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SLF2

Gene
Slf2
Protein
SMC5-SMC6 complex localization factor protein 2
Organism
Mus musculus
Length
1278 amino acids
Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions.
Similarity
Belongs to the FAM178 family.
Mass
143.97 kDa
Sequence
MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTAPAAAGKRTESPGDRKQSIIDFFKPAAKQDKHMLDSPQKSNIKYRGNGLSITGTEQFERKLSSPKKLKPKRMSSEESPILEAFMKGGKEHHKDRGVHESRRPCMSLSKYLPKGAGIYAPSSYRLPKEIKAQKKKHQSPERRKSLFIHESNREKNDRDRGKNSEDSRKQATATEGDIFKHSSRSISSRSSLSRHHPGESTLGARFQLSLASYWREREQKKLRKEQMEQRINSENSFSEASNLSLKSSGVGKNCKPRHEHSKHTEAVPGKSNLSTLENGHLSRKRSSSDSWELSGSKQNKFSDKRTEELCGLRPEKHKRTYHTKSKRVLSREAPRHIPSERKVYQTHCTEDSWWCSALGRHSQGAGKTVSRGMSIASTLRLYLGRVISQLWKMDISQEKDHLQTRGNFQALNRINSPTKEQRNSVDSDLKSTKEPIIPKARESFLEKRPDTSHQREKFIRHIALKTPGGVLRLEDIAKEPEDETDRSSADSAPSNAGHHSSRNSDQVHSASTKETKIQKPHLPLPQEKSTIKRASNLQKNKPAGSVTSKETKLPLLSHVPSAVSSRVPLNAKNCTLPVPKKDKERSSSKERSGHSTESSKHKEHRAKTIKAVSNESSGKNSGGSLHSEYAPPTASPPAALEVVPSVPSPAAPSDKESSGNSNAGSNALKRKFRGDFDSDEESLGYTLESDEEEETLKSLEEIMALNFSRTPTTSGKPPAVSKGLRSQSSDMKEYAQSGTYTNTLERLVKEMEDTQRLDELQKKLQEDIRQGRGIKSPLRTGDQDSTDDGDGLLEEHREFLKKFSVTVDAIPDHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGESAVEKLILKSGKTDQIFLTTQGFLTTAYHYVQCPVPVLKWLFRMMSVHTDCIVSVQILSTLMEITIRNDTFSDSPVWPWIPSLSDIAAVFFNMGVGFGSLFPLETLQPDFNEENLISETQKTLGGKESEDSPYSPVFSALPETNILNVVKFLGLCTSIHPEGYQDGELMLLILMLFKMSLEKELKQIPLVDFQSLLINLMKNIRDWNTKVHELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVMMSKLLDEKHEDIPNANNLQISVLHRYLVQMKPSDLLKKMVLKKRAEQPNETIDDSLHLELEKQAYYLTYILLHLVGEVSCSHSLSSGQRKHFVLLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS

Gene
SLF2
Protein
SMC5-SMC6 complex localization factor protein 2
Organism
Pongo abelii
Length
1174 amino acids
Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions.
Similarity
Belongs to the FAM178 family.
Mass
132.017 kDa
Sequence
MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTAHAAAGKRTESPGDRKQSIIDFFKPASKQGRHMLDSPQKSNIKYGGSRLSITGTERFERKLSSPKKSKTKRVPPEKSPIIEAFMKGVKEHHEDHGIHESCRPCVSLASKYLAKGTNIYVPSSYHLAKEMKSLKKNHRSPERRKSLFIHENNEKNDRDRGKTNADSKKQTTVAEADIFKNSSRSLSSRSSLSRHHPGESPLGAKFQLSLASYCRERELKRLRKEQMEQRINSENSFSEASNLSLKSSSIERKYKPRQEQRKQNDVIPGKNNLSNVENGHLSRKRSSSDSWEPTSAGSKQNKFPEKRKRNSVDSDLKSTRESMIPKARESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDISKEPNDETDCSSAGLAPSNSGSSGHHSTRNSDQIRVAGTKETKMQKPHLPLSQEKSAIKKASNLQKNKTTSSMTKEKETKLPLLSHVPSAGSSLVPLNAKNCALPVSKKDKERSSSKECSGHSTESTKHKEHKAKTNKADSNVSSGKISGGPLCSEYGAPTKSPPAALEVVPCVPSPAAPSDKAPSERESSGNSNAGSSALKRKLRGDFDSDEESLGYNLDSDEEEETLKSLEEIMALNFNQTPATTGKPPALSKELRSQSSDYTGHDHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIRQGRGIKSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDAIPDHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSVHTDCIVSVQILSTLMEITIRNDTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPDFNEDYLVSETQTTSRGKESEDSSYKPIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLINLMKNIRDWNTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHEDVPNASNLQVSVLHRYLVQMKPSDLLKKMVLKKKAEQPDGIIDDSLHLELEKQAYYLTYILLHLVGEVSCSHSFSSGQRKHFVLLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS

Gene
SLF2
Protein
SMC5-SMC6 complex localization factor protein 2
Organism
Homo sapiens
Length
1173 amino acids
Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).
Similarity
Belongs to the FAM178 family.
Mass
131.873 kDa
Sequence
MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTAHAAAGKRTESPGDRKQSIIDFFKPASKQDRHMLDSPQKSNIKYGGSRLSITGTEQFERKLSSPKESKPKRVPPEKSPIIEAFMKGVKEHHEDHGIHESRRPCLSLASKYLAKGTNIYVPSSYHLPKEMKSLKKKHRSPERRKSLFIHENNEKNDRDRGKTNADSKKQTTVAEADIFNNSSRSLSSRSSLSRHHPEESPLGAKFQLSLASYCRERELKRLRKEQMEQRINSENSFSEASSLSLKSSIERKYKPRQEQRKQNDIIPGKNNLSNVENGHLSRKRSSSDSWEPTSAGSKQNKFPEKRKRNSVDSDLKSTRESMIPKARESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDISKEPSDETDGSSAGLAPSNSGNSGHHSTRNSDQIQVAGTKETKMQKPHLPLSQEKSAIKKASNLQKNKTASSTTKEKETKLPLLSRVPSAGSSLVPLNAKNCALPVSKKDKERSSSKECSGHSTESTKHKEHKAKTNKADSNVSSGKISGGPLRSEYGTPTKSPPAALEVVPCIPSPAAPSDKAPSEGESSGNSNAGSSALKRKLRGDFDSDEESLGYNLDSDEEEETLKSLEEIMALNFNQTPAATGKPPALSKGLRSQSSDYTGHVHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIRQGRGIKSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDAIPDHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSVHTDCIVSVQILSTLMEITIRNDTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPDFNEDYLVSETQTTSRGKESEDSSYKPIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLINLMKNIRDWNTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHEDVPNASNLQVSVLHRYLVQMKPSDLLKKMVLKKKAEQPDGIIDDSLHLELEKQAYYLTYILLHLVGEVSCSHSFSSGQRKHFVLLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS