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SIGMAR1

Gene
SIGMAR1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Bos taurus
Length
223 amino acids
Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
24.914 kDa
Sequence
MCWAVGRRWAWAALLLAVAAVLAQVVWLWLGTQSFVFQHEEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEDLQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSSGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDA

Gene
SIGMAR1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Cavia porcellus
Length
223 amino acids
Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
25.311 kDa
Sequence
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP

Gene
SIGMAR1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Homo sapiens
Length
223 amino acids
Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
25.128 kDa
Sequence
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP

Gene
Sigmar1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Mus musculus
Length
223 amino acids
Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane (PubMed:12730355). Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:11149946, PubMed:14622179, PubMed:15571673, PubMed:15777781, PubMed:23332758, PubMed:9425306, PubMed:9603192). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (PubMed:25678561). Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (PubMed:26792191).
Similarity
Belongs to the ERG2 family.
Mass
25.25 kDa
Sequence
MPWAAGRRWAWITLILTIIAVLIQAAWLWLGTQNFVFSREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCILHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWKEGTTKSEVFYPGETVVHGPGEATALEWGPNTWMVEYGRGVIPSTLFFALADTFFSTQDYLTLFYTLRAYARGLRLELTTYLFGQDS

Gene
SIGMAR1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Mustela erminea
Length
223 amino acids
Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
25.145 kDa
Sequence
MQWALGRRWVWAALLLAAAAVLTQVVWLWLGTQSFVFQHEEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTIFSTQDFLTLFYTLRAYARGLRLEFTTYLFGQDS

Gene
Sigmar1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Rattus norvegicus
Length
223 amino acids
Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
25.27 kDa
Sequence
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP

Gene
SIGMAR1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Taricha granulosa
Length
223 amino acids
Function
May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
24.848 kDa
Sequence
MAVLSSRAMRAALGLAVLAVVIQLLRTWLSSKSYLFNQKDIAELAKQHAGMDFEVAFSKIIVELRKKHPGHILPDEDLQWIFVNAGGWMGSMCLLHASLTEYILLFGTAIDTGGHSGRYWADISDTVITGTFRQWKEGTTKSEVFYPGDTIVHVAGEATSVHWSGGTWMVEYGRGFIPSTMGFALADTIFSTQDFCTLFYTFRIYARCLLLETHTYLSELGLS

Gene
SIGMAR1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Trichosurus vulpecula
Length
223 amino acids
Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
25.263 kDa
Sequence
MQWAAGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDS

Gene
SIGMAR1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Gallus gallus
Length
222 amino acids
Function
May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
24.602 kDa
Sequence
MGVAGPWVLRVGLGLGAFALLLQGLRGWLACKRYEFQPAEIAELARHHAGLDHELAFSKIIVELRKKHPGHILPDEDLQWVFVNAGGWMGSMCLLHASLTEYVLLFGTAIDTGGHSGRYWAEIYDTIISGTFRQWKEGTTRSEIYYPGDTIVHQAGEATSVQWSAGTWMVEYGRGFVPSTLAFALADTLFSTQDFITLFYTLRAYTKGLLLEASAFFSTLGC

Gene
sigmar1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Danio rerio
Length
222 amino acids
Function
May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
24.941 kDa
Sequence
MSLIRTILKLVVVVGFLSLTVQFIRHWMANKQYVFTKEEVAKLAKQYAGQDHEQAFSKVVVELRRRYPGHILPDEDLQWVFVNAGGWMGSMCLLHASLTEYVLLFGTAVDTGGHSGRYWAEISDTIISGTFRQWKEGTTKSETYYPGDTIVHSAGEATSVQWSSGTWMVEYGRGFIPSTLGFALADTMFSTQDFLTLFYTARVYVKGMILEASTFLTESGVL

Gene
sigmar1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Xenopus laevis
Length
221 amino acids
Function
May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
24.695 kDa
Sequence
MALWLGLRAVLVVAGLAVLLQLIRGWLSSKSYVFNREEIARLAKEHSGLDYEVAFSKIIVELRKKHPGHILQDEDLQWVFVNAGGWMGSMCLLHASLTEYVLLFGTAVDTGGHSGRYWAEISDTILSGTFRQWKEGTTKSEIFYPGDTIVHEVGEATSVQWSSGTWMVEYGRGFIPSTLAFALADTIFSTQDFLTLFYTVKVYSKALLLEASTHLSQLGFF

Gene
sigmar1
Protein
Sigma non-opioid intracellular receptor 1
Organism
Xenopus tropicalis
Length
221 amino acids
Function
May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
Similarity
Belongs to the ERG2 family.
Mass
24.601 kDa
Sequence
MALWRGLRAVLAVAGLAVAVQLLRGWLGSKSYVFNREEIARLAKEHSGLDYEVAFSKIITELRKKHPGRILPDEDLQWVFVNAGGWMGSMCLLHASLTEYVLLFGTAVDTSGHSGRYWAEISDTILSGTFRQWKEGSTKSEIFYPGDTIVHEVGEATSVQWSAGTWMVEYGRGFIPSTLGFALADTIFSTQDFLTLFYTVKVYGKALLLETSTHLSELGFF