About Products Protein Database Contact

SHLD2

Gene
SHLD2
Protein
Shieldin complex subunit 2
Organism
Pongo abelii
Length
904 amino acids
Function
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
Similarity
Belongs to the SHLD2 family.
Mass
101.802 kDa
Sequence
MSGGSQVHIFWGAPVAPLKMTVSQDTASLMSVADPWKKIHLLYSQHSLYLKDEKQHKNLENYEVPESVGSPDFSGHFLANCMNRHVHVKDDFVRSVSETQNIESQNIHSSRLSDITSSNMQICGFKSTVPHLTEEEKYQKLLSENKIIDEQPKHQSDICGQNFNTNLFQLGHKCAAMLDLVCSTEQINIGPEVVQRECVSTEYHEIQNQCLGLFSSNAVDKSRSEAAVRKASDLKISTDTEFLSIITSSQVAFLAQKKDKGRSPINKGNVNMETEPKASYREIRIPEENSIQLDGFTEAYEGGQNQAYSLELFSPVCRKTENSRIHINSDKGLEEHIGSQELFNSEDKLPPNEIHIELCSSGILCSQLNTFHKSAIKRSCTSEDKVGQSEALSRVLQVAKKMKLISNGGDSAVEMDRRNVSEFKGIKKTSLIKNCDSKSQKYNCLVMVLSPCHVKEINIKFGPNSGSKVPLATVTVIDQSETKKKVFLWRTAAFWAFTVFLGDIILLTDVVIREDQWVGETVLQSTFSSQLLNLGSYSSIQPEEYSSVVSDVVLQDLLAYVSSKHSYLRDLPPRQPQRVNSIDFVELEHLQPDVLVHAVLRVVDFTILTEAVYSYRGQKQKKVMLTVEQAQDQHYVLVLWGPGAAWYPQLQRKKGYIWEFKYLFVQRNYTLENLELHTTPWSSCECLFNDDIRAITFKAKFQKSAPSFVKIPDLATHLEDKCSGVVLIQAQISELAFPITAAQKIALNAHSSLKSIFSSLPNIVYTGCAKCGLELETDENRIYKQCFSCLPFTMKKIYYRPALMTVVDGRHDVCIRVESKLIEKILLNISADCLNRVIVPSSEITYGMVVADLFHSLLAVSAEPCVLKIQSLFVLDENSYPLQQDFSLLDFYSDIVKHGADARL

Gene
Shld2
Protein
Shieldin complex subunit 2
Organism
Mus musculus
Length
891 amino acids
Function
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
Similarity
Belongs to the SHLD2 family.
Mass
99.09 kDa
Sequence
MSQGSQVHIFLGAPVAPLKTTVSQGTASLMSTANAWEKVRLFYKQHSLYLKAGDQEFKNLEDCQVPKGLGPPGLLSGDVLTTSVRRSAQVDEDFKHSASEAQSVKSQVNLSDMTSGQMCGLGDGVQHLPEEEKDQKLQCKNKKITDEQSKNQSDPCVRNFQRDLFALDLKCAAKLDLGCCTEQMSTGTKPEPTGHRERQSQESFSDTRCEPQSEGAVRKASDQRLSAEAEFLSVLTSSQRAFLAQGNDKGQDCINKSTVNMEAEPTGSQGVRRTEGDFSKPGGDFEEESENEQSQVYSLELFSPVCPESESSHSHINPGKNLENTSSQELFSNEENLPPNELCSSHPSTANRSWSCKDDSHHSKALSEVHQVSKKPRMDSNIREAAKAVPQRVMSELKDSKKISLIKNCDSKNQKYNCLVMVLTPCHVKEITIKSGPNSGSKVPLATIVVIDQSEIKKRVVLWRTAAFGALTVFLGDIILLTDVVLYEDQWIGETVLQSTFTSQLLNLGSYSYVQPEKYSNVIANVILQDLLTYVSTKHSYLKDLPQRQPQKMNTVEFVELEQLQPDILVHAVLRVVDVTVLTEALYSYRGQKQRKVVLTVEQAQGQHYVLVLWGPGAAWYTQLQRKKDSIWEFKYLFVQRNSILENLELHTTLWSSCECLFDDDTRAISFKTKFQKNTSSFVKISDLATHLEDKYSGVVLIKAKVSELVFSAAAAQKIALNARSTLQSIFSSLPSIVYAGCAHCGSELETDENRIYRQCLSCLPFVGKKIFYRPALMTIVDGRYNTCVHVGSKMMEQILLNISPDCLNRVIVPSSEVTYGMVASDLLHSLLAVSAEPCVLKIQSLFELDENSYPLQQDFSLLDFCPDSRKLWSPGLSLRAEGTGGIPGKE

Gene
SHLD2
Protein
Shieldin complex subunit 2
Organism
Homo sapiens
Length
835 amino acids
Function
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).
Similarity
Belongs to the SHLD2 family.
Mass
93.705 kDa
Sequence
MSGGSQVHIFWGAPIAPLKITVSEDTASLMSVADPWKKIQLLYSQHSLYLKDEKQHKNLENYKVPESIGSPDLSGHFLANCMNRHVHVKDDFVRSVSETQNIESQKIHSSRLSDITSSNMQICGFKSTVPHFTEEEKYQKLLSENKIRDEQPKHQPDICGKNFNTNLFQLGHKCAAVLDLVCSTEKINIGPEVVQRECVPTEYHEIQNQCLGLFSSNAVDKSRSEAAVRKVSDLKISTDTEFLSIITSSQVAFLAQKKDKRRSPVNKGNVNMETEPKASYGEIRIPEENSIQLDGFTEAYESGQNQAYSLELFSPVCPKTENSRIHINSDKGLEEHTGSQELFSSEDELPPNEIRIELCSSGILCSQLNTFHKSAIKRSCTSEDKVGQSEALSRVLQVAKKMKLISNGGDSAVEMDRRNVSEFKSIKKTSLIKNCDSKSQKYNCLVMVLSPCHVKEINIKFGPNSGSKVPLATVTVIDQSETKKKVFLWRTAAFWAFTVFLGDIILLTDVVIHEDQWIGETVLQSTFSSQLLNLGSYSSIQPEEYSSVVSEVVLQDLLAYVSSKHSYLRDLPPRQPQRVNSIDFVELEHLQPDVLVHAVLRVVDFTILTEAVYSYRGQKQKKVMLTVEQAQDQHYALVLWGPGAAWYPQLQRKKGVVLIKAQISELAFPITASQKIALNAHSSLKSIFSSLPNIVYTGCAKCGLELETDENRIYKQCFSCLPFTMKKIYYRPALMTAIDGRHDVCIRVESKLIEKILLNISADCLNRVIVPSSEITYGMVVADLFHSLLAVSAEPCVLKIQSLFVLDENSYPLQQDFSLLDFYPDIVKHGANARL