLLQFNTAEAGSTTSVSGHGGSGHGSGAAFSANSSMKSAINLGNEKMSPPEEENKIPNNHTDAKISMDGSLNHDLLGPHSLRHNDTDRSSNRSHILTTSANLTEARLPDYRRLFSDELSDLTETFNTMTDALDQHYALLEERVRARTKQLEAAKIEAEAANEAKTVFIANISHELRTPLNGILGMTAISMEETDVNKIRNSLKLIFRSGELLLHILTELLTFSKNVLQRTKLEKRDFCITDVALQIKSIFGKVAKDQRVRLSISLFPNLIRTMVLWGDSNRIIQIVMNLVSNALKFTPVDGTVDVRMKLLGEYDKELSEKKQYKEVYIKKGTEVTENLETTDKYDLPTLSNHRKSVDLESSATSLGSNRDTSTIQEEITKRNTVANESIYKKVNDREKASNDDVSSIVSTTTSSYDNAIFNSQFNKAPGSDDEEGGNLGRPIENPKTWVISIEVEDTGPGIDPSLQESVFHPFVQGDQTLSRQYGGTGLGLSICRQLANMMHGTMKLESKVGVGSKFTFTLPLNQTKEISFADMEFPFEDEFNPESRKNRRVKFSVAKSIKSRQSTSSVATPATNRSSLTNDVLPEVRSKGKHETKDVGNPNMGREEKNDNGGLEQLQEKNIKPSICLTGAEVNEQNSLSSKHRSRHEGLGSVNLDRPFLQSTGTATSSRNIPTVKDDDKNETSVKILVVEDNHVNQEVIKRMLNLEGIENIELACDGQEAFDKVKELTSKGENYNMIFMDVQMPKVDGLLSTKMIRRDLGYTSPIVALTAFADDSNIKECLESGMNGFLSKPIKRPKLKTILTEFCAAYQGKKNNK

SLN1

DELLA protein SLN1

618 amino acids

Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes. Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway. Acts as a negative regulator of GAMYB gene expression.

Belongs to the GRAS family. DELLA subfamily.

65.206 kDa

MKREYQDGGGSGGGGDEMGSSRDKMMVSSSEAGEGEEVDELLAALGYKVRASDMADVAQKLEQLEMAMGMGGPAPDDGFATHLATDTVHYNPTDLSSWVESMLSELNAPPPPLPPAPPQLNASTSSTVTGGGGYFDLPPSVDSSSSTYALRPIISPPVAPADLSADSVRDPKRMRTGGSSTSSSSSSSSSLGGGAARSSVVEAAPPVAAAAAAPALPVVVVDTQEAGIRLVHALLACAEAVQQENLSAAEALVKQIPLLAASQGGAMRKVAAYFGEALARRVFRFRPQPDSSLLDAAFADLLHAHFYESCPYLKFAHFTANQAILEAFAGCRRVHVVDFGIKQGMQWPALLQALALRPGGPPSFRLTGVGPPQPDETDALQQVGWKLAQFAHTIRVDFQYRGLVAATLADLEPFMLQPEGEEDPNEEPEVIAVNSVFEMHRLLAQPGALEKVLGTVRAVRPRIVTVVEQEANHNSGSFLDRFTESLHYYSTMFDSLEGGSSGGPSEVSSGGAAPAAAAGTDQVMSEVYLGRQICNVVACEGTERTERHETLGQWRNRLGNAGFETVHLGSNAYKQASTLLALFAGGDGYKVEEKEGCLTLGWHTRPLIATSAWRLAAP