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SF3B5

Gene
sf3b5
Protein
Splicing factor 3B subunit 5
Organism
Dictyostelium discoideum
Length
94 amino acids
Function
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.
Similarity
Belongs to the SF3B5 family.
Mass
10.709 kDa
Sequence
MSERESLNSQLEHLQMRYVGTGHADISKHEWLTNQHRDSLSSFIGHSSFLSLFSIAENESVGRVRYNTLTKMISPCGPAPKIKDNTMDKEEKND
Protein
Splicing factor 3B subunit 5: sf3b5

Gene
SF3B5
Protein
Splicing factor 3B subunit 5
Organism
Bos taurus
Length
86 amino acids
Function
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.
Similarity
Belongs to the SF3B5 family.
Mass
10.135 kDa
Sequence
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPCGPPADKPEEN
Protein
Splicing factor 3B subunit 5: SF3B5

Gene
SF3B5
Protein
Splicing factor 3B subunit 5
Organism
Homo sapiens
Length
86 amino acids
Function
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).
Similarity
Belongs to the SF3B5 family.
Mass
10.135 kDa
Sequence
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPCGPPADKPEEN
Protein
Splicing factor 3B subunit 5: SF3B5

Gene
Sf3b5
Protein
Splicing factor 3B subunit 5
Organism
Mus musculus
Length
86 amino acids
Function
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.
Similarity
Belongs to the SF3B5 family.
Mass
10.119 kDa
Sequence
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPSGPPADKPEEN
Protein
Splicing factor 3B subunit 5: Sf3b5

Gene
Sf3b5
Protein
Splicing factor 3B subunit 5
Organism
Drosophila melanogaster
Length
85 amino acids
Function
Involved in pre-mRNA splicing as component of spliceosome (PubMed:27185460, PubMed:18981222). As part of the spliceosome complex, plays a role in the regulation of spermatogonial differentiation (PubMed:27035939). When associated with the SAGA transcription regulatory histone acetylation (HAT) complex, might be involved in the transcriptional activation of a subset of SAGA-regulated genes (PubMed:27185460).
Similarity
Belongs to the SF3B5 family.
Mass
9.971 kDa
Sequence
MGERYNIHSQLEHLQSKYIGTGHADTTKFEWLTNQHRDSLASYMGHYDILNYFAIAENESKARVRFNLMERMLQPCGPPPEKLED
Protein
Splicing factor 3B subunit 5: Sf3b5