SLC22A8

Solute carrier family 22 member 8

543 amino acids

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney.

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

59.387 kDa

MTFAELVDRVGSKGPFQLLHTVLLGLPILGMANHNLLQIFTAPTPAHHCRPPPNASAGPWVLPTGLNGKPETCLRFVYPPNASLPNDTRGATEPCLDGWIYNIVDRDSIVTEWDLVCSSSKLKEMAQSVFMAGILVGGLVLGALSDRFGRKPILIFSYLLLGASGSGAAFSPTFSIYAVFRFLCGFSISGISLSTAILNVEWVSTRFRAIKSIAVGFFYTFGQFILPGLAYAIPQWRWLQLTVSVPFLTFFLLSWWLPESIRWMVLSGKSSKALKTLRQVAIFNGKKEEGEKLSLEELKLNLQKEISLAKARHGIADLFRTPVLRRVTLCLSLAWFATGFAYYSLAMGVEEFGVNLYVLQLIFGGVDVPAKFITMLSISYLGRHITEGIVLLLAGGCILALIFVPLDLMTLRTVLAVFGKGCLSGSFSCLFLYTSELYPTVIRQTGMGASNLWARVGSMTAPLVKITGELQPFIPNIIFGTIALLGGSAALFLPETLNRPLPETIEDIETWSLRAKEPKPEPEAEKSSQRIPLQPCEPGPGPS

SLC22A8

Solute carrier family 22 member 8

542 amino acids

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

59.856 kDa

MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS

SLC22A8

Solute carrier family 22 member 8

542 amino acids

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Transports specifically estrone-3-sulfate (E1S), benzylpenicillin (PCG), methotrexate and estradiol-17-beta-glucuromide. Also transports 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), p-amino-hippurate (PAH) and indoxyl sulfate (IS).

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

59.785 kDa

MTFSEILDRVGSMGRFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRLPPNASAGPWVIPMGPNGKPERCLRFVHPSNASLPNDTQRSMEPCLDGWVYNSTKDSIVTEWNLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPVYVVFRFLCGCGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTVGQFILPGLAYAIPQWRWLQLTVSIPFFIFFLSSWWTPESIRWLVLTGKSSKALKILRRVAAFNGKKEEGERLSLEELKLNLQKEISLAKAKYTAADLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDIPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMLSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKEPKQEPEVEKASQRIPLQPYGPDLGSS

SLC22A8

Solute carrier family 22 member 8

542 amino acids

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney.

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

59.847 kDa

MTFSEILDRVGSMGRFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPPNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNETQRATEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFIFFLSSWWTPESIRWLVLSGKSSKALKILRRVAAFNGKKEEGERLSLEELKLNLQKEIALAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLPSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMLSPLVKITGEVQPFIPNIIYGITALLGGSAAFFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS

SLC22A8

Solute carrier family 22 member 8

542 amino acids

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney.

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

59.584 kDa

MTFSEILDRVGSMGPFQFLHVALLGFPILGMANHNLLQIFTATTPSHHCRPPPNASAGPWVLPVNQNGQTERCLRFVHPPNASLPNDTQGATEPCLDGWVYNSTRDTIVTEWDLVCSSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRKPILTCCYLLLAASGSSTAFSPTLPIYMVFRFLCGFSISGISLSTVILNVEWVPTKMRAITSTAIGYCYTIGQFILPGLAYAIPQWRWLQLTVSVPYFIFSLLSWWIPESIRWLVLAGKSSKALKILRRVATFNGKKEEGEKLSLEELKLSLQKDISLAKAKYSTADLFRTPILRRVTLCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSLSYLGRHITQGAALILAGAAILSLIFVPMDMSLLRTILAVFGKGCLSGSFSCLFLYTSELFPTVIRQTGMGISNVWARVGSMISPLVKITGEIQPFIPNIIYGTVALLGGSAALFLPETLNQPLPETLEDMENWFLQSKKLKQEPEAEKASQRIPLQPSGPGVDRS

Slc22a8

Solute carrier family 22 member 8

537 amino acids

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Mediates the uptake of p-amino-hippurate (PAH) and estron sulfate (ES). Also mediates uptake of several organic compounds such as prostaglandin E(2), prostaglandin F(2-alpha), allopurinol, 6-mercaptopurine (6-MP), 5-fluorouracil (5-FU), and L-carnitine.

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

59.246 kDa

MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRPPPNASLEPWVLPLGPNGKPEKCLRFVHLPNASLPNDTQGATEPCLDGWIYNSTRDTIVTEWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQLSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTVEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVSSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLETLNRPLPETIEDIQDWYQQTKKTKQEPEAEKASQTIPLKTGGP

Slc22a8

Solute carrier family 22 member 8

536 amino acids

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Functions as one of the detoxification systems on the choroid plexus (CP) by removing substrates from the cerebrospinal fluid (CSF). Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient. Mediates the uptake from brain of organic anions, such as p-aminohippurate (PAH), ochratoxin A, and estrone sulfate (ES) and a cationic compound, cimetidine in a sodium independent manner. Mediates the uptake of benzylpenicillin (PCG), 2,4-dichloro-phenoxyacetate (2,4-D) and PAH in CP. Mediates the efflux of PAH, pravastatin, pitavastatin and PCG from the cerebrum into the blood circulation across the blood-brain barrier (BBB). Involved in regulating the CSF concentration of H(2)-receptor antagonists at the CP. Mediates the renal uptake of indoxyl sulfate (IS), 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) pravastatin, PCG, dehydroepiandrosterone sulfate (DHEAS) and is partly involved in the renal uptake of temocaprilat and ES.

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

59.186 kDa

MTFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPPPNASIGPWVLPLDPNGKPEKCLRFVHLPNASLPNDTQRATEPCLDGWIYNSTRDTIVIEWDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETIEDIQNWHKQVQKTKQESEAEKASQIIPLKTGG