Protein
Suppressor of ferric uptake 1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Function
Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice.
Sequence
MPTSPTESIPNSSTKEQPILPKMLPTAKSPHTTPAQSPQNSDHHHHHQQTPPQPTDGQQCSNCGTTKTPLWRRAPDGTLICNACGLYYRSNNTHRPVNLKRPPNTIAVVKEEEGSCKGDGRCNGTGGSAACKGCPAYNNRIVAKKALEKSPKNDSSRAPIDKSLKRSTSTDATTEDESSLAIACFNCGTTITPLWRRDDAGNTICNACGLFYRLHGSHRPIKMKRPTIKRRKRNVSDKKSKDEVQMHSSDQSPIVASDPISPTPHNNENNNNVTNITTTTKTPTRSPHYYQPPPQYPYQHHPINSTTSSAINRLPPISYQSPYQTAPLSHSPMQSSSSYSPGASSVIPSSYYPPYSGSGRIPNGPGPVPGPPPPPPPTQSQPHHQQITTSPTSQSYGSLRAPIHITKRGYTPENIRLPSIQLTSSTSSNSETKLPPITNHSEKCCSNCAGPKSLAPMAIDFTASYRFNNIDSQTKLTKEDQNDSEGVSRDNDTRDENKPIKQEEHRSALSIGKLLNG