Protein
SMC5-SMC6 complex localization factor protein 2
Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions.
Similarity
Belongs to the FAM178 family.
Sequence
MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTAPAAAGKRTESPGDRKQSIIDFFKPAAKQDKHMLDSPQKSNIKYRGNGLSITGTEQFERKLSSPKKLKPKRMSSEESPILEAFMKGGKEHHKDRGVHESRRPCMSLSKYLPKGAGIYAPSSYRLPKEIKAQKKKHQSPERRKSLFIHESNREKNDRDRGKNSEDSRKQATATEGDIFKHSSRSISSRSSLSRHHPGESTLGARFQLSLASYWREREQKKLRKEQMEQRINSENSFSEASNLSLKSSGVGKNCKPRHEHSKHTEAVPGKSNLSTLENGHLSRKRSSSDSWELSGSKQNKFSDKRTEELCGLRPEKHKRTYHTKSKRVLSREAPRHIPSERKVYQTHCTEDSWWCSALGRHSQGAGKTVSRGMSIASTLRLYLGRVISQLWKMDISQEKDHLQTRGNFQALNRINSPTKEQRNSVDSDLKSTKEPIIPKARESFLEKRPDTSHQREKFIRHIALKTPGGVLRLEDIAKEPEDETDRSSADSAPSNAGHHSSRNSDQVHSASTKETKIQKPHLPLPQEKSTIKRASNLQKNKPAGSVTSKETKLPLLSHVPSAVSSRVPLNAKNCTLPVPKKDKERSSSKERSGHSTESSKHKEHRAKTIKAVSNESSGKNSGGSLHSEYAPPTASPPAALEVVPSVPSPAAPSDKESSGNSNAGSNALKRKFRGDFDSDEESLGYTLESDEEEETLKSLEEIMALNFSRTPTTSGKPPAVSKGLRSQSSDMKEYAQSGTYTNTLERLVKEMEDTQRLDELQKKLQEDIRQGRGIKSPLRTGDQDSTDDGDGLLEEHREFLKKFSVTVDAIPDHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGESAVEKLILKSGKTDQIFLTTQGFLTTAYHYVQCPVPVLKWLFRMMSVHTDCIVSVQILSTLMEITIRNDTFSDSPVWPWIPSLSDIAAVFFNMGVGFGSLFPLETLQPDFNEENLISETQKTLGGKESEDSPYSPVFSALPETNILNVVKFLGLCTSIHPEGYQDGELMLLILMLFKMSLEKELKQIPLVDFQSLLINLMKNIRDWNTKVHELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVMMSKLLDEKHEDIPNANNLQISVLHRYLVQMKPSDLLKKMVLKKRAEQPNETIDDSLHLELEKQAYYLTYILLHLVGEVSCSHSLSSGQRKHFVLLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS