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SLF1

Gene
SLF1
Protein
SMC5-SMC6 complex localization factor protein 1
Organism
Homo sapiens
Length
1058 amino acids
Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).
Mass
121.05 kDa
Sequence
MEDGTPKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKDNFKAPFYPIQYLGDFLLEKEIQNDEDSQTNSVWTEHSNEETNKDFRKDAGFLEMKGALRETMYRTQKEMQNHEDVNVGSILIQHHKKEKFSGSSKDLKFVKMRNTFGSHTYENQKEIKKKDEDIQRSYTLRRKRKKGKESNCKKGVEHEKIKSTLRRHIYNRDQKEMKNSIFAEYAKESKAMAIKTDVDVVEIKNTLRKHIYRAQAVRYNCIRIDKQPVYNVEVKNAEFPRGVLNLIESLIEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDNIDTFSGRYFHILSALLHLHPPWKSPAMSRYYLELFQCPTCMKGAWSLVEVLIRSCLFNESFCHQISENIGSKVLHLTLLKFFFNLIESEVQHLSQKLYDWSDSQNLKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKFKSNDVFKHELAYLLAGILGAAIDYWIFLGLKMGRNVMRHMSDDLGSYVSLSCDDFSSQELEIFICSFSSSWLQMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGVLGSGKIQVSKKIGQRPCFDSQRTLLMLNGTKQKQVEGLPELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLSRMLLNFCSIFDLSSEFILASKGLTHLNELLMACKSHKETTSVHTDWLLDLYAGNIKTLQKLPHILKELPENLKVCPGVHTEALMITLEMMCRSVMEFS

Gene
SLF1
Protein
SMC5-SMC6 complex localization factor protein 1
Organism
Bos taurus
Length
1055 amino acids
Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions.
Mass
121.017 kDa
Sequence
MEDDAPKHIIQMTGFKVEEKEALGKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGKWVLTKDYIIHSAQSGRWLDETTYEWGYKIEKDSHYSPQMQSAPKRWREELKRTGAPGAFHKWKVVLLVRADKRSDSLVRVLEAGKANVILPKNSPTGITHVIASNARIKAEQEKDDFKAPFYPIQYLEDFLLEKEIHNDEDSQTNSTWKNHSSQEKSNDFRENMGFLEMKGTLKETMCRTQKEMKNHDEDVTISSILTEHQSKERFRDSRKNLKFVKMRNALGRHTYRNQEMKKKDEDIQSIYTLRKKRKKEKERDSRKDIEHDRSTLRKHIYRDQKERKNSVFAGHAKESKTKDIRTNVDIVDLKNALRKHIYRAQAVRYRGIRIDKQPAYNVEVKNAEFPRGILNLIESLIEGQFFKEAIEELSSLQAHYIPPVYLLHALLENILQDNIDTFSGRYFHILSALLHLHPPWKSPAMSTYYLELFQCPTCMKGTWSLIEVLIRSCLFNESFCHQISENIIGSKVLHLTLLKFFFNLIESEVRHLSQKLYDWSDSQSLKITGKAVLLEIFWSGNETSGLLTKPVNMLLEWTIYSHKEKCKSNDVFRHELAYLLTGILGAAIDYWIVLGLNMGRNVMRHMSDDVGSYVSLSCDDFSSQDLEIFISSFSSSWLQMFVAEAVFKKLCLQNSISISSEPLSLQKMVYSYLPALGKTGVRGTRKMQKPKKIGLRPCFESQRALIMLNGAKQKQGEGLPEIPELNLAKCSSSLKRLKKKSEGELSCSKENCPSLVTKINFHKTNLKGETALHRACINNQVDRLILLLSMPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNSKGELPLDYVVSSQIKEELFAITKIEDTVENFHAQAEKHFYHQQLEFGSFLLSRMLLNFCSIFGLSSESLAFKGLTHLSELLIACQNYKETTSVHTDWLLDLYARNIMTLQKLPNALKELPENVKVCPGVHTEALLVTLEVMCRSVTEIS

Gene
Slf1
Protein
SMC5-SMC6 complex localization factor protein 1
Organism
Mus musculus
Length
1054 amino acids
Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions.
Mass
121.004 kDa
Sequence
MEDSATKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGKWVLTKDYIIHSAKSGRWLDETTYEWGYKIEKDSHYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRADKRSDSLVRVLEAGKANVILPKNSPSGITHVIASNARISAEREQENFKAPFYPIQYLGDFLLEKEIQNDEHSQISPAWTKYNNQEKGNDVGFPEMKGAGENMYRTQNKMENHNKNVSDRFVLSEHHKKKFKDFRKDIRSVKKRNTLRRHGLENQKETKKKDKNIQRSYILRKKNKKEGYCKTDDAHDTIRSMLKKRGHYREQKEMKNPLLTDGTKESKTKDVKTNMNLIEIKNALKKQIYKDIYRAQAVRYNCIRVDKQPVYNVEVKNSEFPRGILNLIENLIEGQFFKEAIEELSSLQAHYIPPVCLLHAILENVLQDKIDTFSGRYFHILSALLHLHPPWKSPAMLKYYLELFQCPTCMKGAWDFTEVLIRSCLFNEDFCHQISENISTKVVNLTLLKFFFNLLEGEVRHLSQKLCDWSDSQSLKVTEKAILHEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKCKSNDVFKHELSYLLTGILGAAVDYWIFLGIQMGRNVIRHMSDDLGSYISLSCDDFSSKELEIFICSFSSSWLQMFVAEAIFKKLCLQGPTSTCTEPLSLQKIIDSYLPILGKMDIHGAGKMQSPKKLCQRPCLESQRALLMLNGAKRKQAEGRPELLELNRAKCSSSLKKLKKKSEELSCSKENCPSLVTKMNFHKTNLKGETALHRVCIKNQVEKLIILLSLPGIDINVKDNAGWTPLHEACNYGNTECVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQRGGPELLQQRNSKGELPLDYVLSPKDKEELFAITNIDDTVDNFHAKTQKHFYHQQLEFGSFLLSRMLINFCSIFDLSSEFILAFKGLGHLNELLMACNSDTEASNAHTDWLLDVYARNIKTLKKLPSVLKELPENLNVCPGVHTEALLVTLKMMCQSITELS

Gene
SLF1
Protein
Protein SLF1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
447 amino acids
Function
Regulates the copper-dependent mineralization of copper sulfide complexes on the cell surface in cells cultured in medium containing copper salts.
Mass
50.943 kDa
Sequence
MSSQNLNDNPKNTSSAAEDKKKQTSSLKLAPIPTTSPWKSSSPDSNTVIPVEELRDISKTAKPSKNGSGSIKLTSNTKWTPITPSVIISGSKDTNSKSGKNSKNSKTNKKMKKRGKYNNDINKKDFNGQTNSTSEISNVSNLESKPLDANAKVNIHSSSGATANGNIKRITNNNNSTNGRQSRNYQNRNGKTRYNNNSRHSQAANNAISFPNNYQARPEYIPNASHWLNNNSRNSYKQLSYFRQQQYYNNINYQQQLQTPYYYSMEPIFKSIESIKNQIEFYFSEENLKTDEFLRSKFKKANDGFIPMSLIGKFYRMVNLSLGGDPNLILASMREVLQHKETNHLEIALGSIEGAQKNMADDFNPLENYFIRRENWAEYAMESNFDENDDETEKYNIEKLLGPNDLDNYSYMGYPNFFPSNENGKKSQSYDQGEISRQFEQNLQIND