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SLC2A5

Gene
Slc2a5
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Organism
Rattus norvegicus
Length
502 amino acids
Function
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:26416735, PubMed:8333543, PubMed:9820812). Can mediate the uptake of deoxyglucose, but with low efficiency (PubMed:8333543). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
Similarity
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Mass
55.543 kDa
Sequence
MEKEDQEKTGKLTLVLALATFLAAFGSSFQYGYNVAAVNSPSEFMQQFYNDTYYDRNKENIESFTLTLLWSLTVSMFPFGGFIGSLMVGFLVNNLGRKGALLFNNIFSILPAILMGCSKIAKSFEIIIASRLLVGICAGISSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQLFGLRSVLASEEGWPILLGLTGVPAGLQLLLLPFFPESPRYLLIQKKNESAAEKALQTLRGWKDVDMEMEEIRKEDEAEKAAGFISVWKLFRMQSLRWQLISTIVLMAGQQLSGVNAIYYYADQIYLSAGVKSNDVQYVTAGTGAVNVFMTMVTVFVVELWGRRNLLLIGFSTCLTACIVLTVALALQNTISWMPYVSIVCVIVYVIGHAVGPSPIPALFITEIFLQSSRPSAYMIGGSVHWLSNFIVGLIFPFIQVGLGPYSFIIFAIICLLTTIYIFMVVPETKGRTFVEINQIFAKKNKVSDVYPEKEEKELNDLPPATREQ

Gene
SLC2A5
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Organism
Ovis aries
Length
501 amino acids
Function
Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
Similarity
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Mass
55.547 kDa
Sequence
MEPQDPVKREGRLTPVIVLATLIAAFGSSFQYGYNVATINSPSEFMKDFYNYTYYDRVGEYMNEFYLTLLWSVTVSMFPFGGFLGSLMVGPLVNNLGRKGTLLFNNIFSIVPALLMGFSDLAKSFEMIIVARVLVGICAGLSSNVVPMYLGELAPKNWRGALGVVPQLFITIGILVAQIFGLRSLLANEEGWPILLGLTGIPAVLQLLFLPFFPESPRYLLIQKKDEEAAKRALRRLRGWHDVDAEIEEILEEDRAEKAAGFISVLKLFKMRSLRWQVISIIVLMAGQQLSGVNAIYYYADQIYLSAGVKEDDVQYVTAGTGAVNVLITVCAIFVVELMGRRFLLLLGFSVCFTACCVLTGALAMQDVISWMPYVSIACVISYVIGHALGPSPIPALLVTEIFLQSSRPAAYMVAGTVHWLSNFTVGLVFPFIQVGLGAYSFVIFAVICFLTTVYIFLIIPETKSKTFIEINQIFIKMNKVPGVHPEKEELKEFPPSTARQ

Gene
SLC2A5
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Organism
Bos taurus
Length
501 amino acids
Function
Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
Similarity
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Mass
55.393 kDa
Sequence
MEPQDPVKREGRLTPVIVLATLIAAFGSSFQYGYNVAAINSPSEFMKDFYNYTYYDRVGEYMNEFYLTLLWSVTVSMFPFGGFLGSLMVGPLVNNLGRKGTLLFNNIFSIVPALLMGFSELAKSFEMIIVARVLVGICAGLSSNVVPMYLGELAPKNWRGALGVVPQLFITIGILVAQIFGLRSLLANEEGWPILLGLTGIPAVLQLLFLPFFPESPRYLLIQKKDEAAAKSALRRLRGWHDVDAEIEEILEEDRAEKAVGFISVLKLFKMRSLRWQVISIIVLMAGQQLSGVNAIYYYADQIYLSAGVNEDDVQYVTAGTGAVNVLITVCAIFVVELMGRRFLLLLGFSVCFTACCVLTGALALQDVISWMPYVSIACVISYVIGHALGPSPIPALLVTEIFLQSSRPAAYMVAGTVHWLSNFTVGLVFPFIQVGLGAYSFVIFAVICLLTTVYIFLIIPETKSKTFIEINRIFIKMNKVPGVHPEKEELKEFPPSTARQ

Gene
SLC2A5
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Organism
Equus caballus
Length
501 amino acids
Function
Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
Similarity
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Mass
54.825 kDa
Sequence
MEQQDPIKKEGRLTPVLALATLIAAFGSSFQYGYNVAAVNSPAELMKAFYNETHYSRFSEYISEFSLTLLWSISVSMFPFGGFVGSLMVGPLVNRLGRKGTLLFNNIFSIVPAILMGTSKTARSYEMIILSRLLVGICAGLSSNVVPMYLGELSPKNLRGALGVVPQLFITVGILVAQIVGLRSLLATEEGWPILLGLTAIPAALQLLLLPFFPESPRYLLIQKKDAAAAKNALKRLRGWDDVDAEMEEIQLEDEAEKAAGIISVLTMFRMRSLRWQVISIIILMGGQQLSGVNAIYYYADQIYLSAGVKDQDVQYVTVGTGAVNVLMTICAVFVVEYLGRRALLLLGFSVCFIACCVLTVALALQDRVSWMPYISIVCVISYVIGHALGPSPIPALLITEVFLQSSRSAAYMVGGTVHWLSNFAVGLVFPFIQVGLGAYSFIIFAVICLLTTIYIFLIVPETKGKTFVEINHIFTKMNKVSDVHPAKDELKDIPLSAVEL

Gene
SLC2A5
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Organism
Homo sapiens
Length
501 amino acids
Function
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
Similarity
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Mass
54.974 kDa
Sequence
MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ

Gene
Slc2a5
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Organism
Mus musculus
Length
501 amino acids
Function
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:12031501, PubMed:19091748). Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine (PubMed:19091748, PubMed:26071406). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (PubMed:19091748). Required for the development of high blood pressure in response to high dietary fructose intake (PubMed:19091748).
Similarity
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Mass
55.409 kDa
Sequence
MEEKHQEETGELTLVLALATLIAAFGSSFQYGYNVAAVNSPSEFMQQFYNDTYYDRNEENIESFTLTLLWSLTVSMFPFGGFIGSLMVGTLVNKLGRKGALLFNNIFSILPAILMGCSQIAQSFELIIISRLLVGICAGISSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQLFGLRSLLANEDGWPVLLGLTGVPAGLQLLLLPFFPESPRYLLIQKKDEAAAERALQTLRGWKDVHLEMEEIRKEDEAEKAAGFISVWKLFTMQSLRWQLISMIVLMAGQQLSGVNAIYYYADQIYLSAGVKSDDVQYVTAGTGAVNVFMTILTIFVVELWGRRFLLLVGFSTCLIACLVLTAALALQNTISWMPYISIVCVIVYVIGHALGPSPIPALLITEIFLQSSRPAAYMIGGSVHWLSNFTVGLIFPFIQMGLGPYSFIIFATICFLTTIYIFMVVPETKGRTFIEINQIFTMKNKVSDVYPKKEEELGALPHAILEQ

Gene
SLC2A5
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Organism
Pongo abelii
Length
501 amino acids
Function
Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
Similarity
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Mass
54.982 kDa
Sequence
MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVAKSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLVLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPKEHVQFVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLVACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTLEQ

Gene
SLC2A5
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Organism
Oryctolagus cuniculus
Length
486 amino acids
Function
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:7980458). Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
Similarity
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Mass
53.854 kDa
Sequence
MEQEGQEKKKEGRLTLVLALRTLIAAFGSSFQYAYNVSVCNSPSELMTEFYNDTYYDRTGELIDEFPLTLLWSVTVSMFPSGGFAGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSKVARSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVESQLFITLGILVAQIFGLRSIRQQKGWPILLGLTGGPAAAACPPFFPESPRYLLIGQEPRCRQKALQSLRGWDSVDRELEEIRREDEAARAAGLVSVRALCAMRGLAWQLISVVPLMWQQLSGVNAIYYYDQIYLSPLDTDTQYYTAATGAVNVLMTVCTVFVVESWARLLLLLGFSPLAPTCCVLTAALALQDTVSWMPYISIVCIIVYVIGHAIGPAIRSLYTEIFLQSGRPPTWWGQVHWLSNFTVGLVFPLIQWAGLYSFIIFGVACLSTTVYTFLIVPETKGKSFIEIIRRFIRMNKVEVSPDREELKDFPPDVSE