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SLC51B

Gene
slc51b
Protein
Organic solute transporter subunit beta
Organism
Leucoraja erinacea
Length
182 amino acids
Function
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. May modulate slc51a glycosylation, membrane trafficking and stability activities (By similarity). Able to transport taurocholate, estrone sulfate, digoxin, and prostaglandin E(2), but not p-aminohippurate or S-dinitrophenyl glutathione.
Similarity
Belongs to the OST-beta family.
Mass
20.343 kDa
Sequence
MSGLLKYLFGCFILCLLLQGKTHMTSATISKPHETIDIEKQNMTGERNSTLAQQLSFPMEDPTNWNYAILALAFVVLFLAFLILAQNSRANRTRKMKALNGAGGRNETEADSTQKAMMQYVVEVDNLAETDQMLQSKPTYISLNQVAQTSSPKVLPKEGQILVEWKDGNIGFLYTDSKEDDV

Gene
SLC51B
Protein
Organic solute transporter subunit beta
Organism
Bos taurus
Length
130 amino acids
Function
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities (By similarity).
Similarity
Belongs to the OST-beta family.
Mass
14.599 kDa
Sequence
MNYSEKLTGAPPMTEVPLELLEEMLWFFRVEDATPWNCSMFVLAALVAIISFILLGRNIQANRNQKKLPPEKQTPEVLYLAEGGNKDDKNLTSLTETLLSEKPTLAQGEMEAKCSDVPRVHLPDPQEPES

Gene
SLC51B
Protein
Organic solute transporter subunit beta
Organism
Homo sapiens
Length
128 amino acids
Function
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
Similarity
Belongs to the OST-beta family.
Mass
14.346 kDa
Sequence
MEHSEGAPGDPAGTVVPQELLEEMLWFFRVEDASPWNHSILALAAVVVIISMVLLGRSIQASRKEKMQPPEKETPEVLHLDEAKDHNSLNNLRETLLSEKPNLAQVELELKERDVLSVFLPDVPETES

Gene
Slc51b
Protein
Organic solute transporter subunit beta
Organism
Mus musculus
Length
128 amino acids
Function
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
Similarity
Belongs to the OST-beta family.
Mass
14.684 kDa
Sequence
MDHSAEKAAANAEVPQELLEEMLWYFRAEDAAPWNYSILVLAVLVVMTSMFLLRRSILANRNRKKQPQDKETPEDLHLDDSIMKENNSQVFLRETLISEKPDLAPGEPELKEKDSSLVFLPDPQETES