Function
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), and edaravone sulfate (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), cimetidine (CMD), indoxyl sulfate (IS), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF). PAH uptake is inhibited by furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), diclofenac, carprofen, sulindac, calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), glutarate and alpha-ketoglutarate (By similarity).
Sequence
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTVQNFTAAIPTHHCRPPANANLSKDGGLEAWLPRDRQGQPESCLRFTSPQWGPPFPNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMSLAGIALNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLISVPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVVPQDQSVIRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLVSMTTELYPSVPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTPQQQEHQKYMVPLQASAQEKNGL