SIKE1

Suppressor of IKBKE 1

207 amino acids

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity).

Belongs to the SIKE family.

23.675 kDa

MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGTALPDQYQEDASDIKDMSKYKPHILLSQENTQIRDLQQENRELWVSLEEHQDALELIMSKYRKQMLQLMVAKKAADAEPVLKAHQSHSAEIENQIDRICEMGEVMRKAVQMDDDQFCKIQEKLAQLELENKELRELLSISSESLQVRKESSVDTASQGIK

SIKE1

Suppressor of IKBKE 1

207 amino acids

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

Belongs to the SIKE family.

23.721 kDa

MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGTALPDQYQEDASDMKDMSKYKPHILLSQENTQIRDLQQENRELWISLEEHQDALELIMSKYRKQMLQLMVAKKAVDAEPVLKAHQSHSAEIESQIDRICEMGEVMRKAVQVDDDQFCKIQEKLAQLELENKELRELLSISSESLQARKENSMDTASQAIK

Sike1

Suppressor of IKBKE 1

207 amino acids

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity).

Belongs to the SIKE family.

23.522 kDa

MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGAVLPEQYQEDASDVKDMSKYKPHILLSQENTQIRDLQQENRELWVSLEEHQDALELIMSKYRKQMLQLMVAKKAVDAEPVLKAHQSHSAEIESQIDRICEMGAVMRRAVQVDDNQFCKVQERLAQLELENKELRELLSISSESLQVGKESSVAPASQTIK

SIKE1

Suppressor of IKBKE 1

207 amino acids

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity).

Belongs to the SIKE family.

23.753 kDa

MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGTALPDQYQEDASDMKDMSKYKPHILLSQENTQIRDLQQENRELWISLEEHQDALELIMSKYRKQMLQLMVAKKAVDAEPVLKAHQSHSAEIESQIDRICEMGEVMRKAVQMDDDQFCKIQEKLAQLELENKELRELLSISSESLQARKENSMDTASQAIK

Sike1

Suppressor of IKBKE 1

207 amino acids

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity).

Belongs to the SIKE family.

23.578 kDa

MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGAVLPEQYQEDASDVKDMSKYKPHILLSQENTQIRDLQQENRELWVSLEEHQDALELIMSKYRKQMLQLMVAKQAVDAEPVLKAHQSHSAEIESQIDRICEMGAVMRRAVQVDDNQFCKIQEKLAQLELENKELRELLSISSESLQVGKESSVAPEAQTIR

sike1

Suppressor of IKBKE 1

207 amino acids

Suppressor of IKK-epsilon.

Belongs to the SIKE family.

23.997 kDa

MTCTIDKILQDAKTLLERLKDHDNAAESLIDQSSALHKRVEAMKEVGTAMPEKYQEELADIKDASKLKPHVLLCQENTQIRDLQQENKELWVSLEEHQYALELIMSKYRKQMLQLVANKKPAPTEPVLEAHKTFSSDLECQIDRICVMGDIMRDAIQLDEDKAYNIQEKLAQLELENKELREILSTSKESLHSSKRESEWNFSEKTQ

sike1

Suppressor of IKBKE 1

205 amino acids

Suppressor of IKK-epsilon.

Belongs to the SIKE family.

23.86 kDa

MTCTIDKILQDAKTLLERLKDHDNAAESLIDQSSVLHKRVKAMKEVGTAMPEKYQEELAEIKDASKLRPHVLLCQENTQIRDLQLENKELWLSLEEHQYALELIMSKYRKQMLQLIANKIPAPTEPVLEAHKTFSSDLECQIDRICVIGDAMRKAIQLDEDQAYNIQERLAQLELENKELREILSVRNESLRSSKKESEWNFSEK