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SLC35A1

Gene
SLC35A1
Protein
CMP-sialic acid transporter
Organism
Homo sapiens
Length
337 amino acids
Function
Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function (PubMed:15576474). Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity).
Similarity
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Mass
36.779 kDa
Sequence
MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV

Gene
SLC35A1
Protein
CMP-sialic acid transporter
Organism
Cricetulus griseus
Length
336 amino acids
Function
Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function (PubMed:9310377). Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity).
Similarity
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Mass
36.608 kDa
Sequence
MAQARENVSLFFKLYCLAVMTLVAAAYTVALRYTRTTAKELYFSTTAVCVTEVIKLLISVGLLAKETGSLGRFKASLSENVLGSPKELMKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCGGVILVQWKPAQATKVVVEQSPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIVVTLVGTYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLSFAMGALLVCISIYLYGLPRQDTTCIQQEATSKERVIGV

Gene
Slc35a1
Protein
CMP-sialic acid transporter
Organism
Mus musculus
Length
336 amino acids
Function
Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function (PubMed:8755516, PubMed:10085119, PubMed:30985278). Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter (PubMed:30985278). Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (PubMed:30985278).
Similarity
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Mass
36.453 kDa
Sequence
MAPARENVSLFFKLYCLTVMTLVAAAYTVALRYTRTTAEELYFSTTAVCITEVIKLLISVGLLAKETGSLGRFKASLSENVLGSPKELAKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWISVFMLCGGVTLVQWKPAQATKVVVAQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIVVTLAGTYLSDGAEIQEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVLLFGLQITLSFALGALLVCVSIYLYGLPRQDTTSIQQEATSKERIIGV