Protein
Odorant receptor coreceptor
Function
Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Plays a key role in preferred attraction of females for humans over non-human hosts for blood feeding. Human attraction plays a crucial role in the transmission of dengue and yellow fever by the mosquito. Also required for the response to the insect repellent IR3535; or to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide.
Similarity
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily.
Sequence
MNVQPTKYHGLVLDLMPNIRLMQGFGHFLFRYVNGPVLIRKLYSWWNLIMILLQYFAIMGNLVMNTGDVNELTANTITTLFFTHSVTKFIYVAVNSEHFYRTLGIWNQPNSHSLFAESDARYHSIALAKMRKLLVMVMVTTVLSVVAWITITFFGDSVKNVFDKETNETYTVEIPRLPIKAWYPWDAMSGVPYFFSFIYQAYFLLFSMCQANLADVMFCSWLLFTCEQLQHLKGIMRPLMELSATLDTYRPNSAALFRVASAGSKSELILNEEKDPDTKDFDLNGIYNSKADWGAQFRAPSTLQTFGDNGINGNPNGLTKKQELMVRSAIKYWVERHKHVVRLVSAIGETYGAALLLHMLTSTIKLTLLAYQATKIDALNVYGLTVIGYLVYALAQVFLFCIFGNRLIEESSSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMTISGAKFFTVSLDLFASVLGAVVTYFMVLVQLK