Protein
Sodium/potassium/calcium exchanger 1
Function
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity).
Similarity
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
Sequence
MGKLIRMGAQERRSLWPKRLHWSRPLFLLGMLIIGSTYQYLTSPQGLPTLWAAVSSQHPVKVASRDLSNKEMMMVSSETSKSSSEMEVEAWAPEATAGRDGTPPGIARKNTPSTPRGTASITPAIPNNYSPTPTGTGKVKEDTSATPSGVLNHYTQSRPMVNSYTRLTARGEVKSSRPTQSRGKEEKYSPSPLGRMVNSYAPSTLMTMPRSHGITPRTTVKDREIMATKKMLATNPSKRLVEKTTPTPLKGITDNTPTFLLSDLETDTLTSPRNVVEKKTLTTPRRVDSNSSTNHQGLVGKNNLTTPQGMVLEHTAAVSEGQVTISTMTRSSPTETKASTDAWKVRNPLPRTSAPIIRISSATFRGLLKNPSKAPSTPAAPRVRANPTIQVRHCLVVEPAPVAPTAPSPSWTTAVIPGIPSPSGQPDLYPKAEYPRDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDITFYIFDLMMLILFFLDSLIAWWESVLLLLAYAFYVFTMKWNQQLELWVKEQLNKRPVAKVMALGDLSKPGDGTVVVDEQQDNKKLKLSSMLTRGSSSASLHNSTIRSTIYQLMLHSLDPLGEARPSKDKEEETLIPEAKATPQAKAESKPEEEPAKLPEVTVTPAPAPDVKGDQEEDPGSQGVGAEAENTGERTGGEAEAPAEGENGERSGGDAALGGESEGKAENESEGDIPAERRGDDEDEGEIQAEGGEVKGDEDEGEIQAGEGGEVEGDEDEGEIQAGEGGEVEGDEDEGEIQAGEAGEVEGDEDEGEIQAGEGGEVEGDEDEGEIQAGEAGEVEGDEDEGEIQAGEGGEVKGDEGEIQAGEAGEVEGEDGEVEGGEDEGEIQAGEGGEGETGEQELNAEIQGEAKDDEEGVDGEGGGDGGDSEDEEEEDEEEEDEEEEEEEEEEEEEENEQPLSLEWPETRRKQAIYLFLLPIVFPLWLTVPDVRRLEAKKFFVITFLGSILWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWMLFSLINGLQPVAVSSNGLFCAIVLLFLMLLFVISSIALCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV